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Volumn 6, Issue 11, 2011, Pages 1344-1353

Bivalent histone modifications in stem cells poise miRNA loci for CpG Island hypermethylation in human cancer

Author keywords

Bivalent domains; Cancer specific methylation; Chromatin modification; DNA methylation; Embryonic stem cells; Histone marks; MicroRNAs

Indexed keywords

HISTONE; MICRORNA;

EID: 81055154928     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.6.11.18021     Document Type: Article
Times cited : (15)

References (84)
  • 1
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358:1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 2
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med 17:330-339.
    • Nat Med , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 3
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431:350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 4
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function. Cell 2004; 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 5
    • 0038299558 scopus 로고    scopus 로고
    • Role of microRNAs in plant and animal development
    • Carrington JC, Ambros V. Role of microRNAs in plant and animal development. Science 2003; 301:336-338.
    • (2003) Science , vol.301 , pp. 336-338
    • Carrington, J.C.1    Ambros, V.2
  • 6
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522-531.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 8
    • 20444436381 scopus 로고    scopus 로고
    • Cancer genomics: Small RNAs with big impacts
    • Meltzer PS. Cancer genomics: small RNAs with big impacts. Nature 2005; 435:745-746.
    • (2005) Nature , vol.435 , pp. 745-746
    • Meltzer, P.S.1
  • 10
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007; 104:15805-15810.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3    Liu, Z.4    Zanesi, N.5    Callegari, E.6
  • 11
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 12
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs-microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 13
    • 34247555491 scopus 로고    scopus 로고
    • MicroRNAs as tumor suppressors
    • Hammond SM. MicroRNAs as tumor suppressors. Nat Genet 2007; 39:582-583.
    • (2007) Nat Genet , vol.39 , pp. 582-583
    • Hammond, S.M.1
  • 14
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004; 101:2999-3004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3    Hyslop, T.4    Noch, E.5    Yendamuri, S.6
  • 18
    • 77957940475 scopus 로고    scopus 로고
    • A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    • Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 2010; 18:303-15.
    • (2010) Cancer Cell , vol.18 , pp. 303-315
    • Melo, S.A.1    Moutinho, C.2    Ropero, S.3    Calin, G.A.4    Rossi, S.5    Spizzo, R.6
  • 19
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
    • Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 2009; 41:365-70.
    • (2009) Nat Genet , vol.41 , pp. 365-370
    • Melo, S.A.1    Ropero, S.2    Moutinho, C.3    Aaltonen, L.A.4    Yamamoto, H.5    Calin, G.A.6
  • 20
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99:15524-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3    Bichi, R.4    Zupo, S.5    Noch, E.6
  • 23
    • 27644570319 scopus 로고    scopus 로고
    • A microRNA cluster as a target of genomic amplification in malignant lymphoma
    • Tagawa H, Seto M. A microRNA cluster as a target of genomic amplification in malignant lymphoma. Leukemia 2005; 19:2013-2016.
    • (2005) Leukemia , vol.19 , pp. 2013-2016
    • Tagawa, H.1    Seto, M.2
  • 24
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3:415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 26
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007; 67:1424-9.
    • (2007) Cancer Res , vol.67 , pp. 1424-1429
    • Lujambio, A.1    Ropero, S.2    Ballestar, E.3    Fraga, M.F.4    Cerrato, C.5    Setien, F.6
  • 27
    • 66249148694 scopus 로고    scopus 로고
    • Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia
    • Agirre X, Vilas-Zornoza A, Jimenez-Velasco A, Martin- Subero JI, Cordeu L, Garate L, et al. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res 2009; 69:4443-53.
    • (2009) Cancer Res , vol.69 , pp. 4443-4453
    • Agirre, X.1    Vilas-Zornoza, A.2    Jimenez-Velasco, A.3    Martin-Subero, J.I.4    Cordeu, L.5    Garate, L.6
  • 28
    • 79955526497 scopus 로고    scopus 로고
    • Epigenetic inactivation of the miR-124- 1 in haematological malignancies
    • Wong KY, So CC, Loong F, Chung LP, Lam WW, Liang R, et al. Epigenetic inactivation of the miR-124- 1 in haematological malignancies. PLoS One 2011; 6:19027.
    • (2011) PLoS One , vol.6 , pp. 19027
    • Wong, K.Y.1    So, C.C.2    Loong, F.3    Chung, L.P.4    Lam, W.W.5    Liang, R.6
  • 30
    • 42049104107 scopus 로고    scopus 로고
    • Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
    • Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 2008; 68:2094-105.
    • (2008) Cancer Res , vol.68 , pp. 2094-2105
    • Kozaki, K.1    Imoto, I.2    Mogi, S.3    Omura, K.4    Inazawa, J.5
  • 31
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA- 127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, et al. Specific activation of microRNA- 127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006; 9:435-43.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3    Friedman, J.M.4    Chuang, J.C.5    Coetzee, G.A.6
  • 32
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007; 67:8433-8.
    • (2007) Cancer Res , vol.67 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Y.5
  • 33
    • 78649787634 scopus 로고    scopus 로고
    • Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect
    • Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, et al. Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis 2010; 31:2066-73.
    • (2010) Carcinogenesis , vol.31 , pp. 2066-2073
    • Suzuki, H.1    Yamamoto, E.2    Nojima, M.3    Kai, M.4    Yamano, H.O.5    Yoshikawa, K.6
  • 34
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 2008; 68:4123-32.
    • (2008) Cancer Res , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3    Maruyama, R.4    Imai, K.5    Shinomura, Y.6
  • 35
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • Schwartz YB, Pirrotta V. Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 2007; 8:9-22.
    • (2007) Nat Rev Genet , vol.8 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 36
    • 8844265508 scopus 로고    scopus 로고
    • Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins
    • Ringrose L, Paro R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 2004; 38:413-43.
    • (2004) Annu Rev Genet , vol.38 , pp. 413-443
    • Ringrose, L.1    Paro, R.2
  • 38
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell 2007; 129:823-37.
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.Y.4    Schones, D.E.5    Wang, Z.6
  • 39
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125:315-26.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5    Cuff, J.6
  • 40
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441:349-53.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3    Brambrink, T.4    Medeiros, L.A.5    Lee, T.I.6
  • 41
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006; 20:1123-36.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 42
    • 34447098370 scopus 로고    scopus 로고
    • A chromatin landmark and transcription initiation at most promoters in human cells
    • Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 2007; 130: 77-88.
    • (2007) Cell , vol.130 , pp. 77-88
    • Guenther, M.G.1    Levine, S.S.2    Boyer, L.A.3    Jaenisch, R.4    Young, R.A.5
  • 43
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by Polycomb in human embryonic stem cells
    • Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006; 125:301-13.
    • (2006) Cell , vol.125 , pp. 301-313
    • Lee, T.I.1    Jenner, R.G.2    Boyer, L.A.3    Guenther, M.G.4    Levine, S.S.5    Kumar, R.M.6
  • 44
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007; 448:553-60.
    • (2007) Nature , vol.448 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3    Issac, B.4    Lieberman, E.5    Giannoukos, G.6
  • 45
    • 34548434716 scopus 로고    scopus 로고
    • Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells
    • Pan G, Tian S, Nie J, Yang C, Ruotti V, Wei H, et al. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 2007; 1:299-312.
    • (2007) Cell Stem Cell , vol.1 , pp. 299-312
    • Pan, G.1    Tian, S.2    Nie, J.3    Yang, C.4    Ruotti, V.5    Wei, H.6
  • 46
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007; 39:237-42.
    • (2007) Nat Genet , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3    Cheng, L.4    Schuebel, K.E.5    Cope, L.6
  • 47
    • 33846649587 scopus 로고    scopus 로고
    • Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
    • Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 2007; 39:232-6.
    • (2007) Nat Genet , vol.39 , pp. 232-236
    • Schlesinger, Y.1    Straussman, R.2    Keshet, I.3    Farkash, S.4    Hecht, M.5    Zimmerman, J.6
  • 50
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000; 16:168-74.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 51
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999; 21:163-7.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 52
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007; 447:799-816.
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1    Stamatoyannopoulos, J.A.2    Dutta, A.3    Guigo, R.4    Gingeras, T.R.5    Margulies, E.H.6
  • 53
    • 0035297539 scopus 로고    scopus 로고
    • p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2
    • Esteller M, Cordon-Cardo C, Corn PG, Meltzer SJ, Pohar KS, Watkins DN, et al. p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Res 2001; 61:2816-21.
    • (2001) Cancer Res , vol.61 , pp. 2816-2821
    • Esteller, M.1    Cordon-Cardo, C.2    Corn, P.G.3    Meltzer, S.J.4    Pohar, K.S.5    Watkins, D.N.6
  • 55
    • 0033985151 scopus 로고    scopus 로고
    • Hypermethylationassociated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
    • Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB, et al. Hypermethylationassociated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 2000; 60:129-33.
    • (2000) Cancer Res , vol.60 , pp. 129-133
    • Esteller, M.1    Tortola, S.2    Toyota, M.3    Capella, G.4    Peinado, M.A.5    Baylin, S.B.6
  • 56
    • 0033105363 scopus 로고    scopus 로고
    • Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability
    • Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, et al. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999; 59:1090-5.
    • (1999) Cancer Res , vol.59 , pp. 1090-1095
    • Fleisher, A.S.1    Esteller, M.2    Wang, S.3    Tamura, G.4    Suzuki, H.5    Yin, J.6
  • 59
  • 60
    • 34047234690 scopus 로고    scopus 로고
    • Characterization and identification of microRNA core promoters in four model species
    • Zhou X, Ruan J, Wang G, Zhang W. Characterization and identification of microRNA core promoters in four model species. PLoS Comput Biol 2007; 3:37.
    • (2007) PLoS Comput Biol , vol.3 , pp. 37
    • Zhou, X.1    Ruan, J.2    Wang, G.3    Zhang, W.4
  • 62
    • 70349976210 scopus 로고    scopus 로고
    • MicroRNAs: Novel regulators in the hallmarks of human cancer
    • Ruan K, Fang X, Ouyang G. MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett 2009; 285:116-26.
    • (2009) Cancer Lett , vol.285 , pp. 116-126
    • Ruan, K.1    Fang, X.2    Ouyang, G.3
  • 63
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38:787-93.
    • (2006) Nat Genet , vol.38 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3    Young, J.4    Long, T.I.5    Faasse, M.A.6
  • 64
    • 38649126918 scopus 로고    scopus 로고
    • Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex and histone H3 K4/K27 trimethylation
    • Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, et al. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008; 2:160-9.
    • (2008) Cell Stem Cell , vol.2 , pp. 160-169
    • Fouse, S.D.1    Shen, Y.2    Pellegrini, M.3    Cole, S.4    Meissner, A.5    van Neste, L.6
  • 66
    • 33745865934 scopus 로고    scopus 로고
    • Chromatin in pluripotent embryonic stem cells and differentiation
    • Meshorer E, Misteli T. Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol 2006; 7:540-6.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 540-546
    • Meshorer, E.1    Misteli, T.2
  • 68
    • 33747879037 scopus 로고    scopus 로고
    • Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells
    • Shen Y, Chow J, Wang Z, Fan G. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet 2006; 15:2623-35.
    • (2006) Hum Mol Genet , vol.15 , pp. 2623-2635
    • Shen, Y.1    Chow, J.2    Wang, Z.3    Fan, G.4
  • 69
    • 33645751058 scopus 로고    scopus 로고
    • Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state
    • McGarvey KM, Fahrner JA, Greene E, Martens J, Jenuwein T, Baylin SB. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res 2006; 66:3541-9.
    • (2006) Cancer Res , vol.66 , pp. 3541-3549
    • McGarvey, K.M.1    Fahrner, J.A.2    Greene, E.3    Martens, J.4    Jenuwein, T.5    Baylin, S.B.6
  • 71
    • 23044431656 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin
    • Vakoc CR, Mandat SA, Olenchock BA, Blobel GA. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 2005; 19:381-91.
    • (2005) Mol Cell , vol.19 , pp. 381-391
    • Vakoc, C.R.1    Mandat, S.A.2    Olenchock, B.A.3    Blobel, G.A.4
  • 72
    • 32844459336 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 directly controls DNA methylation
    • Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006; 439:871-4.
    • (2006) Nature , vol.439 , pp. 871-874
    • Vire, E.1    Brenner, C.2    Deplus, R.3    Blanchon, L.4    Fraga, M.5    Didelot, C.6
  • 74
    • 1942503942 scopus 로고    scopus 로고
    • The functions of E(Z)/EZH2- mediated methylation of lysine 27 in histone H3
    • Cao R, Zhang Y. The functions of E(Z)/EZH2- mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 2004; 14:155-64.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 155-164
    • Cao, R.1    Zhang, Y.2
  • 75
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22:5323-35.
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 76
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100:11606-11.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 77
    • 13844315463 scopus 로고    scopus 로고
    • Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
    • Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci USA 2005; 102:1859-64.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1859-1864
    • Kuzmichev, A.1    Margueron, R.2    Vaquero, A.3    Preissner, T.S.4    Scher, M.5    Kirmizis, A.6
  • 78
    • 34248193264 scopus 로고    scopus 로고
    • Stem cell chromatin patterns: An instructive mechanism for DNA hypermethylation?
    • Ohm JE, Baylin SB. Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle 2007; 6:1040-3.
    • (2007) Cell Cycle , vol.6 , pp. 1040-1043
    • Ohm, J.E.1    Baylin, S.B.2
  • 80
    • 78149478781 scopus 로고    scopus 로고
    • Aberrant epigenetic landscape in cancer: How cellular identity goes awry
    • Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 2010; 19:698-711.
    • (2010) Dev Cell , vol.19 , pp. 698-711
    • Berdasco, M.1    Esteller, M.2
  • 81
    • 62549127853 scopus 로고    scopus 로고
    • A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
    • Koch P, Opitz T, Steinbeck JA, Ladewig J, Brustle O. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci USA 2009; 106:3225-30.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3225-3230
    • Koch, P.1    Opitz, T.2    Steinbeck, J.A.3    Ladewig, J.4    Brustle, O.5
  • 83
    • 33846971644 scopus 로고    scopus 로고
    • Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures
    • Nat R, Nilbratt M, Narkilahti S, Winblad B, Hovatta O, Nordberg A. Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia 2007; 55:385-99.
    • (2007) Glia , vol.55 , pp. 385-399
    • Nat, R.1    Nilbratt, M.2    Narkilahti, S.3    Winblad, B.4    Hovatta, O.5    Nordberg, A.6
  • 84
    • 27144543663 scopus 로고    scopus 로고
    • Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs
    • Raymond CK, Roberts BS, Garrett-Engele P, Lim LP, Johnson JM. Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA 2005; 11:1737-44.
    • (2005) RNA , vol.11 , pp. 1737-1744
    • Raymond, C.K.1    Roberts, B.S.2    Garrett-Engele, P.3    Lim, L.P.4    Johnson, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.