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Volumn 2, Issue 11, 2011, Pages 609-632

DISC1: Structure, function, and therapeutic potential for major mental illness

Author keywords

bioinformatics; DISC1; GSK3 ; schizophrenia; structure; therapeutic potential

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3; NEUROLEPTIC AGENT; PHOSPHODIESTERASE IV;

EID: 81455155113     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200062k     Document Type: Review
Times cited : (98)

References (200)
  • 1
    • 0034927864 scopus 로고    scopus 로고
    • Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family
    • DOI 10.1086/321969
    • Blackwood, D. H., Fordyce, A., Walker, M. T., St Clair, D. M., Porteous, D. J., and Muir, W. J. (2001) Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family Am. J. Hum. Genet. 69, 428-433 (Pubitemid 32695214)
    • (2001) American Journal of Human Genetics , vol.69 , Issue.2 , pp. 428-433
    • Blackwood, D.H.R.1    Fordyce, A.2    Walker, M.T.3    St Clair, D.M.4    Porteous, D.J.5    Muir, W.J.6
  • 4
    • 84856118476 scopus 로고    scopus 로고
    • DISC1-binding proteins in neural development, signalling and schizophrenia
    • published online Jan 5, 2011. DOI: 10.1016/j.neuropharm.2010.12.027.
    • Bradshaw, N. J. and Porteous, D. J. (2011) DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology, published online Jan 5, 2011. DOI: 10.1016/j.neuropharm.2010.12.027.
    • (2011) Neuropharmacology
    • Bradshaw, N.J.1    Porteous, D.J.2
  • 5
    • 77950619538 scopus 로고    scopus 로고
    • DISCopathies: Brain disorders related to DISC1 dysfunction
    • Korth, C. (2009) DISCopathies: brain disorders related to DISC1 dysfunction Rev. Neurosci. 20, 321-330
    • (2009) Rev. Neurosci. , vol.20 , pp. 321-330
    • Korth, C.1
  • 7
    • 33745599448 scopus 로고    scopus 로고
    • Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus
    • DOI 10.1007/s00702-005-0414-1
    • Chiba, S., Hashimoto, R., Hattori, S., Yohda, M., Lipska, B., Weinberger, D. R., and Kunugi, H. (2006) Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus J. Neural Transm. 113, 1337-1346 (Pubitemid 44291026)
    • (2006) Journal of Neural Transmission , vol.113 , Issue.9 , pp. 1337-1346
    • Chiba, S.1    Hashimoto, R.2    Hattori, S.3    Yohda, M.4    Lipska, B.5    Weinberger, D.R.6    Kunugi, H.7
  • 10
    • 84856116236 scopus 로고    scopus 로고
    • Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice
    • published online Mar 2, 2011. DOI: 10.1016/j.neuropharm.2011.02.020.
    • Lipina, T. V., Wang, M., Liu, F., and Roder, J. C. (2011) Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology, published online Mar 2, 2011. DOI: 10.1016/j.neuropharm.2011.02.020.
    • (2011) Neuropharmacology
    • Lipina, T.V.1    Wang, M.2    Liu, F.3    Roder, J.C.4
  • 15
    • 43049167463 scopus 로고    scopus 로고
    • Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
    • Leliveld, S. R., Bader, V., Hendriks, P., Prikulis, I., Sajnani, G., Requena, J. R., and Korth, C. (2008) Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease J. Neurosci. 28, 3839-3845
    • (2008) J. Neurosci. , vol.28 , pp. 3839-3845
    • Leliveld, S.R.1    Bader, V.2    Hendriks, P.3    Prikulis, I.4    Sajnani, G.5    Requena, J.R.6    Korth, C.7
  • 17
    • 0037289166 scopus 로고    scopus 로고
    • Evolutionary constraints on the Disrupted in Schizophrenia locus
    • DOI 10.1016/S0888-7543(02)00026-5
    • Taylor, M. S., Devon, R. S., Millar, J. K., and Porteous, D. J. (2003) Evolutionary constraints on the Disrupted in Schizophrenia locus Genomics 81, 67-77 (Pubitemid 36263360)
    • (2003) Genomics , vol.81 , Issue.1 , pp. 67-77
    • Taylor, M.S.1    Devon, R.S.2    Millar, J.K.3    Porteous, D.J.4
  • 18
    • 12244278574 scopus 로고    scopus 로고
    • Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1)
    • DOI 10.1006/geno.2002.7012
    • Ma, L., Liu, Y., Ky, B., Shughrue, P. J., Austin, C. P., and Morris, J. A. (2002) Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1) Genomics 80, 662-672 (Pubitemid 36062653)
    • (2002) Genomics , vol.80 , Issue.6 , pp. 662-672
    • Ma, L.1    Liu, Y.2    Ky, B.3    Shughrue, P.J.4    Austin, C.P.5    Morris, J.A.6
  • 19
    • 0001514262 scopus 로고
    • Statistics of Local Complexity in Amino-Acid-Sequences and Sequence Databases
    • Wootton, J. C. and Federhen, S. (1993) Statistics of Local Complexity in Amino-Acid-Sequences and Sequence Databases Comput. Chem. 17, 149-163
    • (1993) Comput. Chem. , vol.17 , pp. 149-163
    • Wootton, J.C.1    Federhen, S.2
  • 21
    • 13844255387 scopus 로고    scopus 로고
    • Natively unfolded proteins
    • DOI 10.1016/j.sbi.2005.01.002
    • Fink, A. L. (2005) Natively unfolded proteins Curr. Opin. Struct. Biol. 15, 35-41 (Pubitemid 40249507)
    • (2005) Current Opinion in Structural Biology , vol.15 , Issue.SPEC. ISS.1 , pp. 35-41
    • Fink, A.L.1
  • 22
    • 0033578684 scopus 로고    scopus 로고
    • Protein secondary structure prediction based on position-specific scoring matrices
    • DOI 10.1006/jmbi.1999.3091
    • Jones, D. T. (1999) Protein secondary structure prediction based on position-specific scoring matrices J. Mol. Biol. 292, 195-202 (Pubitemid 29435759)
    • (1999) Journal of Molecular Biology , vol.292 , Issue.2 , pp. 195-202
    • Jones, D.T.1
  • 23
    • 44349192171 scopus 로고    scopus 로고
    • Prediction of disordered regions in proteins based on the meta approach
    • DOI 10.1093/bioinformatics/btn195
    • Ishida, T. and Kinoshita, K. (2008) Prediction of disordered regions in proteins based on the meta approach Bioinformatics 24, 1344-1348 (Pubitemid 351737139)
    • (2008) Bioinformatics , vol.24 , Issue.11 , pp. 1344-1348
    • Ishida, T.1    Kinoshita, K.2
  • 24
    • 0034044314 scopus 로고    scopus 로고
    • The PSIPRED protein structure prediction server
    • McGuffin, L. J., Bryson, K., and Jones, D. T. (2000) The PSIPRED protein structure prediction server Bioinformatics 16, 404-405 (Pubitemid 30417087)
    • (2000) Bioinformatics , vol.16 , Issue.4 , pp. 404-405
    • McGuffin, L.J.1    Bryson, K.2    Jones, D.T.3
  • 25
    • 33750011578 scopus 로고    scopus 로고
    • Primate disrupted-in-schizophrenia-1 (DISC1): High divergence of a gene for major mental illnesses in recent evolutionary history
    • DOI 10.1016/j.neures.2006.07.010, PII S0168010206001854
    • Bord, L., Wheeler, J., Paek, M., Saleh, M., Lyons-Warren, A., Ross, C. A., Sawamura, N., and Sawa, A. (2006) Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history Neurosci. Res. 56, 286-293 (Pubitemid 44572537)
    • (2006) Neuroscience Research , vol.56 , Issue.3 , pp. 286-293
    • Bord, L.1    Wheeler, J.2    Paek, M.3    Saleh, M.4    Lyons-Warren, A.5    Ross, C.A.6    Sawamura, N.7    Sawa, A.8
  • 26
    • 1542358787 scopus 로고    scopus 로고
    • Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life
    • DOI 10.1016/j.jmb.2004.02.002, PII S0022283604001482
    • Ward, J. J., Sodhi, J. S., McGuffin, L. J., Buxton, B. F., and Jones, D. T. (2004) Prediction and functional analysis of native disorder in proteins from the three kingdoms of life J. Mol. Biol. 337, 635-645 (Pubitemid 38326883)
    • (2004) Journal of Molecular Biology , vol.337 , Issue.3 , pp. 635-645
    • Ward, J.J.1    Sodhi, J.S.2    McGuffin, L.J.3    Buxton, B.F.4    Jones, D.T.5
  • 27
    • 0037766786 scopus 로고    scopus 로고
    • DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: Regulation and loss of interaction with mutation
    • DOI 10.1093/hmg/ddg162
    • Morris, J. A., Kandpal, G., Ma, L., and Austin, C. P. (2003) DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation Hum. Mol. Genet. 12, 1591-1608 (Pubitemid 36857306)
    • (2003) Human Molecular Genetics , vol.12 , Issue.13 , pp. 1591-1608
    • Morris, J.A.1    Kandpal, G.2    Ma, L.3    Austin, C.P.4
  • 28
    • 0242437914 scopus 로고    scopus 로고
    • Yeast two-hybrid screens implicate DISC1 in brain development and function
    • DOI 10.1016/j.bbrc.2003.10.101
    • Millar, J. K., Christie, S., and Porteous, D. J. (2003) Yeast two-hybrid screens implicate DISC1 in brain development and function Biochem. Biophys. Res. Commun. 311, 1019-1025 (Pubitemid 37393421)
    • (2003) Biochemical and Biophysical Research Communications , vol.311 , Issue.4 , pp. 1019-1025
    • Millar, J.K.1    Christie, S.2    Porteous, D.J.3
  • 30
    • 33845748185 scopus 로고    scopus 로고
    • Disrupted in Schizophrenia 1 interactome: Evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    • DOI 10.1038/sj.mp.4001880, PII 4001880
    • Camargo, L. M., Collura, V., Rain, J. C., Mizuguchi, K., Hermjakob, H., Kerrien, S., Bonnert, T. P., Whiting, P. J., and Brandon, N. J. (2007) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia Mol. Psychiatry 12, 74-86 (Pubitemid 44973664)
    • (2007) Molecular Psychiatry , vol.12 , Issue.1 , pp. 74-86
    • Camargo, L.M.1    Collura, V.2    Rain, J.-C.3    Mizuguchi, K.4    Hermjakob, H.5    Kerrien, S.6    Bonnert, T.P.7    Whiting, P.J.8    Brandon, N.J.9
  • 33
    • 33847081239 scopus 로고    scopus 로고
    • Role of intrinsic disorder in transient interactions of hub proteins
    • Singh, G. P., Ganapathi, M., and Dash, D. (2007) Role of intrinsic disorder in transient interactions of hub proteins Proteins 66, 761-765
    • (2007) Proteins , vol.66 , pp. 761-765
    • Singh, G.P.1    Ganapathi, M.2    Dash, D.3
  • 34
    • 27144464910 scopus 로고    scopus 로고
    • Flexible nets: The roles of intrinsic disorder in protein interaction networks
    • DOI 10.1111/j.1742-4658.2005.04948.x
    • Dunker, A. K., Cortese, M. S., Romero, P., Iakoucheva, L. M., and Uversky, V. N. (2005) Flexible nets. The roles of intrinsic disorder in protein interaction networks FEBS J. 272, 5129-5148 (Pubitemid 41503146)
    • (2005) FEBS Journal , vol.272 , Issue.20 , pp. 5129-5148
    • Dunker, A.K.1    Cortese, M.S.2    Romero, P.3    Iakoucheva, L.M.4    Uversky, V.N.5
  • 35
    • 14644435825 scopus 로고    scopus 로고
    • Intrinsically unstructured proteins and their functions
    • DOI 10.1038/nrm1589
    • Dyson, H. J. and Wright, P. E. (2005) Intrinsically unstructured proteins and their functions Nat Rev. Mol. Cell Biol. 6, 197-208 (Pubitemid 40314921)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.3 , pp. 197-208
    • Dyson, H.J.1    Wright, P.E.2
  • 37
    • 34548389858 scopus 로고    scopus 로고
    • Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels
    • DOI 10.1523/JNEUROSCI.1493-07.2007
    • Murdoch, H., Mackie, S., Collins, D. M., Hill, E. V., Bolger, G. B., Klussmann, E., Porteous, D. J., Millar, J. K., and Houslay, M. D. (2007) Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels J. Neurosci. 27, 9513-9524 (Pubitemid 47358203)
    • (2007) Journal of Neuroscience , vol.27 , Issue.35 , pp. 9513-9524
    • Murdoch, H.1    Mackie, S.2    Collins, D.M.3    Hill, E.V.4    Bolger, G.B.5    Klussmann, E.6    Porteous, D.J.7    Millar, J.K.8    Houslay, M.D.9
  • 38
    • 0000920828 scopus 로고
    • The Packing of Alpha-Helices - Simple Coiled-Coils
    • Crick, F. H. C. (1953) The Packing of Alpha-Helices-Simple Coiled-Coils Acta Crystallogr. 6, 689-697
    • (1953) Acta Crystallogr. , vol.6 , pp. 689-697
    • Crick, F.H.C.1
  • 39
    • 0035252931 scopus 로고    scopus 로고
    • Coiled coils: A highly versatile protein folding motif
    • DOI 10.1016/S0962-8924(00)01898-5, PII S0962892400018985
    • Burkhard, P., Stetefeld, J., and Strelkov, S. V. (2001) Coiled coils: a highly versatile protein folding motif Trends Cell Biol. 11, 82-88 (Pubitemid 32144755)
    • (2001) Trends in Cell Biology , vol.11 , Issue.2 , pp. 82-88
    • Burkhard, P.1    Stetefeld, J.2    Strelkov, S.V.3
  • 40
    • 70350683807 scopus 로고    scopus 로고
    • CCHMM-PROF: A HMM-based coiled-coil predictor with evolutionary information
    • Bartoli, L., Fariselli, P., Krogh, A., and Casadio, R. (2009) CCHMM-PROF: a HMM-based coiled-coil predictor with evolutionary information Bioinformatics 25, 2757-2763
    • (2009) Bioinformatics , vol.25 , pp. 2757-2763
    • Bartoli, L.1    Fariselli, P.2    Krogh, A.3    Casadio, R.4
  • 41
    • 0026356891 scopus 로고
    • Predicting coiled coils from protein sequences
    • Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting coiled coils from protein sequences Science 252, 1162-1164 (Pubitemid 21917026)
    • (1991) Science , vol.252 , Issue.5009 , pp. 1162-1164
    • Lupas, A.1    Van Dyke, M.2    Stock, J.3
  • 42
    • 0035999986 scopus 로고    scopus 로고
    • An HMM model for coiled-coil domains and a comparison with PSSM-based predictions
    • Delorenzi, M. and Speed, T. (2002) An HMM model for coiled-coil domains and a comparison with PSSM-based predictions Bioinformatics 18, 617-625 (Pubitemid 34521050)
    • (2002) Bioinformatics , vol.18 , Issue.4 , pp. 617-625
    • Delorenzi, M.1    Speed, T.2
  • 43
    • 0030987407 scopus 로고    scopus 로고
    • MultiCoil: A program for predicting two- and three-stranded coiled coils
    • Wolf, E., Kim, P. S., and Berger, B. (1997) MultiCoil: a program for predicting two- and three-stranded coiled coils Protein Sci. 6, 1179-1189 (Pubitemid 27260152)
    • (1997) Protein Science , vol.6 , Issue.6 , pp. 1179-1189
    • Wolf, E.1    Kim, P.S.2    Berger, B.3
  • 44
    • 32144456009 scopus 로고    scopus 로고
    • Paircoil2: Improved prediction of coiled coils from sequence
    • DOI 10.1093/bioinformatics/bti797
    • McDonnell, A. V., Jiang, T., Keating, A. E., and Berger, B. (2006) Paircoil2: improved prediction of coiled coils from sequence Bioinformatics 22, 356-358 (Pubitemid 43205384)
    • (2006) Bioinformatics , vol.22 , Issue.3 , pp. 356-358
    • McDonnell, A.V.1    Jiang, T.2    Keating, A.E.3    Berger, B.4
  • 45
    • 23144450570 scopus 로고    scopus 로고
    • REPPER - Repeats and their periodicities in fibrous proteins
    • Gruber, M., Soding, J., and Lupas, A. N. (2005) REPPER-repeats and their periodicities in fibrous proteins Nucleic Acids Res. 33, W239-W243
    • (2005) Nucleic Acids Res. , vol.33
    • Gruber, M.1    Soding, J.2    Lupas, A.N.3
  • 47
    • 33747788700 scopus 로고    scopus 로고
    • Comparative analysis of coiled-coil prediction methods
    • DOI 10.1016/j.jsb.2006.03.009, PII S1047847706000815, Fibrous Protein Structure
    • Gruber, M., Soding, J., and Lupas, A. N. (2006) Comparative analysis of coiled-coil prediction methods J. Struct. Biol. 155, 140-145 (Pubitemid 44278640)
    • (2006) Journal of Structural Biology , vol.155 , Issue.2 , pp. 140-145
    • Gruber, M.1    Soding, J.2    Lupas, A.N.3
  • 51
    • 80052823280 scopus 로고    scopus 로고
    • Convergence of two independent mental disease genes on the protein level: Recruitment of dysbindin to cell-invasive DISC1 aggresomes
    • published online Apr 29, 2011. DOI: 10.1016/j.biopsych.2011.03.027.
    • Ottis, P., Bader, V., Trossbach, S. V., Kretzschmar, H., Michel, M., Leliveld, S. R., and Korth, C. (2011) Convergence of two independent mental disease genes on the protein level: Recruitment of dysbindin to cell-invasive DISC1 aggresomes. Biol. Psychiatry, published online Apr 29, 2011. DOI: 10.1016/j.biopsych.2011.03.027.
    • (2011) Biol. Psychiatry
    • Ottis, P.1    Bader, V.2    Trossbach, S.V.3    Kretzschmar, H.4    Michel, M.5    Leliveld, S.R.6    Korth, C.7
  • 53
    • 32044459935 scopus 로고    scopus 로고
    • Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat
    • DOI 10.1016/j.str.2005.10.010, PII S0969212606000463
    • Deng, Y., Liu, J., Zheng, Q., Eliezer, D., Kallenbach, N. R., and Lu, M. (2006) Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat Structure 14, 247-255 (Pubitemid 43202014)
    • (2006) Structure , vol.14 , Issue.2 , pp. 247-255
    • Deng, Y.1    Liu, J.2    Zheng, Q.3    Eliezer, D.4    Kallenbach, N.R.5    Lu, M.6
  • 54
    • 37849027790 scopus 로고    scopus 로고
    • Crystal structure of the leucine zipper domain of small-conductance Ca2+-activated K+ (SK(Ca)) channel from Rattus norvegicus
    • Kim, J. Y., Kim, M. K., Kang, G. B., Park, C. S., and Eom, S. H. (2008) Crystal structure of the leucine zipper domain of small-conductance Ca2+-activated K+ (SK(Ca)) channel from Rattus norvegicus Proteins 70, 568-571
    • (2008) Proteins , vol.70 , pp. 568-571
    • Kim, J.Y.1    Kim, M.K.2    Kang, G.B.3    Park, C.S.4    Eom, S.H.5
  • 56
    • 70349449896 scopus 로고    scopus 로고
    • Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif
    • Xu, Q. and Minor, D. L., Jr. (2009) Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif Protein Sci. 18, 2100-2114
    • (2009) Protein Sci. , vol.18 , pp. 2100-2114
    • Xu, Q.1    Minor Jr., D.L.2
  • 58
    • 17744391567 scopus 로고    scopus 로고
    • Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia
    • DOI 10.1038/sj.mp.4000784
    • Millar, J. K., Christie, S., Anderson, S., Lawson, D., Loh, D. H. W., Devon, R. S., Arveiler, B., Muir, W. J., Blackwood, D. H. R., and Porteous, D. J. (2001) Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia Mol. Psychiatry 6, 173-178 (Pubitemid 32187867)
    • (2001) Molecular Psychiatry , vol.6 , Issue.2 , pp. 173-178
    • Millar, J.K.1    Christie, S.2    Anderson, S.3    Lawson, D.4    Loh, D.H.-W.5    Devon, R.S.6    Arveiler, B.7    Muir, W.J.8    Blackwood, D.H.R.9    Porteous, D.J.10
  • 59
    • 2342539835 scopus 로고    scopus 로고
    • Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
    • DOI 10.1016/j.mcn.2004.01.013, PII S1044743104000259
    • James, R., Adams, R. R., Christie, S., Buchanan, S. R., Porteous, D. J., and Millar, J. K. (2004) Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria Mol. Cell. Neurosci. 26, 112-122 (Pubitemid 38581027)
    • (2004) Molecular and Cellular Neuroscience , vol.26 , Issue.1 , pp. 112-122
    • James, R.1    Adams, R.R.2    Christie, S.3    Buchanan, S.R.4    Porteous, D.J.5    Millar, J.K.6
  • 60
    • 0042622356 scopus 로고    scopus 로고
    • Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    • DOI 10.1038/sj.mp.4001352
    • Miyoshi, K., Honda, A., Baba, K., Taniguchi, M., Oono, K., Fujita, T., Kuroda, S., Katayama, T., and Tohyama, M. (2003) Disrupted-in-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth Mol. Psychiatry 8, 685-694 (Pubitemid 36976300)
    • (2003) Molecular Psychiatry , vol.8 , Issue.7 , pp. 685-694
    • Miyoshi, K.1    Honda, A.2    Baba, K.3    Taniguchi, M.4    Oono, K.5    Fujita, T.6    Kuroda, S.7    Katayama, T.8    Tohyama, M.9
  • 62
    • 79551529431 scopus 로고    scopus 로고
    • DISC1 and Huntington's Disease - Overlapping Pathways of Vulnerability to Neurological Disorder?
    • Boxall, R., Porteous, D. J., and Thomson, P. A. (2011) DISC1 and Huntington's Disease-Overlapping Pathways of Vulnerability to Neurological Disorder? PloS One 6, e16263
    • (2011) PloS One , vol.6 , pp. 16263
    • Boxall, R.1    Porteous, D.J.2    Thomson, P.A.3
  • 63
    • 77955389367 scopus 로고    scopus 로고
    • Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development
    • Young-Pearse, T. L., Suth, S., Luth, E. S., Sawa, A., and Selkoe, D. J. (2010) Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development J. Neurosci. 30, 10431-10440
    • (2010) J. Neurosci. , vol.30 , pp. 10431-10440
    • Young-Pearse, T.L.1    Suth, S.2    Luth, E.S.3    Sawa, A.4    Selkoe, D.J.5
  • 68
    • 77954504217 scopus 로고    scopus 로고
    • Dixdc1 is a critical regulator of DISC1 and embryonic cortical development
    • Singh, K. K., Ge, X., Mao, Y., Drane, L., Meletis, K., Samuels, B. A., and Tsai, L.-H. (2010) Dixdc1 is a critical regulator of DISC1 and embryonic cortical development Neuron 67, 33-48
    • (2010) Neuron , vol.67 , pp. 33-48
    • Singh, K.K.1    Ge, X.2    Mao, Y.3    Drane, L.4    Meletis, K.5    Samuels, B.A.6    Tsai, L.-H.7
  • 69
    • 27744442959 scopus 로고    scopus 로고
    • A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3
    • DOI 10.1016/j.bbrc.2005.10.013, PII S0006291X05022394
    • Ogawa, F., Kasai, M., and Akiyama, T. (2005) A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3 Biochem. Biophys. Res. Commun. 338, 771-776 (Pubitemid 41597710)
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , Issue.2 , pp. 771-776
    • Ogawa, F.1    Kasai, M.2    Akiyama, T.3
  • 70
    • 70349130726 scopus 로고    scopus 로고
    • DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    • Kim, J. Y., Duan, X., Liu, C. Y., Jang, M.-H., Guo, J. U., Pow-anpongkul, N., Kang, E., Song, H., and Ming, G.-l. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 Neuron 63, 761-773
    • (2009) Neuron , vol.63 , pp. 761-773
    • Kim, J.Y.1    Duan, X.2    Liu, C.Y.3    Jang, M.-H.4    Guo, J.U.5    Pow-Anpongkul, N.6    Kang, E.7    Song, H.8    Ming, G.-L.9
  • 82
    • 79955021466 scopus 로고    scopus 로고
    • Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling
    • Chen, S.-Y., Huang, P.-H., and Cheng, H.-J. (2011) Disrupted-in- Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling Proc. Natl. Acad. Sci. U.S.A. 108, 5861-5866
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 5861-5866
    • Chen, S.-Y.1    Huang, P.-H.2    Cheng, H.-J.3
  • 83
    • 23744517093 scopus 로고    scopus 로고
    • A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder
    • DOI 10.1038/sj.mp.4001667
    • Sachs, N. A., Sawa, A., Holmes, S. E., Ross, C. A., DeLisi, L. E., and Margolis, R. L. (2005) A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder Mol. Psychiatry 10, 758-764 (Pubitemid 41129048)
    • (2005) Molecular Psychiatry , vol.10 , Issue.8 , pp. 758-764
    • Sachs, N.A.1    Sawa, A.2    Holmes, S.E.3    Ross, C.A.4    DeLisi, L.E.5    Margolis, R.L.6
  • 84
    • 0027756896 scopus 로고
    • A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
    • Harbury, P. B., Zhang, T., Kim, P. S., and Alber, T. (1993) A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants Science 262, 1401-1407
    • (1993) Science , vol.262 , pp. 1401-1407
    • Harbury, P.B.1    Zhang, T.2    Kim, P.S.3    Alber, T.4
  • 85
    • 0027934571 scopus 로고
    • Crystal structure of an isoleucine-zipper trimer
    • DOI 10.1038/371080a0
    • Harbury, P. B., Kim, P. S., and Alber, T. (1994) Crystal structure of an isoleucine-zipper trimer Nature 371, 80-83 (Pubitemid 24277468)
    • (1994) Nature , vol.371 , Issue.6492 , pp. 80-83
    • Harbury, P.B.1    Kim, P.S.2    Alber, T.3
  • 87
    • 38649101571 scopus 로고    scopus 로고
    • Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia
    • Song, W., Li, W., Feng, J., Heston, L. L., Scaringe, W. A., and Sommer, S. S. (2008) Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia Biochem. Biophys. Res. Commun. 367, 700-706
    • (2008) Biochem. Biophys. Res. Commun. , vol.367 , pp. 700-706
    • Song, W.1    Li, W.2    Feng, J.3    Heston, L.L.4    Scaringe, W.A.5    Sommer, S.S.6
  • 88
    • 70350459011 scopus 로고    scopus 로고
    • Understanding the role of DISC1 in psychiatric disease and during normal development
    • Brandon, N. J., Millar, J. K., Korth, C., Sive, H., Singh, K. K., and Sawa, A. (2009) Understanding the role of DISC1 in psychiatric disease and during normal development J. Neurosci. 29, 12768-12775
    • (2009) J. Neurosci. , vol.29 , pp. 12768-12775
    • Brandon, N.J.1    Millar, J.K.2    Korth, C.3    Sive, H.4    Singh, K.K.5    Sawa, A.6
  • 90
    • 2942564430 scopus 로고    scopus 로고
    • Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
    • DOI 10.1002/pmic.200300771
    • Blom, N., Sicheritz-Ponten, T., Gupta, R., Gammeltoft, S., and Brunak, S. (2004) Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence Proteomics 4, 1633-1649 (Pubitemid 38738322)
    • (2004) Proteomics , vol.4 , Issue.6 , pp. 1633-1649
    • Blom, N.1    Sicheritz-Ponten, T.2    Gupta, R.3    Gammeltoft, S.4    Brunak, So.5
  • 91
    • 0033579464 scopus 로고    scopus 로고
    • Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
    • DOI 10.1006/jmbi.1999.3310
    • Blom, N., Gammeltoft, S., and Brunak, S. (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites J. Mol. Biol. 294, 1351-1362 (Pubitemid 30008805)
    • (1999) Journal of Molecular Biology , vol.294 , Issue.5 , pp. 1351-1362
    • Blom, N.1    Gammeltoft, S.2    Brunak, S.3
  • 96
    • 66249140566 scopus 로고    scopus 로고
    • DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release
    • Eastwood, S. L., Hodgkinson, C. A., and Harrison, P. J. (2009) DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release Mol. Psychiatry 14, 556-557
    • (2009) Mol. Psychiatry , vol.14 , pp. 556-557
    • Eastwood, S.L.1    Hodgkinson, C.A.2    Harrison, P.J.3
  • 97
    • 79151471696 scopus 로고    scopus 로고
    • Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons
    • Atkin, T. A., MacAskill, A. F., Brandon, N. J., and Kittler, J. T. (2011) Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons Mol. Psychiatry 16, 122-124
    • (2011) Mol. Psychiatry , vol.16 , pp. 122-124
    • Atkin, T.A.1    MacAskill, A.F.2    Brandon, N.J.3    Kittler, J.T.4
  • 104
    • 24044481269 scopus 로고    scopus 로고
    • Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
    • DOI 10.1016/j.neulet.2005.07.004, PII S0304394005007858
    • Thomson, P. A., Harris, S. E., Starr, J. M., Whalley, L. J., Porteous, D. J., and Deary, I. J. (2005) Association between genotype at an exonic SNP in DISC1 and normal cognitive aging Neurosci. Lett. 389, 41-45 (Pubitemid 41219431)
    • (2005) Neuroscience Letters , vol.389 , Issue.1 , pp. 41-45
    • Thomson, P.A.1    Harris, S.E.2    Starr, J.M.3    Whalley, L.J.4    Porteous, D.J.5    Deary, I.J.6
  • 105
    • 34247569983 scopus 로고    scopus 로고
    • Disrupted in Schizophrenia 1 Genotype and Positive Symptoms in Schizophrenia
    • DOI 10.1016/j.biopsych.2006.07.023, PII S0006322306009346, Multiple Genotypes and Brain Development in Schizophrenia
    • DeRosse, P., Hodgkinson, C. A., Lencz, T., Burdick, K. E., Kane, J. M., Goldman, D., and Malhotra, A. K. (2007) Disrupted in Schizophrenia 1 Genotype and Positive Symptoms in Schizophrenia Biol. Psychiatry 61, 1208-1210 (Pubitemid 46669457)
    • (2007) Biological Psychiatry , vol.61 , Issue.10 , pp. 1208-1210
    • DeRosse, P.1    Hodgkinson, C.A.2    Lencz, T.3    Burdick, K.E.4    Kane, J.M.5    Goldman, D.6    Malhotra, A.K.7
  • 106
    • 77955293516 scopus 로고    scopus 로고
    • The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain
    • Eastwood, S. L., Walker, M., Hyde, T. M., Kleinman, J. E., and Harrison, P. J. (2010) The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain Hum. Mol. Genet. 19, 2487-2496
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 2487-2496
    • Eastwood, S.L.1    Walker, M.2    Hyde, T.M.3    Kleinman, J.E.4    Harrison, P.J.5
  • 112
    • 77956507253 scopus 로고    scopus 로고
    • DISC1 regulates primary cilia that display specific dopamine receptors
    • Marley, A. and von Zastrow, M. (2010) DISC1 regulates primary cilia that display specific dopamine receptors PLoS One 5, e10902
    • (2010) PLoS One , vol.5 , pp. 10902
    • Marley, A.1    Von Zastrow, M.2
  • 113
    • 28344457312 scopus 로고    scopus 로고
    • Disrupted in Schizophrenia 1 (DISC1): Subcellular targeting and induction of ring mitochondria
    • DOI 10.1016/j.mcn.2005.08.021, PII S1044743105002198
    • Millar, J. K., James, R., Christie, S., and Porteous, D. J. (2005) Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria Mol. Cell. Neurosci. 30, 477-484 (Pubitemid 41721166)
    • (2005) Molecular and Cellular Neuroscience , vol.30 , Issue.4 , pp. 477-484
    • Millar, J.K.1    James, R.2    Christie, S.3    Porteous, D.J.4
  • 114
    • 33744985583 scopus 로고    scopus 로고
    • DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex
    • DOI 10.1002/cne.21007
    • Kirkpatrick, B., Xu, L., Cascella, N., Ozeki, Y., Sawa, A., and Roberts, R. C. (2006) DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex J. Comp. Neurol. 497, 436-450 (Pubitemid 43865795)
    • (2006) Journal of Comparative Neurology , vol.497 , Issue.3 , pp. 436-450
    • Kirkpatrick, B.1    Xu, L.2    Cascella, N.3    Ozeki, Y.4    Sawa, A.5    Roberts, R.C.6
  • 116
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon, D., Roberts, B. L., Richardson, W. D., and Smith, A. E. (1984) A short amino acid sequence able to specify nuclear location Cell 39, 499-509 (Pubitemid 15198589)
    • (1984) Cell , vol.39 , Issue.II3 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 117
    • 0032972509 scopus 로고    scopus 로고
    • PSORT: A program for detecting sorting signals in proteins and predicting their subcellular localization
    • Nakai, K. and Horton, P. (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization Trends Biochem. Sci. 24, 34-36
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 34-36
    • Nakai, K.1    Horton, P.2
  • 118
    • 0026078249 scopus 로고
    • Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
    • Robbins, J., Dilworth, S. M., Laskey, R. A., and Dingwall, C. (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence Cell 64, 615-623 (Pubitemid 121002977)
    • (1991) Cell , vol.64 , Issue.3 , pp. 615-623
    • Robbins, J.1    Dilworth, S.M.2    Laskey, R.A.3    Dingwall, C.4
  • 119
    • 0017068246 scopus 로고
    • Antipsychotic drug doses and neuroleptic/dopamine receptors
    • Seeman, P., Lee, T., Chau-Wong, M., and Wong, K. (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors Nature 261, 717-719
    • (1976) Nature , vol.261 , pp. 717-719
    • Seeman, P.1    Lee, T.2    Chau-Wong, M.3    Wong, K.4
  • 120
    • 0034025771 scopus 로고    scopus 로고
    • 2 occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
    • DOI 10.1176/appi.ajp.157.4.514
    • Kapur, S., Zipursky, R., Jones, C., Remington, G., and Houle, S. (2000) Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia Am. J. Psychiatry 157, 514-520 (Pubitemid 30191189)
    • (2000) American Journal of Psychiatry , vol.157 , Issue.4 , pp. 514-520
    • Kapur, S.1    Zipursky, R.2    Jones, C.3    Remington, G.4    Houle, S.5
  • 121
    • 65349120160 scopus 로고    scopus 로고
    • The dopamine hypothesis of schizophrenia: Version III - The final common pathway
    • Howes, O. D. and Kapur, S. (2009) The dopamine hypothesis of schizophrenia: version III - the final common pathway Schizophr. Bull. 35, 549-562
    • (2009) Schizophr. Bull. , vol.35 , pp. 549-562
    • Howes, O.D.1    Kapur, S.2
  • 122
    • 84862754823 scopus 로고    scopus 로고
    • Schizophrenia Research Forum. Available at
    • Abi-Dargham, A. (2005) The Dopamine Hypothesis of Schizophrenia. Schizophrenia Research Forum. Available at: http://www.schizophreniaforum.org/ for/curr/AbiDargham/default.asp
    • (2005) The Dopamine Hypothesis of Schizophrenia
    • Abi-Dargham, A.1
  • 123
    • 35048842703 scopus 로고    scopus 로고
    • Relationship of catechol-O-methyltransferase to schizophrenia and its correlates: Evidence for associations and complex interactions
    • DOI 10.1080/10673220701650409, PII 782902180
    • Lewandowski, K. E. (2007) Relationship of catechol-O-methyltransferase to schizophrenia and its correlates: evidence for associations and complex interactions Harvard Rev. Psychiatry 15, 233-244 (Pubitemid 47557207)
    • (2007) Harvard Review of Psychiatry , vol.15 , Issue.5 , pp. 233-244
    • Lewandowski, K.E.1
  • 124
    • 33846363929 scopus 로고    scopus 로고
    • Evidence for statistical epistasis between catechol-O -methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    • DOI 10.1007/s00439-006-0257-3
    • Nicodemus, K. K., Kolachana, B. S., Vakkalanka, R., Straub, R. E., Giegling, I., Egan, M. F., Rujescu, D., and Weinberger, D. R. (2007) Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia Hum. Genet. 120, 889-906 (Pubitemid 46128844)
    • (2007) Human Genetics , vol.120 , Issue.6 , pp. 889-906
    • Nicodemus, K.K.1    Kolachana, B.S.2    Vakkalanka, R.3    Straub, R.E.4    Giegling, I.5    Egan, M.F.6    Rujescu, D.7    Weinberger, D.R.8
  • 126
    • 79951813355 scopus 로고    scopus 로고
    • Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: Evidence for neurodevelopmental origin of major psychiatric disorders
    • Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., Vogel, M. W., Ross, C. A., and Pletnikov, M. V. (2011) Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders Mol. Psychiatry 16, 293-306
    • (2011) Mol. Psychiatry , vol.16 , pp. 293-306
    • Ayhan, Y.1    Abazyan, B.2    Nomura, J.3    Kim, R.4    Ladenheim, B.5    Krasnova, I.N.6    Sawa, A.7    Margolis, R.L.8    Cadet, J.L.9    Mori, S.10    Vogel, M.W.11    Ross, C.A.12    Pletnikov, M.V.13
  • 128
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt, D. C. and Zukin, S. R. (1991) Recent advances in the phencyclidine model of schizophrenia Am. J. Psychiatry 148, 1301-1308
    • (1991) Am. J. Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 130
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • DOI 10.1016/S0140-6736(03)12379-3
    • Harrison, P. J. and Owen, M. J. (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications Lancet 361, 417-419 (Pubitemid 36164980)
    • (2003) Lancet , vol.361 , Issue.9355 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2
  • 133
    • 79958782146 scopus 로고    scopus 로고
    • NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1)
    • Namba, T., Ming, G. L., Song, H., Waga, C., Enomoto, A., Kaibuchi, K., Kohsaka, S., and Uchino, S. (2011) NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1) J. Neurochem. 118, 34-44
    • (2011) J. Neurochem. , vol.118 , pp. 34-44
    • Namba, T.1    Ming, G.L.2    Song, H.3    Waga, C.4    Enomoto, A.5    Kaibuchi, K.6    Kohsaka, S.7    Uchino, S.8
  • 134
    • 56649097561 scopus 로고    scopus 로고
    • Looking at Lithium: Molecular Moods and Complex Behaviour
    • Beaulieu, J. M. and Caron, M. G. (2008) Looking at Lithium: Molecular Moods and Complex Behaviour Mol. Interventions 8, 230-241
    • (2008) Mol. Interventions , vol.8 , pp. 230-241
    • Beaulieu, J.M.1    Caron, M.G.2
  • 136
    • 77749243065 scopus 로고    scopus 로고
    • The neuron-specific isoform of glycogen synthase kinase-3 beta is required for axon growth
    • Castano, Z., Gordon-Weeks, P. R., and Kypta, R. M. (2010) The neuron-specific isoform of glycogen synthase kinase-3 beta is required for axon growth J. of Neurochem. 113, 117-130
    • (2010) J. of Neurochem. , vol.113 , pp. 117-130
    • Castano, Z.1    Gordon-Weeks, P.R.2    Kypta, R.M.3
  • 137
    • 79956086832 scopus 로고    scopus 로고
    • Genetic inactivation of GSK3alpha rescues spine deficits in Disc1-L100P mutant mice
    • Lee, F. H., Kaidanovich-Beilin, O., Roder, J. C., Woodgett, J. R., and Wong, A. H. (2011) Genetic inactivation of GSK3alpha rescues spine deficits in Disc1-L100P mutant mice Schizophr. Res. 129, 74-79
    • (2011) Schizophr. Res. , vol.129 , pp. 74-79
    • Lee, F.H.1    Kaidanovich-Beilin, O.2    Roder, J.C.3    Woodgett, J.R.4    Wong, A.H.5
  • 138
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery
    • DOI 10.1042/0264-6021:3590001
    • Frame, S. and Cohen, P. (2001) GSK3 takes centre stage more than 20 years after its discovery Biochem. J. 359, 1-16 (Pubitemid 32939202)
    • (2001) Biochemical Journal , vol.359 , Issue.1 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 140
    • 11244277000 scopus 로고    scopus 로고
    • Expression of disrupted in Schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment
    • DOI 10.1038/sj.mp.4001574
    • Schurov, I., Handford, E. J., Brandon, N. J., and Whiting, P. J. (2004) Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment Mol. Psychiatry 9, 1100-1110 (Pubitemid 40065455)
    • (2004) Molecular Psychiatry , vol.9 , Issue.12 , pp. 1100-1110
    • Schurov, I.L.1    Handford, E.J.2    Brandon, N.J.3    Whiting, P.J.4
  • 141
    • 0036214671 scopus 로고    scopus 로고
    • Synaptic plasticity and mood disorders
    • Duman, R. S. (2002) Synaptic plasticity and mood disorders Molecular psychiatry 7 (Suppl 1) S29-34
    • (2002) Molecular Psychiatry , vol.7 , Issue.SUPPL. 1 , pp. 29-34
    • Duman, R.S.1
  • 142
    • 0029133577 scopus 로고
    • A molecular switch for the consolidation of long-term memory: CAMP-inducible gene expression
    • Alberini, C. M., Ghirardi, M., Huang, Y. Y., Nguyen, P. V., and Kandel, E. R. (1995) A molecular switch for the consolidation of long-term memory: cAMP-inducible gene expression Ann. N.Y. Acad. Sci. 758, 261-286
    • (1995) Ann. N.Y. Acad. Sci. , vol.758 , pp. 261-286
    • Alberini, C.M.1    Ghirardi, M.2    Huang, Y.Y.3    Nguyen, P.V.4    Kandel, E.R.5
  • 143
    • 62149131337 scopus 로고    scopus 로고
    • Compartmentalized signalling: Spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
    • Baillie, G. S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases FEBS J. 276, 1790-1799
    • (2009) FEBS J. , vol.276 , pp. 1790-1799
    • Baillie, G.S.1
  • 145
    • 0035224063 scopus 로고    scopus 로고
    • Sub-family selective actions in the ability of Erk2MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases
    • Baillie, G. S., MacKenzie, S. J., McPhee, I., and Houslay, M. D. (2000) Sub-family selective actions in the ability of Erk2MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases Br. J. Pharmacol. 131, 811-819
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 811-819
    • Baillie, G.S.1    MacKenzie, S.J.2    McPhee, I.3    Houslay, M.D.4
  • 146
    • 0037443097 scopus 로고    scopus 로고
    • PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
    • DOI 10.1042/BJ20021698
    • Houslay, M. D. and Adams, D. R. (2003) PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization Biochem. J. 370, 1-18 (Pubitemid 36259414)
    • (2003) Biochemical Journal , vol.370 , Issue.1 , pp. 1-18
    • Houslay, M.D.1    Adams, D.R.2
  • 147
    • 5444251165 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications
    • DOI 10.1016/j.neuroscience.2004.07.038, PII S0306452204006530
    • Maxwell, C. R., Kanes, S. J., Abel, T., and Siegel, S. J. (2004) Phosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications Neuroscience 129, 101-107 (Pubitemid 39360946)
    • (2004) Neuroscience , vol.129 , Issue.1 , pp. 101-107
    • Maxwell, C.R.1    Kanes, S.J.2    Abel, T.3    Siegel, S.J.4
  • 148
    • 1342264246 scopus 로고    scopus 로고
    • Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    • DOI 10.1016/j.tips.2004.01.003
    • O'Donnell, J. M. and Zhang, H.-T. (2004) Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4) Trends Pharmacol. Sci. 25, 158-163 (Pubitemid 38264507)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.3 , pp. 158-163
    • O'Donnell, J.M.1    Zhang, H.-T.2
  • 149
    • 33751527380 scopus 로고    scopus 로고
    • Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity
    • DOI 10.1016/j.neuroscience.2006.09.026, PII S0306452206012516
    • Kanes, S. J., Tokarczyk, J., Siegel, S. J., Bilker, W., Abel, T., and Kelly, M. P. (2007) Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity Neuroscience 144, 239-246 (Pubitemid 44839057)
    • (2007) Neuroscience , vol.144 , Issue.1 , pp. 239-246
    • Kanes, S.J.1    Tokarczyk, J.2    Siegel, S.J.3    Bilker, W.4    Abel, T.5    Kelly, M.P.6
  • 158
    • 79959620323 scopus 로고    scopus 로고
    • Co-ordinated action of DISC1, PDE4B and GSK3beta in modulation of cAMP signalling
    • Carlyle, B. C., Mackie, S., Christie, S., Millar, J. K., and Porteous, D. J. (2011) Co-ordinated action of DISC1, PDE4B and GSK3beta in modulation of cAMP signalling Mol. Psychiatry 16, 693-694
    • (2011) Mol. Psychiatry , vol.16 , pp. 693-694
    • Carlyle, B.C.1    MacKie, S.2    Christie, S.3    Millar, J.K.4    Porteous, D.J.5
  • 160
    • 0020195709 scopus 로고
    • Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5
    • Hemmings, B. A., Aitken, A., Cohen, P., Rymond, M., and Hofmann, F. (1982) Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5 Eur. J. Biochem. 127, 473-481
    • (1982) Eur. J. Biochem. , vol.127 , pp. 473-481
    • Hemmings, B.A.1    Aitken, A.2    Cohen, P.3    Rymond, M.4    Hofmann, F.5
  • 162
    • 0034461612 scopus 로고    scopus 로고
    • Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β
    • DOI 10.1128/MCB.20.24.9356-9363.2000
    • Li, M., Wang, X., Meintzer, M. K., Laessig, T., Birnbaum, M. J., and Heidenreich, K. A. (2000) Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta Mol. Cell. Biol. 20, 9356-9363 (Pubitemid 32246120)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.24 , pp. 9356-9363
    • Li, M.1    Wang, X.2    Meintzer, M.K.3    Laessig, T.4    Birnbaum, M.J.5    Heidenreich, K.A.6
  • 163
    • 34548129274 scopus 로고    scopus 로고
    • The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics
    • DOI 10.1016/j.neubiorev.2007.04.002, PII S0149763407000346
    • O'Donnell, K. C. and Gould, T. D. (2007) The behavioral actions of lithium in rodent models: leads to develop novel therapeutics Neurosci. Biobehav. Rev. 31, 932-962 (Pubitemid 47299256)
    • (2007) Neuroscience and Biobehavioral Reviews , vol.31 , Issue.6 , pp. 932-962
    • O'Donnell, K.C.1    Gould, T.D.2
  • 164
    • 3342955475 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium
    • DOI 10.1523/JNEUROSCI.4753-03.2004
    • O'Brien, W. T., Harper, A. D., Jove, F., Woodgett, J. R., Maretto, S., Piccolo, S., and Klein, P. S. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium J. Neurosci. 24, 6791-6798 (Pubitemid 38993901)
    • (2004) Journal of Neuroscience , vol.24 , Issue.30 , pp. 6791-6798
    • O'Brien, W.T.1    Harper, A.D.2    Jove, F.3    Woodgett, J.R.4    Maretto, S.5    Piccolo, S.6    Klein, P.S.7
  • 168
    • 10644255687 scopus 로고    scopus 로고
    • AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
    • DOI 10.1017/S1461145704004535
    • Gould, T. D., Einat, H., Bhat, R., and Manji, H. K. (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test Int. J. Neuropsychopharmacol. 7, 387-390 (Pubitemid 39648068)
    • (2004) International Journal of Neuropsychopharmacology , vol.7 , Issue.4 , pp. 387-390
    • Gould, T.D.1    Einat, H.2    Bhat, R.3    Manji, H.K.4
  • 169
    • 1342308071 scopus 로고    scopus 로고
    • The effects of clozapine on the GSK-3-mediated signaling pathway
    • DOI 10.1016/S0014-5793(04)00082-1
    • Kang, U. G., Seo, M. S., Roh, M. S., Kim, Y., Yoon, S. C., and Kim, Y. S. (2004) The effects of clozapine on the GSK-3-mediated signaling pathway FEBS Lett. 560, 115-119 (Pubitemid 38264303)
    • (2004) FEBS Letters , vol.560 , Issue.1-3 , pp. 115-119
    • Kang, U.G.1    Seo, M.S.2    Roh, M.-S.3    Kim, Y.4    Yoon, S.C.5    Kim, Y.S.6
  • 170
  • 171
    • 0035943699 scopus 로고    scopus 로고
    • The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    • Yuan, P. X., Huang, L. D., Jiang, Y. M., Gutkind, J. S., Manji, H. K., and Chen, G. (2001) The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth J. Biol. Chem. 276, 31674-31683
    • (2001) J. Biol. Chem. , vol.276 , pp. 31674-31683
    • Yuan, P.X.1    Huang, L.D.2    Jiang, Y.M.3    Gutkind, J.S.4    Manji, H.K.5    Chen, G.6
  • 172
    • 0033579301 scopus 로고    scopus 로고
    • Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
    • DOI 10.1126/science.286.5448.2358
    • Riccio, A., Ahn, S., Davenport, C. M., Blendy, J. A., and Ginty, D. D. (1999) Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons Science 286, 2358-2361 (Pubitemid 30016901)
    • (1999) Science , vol.286 , Issue.5448 , pp. 2358-2361
    • Riccio, A.1    Ahn, S.2    Davenport, C.M.3    Blendy, J.A.4    Ginty, D.D.5
  • 173
    • 0036310511 scopus 로고    scopus 로고
    • BDNF-mediated signal transduction is modulated by GSK3β and mood stabilizing agents
    • DOI 10.1046/j.1471-4159.2002.00939.x
    • Mai, L., Jope, R. S., and Li, X. H. (2002) BDNF-mediated signal transduction is modulated by GSK3 beta and mood stabilizing agents J. Neurochem. 82, 75-83 (Pubitemid 34755251)
    • (2002) Journal of Neurochemistry , vol.82 , Issue.1 , pp. 75-83
    • Mai, L.1    Jope, R.S.2    Li, X.3
  • 174
    • 0033515699 scopus 로고    scopus 로고
    • Sustained phosphorylation and activation of protein kinase B correlates with brain-derived neurotrophic factor and insulin stimulated survival of cerebellar granule cells
    • DOI 10.1016/S0304-3940(99)00166-4, PII S0304394099001664
    • Foulstone, E. J., Tavare, J. M., and Gunn-Moore, F. J. (1999) Sustained phosphorylation and activation of protein kinase B correlates with brain-derived neurotrophic factor and insulin stimulated survival of cerebellar granule cells Neurosci. Lett. 264, 125-128 (Pubitemid 29195965)
    • (1999) Neuroscience Letters , vol.264 , Issue.1-3 , pp. 125-128
    • Foulstone, E.J.1    Tavare, J.M.2    Gunn-Moore, F.J.3
  • 175
    • 1842579578 scopus 로고    scopus 로고
    • ERK1/2 Activation Is Necessary for BDNF to Increase Dendritic Spine Density in Hippocampal CA1 Pyramidal Neurons
    • DOI 10.1101/lm.67804
    • Alonso, M., Medina, J. H., and Pozzo-Miller, L. (2004) ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons Learn. Mem. 11, 172-178 (Pubitemid 38456599)
    • (2004) Learning and Memory , vol.11 , Issue.2 , pp. 172-178
    • Alonso, M.1    Medina, J.H.2    Pozzo-Miller, L.3
  • 176
    • 0028815653 scopus 로고
    • Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
    • Nibuya, M., Morinobu, S., and Duman, R. S. (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J. Neurosci. 15, 7539-7547
    • (1995) J. Neurosci. , vol.15 , pp. 7539-7547
    • Nibuya, M.1    Morinobu, S.2    Duman, R.S.3
  • 177
    • 0028970281 scopus 로고
    • Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
    • Smith, M. A., Makino, S., Kvetnansky, R., and Post, R. M. (1995) Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus J. Neurosci. 15, 1768-1777
    • (1995) J. Neurosci. , vol.15 , pp. 1768-1777
    • Smith, M.A.1    Makino, S.2    Kvetnansky, R.3    Post, R.M.4
  • 178
    • 0031031001 scopus 로고    scopus 로고
    • Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
    • DOI 10.1016/S0091-3057(96)00169-4, PII S0091305796001694
    • Siuciak, J. A., Lewis, D. R., Wiegand, S. J., and Lindsay, R. M. (1997) Antidepressant-like effect of brain-derived neurotrophic factor (BDNF) Pharmacol., Biochem. Behav. 56, 131-137 (Pubitemid 27016116)
    • (1997) Pharmacology Biochemistry and Behavior , vol.56 , Issue.1 , pp. 131-137
    • Siuciak, J.A.1    Lewis, D.R.2    Wiegand, S.J.3    Lindsay, R.M.4
  • 179
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378, 785-789 (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 180
    • 0034806590 scopus 로고    scopus 로고
    • Creb DNA binding activity is inhibited by glycogen synthase kinase-3β and facilitated by lithium
    • DOI 10.1046/j.1471-4159.2001.00495.x
    • Grimes, C. A. and Jope, R. S. (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium J. Neurochem. 78, 1219-1232 (Pubitemid 32899754)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.6 , pp. 1219-1232
    • Grimes, C.A.1    Jope, R.S.2
  • 181
    • 0035338399 scopus 로고    scopus 로고
    • Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect
    • DOI 10.1016/S0006-3223(00)01114-8, PII S0006322300011148
    • Chen, A. C., Shirayama, Y., Shin, K. H., Neve, R. L., and Duman, R. S. (2001) Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect Biol. Psychiatry 49, 753-762 (Pubitemid 32452296)
    • (2001) Biological Psychiatry , vol.49 , Issue.9 , pp. 753-762
    • Chen, A.C.-H.1    Shirayama, Y.2    Shin, K.-H.3    Neve, R.L.4    Duman, R.S.5
  • 182
    • 0034213455 scopus 로고    scopus 로고
    • CAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
    • Thome, J., Sakai, N., Shin, K. H., Steffen, C., Zhang, Y. J., Impey, S., Storm, D., and Duman, R. S. (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment J. Neurosci. 20, 4030-4036 (Pubitemid 30365673)
    • (2000) Journal of Neuroscience , vol.20 , Issue.11 , pp. 4030-4036
    • Thome, J.1    Sakai, N.2    Shin, K.-H.3    Steffen, C.4    Zhang, Y.-J.5    Impey, S.6    Storm, D.7    Duman, R.S.8
  • 183
    • 0037688084 scopus 로고    scopus 로고
    • Finding the intracellular signaling pathways affected by mood disorder treatments
    • DOI 10.1016/S0896-6273(03)00195-8
    • Coyle, J. T. and Duman, R. S. (2003) Finding the intracellular signaling pathways affected by mood disorder treatments Neuron 38, 157-160 (Pubitemid 36555643)
    • (2003) Neuron , vol.38 , Issue.2 , pp. 157-160
    • Coyle, J.T.1    Duman, R.S.2
  • 184
    • 0032852479 scopus 로고    scopus 로고
    • CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
    • DOI 10.1146/annurev.biochem.68.1.821
    • Shaywitz, A. J. and Greenberg, M. E. (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals Annu. Rev. Biochem. 68, 821-861 (Pubitemid 29449210)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 821-861
    • Shaywitz, A.J.1    Greenberg, M.E.2
  • 185
    • 0036909443 scopus 로고    scopus 로고
    • Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
    • DOI 10.1016/S0028-3908(02)00215-0
    • De Sarno, P., Li, X., and Jope, R. S. (2002) Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium Neuropharmacology 43, 1158-1164 (Pubitemid 36009369)
    • (2002) Neuropharmacology , vol.43 , Issue.7 , pp. 1158-1164
    • De Sarno, P.1    Li, X.2    Jope, R.S.3
  • 186
    • 0842310838 scopus 로고    scopus 로고
    • Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
    • DOI 10.1038/ng1296
    • Emamian, E. S., Hall, D., Birnbaum, M. J., Karayiorgou, M., and Gogos, J. A. (2004) Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia Nat. Genet. 36, 131-137 (Pubitemid 38174370)
    • (2004) Nature Genetics , vol.36 , Issue.2 , pp. 131-137
    • Emamian, E.S.1    Hall, D.2    Birnbaum, M.J.3    Karayiorgou, M.4    Gogos, J.A.5
  • 187
    • 30544449810 scopus 로고    scopus 로고
    • Control of dendritic arborization by the phosphoinositide-3′- kinase- Akt-mammalian target of rapamycin pathway
    • DOI 10.1523/JNEUROSCI.2270-05.2005
    • Jaworski, J., Spangler, S., Seeburg, D. P., Hoogenraad, C. C., and Sheng, M. (2005) Control of dendritic arborization by the phosphoinositide-kinase-Akt- mammalian target of rapamycin pathway J. Neurosci. 25, 11300-11312 (Pubitemid 43083704)
    • (2005) Journal of Neuroscience , vol.25 , Issue.49 , pp. 11300-11312
    • Jaworski, J.1    Spangler, S.2    Seeburg, D.P.3    Hoogenraad, C.C.4    Sheng, M.5
  • 188
    • 0242384747 scopus 로고    scopus 로고
    • Beta-catenin is critical for dendritic morphogenesis
    • Yu, X. and Malenka, R. C. (2003) beta-catenin is critical for dendritic morphogenesis Nat. Neurosci. 6, 1169-1177
    • (2003) Nat. Neurosci. , vol.6 , pp. 1169-1177
    • Yu, X.1    Malenka, R.C.2
  • 189
    • 0037014456 scopus 로고    scopus 로고
    • Depolarization drives β-catenin into neuronal spines promoting changes in synaptic structure and function
    • DOI 10.1016/S0896-6273(02)00764-X
    • Murase, S., Mosser, E., and Schuman, E. M. (2002) Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function Neuron 35, 91-105 (Pubitemid 34804325)
    • (2002) Neuron , vol.35 , Issue.1 , pp. 91-105
    • Murase, S.1    Mosser, E.2    Schuman, E.M.3
  • 193
    • 70349117654 scopus 로고    scopus 로고
    • How DISC1 Regulates Postnatal Brain Development: Girdin Gets in on the AKT
    • Porteous, D. and Millar, K. (2009) How DISC1 Regulates Postnatal Brain Development: Girdin Gets In on the AKT Neuron 63, 711-713
    • (2009) Neuron , vol.63 , pp. 711-713
    • Porteous, D.1    Millar, K.2
  • 194
    • 0034843597 scopus 로고    scopus 로고
    • AL2CO: Calculation of positional conservation in a protein sequence alignment
    • Pei, J. and Grishin, N. V. (2001) AL2CO: calculation of positional conservation in a protein sequence alignment Bioinformatics 17, 700-712 (Pubitemid 32851378)
    • (2001) Bioinformatics , vol.17 , Issue.8 , pp. 700-712
    • Pei, J.1    Grishin, N.V.2
  • 195
    • 34447287515 scopus 로고    scopus 로고
    • PC12 cell model of inducible expression of mutant DISC1: New evidence for a dominant-negative mechanism of abnormal neuronal differentiation
    • DOI 10.1016/j.neures.2007.03.003, PII S0168010207001125
    • Pletnikov, M. V., Xu, Y., Ovanesov, M. V., Kamiya, A., Sawa, A., and Ross, C. A. (2007) PC12 cell model of inducible expression of mutant DISC1: New evidence for a dominant-negative mechanism of abnormal neuronal differentiation Neurosci. Res. 58, 234-244 (Pubitemid 47042268)
    • (2007) Neuroscience Research , vol.58 , Issue.3 , pp. 234-244
    • Pletnikov, M.V.1    Xu, Y.2    Ovanesov, M.V.3    Kamiya, A.4    Sawa, A.5    Ross, C.A.6
  • 198
    • 50149121170 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus
    • Meyer, K. D. and Morris, J. A. (2008) Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus Gene Expression Patterns 8, 494-501
    • (2008) Gene Expression Patterns , vol.8 , pp. 494-501
    • Meyer, K.D.1    Morris, J.A.2


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