Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: Implications for schizophrenia and other major neurological disorders

Molecular and Cellular Neuroscience

Volumn 25, Issue 1, 2004, Pages 42-55

  Brandon, N J ^a,c   Handford, E J ^a   Schurov, I ^a   Rain, J C ^b   Pelling, M ^a   Duran Jimeniz, B ^a   Camargo, L M ^a   Oliver, K R ^a   Beher, D ^a   Shearman, M S ^a   Whiting, P J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b Hybrigenics SA   (France)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL INTERACTION; CONTROLLED STUDY; DISRUPTED IN SCHIZOPHRENIA 1 GENE; GENE; GENE TRANSLOCATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; NUDEL GENE; PERINATAL PERIOD; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; SCHIZOPHRENIA;

EID: 10744229990     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2003.09.009     Document Type: Article

References (36)

1. Beranger F., Aresta S., de Gunzburg J., Camonis J. Getting more from the two-hybrid system: N-terminal fusions to LexA are efficient and sensitive baits for two-hybrid studies. Nucleic Acids Res. 25:1997;2035-2036.
2. Brandon N.J., Uren J.M., Kittler J.T., Wang H., Olsen R., Parker P.J., Moss S.J. Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J. Neurosci. 19:1999;9228-9234.
3. Chumakov I.et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 99:2002;13675-13680.
4. Clark G.D., Assadi A.H., Zhang G., Renfro A.L., McNeil R.S., Eichele G. Genetic and biochemical role of pafah1b complex in brain development. Society for Neuroscience. 2002;. (Program No. 128.24.).
5. Costa E., Davis J., Pesold C., Tueting P., Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr. Opin. Pharmacol. 2:2002;56-62.
6. Dhavan R., Tsai L.-H. A decade of CDK5. Nat. Rev., Mol. Cell Biol. 2:2001;749-759.
7. Dobyns W.B., Reiner O., Carrozzo R., Ledbetter D.H. Lissencephaly: a human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13. J. Am. Med. Assoc. 270:1993;2838-2842.
8. Efimov V.P., Morris N.R. The Lis1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J. Cell Biol. 150:2000;681-688.
9. Ekelund J., Hovatta I., Parker A., Paunio T., Varilo T., Martin R., Suhonen J., Ellonen P., Chan G., Sinsheimer J.S., Sobel E., Juvonen H., Arajarvi R., Partonen T., Suvisaari J., Lonnqvist J., Meyer J., Peltonen L. Chromosome 1 loci in Finnish schizophrenia families. Hum. Mol. Genet. 10:2001;1611-1617.
10. Faulkner N.E., Dujardin D.L., Tai C., Vaughan K.T., O'Connell C.B., Wang Y., Vallee R.B. A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat. Cell Biol. 2:2000;784-791.
11. Feng Y., Olson E.C., Stukenberg P.T., Flanagan L.A., Kirschner M.W., Walsh C.A. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 28:2000;665-679.
12. Fromont-Racine M., Rain J.C., Legrain P. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat. Genet. 16:1997;277-282.
13. Fromont-Racine M., Rain J.C., Legrain P. Building protein-protein networks by two-hybrid mating strategy. Methods Enzymol. 350:2002;513-524.
14. Gottesman I.I. Schizophrenia Genesis: The Origins of Madness. 1991;Freeman, New York.
15. Gottesman I.I., Bertelsen A. Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischers's Danish identical and fraternal discordant twins. Arch. Gen. Psychiatry. 46:1989;867-872.
16. Guidotti A., Auta J., Davis J.M., Di-Giorgi-Gerevini V., Dwivedi Y., Grayson D.R., Impagnatiello F., Pandey G., Pesold C., Sharma R., Uzunov D., Costa E., DiGiorgi Gerevini V. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry. 57:2000;1061-1069.
17. Hong S.E., Shugart Y.Y., Huang D.T., Shahwan S.A., Grant P.E., Hourihane J.O., Martin N.D., Walsh C.A. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat. Genet. 26:2000;93-96.
18. Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzunov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P., Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15718-15723.
19. Kitagawa M., Umezu M., Aoki J., Koizumi H., Arai H., Inoue K. Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. FEBS Lett. 479:2000;57-62.
20. Lewis D.A., Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu. Rev. Neurosci. 25:2002;409-432.
21. Ling L., Goeddel D.V. MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network. J. Biol. Chem. 275:2000;23852-23860.
22. Lo Nigro C., Chong S.S., Smith A.C.M., Dobyns W.B., Carrozzo R., Ledbetter D.H. Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. Hum. Mol. Genet. 6:1997;157-164.
23. Ma L., Liu Y., Ky B., Shughrue P.J., Austin C.P., Morris J.A. Cloning and characterization of DISC1, the mouse ortholog of DISC1 (Disrupted-in- Schizophrenia 1). Genomics. 80:2002;662-672.
24. Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S., Semple C.A., Devon R.S., Clair D.M., Muir W.J., Blackwood D.H., Porteous D.J. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet. 9:2000;1415-1423.
25. Niethammer M., Smith D.S., Ayala R., Peng J., Ko J., Lee M.-S., Morabito M., Tsai L.-H. Nudel is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 28:2000;697-711.
26. Oliver K.R., Wainwright A., Edvinsson L., Pickard J.D., Hill R.G. Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity modifying proteins in human cerebral vasculature. J. Cereb. Blood Flow Metab. 22:2002;620-629.
27. Ozeki Y., Tomoda T., Kleiderlein J., Kamiya A., Bord L., Fujii K., Okawa M., Yamada N., Hatten M.E., Snyder S.H., Ross C.A., Sawa A. Disrupted-in- Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Natl. Acad. Sci. U. S. A. 100:2002;289-294.
28. Reiner O., Carrozzo R., Shen Y., Wehnert M., Faustinella F., Dobyns W.B., Caskey C.T., Ledbetter D.H. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature. 364:1993;717-721.
29. Sasaki S., Shionoya A., Ishida M., Gambello M.J., Yingling J., Wynshaw-Boris A., Hirotsune S. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron. 28:2000;681-696.
30. Sawa A., Snyder S.H. Schizophrenia: diverse approaches to a complex disease. Science. 296:2002;692-695.
31. Smith D.S., Niethammer M., Ayala R., Zhou Y., Gambello M.J., Wynshaw-Boris A., Tsai L.-H. Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1. Nat. Cell Biol. 2:2000;767-775.
32. Stearns T., Evans L., Kirschner M. Gamma-tubulin is a highly conserved component of the centrosome. Cell. 65:1991;825-836.
33. Steffannson H.et al. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 7:2002;877-892.
34. Straub R.E.et al. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 71:2002;337-348.
35. Sweeney K.J., Prokscha A., Eichele G. NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech. Dev. 101:2001;21-33.
36. Vojtek A.B., Hollenberg S.M. Ras-Raf interaction: two-hybrid analysis. Methods Enzymol. 255:1995;331-342.