Expression of disrupted in Schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment

Molecular Psychiatry

Volumn 9, Issue 12, 2004, Pages 1100-1110

  Schurov, I L ^a   Handford, E J ^a   Brandon, N J ^a   Whiting, P J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Brain; Development; DISC1; Schizophrenia

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN STEM; CEREBELLUM; EMBRYO; GENE DISRUPTION; GENE TRANSLOCATION; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHIZOPHRENIA; WESTERN BLOTTING;

ANIMALS; BRAIN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; NERVE TISSUE PROTEINS; NEURONS; ORGANOGENESIS; PROTEIN ISOFORMS; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 11244277000     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001574     Document Type: Article

References (56)

1. Stevens JR. Schizophrenia: reproductive hormones and the brain. Am J Psychiatry 2002; 159: 713-719.
2. Harrison PJ. Schizophrenia: a disorder of neurodevelopment? Curr Opin Neurobiol 1997; 7: 285-289.
3. Lewis DA, Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 2002; 25: 409-432.
4. Weinberger DR, Torrey EF, Neophytides AN, Wyatt RJ. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 1979; 36: 735-739.
5. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999; 122: 593-624.
6. Lafargue T, Brasic J. Neurodevelopmental hypthesis of schizophrenia: a central sensory disturbance. Med Hypotheses 2000; 55: 314-318.
7. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44: 660-669.
8. Millar JK, Wilson-Arman JC, Anderson S, Christie S, Taylor MS, Semple CA et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9: 1415-1423.
9. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001; 10: 1611-1617.
10. Hennah W, Varilo T, Kestilä M, Paunio T, Arajärvi JH, Haukka J et al. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum Mol Genetics 2003; 12: 13151-13159.
11. Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 2003; 8: 445-452.
12. Brandon NJ, Handford EJ, Schurov I, Rain J-C, Felling M, Duran-Jimeniz B et al. Disrupted in Schizophrenia1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci 2004; 25: 42-55.
13. Dobyns WB, Reiner O, Carrozzo R, Ledbetter DH. Lissencephaly: a human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13. J Am Med Assoc 1993; 270: 2838-2842.
14. Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron 2000; 28: 665-679.
15. Efimov VP, Morris NR. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J Cell Biol 2000; 150: 681-688.
16. Efimov VP. Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects. Mol Biol Cell 2003; 14: 871-888.
17. Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS et al. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 2000; 28: 697-711.
18. Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A et al. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 2000; 28: 681-696.
19. Sweeney KJ, Prokscha A, Eichele G. NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech Dev 2001; 101: 21-33.
20. Ross ME, Walsh CA. Human brain malformations and their lessons for neuronal migration. Annu Rev Neurosci 2001; 24: 1041-1070.
21. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fuji K et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 2003; 100: 289-294.
22. Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry 2003; 8: 685-694.
23. Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. NeuroReport 2003; 14: 951-954.
24. Nardi C, Lipska BK, Kozlovsky N, Weinberger DR, Belmaker RH, Agam G. Glycogen synthase kinase (GSK)-Sb levels and activity in a neurodevelopmental rat model of schizophrenia. Dev Brain Res 2003; 141: 33-37.
25. Schneider M, Koch M. Chronic pubertal, but not adult chronic carmabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmcology 2003; 28: 1760-1769.
26. Cunningham MG, Bhattacharyya S, Benes FM. Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence. J Comp Neurology 2002; 453: 116-130.
27. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity modifying proteins in human cerebral vasculature. J Cereb Blood Flow Metab 2002; 22: 620-629.
28. Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (disrupted-in-schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 2003; 12: 1591-1608.
29. James R, Adams RR, Christie S, Buchanan SR, Porteous DJ, Millar JK. Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci 2004; 26: 112-122.
30. O'Donovan MC, Williams NM, Owen MJ. Recent advances in the genetics of schizophrenia. Hum Mol Genetics 2003; 12; R125-R133.
31. Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science 2002; 269: 692-695.
32. Millar JK, Christie S, Porteous DJ. Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun 2003; 311: 1019-1025.
33. Ma L, Liu Y, Ky B, Shughrue PJ, Austin CP, Morris JA. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (disrupted-in- schizophrenia 1). Genomics 2002; 80: 662-672.
34. Honda A, Miyoshi K, Baba K, Taniguchi M, Koyama Y, Kuroda S et al. Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain. Mol Brain Res 2004; 122: 89-92.
35. Innocenti GM, Ansermet F, Parnas J. Schizophrenia, neurodevelopment and corpus callosum. Mol Psychiatry 2003; 8: 261-274.
36. Lieberman JA, Perkins D, Belger A, Chakos M, Jarskov F, Boteva K et al. The early stage of schizophrenia:speculations on patogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 2001; 50: 884-897.
37. Berretta S, Munno DW, Benes FM. Amygdalar activation alters the hippocampal GABA system: 'partial' modeling for postmortem changes in schizophrenia. J Comper Neurobiol 2001; 431: 129-138.
38. Smith GN, Lang DJ, Kopala LC, Lapointe JS, Falkai P, Honer WG. Developmental abnormalities of the hippocampus in first-episode schizophrenia. Biol Psychiatry 2003; 53: 555-561.
39. Benes FM, Vincent SL, Todtenkopf M. The density of pyramidal and nonpyramidal neurons in anterior cingulated cortex of schizophrenic and bipolar subjects. Biol Psychiatry 2001; 50: 395-406.
40. Benes FM, McSparren J, Bird ED, Vincent SL. Deficits in small interneurons in prefrontal and cingulated cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991; 48: 996-1001.
41. Reynolds GP, Zhang ZJ, Beasley CL. Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity. Brain Res Bull 2001; 55: 579-584.
42. Reynolds GP, Beasley CL. GABAergic neuronal subtypes in the human frontal cortex-development and deficits in schizophrenia. J Chem Neuroanat 2001; 22: 95-100.
43. Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 2002; 42: 165-179.
44. Sawa A, Snyder SH. Schizophrenia: neural mechanisms for novel therapies. Mol Medicine 2003; 3-9.
45. Lewis DA, Volk DW, Hashimoto T. Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology 2004; 174: 143-150.
46. Wassef A, Baker J, Kochan LD. GABA and schizophrenia: a review of basic science and clinical studies. J Clin Psychopharmacol 2003; 23: 601-640.
47. Eyles DW, McGrath JJ, Reynolds GP. Neuronal calcium-binding proteins and schizophrenia. Schizophr Res 2002; 57: 27-34.
48. Todtenkopf MS, Benes FM. Distribution of glutamate decarboxylase65- immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain. Synapse 1998; 29: 323-332.
49. Benes FM, Todtenkopf MS, Vincent SL. Meta-analysis of nonpyramidal neuron (NP) loss in layer II in anterior cingulated cortex (ACCx-II) from three studies of postmortem schizophrenic (SZ) brain. Soc Neurosci Abst 1998; 24: 1275.
50. Dean B, Hussain T, Hayes W, Scan E, Kitsoulis S, Hill C et al. Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex. J Neurochem 1999; 72: 1593-1599.
51. Benes FM, Khan Y, Vincent SL, Wickramasinghe R. Differences in the subregional and cellular distribution of GABA-A receptor binding in the hippocampal formation of schizophrenic brain. Synapse 1996; 22: 338-349.
52. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
53. Kaufman MH. The Atlas of Mouse Development. Academic Press: Cambridge, 2001.
54. Bunney BG, Potkin SG, Bunney WE. Neuropathological studies of brain tissue in schizophrenia. J Psychiatr Res 1997; 31: 159-173.
55. Heinz A, Romero B, Gallinat J, Juckel G, Weinberger DR. Molecular brain imaging and the neurobiology and genetics of schizophrenia. Pharmacopsychiatry 2003; 36: 152-157.
56. Andreasen NC. Pieces of the schizophrenia puzzle fall into place. Neuron 1996; 16: 697-700.