Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1

Genes and Development

Volumn 10, Issue 18, 1996, Pages 2335-2347

  Brass, Abraham L ^a   Kehrli, Eli ^a   Eisenbeis, Charles F ^a   Storb, Ursula ^a   Singh, Harinder ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Ets; Immunoglobulin; IRF; ternary complex; transcription factor

Indexed keywords

MUTANT PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; DNA TRANSFECTION; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN;

EID: 0029763203     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.18.2335     Document Type: Article

References (50)

1. Beg, A.A., S.M. Ruben, R.I. Scheinman, S. Haskill, C.A. Rosen, and A.S. Baldwin Jr. 1992. IκB interacts with the nuclear localization sequences of the subunits of NF-κB: A mechanism for cytoplasmic retention. Genes & Dev. 6: 1899-19213.
2. Bender, A. and G.F. Sprague. 1987. MATα1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes. Cell 50: 681-691.
3. Bluyssen, A., R. Vlietstra, A. Van Der Made, and J. Trapman. 1994. The interferon-stimulated gene 54 K promoter contains two adjacent functional interferon-stimulated response elements of different strength, which act synergistically for maximal interferon-α inducibility. Eur. J. Biochem. 220: 395-402.
4. Bovolenta, C., P. Driggers, M. Marks, J. Medin, A. Politis, S. Vogel, D. Levy, K. Sakaguchi, E. Appella, J. Coligan, and K. Ozato. 1994. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc. Natl. Acad. Sci. 91: 5046-5050.
5. Dalton, S. and R. Treisman. 1992. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element, Cell 68: 597-612.
6. Defranco, A. 1993. B lymphocyte activation, In Fundamental immunology (ed. W.E. Paul), pp. 505-529. Raven Press Ltd., New York, NY.
7. Driggers, P., D. Ennist, S. Gleason, W.-H. Mak, M. Marks, B.-Z. Levi, J. Flanagan, E. Appella, and K. Ozato. 1990. An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. 87: 3743-3747.
8. Eisenbeis, C., H. Singh, and U. Storb. 1993. PU. 1 is a component of a multi-protein complex which binds an essential site in the murine immunoglobulin λ 2-4 enhancer. Mol. Cell. Biol. 13: 6452-6461.
9. _. 1995. Pip, a novel IRF family member, is a lymphoid-specific, PU. 1-dependent transcriptional activator. Genes & Dev. 9: 1377-1387.
10. Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I.A. Wilson, R.A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell. Biol. 8: 2159-2165.
11. Friedman, R., T. Merigan, and T. Sreevalsan. 1986. Interferons as cell growth inhibitors and antitumor factors. Alan R. Liss, New York, NY.
12. Fujita, T., Y. Kimura, M. Miyamoto, L. Barsoumian, and T. Taniguchi. 1989. Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1. Nature 337: 270-272.
13. Galson, D., J. Hensold, T. Bishop, M. Schalling, A. D'Andrea, C. Jones, P. Auron, and D. Housman. 1993. Mouse β-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and testis. Mol. Cell. Biol. 13: 2929-2941.
14. Garnier, J., D.J. Osguthorpe, and B. Robson. 1978. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol Biol. 120: 97-120.
15. Cashier, A., S. Swaminathan, and V. Sukhatme. 1993. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol. Cell. Biol. 13: 4556-4571.
16. Gorman, C.M., L.F. Moffat, and B.H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2: 1044-1051.
17. Harada, H., T. Fujita, M. Miyamoto, Y. Kimura, M. Maruyama, A. Furia, T. Miyata, and T. Taniguchi. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN-β and IFN-inducible genes. Cell 58: 729-739.
18. Harada, H., K. Willison, J. Sakakibara, M. Miyamoto, T. Fujita, and T. Taniguchi. 1990. Absence of the type 1 IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell 63: 303-312.
19. κ joining. Cell 83: 1113-1123.
20. Ho, S., H. Hunt, R. Horton, J. Pullen, and L. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77: 51-59.
21. Jonsen, M., J. Petersen, Q.-P. Xu, and B. Graves. 1996. Characterization of the cooperative function of inhibitory sequences in ets-1. Mol. Cell. Biol. 16: 2065-2073.
22. Judde, J. and E. Max. 1992. Characterization of the human immunoglobulin kappa gene 3′ enhancer: Functional importance of three motifs that demonstrate B-cell-specific in vivo footprints. Mol. Cell. Biol. 12: 5206-5216.
23. Katan, M., A. Haigh, C.P. Verrijer, P.C. van der Vliet, and P. O'Hare. 1990. Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex. Nucleic Acids Res. 18: 6871-6880.
24. Klemsz, M., S. McKercher, A. Celada, C. Van Beveren, and R. Maki. 1990. The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene. Cell 61: 113-124.
25. Kristie, T.M., J.H. LeBowitz, and P.A. Sharp. 1989. The octamer-binding proteins form multi-protein-DNA complexes with the HSV alpha TIF regulatory protein. EMBO J. 8: 4229-4238.
26. Lillie, J. and M. Green. 1989. Transcription activation by the adenovirus E1a protein. Nature 338: 39-44.
27. McKnight, S. 1996. Transcription revisited: A commentary on the 1995 Cold Spring Harbor Laboratory meeting, "Mechanisms of eukaryotic transcription". Genes & Dev. 10: 367-348.
28. McKnight, S. and Y. Yamamoto. 1992. Transcriptional regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Maniatis, T., S. Goodbourn, and J.A. Fisher. 1987. Regulation of inducible and tissue-specific gene expression. Science 236: 1237-1245.
30. Matsuyama, T., A. Grossman, H.-W. Mittrucker, D. Siderovski, F. Kiefer, T. Kawakami, C.D. Richardson, T. Taniguchi, S. Yoshinaga, and T. Mak. 1995. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res. 23: 2127-2136.
31. Nelson, N., M. Marks, P. Driggers, and K. Ozato. 1993. Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Mol. Cell. Biol. 13: 588-599.
32. Olson, M., E. Scott, A. Hack, G. Su, D. Tenen, H. Singh, and M. Simon. 1995. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 3: 703-714.
33. Parker, D., K. Ferreri, T. Nakajima, V. LaMorte, R. Evans, S. Koerber, C. Hoeger, and M. Montminy. 1996. Phosphorylation of CREB at ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16: 694-703.
34. Peterson, J.M., J.J. Skalicky, L.W. Donaldson, L.P. McIntosh, T. Alber, and B.J. Graves. 1995. Modulation of transcription factor ets-1 DNA binding: DNA-induced unfolding of an a helix. Science 269: 1866-1869.
35. Pongubala, J., S. Nagulapalli, M. Klemsz, S. McKercher, R. Maki, and M. Atchison. 1992. PU.1 recruits a second nuclear factor to a site important for immunoglobulin κ 3′ enhancer activity. Mol. Cell. Biol. 12: 368-378.
36. Pongubala, J., C. Van Beveren, S. Nagulapalli, M. Klemsz, S. McKercher, R. Maki, and M. Atchison. 1993. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259: 1622-1625.
37. Roberts, S. and M. Green. 1995. Dichotomous regulators. Nature 375: 105-106.
38. Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152: 704-720.
39. Schindler, C. and J. Darnell. 1995. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu. Rev. Biochem. 64: 621-651.
40. Scott, E., M. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573-1577.
41. Serwe, M. and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12: 2321-2327.
42. Sharf, R., A. Azriel, F. Lejbkowicz, S. Winograd, R. Ehrlich, and B.Z. Levi. 1995. Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. J. Biol. Chem. 270: 13063-13069.
43. Shin, M. and M. Koshland. 1993. Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes & Dev. 7: 2006-2015.
44. Staudt, L. and M. Lenardo. 1991. Immunoglobulin gene transcription. Annu. Rev. Immunol. 9: 373-398.
45. Taniguchi, T., H. Harada, and M. Lamphier. 1995. Regulation of the interferon system and cell growth by the IRF transcription factors. J. Cancer Res. Clin. Oncol. 121: 516-520.
46. Thornton, A.M., R.M. Buller, A.L. DeVico, I.M. Wang, and K. Ozato. 1996. Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by dominant negative factor of the interferon regulatory factor family expressed in monocytic cells. Proc. Natl. Acad. Sci. 93: 383-387.
47. Veals, S., C. Schindler, D. Leonard, X.-Y. Fu, R. Aebersold, J. Darnell, and D. Levy. 1992. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and myb families of DNA-binding proteins. Mol. Cell Biol. 12: 3315-3324.
48. Veals, S., T. Santa Maria, and D. Levy. 1993. Two domains of ISGF3λ that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity. Mol. Cell. Biol. 13: 196-206.
49. κ rearrangement. Immunity 4: 377-385.
50. Yamagata, T., J. Nishida, T. Tanaka, R. Sakai, K. Mitani, M. Yoshida, T. Taniguchi, Y. Yazaki, and H. Hirai. 1996. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol. Cell. Biol. 16: 1283-1294.