Use of a steroid cyclic disulfide anchor in constructing gold nanoparticle-oligonucleotide conjugates

Bioconjugate Chemistry

Volumn 11, Issue 2, 2000, Pages 289-291

  Letsinger, R L ^a   Elghanian, R ^a   Viswanadham, G ^a   Mirkin, C A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034023478     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990152n     Document Type: Article

References (10)

1. Storhoff, J. J., Elghanian, R., Mucic, R. C., Mirkin, C. A., and Letsinger, R. L. (1998) One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes. J. Am. Chem. Soc. 120, 1959-1964.
2. Elghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L., and Mirkin, C. A. (1997) Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles. Science 277, 1078-1081.
3. Mucic, R. C., Storhoff, J. J., Mirkin, C. A., and Letsinger, R. L. (1998) DNA-Directed Synthesis of Binary Nanoparticle Network Materials. J. Am. Chem. Soc. 120, 12674-12675.
4. Mitchell, G. P., Mirkin, C. A., and Letsinger, R. L. (1999) The Programmed Assembly of DNA Functionalized Quantum Dots. J. Am. Chem. Soc. 121, 8122-8123.
5. Nuzzo, R. G., and Allara, D. L. (1983) Adsorption of Bifunctional Organic Disulfides on Gold Surfaces. J. Am. Chem. Soc. 105, 4481-4483.
6. Ulman, A. (1995) Surface Absorption of Monolayers. MRS Bulletin, June 46-51.
7. For examples of hydrophobic interactions in steroid-oligonucleotide conjugates, see (a) Letsinger, R. L, Chaturvedi, S. K., Farooqui, F., and Salunkhe, M. (1993) Use of Hydrophobic Substituents in Controlling Self-Assembly of Oligonucleotides. J. Am. Chem. Soc. 115, 7535-7536;
8. (b) Letsinger, R. L., and Chaturvedi, S. (1998) Tailored Hydrophobic Cavities in Oligonucleotide-Steroid Conjugates. Bioconjugate Chem. 9, 826-830.
9. Mucic, R. C. (1999) Synthetic Programmable Nanoparticle Assembly Using DNA, Ph.D. Thesis, Northwestern University.
10. Zhong, C.-J., Brush, R. C., Anderegg, J., Porter, M. D. (1999) Langmuir 15, 518-525.