Nanoparticles in molecular diagnostics

Progress in Molecular Biology and Translational Science

Volumn 104, Issue , 2011, Pages 427-488

  Baptista, Pedro V ^a   Doria, Gonalo ^a   Quaresma, Pedro ^a,b   Cavadas, Miguel ^a   Neves, Cristina S ^b   Gomes, Inês ^a   Eaton, Peter ^b   Pereira, Eulália ^b   Franco, Ricardo ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Bionanotechnology; Gold nanoparticles; Immunoassay; Magnetic nanoparticles; Molecular diagnostics; Nucleic acid detection; Quantum dots

Indexed keywords

EID: 81255166832     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-416020-0.00011-5     Document Type: Chapter

References (316)

1. R.A. Sperling, and W.J. Parak Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles Philos Trans R Soc A Math Phys Eng Sci 368 2010 1333 1383
2. L. Dai Carbon nanotechnology 2006 Elsevier Amsterdam
3. C.S.S.R. Kumar Nanomaterials for Biosensors. Nanotechnologies for Life Sciences, 10 vols 2007 Wiley-VCH Weinheim 8
4. M. Lhadi Hybrid nanocomposites for nanotechnology 2009 Springer New York
5. R. Datar, S. Kim, S. Jeon, P. Hesketh, S. Manalis, and A. Boisen Cantilever sensors: nanomechanical tools for diagnostics Mrs Bulletin 34 2009 449 454
6. C.B. Jacobs, M.J. Peairs, and B.J. Venton Review: carbon nanotube based electrochemical sensors for biomolecules Anal Chim Acta 662 2010 105 127
7. W.R. Algar, A.J. Tavares, and U.J. Krull Beyond labels: a review of the application of quantum dots as integrated components of assays, bioprobes, and biosensors utilizing optical transduction Anal Chim Acta 673 2010 1 25
8. D. Geho, N. Lahar, P. Gurnani, M. Huebschman, P. Herrmann, and V. Espina Pegylated, streptavidin-conjugated quantum dots are effective detection elements for reverse-phase protein microarrays Bioconjug Chem 16 2005 559 566 (Pubitemid 40696047)
9. D. Gerion, F.Q. Chen, B. Kannan, A.H. Fu, W.J. Parak, and D.J. Chen Roomerature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays Anal Chem 75 2003 4766 4772 (Pubitemid 37139776)
10. M. Dequaire, C. Degrand, and B. Limoges An electrochemical metalloimmunoassay based on a colloidal gold label Anal Chem 72 2000 5521 5528
11. H.P. Huang, J.J. Li, Y.L. Tan, J.J. Zhou, and J.J. Zhu Quantum dot-based DNA hybridization by electrochemiluminescence and anodic stripping voltammetry Analyst 135 2010 1773 1778
12. C. Leng, G. Lai, F. Yan, and H. Ju Gold nanoparticle as an electrochemical label for inherently crosstalk-free multiplexed immunoassay on a disposable chip Anal Chim Acta 666 2010 97 101
13. X. Mao, M. Baloda, A.S. Gurung, Y. Lin, and G. Liu Multiplex electrochemical immunoassay using gold nanoparticle probes and immunochromatographic strips Electrochem Commun 10 2008 1636 1640
14. S. Marin, and A. Merkoci Direct electrochemical stripping detection of cystic-fibrosis-related DNA linked through cadmium sulfide quantum dots Nanotechnology 20 2009 055101
15. R.A. Alvarez-Puebla, and L.M. Liz-Marzan SERS-based diagnosis and biodetection Small 6 2010 604 610
16. P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, and I. Gomes Gold nanoparticles for the development of clinical diagnosis methods Anal Bioanal Chem 391 2008 943 950
17. M. De, P.S. Ghosh, and V.M. Rotello Applications of nanoparticles in biology Adv Mater 20 2008 4225 4241
18. S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, and L.V. Elst Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications Chem Rev 108 2008 2064 2110
19. S. Kinge, M. Crego-Calama, and D.N. Reinhoudt Self-assembling nanoparticles at surfaces and interfaces Chemphyschem 9 2008 20 42
20. B.L. Cushing, V.L. Kolesnichenko, and C.J. O'Connor Recent advances in the liquid-phase syntheses of inorganic nanoparticles Chem Rev 104 2004 3893 3946
21. H. Goesmann, and C. Feldmann Nanoparticulate functional materials Angew Chem Int Ed 49 2010 1362 1395
22. A.H. Lu, E.L. Salabas, and F. Schuth Magnetic nanoparticles: synthesis, protection, functionalization, and application Angew Chem Int Ed 46 2007 1222 1244
23. J. Park, J. Joo, S.G. Kwon, Y. Jang, and T. Hyeon Synthesis of monodisperse spherical nanocrystals Angew Chem Int Ed 46 2007 4630 4660 (Pubitemid 46997457)
24. S. Chen, L. Liu, J. Zhou, and S. Jiang Controlling antibody orientation on charged self-assembled monolayers Langmuir 19 2003 2859 2864
25. R.L. Letsinger, R. Elghanian, G. Viswanadham, and C.A. Mirkin Use of a steroid cyclic disulfide anchor in constructing gold nanoparticle- oligonucleotide conjugates Bioconjug Chem 11 2000 289 291 (Pubitemid 30174496)
26. J. Kimling, M. Maier, B. Okenve, V. Kotaidis, H. Ballot, and A. Plech Turkevich method for gold nanoparticle synthesis revisited J Phys Chem B 110 2006 15700 15707 (Pubitemid 44366341)
27. J. Turkevich, P.C. Stevenson, and J. Hillier A study of the nucleation and growth processes in the synthesis of colloidal gold Discuss Faraday Soc 11 1951 55 75
28. G. Prencipe, S.M. Tabakman, K. Welsher, Z. Liu, A.P. Goodwin, and L. Zhang PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation J Am Chem Soc 131 2009 4783 4787
29. X.Y. Wu, H.J. Liu, J.Q. Liu, K.N. Haley, J.A. Treadway, and J.P. Larson Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots Nat Biotechnol 21 2003 41 46 (Pubitemid 36055825)
30. L.X. Chen, T. Liu, M.C. Thurnauer, R. Csencsits, and T. Rajh Fe2O3 nanoparticle structures investigated by X-ray absorption near-edge structure, surface modifications, and model calculations J Phys Chem B 106 2002 8539 8546 (Pubitemid 35390065)
31. S. Peng, C. Wang, J. Xie, and S. Sun Synthesis and stabilization of monodisperse Fe nanoparticles J Am Chem Soc 128 2006 10676 10677 (Pubitemid 44277746)
32. C. Xu, K. Xu, H. Gu, R. Zheng, H. Liu, and X. Zhang Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles J Am Chem Soc 126 2004 9938 9939 (Pubitemid 39079411)
33. S. Sun, and H. Zeng Size-controlled synthesis of magnetite nanoparticles J Am Chem Soc 124 2002 8204 8205 (Pubitemid 34875378)
34. S.K. Basiruddin, A. Saha, N. Pradhan, and N.R. Jana Advances in coating chemistry in deriving soluble functional nanoparticle J Phys Chem C 114 2010 11009 11017
35. D. Knopp, D.P. Tang, and R. Niessner Bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles Anal Chim Acta 647 2009 14 30
36. N. Nitin, D.J. Javier, and R. Richards-Kortum Oligonucleotide-coated metallic nanoparticles as a flexible platform for molecular imaging agents Bioconjug Chem 18 2007 2090 2096 (Pubitemid 350220013)
37. G.T. Hermanson Bioconjugate techniques 2nd ed. 2008 Academic Press Oxford
38. J.-H. Lee, Y.-w. Jun, S.-I. Yeon, J.-S. Shin, and J. Cheon Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma Angew Chem Int Ed 45 2006 8160 8162 (Pubitemid 44974152)
39. A. Housni, H. Cai, S. Liu, S.H. Pun, and R. Narain Facile preparation of glyconanoparticles and their bioconjugation to streptavidin Langmuir 23 2007 5056 5061 (Pubitemid 46731992)
40. J.M. Abad, S.F.L. Mertens, M. Pita, V.M. Fernández, and D.J. Schiffrin Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins J Am Chem Soc 127 2005 5689 5694 (Pubitemid 40569880)
41. C.J. Murphy, A.M. Gole, S.E. Hunyadi, J.W. Stone, P.N. Sisco, and A. Alkilany Chemical sensing and imaging with metallic nanorods Chem Commun 2008 544 557
42. P. Ghosh, G. Han, M. De, C.K. Kim, and V.M. Rotello Gold nanoparticles in delivery applications Adv Drug Deliv Rev 60 2008 1307 1315
43. P.V. Baptista, M. Koziol-Montewka, J. Paluch-Oles, G. Doria, and R. Franco Gold-nanoparticle-probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples Clin Chem 52 2006 1433 1434 (Pubitemid 43956043)
44. G. Doria, R. Franco, and P. Baptista Nanodiagnostics: fast colorimetric method for single nucleotide polymorphism/mutation detection IET Nanobiotechnol 1 2007 53 57 (Pubitemid 47209800)
45. G. Doria, M. Larguinho, J.T. Dias, E. Pereira, R. Franco, and P.V. Baptista Gold-silver-alloy nanoprobes for one-pot multiplex DNA detection Nanotechnology 21 2010 255101
46. C.A. Mirkin, R.L. Letsinger, R.C. Mucic, and J.J. Storhoff A DNA-based method for rationally assembling nanoparticles into macroscopic materials Nature 382 1996 607 609 (Pubitemid 26268949)
47. K. Sato, K. Hosokawa, and M. Maeda Rapid aggregation of gold nanoparticles induced by non-cross-linking DNA hybridization J Am Chem Soc 125 2003 8102 8103 (Pubitemid 36828566)
48. Y.L. Jung, C. Jung, H. Parab, T. Li, and H.G. Park Direct colorimetric diagnosis of pathogen infections by utilizing thiol-labeled PCR primers and unmodified gold nanoparticles Biosens Bioelectron 25 2010 1941 1946
49. H. Li, and L.J. Rothberg Label-free colorimetric detection of specific sequences in genomic DNA amplified by the polymerase chain reaction J Am Chem Soc 126 2004 10958 10961 (Pubitemid 39180580)
50. H.X. Li, and L. Rothberg Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles Proc Natl Acad Sci USA 101 2004 14036 14039 (Pubitemid 39305025)
51. S.M. Shawky, D. Bald, and H.M.E. Azzazy Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles Clin Biochem 43 2010 1163 1168
52. D. Aili, R. Selegard, L. Baltzer, K. Enander, and B. Liedberg Colorimetric protein sensing by controlled assembly of gold nanoparticles functionalized with synthetic receptors Small 5 2009 2445 2452
53. S. Gupta, H. Andresen, J.E. Ghadiali, and M.M. Stevens Kinase-actuated immunoaggregation of peptide-conjugated gold nanoparticles Small 6 2010 1509 1513
54. C.S. Thaxton, R. Elghanian, A.D. Thomas, S.I. Stoeva, J.S. Lee, and N.D. Smith Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy Proc Natl Acad Sci USA 106 2009 18437 18442
55. K. Aslan, J.R. Lakowicz, and C.D. Geddes Nanogold-plasmon-resonance-based glucose sensing Anal Biochem 330 2004 145 155 (Pubitemid 38746986)
56. S. Eustis, and M.A. El-Sayed Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes Chem Soc Rev 35 2006 209 217 (Pubitemid 43327142)
57. P. Anger, P. Bharadwaj, and L. Novotny Enhancement and quenching of single-molecule fluorescence Phys Rev Lett 96 2006 113002
58. J.I. Gersten Theory of fluorophore-metallic surface interactions G.a. Lakowicz, Radiative decay engineering Vol. 8 2005 Plenum Press New York 197 221
59. S. Kuhn, U. Hakanson, L. Rogobete, and V. Sandoghdar Enhancement of single-molecule fluorescence using a gold nanoparticle as an optical nanoantenna Phys Rev Lett 97 2006 017402
60. U.H.F. Bunz, and V.M. Rotello Gold nanoparticle-fluorophore complexes: sensitive and discerning "noses" for biosystems sensing Angew Chem Int Ed 49 2010 3268 3279
61. R.L. Phillips, O.R. Miranda, C.C. You, V.M. Rotello, and U.H.F. Bunz Rapid and efficient identification of bacteria using gold-nanoparticle - poly(para-phenyleneethynylene) constructs Angew. Chem. Int. Ed. 47 2008 2590 2594
62. M. De, S. Rana, H. Akpinar, O.R. Miranda, R.R. Arvizo, and U.H.F. Bunz Sensing of proteins in human serum using conjugates of nanoparticles and green fluorescent protein Nat Chem 1 2009 461 465
63. C.C. You, O.R. Miranda, B. Gider, P.S. Ghosh, I.B. Kim, and B. Erdogan Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors Nat Nanotechnol 2 2007 318 323 (Pubitemid 46882982)
64. D. Astruc Electron transfer and radical processes in transition metal chemistry 1995 Wiley-VCH Weinheim
65. E. Katz, and I. Willner Integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications Angew. Chem. Int. Ed. 43 2004 6042 6108 (Pubitemid 39611873)
66. M.T. Castaneda, S. Alegret, and A. Merkoci Electrochemical sensing of DNA using gold nanoparticles Electroanalysis 19 2007 743 753
67. R. Rossetti, and L. Brus Electron-hole recombination emission as a probe of surface-chemistry in aqueous Cds colloids J Phys Chem 86 1982 4470 4472
68. T. Vossmeyer, L. Katsikas, M. Giersig, I.G. Popovic, K. Diesner, and A. Chemseddine Cds nanoclusters - synthesis, characterization, size-dependent oscillator strength, temperature shift of the excitonic-transition energy, and reversible absorbency shift J Phys Chem 98 1994 7665 7673
69. X.H. Gao, L.L. Yang, J.A. Petros, F.F. Marshal, J.W. Simons, and S.M. Nie In vivo molecular and cellular imaging with quantum dots Curr Opin Biotechnol 16 2005 63 72 (Pubitemid 40249760)
70. J. McBride, J. Treadway, L.C. Feldman, S.J. Pennycook, and S.J. Rosenthal Structural basis for near unity quantum yield core/shell nanostructures Nano Lett 6 2006 1496 1501 (Pubitemid 44195335)
71. W.C.W. Chan, D.J. Maxwell, X.H. Gao, R.E. Bailey, M.Y. Han, and S.M. Nie Luminescent quantum dots for multiplexed biological detection and imaging Curr Opin Biotechnol 13 2002 40 46 (Pubitemid 34146546)
72. P. Tallury, A. Malhotra, L.M. Byrne, and S. Santra Nanobioimaging and sensing of infectious diseases Adv Drug Deliv Rev 62 2010 424 437
73. X. Michalet, F.F. Pinaud, L.A. Bentolila, J.M. Tsay, S. Doose, and J.J. Li Quantum dots for live cells, in vivo imaging, and diagnostics Science 307 2005 538 544 (Pubitemid 40165671)
74. D. Gerion, F. Pinaud, S.C. Williams, W.J. Parak, D. Zanchet, and S. Weiss Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots J Phys Chem B 105 2001 8861 8871 (Pubitemid 35338761)
75. C.B. Murray, D.J. Norris, and M.G. Bawendi Synthesis and characterization of nearly monodisperse Cde (E = S, Se, Te) semiconductor nanocrystallites J Am Chem Soc 115 1993 8706 8715
76. T. Jamieson, R. Bakhshi, D. Petrova, R. Pocock, M. Imani, and A.M. Seifalian Biological applications of quantum dots Biomaterials 28 2007 4717 4732 (Pubitemid 47259173)
77. M. Kuno, D.P. Fromm, H.F. Hamann, A. Gallagher, and D.J. Nesbitt "On"/"off" fluorescence intermittency of single semiconductor quantum dots J Chem Phys 115 2001 1028 1040 (Pubitemid 32680644)
78. B. Mahler, P. Spinicelli, S. Buil, X. Quelin, J.P. Hermier, and B. Dubertret Towards non-blinking colloidal quantum dots Nat Mater 7 2008 659 664
79. S.J. Rosenthal, J. McBride, S.J. Pennycook, and L.C. Feldman Synthesis, surface studies, composition and structural characterization of CdSe, core/shell and biologically active nanocrystals Surf Sci Rep 62 2007 111 157 (Pubitemid 46551276)
80. C. Kirchner, T. Liedl, S. Kudera, T. Pellegrino, A.M. Javier, and H.E. Gaub Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles Nano Lett 5 2005 331 338 (Pubitemid 40308295)
81. B. Dubertret, P. Skourides, D.J. Norris, V. Noireaux, A.H. Brivanlou, and A. Libchaber In vivo imaging of quantum dots encapsulated in phospholipid micelles Science 298 2002 1759 1762 (Pubitemid 35404113)
82. V.A. Fonoberov, K.A. Alim, A.A. Balandin, F.X. Xiu, and J.L. Liu Photoluminescence investigation of the carrier recombination processes in ZnO quantum dots and nanocrystals Phys Rev B 73 2006 165317
83. L. Spanhel Colloidal ZnO nanostructures and functional coatings: a survey J Sol-Gel Sci Technol 39 2006 7 24 (Pubitemid 44202068)
84. F. Erogbogbo, K.T. Yong, I. Roy, G.X. Xu, P.N. Prasad, and M.T. Swihart Biocompatible luminescent silicon quantum dots for imaging of cancer cells ACS Nano 2 2008 873 878
85. J.H. Warner, A. Hoshino, K. Yamamoto, and R.D. Tilley Water-soluble photoluminescent silicon quantum dots Angew Chem Int Ed 44 2005 4550 4554 (Pubitemid 41026391)
86. W.J. Parak, D. Gerion, D. Zanchet, A.S. Woerz, T. Pellegrino, and C. Micheel Conjugation of DNA to silanized colloidal semiconductor nanocrystalline quantum dots Chem Mater 14 2002 2113 2119
87. S.T. Selvan, T.T. Tan, and J.Y. Ying Robust, non-cytotoxic, silica-coated CdSe quantum dots with efficient photoluminescence Adv Mater 17 2005 1620 1625 (Pubitemid 40963859)
88. W.H. Tan, K.M. Wang, X.X. He, X.J. Zhao, T. Drake, and L. Wang Bionanotechnology based on silica nanoparticles Med Res Rev 24 2004 621 638 (Pubitemid 39038230)
89. W. Lian, S.A. Litherland, H. Badrane, W.H. Tan, D.H. Wu, and H.V. Baker Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles Anal Biochem 334 2004 135 144 (Pubitemid 39304084)
90. S. Santra, P. Zhang, K.M. Wang, R. Tapec, and W.H. Tan Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers Anal Chem 73 2001 4988 4993 (Pubitemid 32980123)
91. L.M. Rossi, L.F. Shi, F.H. Quina, and Z. Rosenzweig Stober synthesis of monodispersed luminescent silica nanoparticles for bioanalytical assays Langmuir 21 2005 4277 4280 (Pubitemid 40683352)
92. X. Zhao, R. Tapec-Dytioco, and W. Tan Ultrasensitive DNA detection using highly fluorescent bioconjugated nanoparticles J Am Chem Soc 125 2003 11474 11475 (Pubitemid 37210079)
93. R. Nyffenegger, C. Quellet, and J. Ricka Synthesis of fluorescent, monodisperse, colloidal silica particles J Colloid Interface Sci 159 1993 150 157
94. T. Zhang, J.L. Stilwell, D. Gerion, L. Ding, O. Elboudwarej, and P.A. Cooke Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements Nano Lett 6 2006 800 808
95. R.P.A. Dullens, M. Claesson, D. Derks, A. van Blaaderen, and W.K. Kegel Monodisperse core-shell poly(methyl methacrylate) latex colloids Langmuir 19 2003 5963 5966
96. K. Aguilar-Arteaga, J.A. Rodriguez, and E. Barrado Magnetic solids in analytical chemistry: a review Anal Chim Acta 674 2010 157 165
97. J. Li, S. Song, D. Li, Y. Su, Q. Huang, and Y. Zhao Multi-functional crosslinked Au nanoaggregates for the amplified optical DNA detection Biosens Bioelectron 24 2009 3311 3315
98. L.M. Rossi, A.D. Quach, and Z. Rosenzweig Glucose oxidase-magnetite nanoparticle bioconjugate for glucose sensing Anal Bioanal Chem 380 2004 606 613
99. R. De Palma, G. Reekmans, C.X. Liu, R. Wirix-Speetjens, W. Laureyn, and O. Nilsson Magnetic bead sensing platform for the detection of proteins Anal Chem 79 2007 8669 8677 (Pubitemid 350171378)
100. O.A. Loaiza, S. Campuzano, M. Pedrero, M.I. Pividori, P. Garcia, and J.M. Pingarron Disposable magnetic DNA sensors for the determination at the attomolar level of a specific enterobacteriaceae family gene Anal Chem 80 2008 8239 8245
101. P. Hu, C.Z. Huang, Y.F. Li, J. Ling, Y.L. Liu, and L.R. Fei Magnetic particle-based sandwich sensor with DNA-modified carbon nanotubes as recognition elements for detection of DNA hybridization Anal Chem 80 2008 1819 1823 (Pubitemid 351429590)
102. J.P. Li, and H.D. Gao A renewable potentiometric immunosensor based on Fe3O4 nanoparticles immobilized anti-IgG Electroanalysis 20 2008 881 887
103. A. Erdem, H. Karadeniz, G. Mayer, M. Famulok, and A. Caliskan Electrochemical sensing of aptamer-protein interactions using a magnetic particle assay and single-use sensor technology Electroanalysis 21 2009 1278 1284
104. D. Huska, J. Hubalek, V. Adam, D. Vajtr, A. Horna, and L. Trnkova Automated nucleic acids isolation using paramagnetic microparticles coupled with electrochemical detection Talanta 79 2009 402 411
105. H. Karadeniz, A. Erdem, F. Kuralay, and F. Jelen Indicator-based and indicator-free magnetic assays connected with disposable electrochemical nucleic acid sensor system Talanta 78 2009 187 192
106. J.-L. Guesdon, and S. Avrameas Magnetic solid phase enzyme-immunoassay Immunochemistry 14 1977 443 447
107. J.C. Antoine, T.R.S. Ternynck, M. Rodrigot, and S. Avrameas Lymphoid cell fractionation on magnetic polyacrylamide-agarose beads Immunochemistry 15 1978 443 452 (Pubitemid 9015375)
108. R.S. Molday, S.P.S. Yen, and A. Rembaum Application of magnetic microspheres in labelling and separation of cells Nature 268 1977 437 438
109. R. Hao, R. Xing, Z. Xu, Y. Hou, S. Gao, and S. Sun Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles Adv Mater 22 2010 2729 2742
110. U. Jeong, X. Teng, Y. Wang, H. Yang, and Y. Xia Superparamagnetic colloids: controlled synthesis and niche applications Adv Mater 19 2007 33 60 (Pubitemid 46144809)
111. A. Sandhu, H. Handa, and M. Abe Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics Nanotechnology 21 2010 442001
112. G.P. Hatch, and R.E. Stelter Magnetic design considerations for devices and particles used for biological high-gradient magnetic separation (HGMS) systems J Magn Magn Mater 225 2001 262 276 (Pubitemid 32335306)
113. T. Rheinlander, R. Kotitz, W. Weitschies, and W. Semmler Magnetic fractionation of magnetic fluids J Magn Magn Mater 219 2000 219 228
114. L.R. Moore, A.R. Rodriguez, P.S. Williams, K. McCloskey, B.J. Bolwell, and M. Nakamura Progenitor cell isolation with a high-capacity quadrupole magnetic flow sorter J Magn Magn Mater 225 2001 277 284 (Pubitemid 32335307)
115. C.M. Earhart, R.J. Wilson, R.L. White, N. Pourmand, and S.X. Wang Microfabricated magnetic sifter for high-throughput and high-gradient magnetic separation J Magn Magn Mater 321 2009 1436 1439
116. M.A.M. Gijs Magnetic bead handling on-chip: new opportunities for analytical applications Microfluid Nanofluid 1 2004 22 40 (Pubitemid 41166499)
117. M.A.M. Gijs, F. Lacharme, and U. Lehmann Microfluidic applications of magnetic particles for biological analysis and catalysis Chem Rev 110 2010 1518 1563
118. N. Pamme Magnetism and microfluidics Lab Chip 6 2006 24 38
119. J.F. Peter, and A.M. Otto Magnetic particles as powerful purification tool for high sensitive mass spectrometric screening procedures Proteomics 10 2010 628 633
120. K.E. McCloskey, L.R. Moore, M. Hoyos, A. Rodriguez, J.J. Chalmers, and M. Zborowski Magnetophoretic cell sorting is a function of antibody binding capacity Biotechnol Prog 19 2003 899 907 (Pubitemid 36715137)
121. O. Lara, X.D. Tong, M. Zborowski, and J.J. Chalmers Enrichment of rare cancer cells through depletion of normal cells using density and flow-through, immunomagnetic cell separation Exp Hematol 32 2004 891 904 (Pubitemid 39410703)
122. N. Xia, T.P. Hunt, B.T. Mayers, E. Alsberg, G.M. Whitesides, and R.M. Westervelt Combined microfluidic-micromagnetic separation of living cells in continuous flow Biomed Microdevices 8 2006 299 308 (Pubitemid 44697345)
123. J.S. Kim, and F.S. Ligler Utilization of microparticles in next-generation assays for microflow cytometers Anal Bioanal Chem 398 2010 2373 2382
124. M. Arruebo, M. Valladares, and A. Gonzalez-Fernandez Antibody-conjugated nanoparticles for biomedical applications J Nanomater 2009 Article ID 439389, 24 pages
125. J. Wang, A.-N. Kawde, A. Erdem, and M. Salazar Magnetic bead-based label-free electrochemical detection of DNA hybridization Analyst 126 2001 2020 2024 (Pubitemid 33097136)
126. J. Wang, D. Xu, A. Erdem, R. Polsky, and M.A. Salazar Genomagnetic electrochemical assays of DNA hybridization Talanta 56 2002 931 938 (Pubitemid 34241912)
127. E.H. Chowdhury, and T. Akaike Bio-functional inorganic materials: an attractive branch of gene-based nano-medicine delivery for 21st century Curr Gene Ther 5 2005 669 676 (Pubitemid 43009510)
128. J.B. Haun, T.J. Yoon, H. Lee, and R. Weissleder Magnetic nanoparticle biosensors Wiley Interdiscip Rev Nanomed Nanobiotechnol 2 2010 291 304
129. J.C. Venter, M.D. Adams, E.W. Myers, P.W. Li, R.J. Mural, and G.G. Sutton The sequence of the human genome Science 291 2001 1304 1351 (Pubitemid 32173090)
130. E.A. Feingold, P.J. Good, M.S. Guyer, S. Kamholz, L. Liefer, and K. Wetterstrand The ENCODE (ENCyclopedia of DNA elements) Project Science 306 2004 636 640 (Pubitemid 39440902)
131. D. Altshuler, L.D. Brooks, A. Chakravarti, F.S. Collins, M.J. Daly, and P. Donnelly A haplotype map of the human genome Nature 437 2005 1299 1320
132. J.L. Weber, D. David, J. Heil, Y. Fan, C.F. Zhao, and G. Marth Human diallelic insertion/deletion polymorphisms Am J Hum Genet 71 2002 854 862 (Pubitemid 135750517)
133. J. Bell Predicting disease using genomics Nature 429 2004 453 456 (Pubitemid 38715139)
134. C.W. Dykes Genes, disease and medicine Br J Clin Pharmacol 42 1996 683 695 (Pubitemid 26417609)
135. R.D. Abramson, and T.W. Myers Nucleic acid amplification technologies Curr Opin Biotechnol 4 1993 41 47 (Pubitemid 23073858)
136. M. Arya, I.S. Shergill, M. Williamson, L. Gommersall, N. Arya, and H.R.H. Patel Basic principles of real-time quantitative PCR Expert Rev Mol Diagn 5 2005 209 219 (Pubitemid 40396226)
137. H.A. Erlich, D. Gelfand, and J.J. Sninsky Recent advances in the polymerase chain-reaction Science 252 1991 1643 1651
138. K. Mullis, F. Faloona, S. Scharf, R. Saiki, G. Horn, and H. Erlich Specific enzymatic amplification of DNA in vitro - the polymerase chain-reaction Cold Spring Harb Symp Quant Biol 51 1986 263 273 (Pubitemid 17076711)
139. C.R. Newton, A. Graham, L.E. Heptinstall, S.J. Powell, C. Summers, and N. Kalsheker Analysis of any point mutation in DNA - the amplification refractory mutation system (arms) Nucleic Acids Res 17 1989 2503 2516 (Pubitemid 19103235)
140. J. Mackay, and O. Landt Real-time PCR fluorescent chemistries Methods Mol Biol 353 2007 237 261 (Pubitemid 350183281)
141. Y. Enomoto, T. Yoshikawa, M. Ihira, S. Akimoto, F. Miyake, and C. Usui Rapid diagnosis of herpes simplex virus infection by a loop-mediated isothermal amplification method J Clin Microbiol 43 2005 951 955 (Pubitemid 40256070)
142. P. Gill, and A. Ghaemi Nucleic acid isothermal amplification technologies - a review Nucleosides Nucleotides Nucleic Acids 27 2008 224 243 (Pubitemid 351220650)
143. U.B. Gyllensten, and H.A. Erlich Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus Proc Natl Acad Sci USA 85 1988 7652 7656
144. H. Kaneko, T. Iida, K. Aoki, S. Ohno, and T. Suzutani Sensitive and rapid detection of herpes simplex virus and varicella-zoster virus DNA by loop-mediated isothermal amplification J Clin Microbiol 43 2005 3290 3296 (Pubitemid 40981338)
145. K. Nagamine, K. Watanabe, K. Ohtsuka, T. Hase, and T. Notomi Loop-mediated isothermal amplification reaction using a nondenatured template Clin Chem 47 2001 1742 1743 (Pubitemid 32781605)
146. T. Notomi, H. Okayama, H. Masubuchi, T. Yonekawa, K. Watanabe, and N. Amino Loop-mediated isothermal amplification of DNA Nucleic Acids Res 28 2000 e63
147. M. Parida, S. Sannarangaiah, P.K. Dash, P.V.L. Rao, and K. Morita Loop mediated isothermal amplification (LAMP): a new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases Rev Med Virol 18 2008 407 421
148. J.A. Sanchez, K.E. Pierce, J.E. Rice, and L.J. Wangh Linear-after-the- exponential (LATE)-PCR: an advanced method of asymmetric PCR and its uses in quantitative real-time analysis Proc Natl Acad Sci USA 101 2004 1933 1938 (Pubitemid 38228993)
149. J. SantaLucia A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics Proc Natl Acad Sci USA 95 1998 1460 1465 (Pubitemid 28103414)
150. D.H. Turner Thermodynamics of base pairing Curr Opin Struct Biol 6 1996 299 304 (Pubitemid 26197428)
151. J.C. Alwine, D.J. Kemp, and G.R. Stark Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes Proc Natl Acad Sci USA 74 1977 5350 5354
152. E.M. Southern Detection of specific sequences among DNA fragments separated by gel-electrophoresis J Mol Biol 98 3 1975 503 517
153. E.V. Volpi, and J.M. Bridger FISH glossary: an overview of the fluorescence in situ hybridization technique Biotechniques 45 2008 385 386
154. M. Dufva Introduction to microarray technology Methods Mol Biol 529 2009 1 22
155. T. Niazov, V. Pavlov, Y. Xiao, R. Gill, and I. Willner DNAzyme-functionalized Au nanoparticles for the amplified detection of DNA or telomerase activity Nano Lett 4 2004 1683 1687 (Pubitemid 39297445)
156. K. Glynou, P.C. Ioannou, T.K. Christopoulos, and V. Syriopoulou Oligonucleotide-functionalized gold nanoparticles as probes in a dry-reagent strip biosensor for DNA analysis by hybridization Anal Chem 75 2003 4155 4160 (Pubitemid 37012548)
157. D.P. Kalogianni, V. Bravou, T.K. Christopoulos, P.C. Ioannou, and N.C. Zoumbos Dry-reagent disposable dipstick test for visual screening of seven leukemia-related chromosomal translocations Nucleic Acids Res 35 2007 e23
158. I.K. Litos, P.C. Ioannou, T.K. Christopoulos, J. Traeger-Synodinos, and E. Kanavakis Genotyping of single-nucleotide polymorphisms by primer extension reaction in a dry-reagent dipstick format Anal Chem 79 2007 395 402 (Pubitemid 46106103)
159. Y.Q. He, K. Zeng, A.S. Gurung, M. Baloda, H. Xu, and X.B. Zhang Visual detection of single-nucleotide polymorphism with hairpin oligonucleotide- functionalized gold nanoparticles Anal Chem 82 2010 7169 7177
160. D.P. Kalogianni, T. Koraki, T.K. Christopoulos, and P.C. Ioannou Nanoparticle-based DNA biosensor for visual detection of genetically modified organisms Biosens Bioelectron 21 2006 1069 1076 (Pubitemid 41815115)
161. H. Lee, S.W. Joo, S.Y. Lee, C.H. Lee, K.A. Yoon, and K. Lee Colorimetric genotyping of single nucleotide polymorphism based on selective aggregation of unmodified gold nanoparticles Biosens Bioelectron 26 2010 730 735
162. H. Lee, T. Kang, K.A. Yoon, S.Y. Lee, S.W. Joo, and K. Lee Colorimetric detection of mutations in epidermal growth factor receptor using gold nanoparticle aggregation Biosens Bioelectron 25 2010 1669 1674
163. J.H. Kim, and B.H. Chung Naked eye detection of mutagenic DNA photodimers using gold nanoparticles Biosens Bioelectron 26 2011 2805 2809
164. Z.F. Ma, L. Tian, T.T. Wang, and C.G. Wang Optical DNA detection based on gold nanorods aggregation Anal Chim Acta 673 2010 179 184
165. H.X. Li, and L.J. Rothberg DNA sequence detection using selective fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles Anal Chem 76 2004 5414 5417 (Pubitemid 39249424)
166. R.Q. Liang, W. Li, Y. Li, C.Y. Tan, J.X. Li, and Y.X. Jin An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe Nucleic Acids Res 33 2005 e17
167. A. Charrier, N. Candoni, N. Liachenko, and F. Thibaudau 2D aggregation and selective desorption of nanoparticle probes: a new method to probe DNA mismatches and damages Biosens Bioelectron 22 2007 1881 1886 (Pubitemid 46349620)
168. A. Charrier, N. Candoni, and F. Thibaudau DNA detection method based on the two-dimensional aggregation and selective desorption of nanoparticle probes J Phys Chem B 110 2006 12896 12900 (Pubitemid 44115618)
169. R. Elghanian, J.J. Storhoff, R.C. Mucic, R.L. Letsinger, and C.A. Mirkin Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles Science 277 1997 1078 1081 (Pubitemid 27371624)
170. D. Murphy, P. O'Brien, and G. Redmond Sub-picomole colorimetric single nucleotide polymorphism discrimination using oligonucleotide-nanoparticle conjugates Analyst 129 2004 970 974 (Pubitemid 39434037)
171. R.A. Reynolds, C.A. Mirkin, and R.L. Letsinger Homogeneous, nanoparticle-based quantitative colorimetric detection of oligonucleotides J Am Chem Soc 122 2000 3795 3796 (Pubitemid 30233461)
172. J.J. Storhoff, A.D. Lucas, V. Garimella, Y.P. Bao, and U.R. Muller Homogeneous detection of unamplified genomic DNA sequences based on colorimetric scatter of gold nanoparticle probes Nat Biotechnol 22 2004 883 887 (Pubitemid 38886609)
173. M.K. Beissenhirtz, R. Elnathan, Y. Weizmann, and I. Willner The aggregation of Au nanoparticles by an autonomous DNA machine detects viruses Small 3 2007 375 379 (Pubitemid 46420237)
174. K. Sato, K. Hosokawa, and M. Maeda Non-cross-linking gold nanoparticle aggregation as a detection method for single-base substitutions Nucleic Acids Res 33 2005 e4
175. P.V. Baptista Principles in genetic risk assessment J Ther Clin Risk Manag 1 2005 15 20
176. K. Sato, M. Onoguchi, Y. Sato, K. Hosokawa, and M. Maeda Non-cross-linking gold nanoparticle aggregation for sensitive detection of single-nucleotide polymorphisms: optimization of the particle diameter Anal Biochem 350 2006 162 164 (Pubitemid 43247640)
177. T.A. Taton, C.A. Mirkin, and R.L. Letsinger Scanometric DNA array detection with nanoparticle probes Science 289 2000 1757 1760
178. Y.P. Bao, M. Huber, T.F. Wei, S.S. Marla, J.J. Storhoff, and U.R. Muller SNP identification in unamplified human genomic DNA with gold nanoparticle probes Nucleic Acids Res 33 2005 e15
179. M. Huber, T.F. Wei, U.R. Muller, P.A. Lefebvre, S.S. Marla, and Y.P. Bao Gold nanoparticle probe-based gene expression analysis with unamplified total human RNA Nucleic Acids Res 32 2004 e137
180. J.J. Storhoff, S.S. Marla, P. Bao, S. Hagenow, H. Mehta, and A. Lucas Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system Biosens Bioelectron 19 2004 875 883 (Pubitemid 38201338)
181. A. Bonanni, M.J. Esplandiu, and M. del Valle Impedimetric genosensing of DNA polymorphism correlated to cystic fibrosis: a comparison among different protocols and electrode surfaces Biosens Bioelectron 26 2010 1245 1251
182. X.M. Li, P.Y. Fu, J.M. Liu, and S.S. Zhang Biosensor for multiplex detection of two DNA target sequences using enzyme-functionalized Au nanoparticles as signal amplification Anal Chim Acta 673 2010 133 138
183. Z.P. Wang, J.Q. Hu, Y. Jin, X. Yao, and J.H. Li In situ amplified chemiluminescent detection of DNA and immunoassay of IgG using special-shaped gold nanoparticles as label Clin Chem 52 2006 1958 1961 (Pubitemid 44470705)
184. M.J.A. Shiddiky, and Y.B. Shim Trace analysis of DNA: preconcentration, separation, and electrochemical detection in microchip electrophoresis using Au nanoparticles Anal Chem 79 2007 3724 3733 (Pubitemid 46799069)
185. C. Nogues, S.R. Cohen, S. Daube, N. Apter, and R. Naaman Sequence dependence of charge transport properties of DNA J Phys Chem B 110 2006 8910 8913 (Pubitemid 43828976)
186. M. Ozsoz, A. Erdem, K. Kerman, D. Ozkan, B. Tugrul, and N. Topcuoglu Electrochemical genosensor based on colloidal gold nanoparticles for the detection of Factor V Leiden mutation using disposable pencil graphite electrodes Anal Chem 75 2003 2181 2187 (Pubitemid 36542362)
187. J. Wang, R. Polsky, and D.K. Xu Silver-enhanced colloidal gold electrochemical stripping detection of DNA hybridization Langmuir 17 2001 5739 5741 (Pubitemid 35330730)
188. J. Wang, D.K. Xu, A.N. Kawde, and R. Polsky Metal nanoparticle-based electrochemical stripping potentiometric detection of DNA hybridization Anal Chem 73 2001 5576 5581 (Pubitemid 33108570)
189. C.S. Ah, Y.J. Yun, H.J. Park, S.K. Jung, W.-J. Kim, and D.H. Ha Electric detection of DNA hybridization by nanoparticle nanoswitch Curr Appl Phys 6 2006 e157 e160
190. J. Zhang, S.P. Song, L.Y. Zhang, L.H. Wang, H.P. Wu, and D. Pan Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes J Am Chem Soc 128 2006 8575 8580
191. M.T. Castaneda, A. Merkoci, M. Pumera, and S. Alegret Electrochemical genosensors for biomedical applications based on gold nanoparticles Biosens Bioelectron 22 2007 1961 1967 (Pubitemid 46349632)
192. M.P.N. Bui, T.J. Baek, and G.H. Seong Gold nanoparticle aggregation-based highly sensitive DNA detection using atomic force microscopy Anal Bioanal Chem 388 2007 1185 1190 (Pubitemid 47150039)
193. P.C. Ray, G.K. Darbha, A. Ray, J. Walker, and W. Hardy Gold nanoparticle based FRET for DNA detection Plasmonics 2 2007 173 183 (Pubitemid 350015117)
194. Y.W.C. Cao, R.C. Jin, and C.A. Mirkin Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection Science 297 2002 1536 1540 (Pubitemid 34970997)
195. L. He, M.D. Musick, S.R. Nicewarner, F.G. Salinas, S.J. Benkovic, and M.J. Natan Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization J Am Chem Soc 122 2000 9071 9077
196. Y.A. Li, A.W. Wark, H.J. Lee, and R.M. Corn Single-nucleotide polymorphism genotyping by nanoparticle-enhanced surface plasmon resonance imaging measurements of surface ligation reactions Anal Chem 78 2006 3158 3164 (Pubitemid 43726138)
197. X. Yao, X. Li, F. Toledo, C. Zurita-Lopez, M. Gutova, and J. Momand Sub-attomole oligonucleotide and p53 cDNA determinations via a high-resolution surface plasmon resonance combined with oligonucleotide-capped gold nanoparticle signal amplification Anal Biochem 354 2006 220 228
198. Y. Sato, K. Sato, K. Hosokawa, and M. Maeda Surface plasmon resonance imaging on a microchip for detection of DNA-modified gold nanoparticles deposited onto the surface in a non-cross-linking configuration Anal Biochem 355 2006 125 131 (Pubitemid 44041402)
199. S.R. Harry, D.J. Hicks, K.I. Amiri, and D.W. Wright Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells Chem Commun 46 2010 5557 5559
200. M.G. Cerruti, M. Sauthier, D. Leonard, D. Liu, G. Duscher, and D.L. Feldheim Gold and silica-coated gold nanoparticles as thermographic labels for DNA detection Anal Chem 78 2006 3282 3288
201. R. Kanjanawarut, and X.D. Su Colorimetric detection of DNA using unmodified metallic nanoparticles and peptide nucleic acid probes Anal Chem 81 2009 6122 6129
202. Q.F. Xu, J. Liu, Z.K. He, and S. Yang Superquenching acridinium ester chemiluminescence by gold nanoparticles for DNA detection Chem Commun 46 2010 8800 8802
203. C.S. Thaxton, D.G. Georganopoulou, and C.A. Mirkin Gold nanoparticle probes for the detection of nucleic acid targets Clin Chim Acta 363 2006 120 126 (Pubitemid 41745229)
204. J.J. Storhoff, R. Elghanian, R.C. Mucic, C.A. Mirkin, and R.L. Letsinger One-pot colorimetric differentiation of polynucleotides with single base imperfections using gold nanoparticle probes J Am Chem Soc 120 1998 1959 1964 (Pubitemid 28179167)
205. J.S. Li, T. Deng, X. Chu, R.H. Yang, J.H. Jiang, and G.L. Shen Rolling circle amplification combined with gold nanoparticle aggregates for highly sensitive identification of single-nucleotide polymorphisms Anal Chem 82 2010 2811 2816
206. W.J. Qin, O.S. Yim, P.S. Lai, and L.Y.L. Yung Dimeric gold nanoparticle assembly for detection and discrimination of single nucleotide mutation in Duchenne muscular dystrophy Biosens Bioelectron 25 2010 2021 2025
207. P. Baptista, G. Doria, D. Henriques, E. Pereira, and R. Franco Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticles J Biotechnol 119 2005 111 117 (Pubitemid 41219540)
208. J. Conde, J. de la Fuente, and P. Baptista RNA quantification using gold nanoprobes - application to cancer diagnostics J Nanobiotechnol 8 2010 5
209. P. Costa, A. Amaro, A. Botelho, J. Inácio, and P.V. Baptista Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex Clin Microbiol Infect 16 2010 1464 1469
210. G. Doria, B.G. Baumgartner, R. Franco, and P.V. Baptista Optimizing Au-nanoprobes for specific sequence discrimination Colloids Surf B Biointerfaces 77 2010 122 124
211. B. Veigas, D. Machado, J. Perdigao, I. Portugal, I. Couto, and M. Viveiros Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis Nanotechnology 21 2010 415101
212. I. Bernacka-Wojcik, R. Senadeera, P.J. Wojcik, L.B. Silva, G. Doria, and P. Baptista Inkjet printed and "doctor blade" TiO2 photodetectors for DNA biosensors Biosens Bioelectron 25 2010 1229 1234
213. R. Martins, P. Baptista, L. Raniero, G. Doria, L. Silva, and R. Franco Amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences using gold nanoparticle probes Appl Phys Lett 90 2007 023903
214. L.B. Silva, P. Baptista, L. Raniero, G. Doria, R. Martins, and E. Fortunato Characterization of optoelectronic platform using an amorphous/nanocrystalline silicon biosensor for the specific identification of nucleic acid sequences based on gold nanoparticle probes Sensor Actuat B-Chem 132 2008 508 511
215. L.B. Silva, B. Veigas, G. Doria, P. Costa, J. Inácio, and R. Martins Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex Biosens Bioelectron 26 2011 2012 2017
216. P. Hazarika, B. Ceyhan, and C.M. Niemeyer Reversible switching of DNA-gold nanoparticle aggregation Angew Chem Int Ed 43 2004 6469 6471 (Pubitemid 40029497)
217. S.J. Park, T.A. Taton, and C.A. Mirkin Array-based electrical detection of DNA with nanoparticle probes Science 295 2002 1503 1506 (Pubitemid 34174000)
218. T. Kang, S.M. Yoo, I. Yoon, S.Y. Lee, and B. Kim Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor Nano Lett 10 2010 1189 1193
219. H. Zhang, M.H. Harpster, H.J. Park, P.A. Johnson, and W.C. Wilson Surface-enhanced Raman scattering detection of DNA derived from the West Nile virus genome using magnetic capture of Raman-active gold nanoparticles Anal Chem 83 2010 254 260
220. X. Qian, X. Zhou, and S. Nie Surface-enhanced Raman nanoparticle beacons based on bioconjugated gold nanocrystals and long range plasmonic coupling J Am Chem Soc 130 2008 14934 14935
221. I.K. Litos, P.C. Ioannou, T.K. Christopoulos, J. Traeger-Synodinos, and E. Kanavakis Multianalyte, dipstick-type, nanoparticle-based DNA biosensor for visual genotyping of single-nucleotide polymorphisms Biosens Bioelectron 24 2009 3135 3139
222. Y.Y. Zhang, Z.W. Tang, J. Wang, H. Wu, A.H. Maham, and Y.H. Lin Hairpin DNA switch for ultrasensitive spectrophotometric detection of DNA hybridization based on gold nanoparticles and enzyme signal amplification Anal Chem 82 2010 6440 6446
223. Y.C. Cao, R.C. Jin, S. Thaxton, and C.A. Mirkin A two-color-change, nanoparticle-based method for DNA detection Talanta 67 2005 449 455 (Pubitemid 41240579)
224. J.S. Lee, A.K.R. Lytton-Jean, S.J. Hurst, and C.A. Mirkin Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties Nano Lett 7 2007 2112 2115 (Pubitemid 47197600)
225. G.X. Jiang, A.S. Susha, A.A. Lutich, F.D. Stefani, J. Feldmann, and A.L. Rogach Cascaded FRET in conjugated polymer/quantum dot/dye-labeled DNA complexes for DNA hybridization detection ACS Nano 3 2009 4127 4131
226. J. Lee, Y. Choi, J. Kim, E. Park, and R. Song Positively charged compact quantum dot-DNA complexes for detection of nucleic acids Chemphyschem 10 2009 806 811
227. I.L. Medintz, and H. Mattoussi Quantum dot-based resonance energy transfer and its growing application in biology Phys Chem Chem Phys 11 2009 17 45
228. F. Patolsky, R. Gill, Y. Weizmann, T. Mokari, U. Banin, and I. Willner Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots J Am Chem Soc 125 2003 13918 13919 (Pubitemid 37420871)
229. C.Y. Zhang, H.C. Yeh, M.T. Kuroki, and T.H. Wang Single-quantum-dot-based DNA nanosensor Nat Mater 4 2005 826 831
230. D. Zhou, L. Ying, X. Hong, E.A. Hall, C. Abell, and D. Klenerman A compact functional quantum dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection Langmuir 24 2008 1659 1664 (Pubitemid 351500913)
231. C.Y. Zhang, and J. Hu Single quantum dot-based nanosensor for multiple DNA detection Anal Chem 82 2010 1921 1927
232. T. Heyduk, and E. Heyduk Molecular beacons for detecting DNA binding proteins Nat Biotechnol 20 2002 171 176 (Pubitemid 34158033)
233. I.L. Medintz, L. Berti, T. Pons, A.F. Grimes, D.S. English, and A. Alessandrini A reactive peptidic linker for self-assembling hybrid quantum dot-DNA bioconjugates Nano Lett 7 2007 1741 1748 (Pubitemid 47140455)
234. A. Agrawal, C.Y. Zhang, T. Byassee, R.A. Tripp, and S.M. Nie Counting single native biomolecules and intact viruses with color-coded nanoparticles Anal Chem 78 2006 1061 1070 (Pubitemid 43271835)
235. L. Dyadyusha, H. Yin, S. Jaiswal, T. Brown, J.J. Baumberg, and F.P. Booy Quenching of CdSe quantum dot emission, a new approach for biosensing Chem Commun 2005 3201 3203 (Pubitemid 41002394)
236. H. Kuang, S. Zhao, W. Chen, W. Ma, Q. Yong, and L. Xu Rapid DNA detection by interface PCR on nanoparticles Biosens Bioelectron 26 2011 2495 2499
237. Y. Xu, and Q.G. Li Multiple fluorescent labeling of silica nanoparticles with lanthanide chelates for highly sensitive time-resolved Immunofluorometric assays Clin Chem 53 2007 1503 1510 (Pubitemid 47206348)
238. E. Herz, A. Burns, D. Bonner, and U. Wiesner Large stokes-shift fluorescent silica nanoparticles with enhanced emission over free dye for single excitation multiplexing Macromol Rapid Commun 30 2009 1907 1910
239. J. Xu, J. Liang, J. Li, and W. Yang Multicolor dye-doped silica nanoparticles independent of FRET Langmuir 26 2010 15722 15725
240. X.C. Zhou, and J.Z. Zhou Improving the signal sensitivity and photostability of DNA hybridizations on microarrays by using dye-doped core-shell silica nanoparticles Anal Chem 76 2004 5302 5312
241. J.L. Yan, M.C. Estevez, J.E. Smith, K.M. Wang, X.X. He, and L. Wang Dye-doped nanoparticles for bioanalysis Nano Today 2 2007 44 50 (Pubitemid 46695432)
242. E. Herz, T. Marchincin, L. Connelly, D. Bonner, A. Burns, and S. Switalski Relative quantum yield measurements of coumarin encapsulated in core-shell silica nanoparticles J Fluoresc 20 2010 67 72
243. S. Santra, B. Liesenfeld, C. Bertolino, D. Dutta, Z.H. Cao, and W.H. Tan Fluorescence lifetime measurements to determine the core-shell nanostructure of FITC-doped silica nanoparticles: an optical approach to evaluate nanoparticle photostability J Lumin 117 2006 75 82 (Pubitemid 41654564)
244. X. Chen, M.C. Estevez, Z. Zhu, Y.-F. Huang, Y. Chen, and L. Wang Using aptamer-conjugated fluorescence resonance energy transfer nanoparticles for multiplexed cancer cell monitoring Anal Chem 81 2009 7009 7014
245. L. Wang, C. Yang, and W. Tan Dual-luminophore-doped silica nanoparticles for multiplexed signaling Nano Lett 5 2004 37 43
246. P. Sharma, S. Brown, G. Walter, S. Santra, and B. Moudgil Nanoparticles for bioimaging Adv Colloid Interface Sci 123-126 2006 471 485 (Pubitemid 44665822)
247. J.E. Smith, L. Wang, and W.T. Tan Bioconjugated silica-coated nanoparticles for bioseparation and bioanalysis Trac-Trend Anal Chem 25 2006 848 855 (Pubitemid 44508642)
248. R. Tapec, X.J.J. Zhao, and W.H. Tan Development of organic dye-doped silica nanoparticles for bioanalysis and biosensors J Nanosci Nanotechnol 2 2002 405 409 (Pubitemid 135714153)
249. T. Deng, J.S. Li, J.H. Jiang, G.L. Shen, and R.Q. Yu Preparation of near-IR fluorescent nanoparticles for fluorescence-anisotropy-based immunoagglutination assay in whole blood Adv Funct Mater 16 2006 2147 2155 (Pubitemid 44672584)
250. N.N. Zhu, H. Cai, P.G. He, and Y.Z. Fang Tris(2,2′'-bipyridyl) cobalt(III)-doped silica nanoparticle DNA probe for the electrochemical detection of DNA hybridization Anal Chim Acta 481 2003 181 189 (Pubitemid 36316025)
251. P. Tallury, S. Kar, S. Bamrungsap, Y.F. Huang, W.H. Tand, and S. Santra Ultra-small water-dispersible fluorescent chitosan nanoparticles: synthesis, characterization and specific targeting Chem Commun 2009 2347 2349
252. C. Wu, C. Szymanski, and J. McNeill Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles Langmuir 22 2006 2956 2960
253. C. Wu, T. Schneider, M. Zeigler, J. Yu, P.G. Schiro, and D.R. Burnham Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting J Am Chem Soc 132 2010 15410 15417
254. J.R. Taylor, M.M. Fang, and S.M. Nie Probing specific sequences on single DNA molecules with bioconjugated fluorescent nanoparticles Anal Chem 72 2000 1979 1986 (Pubitemid 30316570)
255. S. Tang, M. Moayeri, Z. Chen, H. Harma, J. Zhao, and H. Hu Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles Clin Vaccine Immunol 16 2009 408 413
256. A. Valanne, S. Huopalahti, T. Soukka, R. Vainionpaa, T. Lovgren, and H. Harma A sensitive adenovirus immunoassay as a model for using nanoparticle label technology in virus diagnostics J Clin Virol 33 2005 217 223 (Pubitemid 40720441)
257. B.H. Weigl, R.L. Bardell, and C. Cabrera Introduction to microfluidic techniques R.S. Marks, D.C. Cullen, I. Karube, C.R. Lowe, H.H. Weetall, Handbook of biosensors and biochips 2007 John Wiley & Sons, Ltd. Cambridge
258. W. Laureyn, T. Stakenborg, and P. Jacobs Genetic and other DNA-based biosensor applications R.S. Marks, D.C. Cullen, I. Karube, C.R. Lowe, H.H. Weetall, Handbook of biosensors and biochips 2007 John Wiley & Sons, Ltd. Cambridge 1 19
259. B. Kuswandi, J. Nuriman, J. Huskens, and W. Verboom Optical sensing systems for microfluidic devices: a review Anal Chim Acta 601 2007 141 155 (Pubitemid 47505229)
260. G.M. Whitesides The origins and the future of microfluidics Nature 442 2006 368 373 (Pubitemid 44264779)
261. X. Chu, Z.F. Xiang, X. Fu, S.P. Wang, G.L. Shen, and R.Q. Yu Silver-enhanced colloidal gold metalloimmunoassay for Schistosoma japonicum antibody detection J Immunol Methods 301 2005 77 88 (Pubitemid 40965542)
262. L.J. Lai, Y.W. Yang, Y.K. Lin, L.L. Huang, and Y.H. Hsieh Surface characterization of immunosensor conjugated with gold nanoparticles based on cyclic voltammetry and X-ray photoelectron spectroscopy Colloids Surf B Biointerfaces 68 2009 130 135
263. A.P. Fan, Z.J. Cao, H.A. Li, M. Kai, and J.Z. Lu Chemiluminescence platforms in immunoassay and DNA analyses Anal Sci 25 2009 587 597
264. Z.-P. Li, Y.-C. Wang, C.-H. Liu, and Y.-K. Li Development of chemiluminescence detection of gold nanoparticles in biological conjugates for immunoassay Anal Chim Acta 551 2005 85 91 (Pubitemid 41394002)
265. A.P. Fan, C.W. Lau, and J.Z. Lu Magnetic bead-based chemiluminescent metal immunoassay with a colloidal gold label Anal Chem 77 2005 3238 3242
266. D.H. Hu, H.Y. Han, R. Zhou, F. Dong, W.C. Bei, and F. Jia Gold(III) enhanced chemiluminescence immunoassay for detection of antibody against ApxIV of Actinobacillus pleuropneumoniae Analyst 133 2008 768 773 (Pubitemid 351713322)
267. C.F. Duan, Y.Q. Yu, and H. Cui Gold nanoparticle-based immunoassay by using non-stripping chemiluminescence detection Analyst 133 2008 1250 1255
268. J. Das, M.A. Aziz, and H. Yang A nanocatalyst-based assay for proteins: DNA-free ultrasensitive electrochemical detection using catalytic reduction of p-nitrophenol by gold-nanoparticle labels J Am Chem Soc 128 2006 16022 16023 (Pubitemid 44936580)
269. A. Ambrosi, F. Airó, and A. Merkoi Enhanced gold nanoparticle based ELISA for a breast cancer biomarker Anal Chem 82 2009 1151 1156
270. S.-B. Zhang, Z.-S. Wu, M.-M. Guo, G.-L. Shen, and R.-Q. Yu A novel immunoassay strategy based on combination of chitosan and a gold nanoparticle label Talanta 71 2007 1530 1535 (Pubitemid 46282830)
271. R. Wilson The use of gold nanoparticles in diagnostics and detection Chem Soc Rev 37 2008 2028 2045
272. L.R. Hirsch, J.B. Jackson, A. Lee, N.J. Halas, and J. West A whole blood immunoassay using gold nanoshells Anal Chem 75 2003 2377 2381 (Pubitemid 36582822)
273. B. Khlebtsov, and N. Khlebtsov Enhanced solid-phase immunoassay using gold nanoshells: effect of nanoparticle optical properties Nanotechnology 19 2008 435703
274. J.M. Nam, C.S. Thaxton, and C.A. Mirkin Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins Science 301 2003 1884 1886 (Pubitemid 37221389)
275. H.D. Hill, and C.A. Mirkin The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange Nat Protoc 1 2006 324 336
276. D. Kim, W.L. Daniel, and C.A. Mirkin Microarray-based multiplexed scanometric immunoassay for protein cancer markers using gold nanoparticle probes Anal Chem 81 2009 9183 9187
277. M. Manimaran, and N.R. Jana Detection of protein molecules by surface-enhanced Raman spectroscopy-based immunoassay using 2-5 nm gold nanoparticle lables J Raman Spectrosc 38 2007 1326 1331
278. C.Y. Song, Z.Y. Wang, J. Yang, R.H. Zhang, and Y.P. Cui Preparation of 2-mercaptobenzothiazole-labeled immuno-Au aggregates for SERS-based immunoassay Colloids Surf B Biointerfaces 81 2010 285 288
279. A. Matschulat, D. Drescher, and J. Kneipp Surface-enhanced Raman scattering hybrid nanoprobe multiplexing and imaging in biological systems ACS Nano 4 2010 3259 3269
280. H.H. Cai, P.H. Yang, J. Feng, and J.Y. Cai Immunoassay detection using functionalized gold nanoparticle probes coupled with resonance Rayleigh scattering Sensors Actuat B Chem 135 2009 603 609
281. X. Liu, Q. Dai, L. Austin, J. Coutts, G. Knowles, and J. Zou A one-step homogeneous immunoassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering J Am Chem Soc 130 2008 2780 2782 (Pubitemid 351416236)
282. P.K. Jain, X.H. Huang, I.H. El-Sayed, and M.A. El-Sayed Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine Acc Chem Res 41 2008 1578 1586
283. N.G. Khlebtsov Anisotropic properties of plasmonic nanoparticles: depolarized light scattering, dichroism, and birefringence J Nanophotonics 4 2010 041587
284. H.W. Huang, C.R. Tang, Y.L. Zeng, X.Y. Yu, B. Liao, and X.D. Xia Label-free optical biosensor based on localized surface plasmon resonance of immobilized gold nanorods Colloids Surf B Biointerfaces 71 2009 96 101
285. S. Lee, K.M. Mayer, and J.H. Hafner Improved localized surface plasmon resonance immunoassay with gold bipyramid substrates Anal Chem 81 2009 4450 4455
286. K.M. Mayer, F. Hao, S. Lee, P. Nordlander, and J.H. Hafner A single molecule immunoassay by localized surface plasmon resonance Nanotechnology 21 2010 255503
287. E. Dulkeith, M. Ringler, T.A. Klar, J. Feldmann, A.M. Javier, and W.J. Parak Gold nanoparticles quench fluorescence by phase induced radiative rate suppression Nano Lett 5 2005 585 589 (Pubitemid 40609724)
288. Z.F. Peng, Z.P. Chen, J.H. Jiang, X.B. Zhang, G.L. Shen, and R.Q. Yu A novel immunoassay based on the dissociation of immunocomplex and fluorescence quenching by gold nanoparticles Anal Chim Acta 583 2007 40 44
289. L.M. Ao, F. Gao, B.F. Pan, R. He, and D.X. Cui Fluoroimmunoassay for antigen based on fluorescence quenching signal of gold nanoparticles Anal Chem 78 2006 1104 1106 (Pubitemid 43271839)
290. S. Mayilo, B. Ehlers, M. Wunderlich, T.A. Klar, H.P. Josel, and D. Heindl Competitive homogeneous digoxigenin immunoassay based on fluorescence quenching by gold nanoparticles Anal Chim Acta 646 2009 119 122
291. S. Mayilo, M.A. Kloster, M. Wunderlich, A. Lutich, T.A. Klar, and A. Nichtl Long-range fluorescence quenching by gold nanoparticles in a sandwich immunoassay for cardiac troponin T Nano Lett 9 2009 4558 4563
292. W.C.W. Chan, and S.M. Nie Quantum dot bioconjugates for ultrasensitive nonisotopic detection Science 281 1998 2016 2018 (Pubitemid 28475486)
293. E.R. Goldman, G.P. Anderson, P.T. Tran, H. Mattoussi, P.T. Charles, and J.M. Mauro Conjugation of luminescent quantum dots with antibodies using an engineered adaptor protein to provide new reagents for fluoroimmunoassays Anal Chem 74 2002 841 847 (Pubitemid 34160551)
294. M.M. Sun, L.Y. Du, S.Q. Gao, Y.H. Bao, and S.H. Wang Determination of 17 beta-oestradiol by fluorescence immunoassay with streptavidin-conjugated quantum dots as label Steroids 75 2010 400 403
295. M. Bruchez, M. Moronne, P. Gin, S. Weiss, and A.P. Alivisatos Semiconductor nanocrystals as fluorescent biological labels Science 281 1998 2013 2016 (Pubitemid 28475485)
296. M. Seydack Nanoparticle labels in immunosensing using optical detection methods Biosens Bioelectron 20 2005 2454 2469 (Pubitemid 40613010)
297. G. Rousserie, A. Sukhanova, K. Even-Desrumeaux, F. Fleury, P. Chames, and D. Baty Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays Crit Rev Oncol Hematol 74 2010 1 15
298. S. Pathak, M.C. Davidson, and G.A. Silva Characterization of the functional binding properties of antibody conjugated quantum dots Nano Lett 7 2007 1839 1845 (Pubitemid 47197555)
299. A.A. Ghazani, J.A. Lee, J. Klostranec, Q. Xiang, R.S. Dacosta, and B.C. Wilson High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals Nano Lett 6 2006 2881 2886 (Pubitemid 46129588)
300. J. Aveyard, P. Nolan, and R. Wilson Improving the sensitivity of immunoassays by tuning gold nanoparticles to the tipping point Anal Chem 80 2008 6001 6005
301. Y. Liu, M. Zhong, G. Shan, Y. Li, B. Huang, and G. Yang Biocompatible ZnO/Au nanocomposites for ultrasensitive DNA detection using resonance Raman scattering J Phys Chem B 112 2008 6484 6489
302. Y.D. Jin, and X.H. Gao Plasmonic fluorescent quantum dots Nat Nanotechnol 4 2009 571 576
303. B. Tang, L. Cao, K. Xu, L. Zhuo, J. Ge, and Q. Li A new nanobiosensor for glucose with high sensitivity and selectivity in serum based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots and Au nanoparticles Chem-Eur J 14 2008 3637 3644
304. M.M. Maye, O. Gang, and M. Cotlet Photoluminescence enhancement in CdSe/ZnS-DNA linked-Au nanoparticle heterodimers probed by single molecule spectroscopy Chem Commun 46 2010 6111 6113
305. M.Y. Han, X.H. Gao, J.Z. Su, and S. Nie Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules Nat Biotechnol 19 2001 631 635 (Pubitemid 32625432)
306. H.X. Xu, M.Y. Sha, E.Y. Wong, J. Uphoff, Y.H. Xu, and J.A. Treadway Multiplexed SNP genotyping using the Qbead (TM) system: a quantum dot-encoded microsphere-based assay Nucleic Acids Res 31 2003 e43
307. A.S. de Dios, and M.E. Diaz-Garcia Multifunctional nanoparticles: analytical prospects Anal Chim Acta 666 2010 1 22
308. H.N. Kim, M.H. Lee, H.J. Kim, J.S. Kim, and J. Yoon A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions Chem Soc Rev 37 2008 1465 1472
309. T. Pellegrino, S. Kudera, T. Liedl, A.M. Javier, L. Manna, and W.J. Parak On the development of colloidal nanoparticles towards multifunctional structures and their possible use for biological applications Small 1 2005 48 63 (Pubitemid 43951803)
310. H.H.P. Yiu, H.J. Niu, E. Biermans, G. van Tendeloo, and M.J. Rosseinsky Designed multifunctional nanocomposites for biomedical applications Adv Funct Mater 20 2010 1599 1609
311. Y.-P. Ho, and K.W. Leong Quantum dot-based theranostics Nanoscale 2 2010 60 68
312. A.M. Smith, H.W. Duan, A.M. Mohs, and S.M. Nie Bioconjugated quantum dots for in vivo molecular and cellular imaging Adv Drug Deliv Rev 60 2008 1226 1240
313. P. Yager, T. Edwards, E. Fu, K. Helton, K. Nelson, and M.R. Tam Microfluidic diagnostic technologies for global public health Nature 442 2006 412 418 (Pubitemid 44264785)
314. D. Farrell, J. Alper, K. Ptak, N.J. Panaro, P. Grodzinski, and A.D. Barker Recent advances from the national cancer institute alliance for nanotechnology in cancer ACS Nano 4 2010 589 594
315. A. Gomez-Hens, J.M. Fernandez-Romero, and M.P. Aguilar-Caballos Control of tumor markers using nanotechnology Mini Rev Med Chem 9 2009 1064 1074
316. J.F. Rusling, C.V. Kumar, J.S. Gutkind, and V. Patel Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer Analyst 135 2010 2496 2511