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Volumn 12, Issue 10, 2011, Pages 6469-6501

Metabolomics of oxidative stress in recent studies of Endogenous and exogenously administered intermediate metabolites

Author keywords

Brain; Chemometrics; Heart; Kidney; Liver; Metabolomics; Metabonomics; Multivariate analysis; NMR; Oxidative stress; Principal component analysis; Proteomics; Targeted profiling; Transcriptionomics

Indexed keywords

ADENOSINE TRIPHOSPHATE; FRUCTOSE 1,6 BISPHOSPHATE; PYRUVIC ACID; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 80055034402     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12106469     Document Type: Review
Times cited : (52)

References (150)
  • 2
    • 33749529146 scopus 로고    scopus 로고
    • Pattern recognition and biomarker validation using quantitative H-1-NMR-based metabolomics
    • Serkova, N.J.; Niemann, C.U. Pattern recognition and biomarker validation using quantitative H-1-NMR-based metabolomics. Expert Rev. Mol. Diagn. 2006, 6, 717-731.
    • (2006) Expert Rev. Mol. Diagn , vol.6 , pp. 717-731
    • Serkova, N.J.1    Niemann, C.U.2
  • 3
    • 85047685525 scopus 로고    scopus 로고
    • Biochemical mechanisms of nephrotoxicity: Application for metabolomics
    • Serkova, N.J.; Niemann, C.U. Biochemical mechanisms of nephrotoxicity: Application for metabolomics. Expert Opin. Drug Metab. Toxicol. 2007, 3, 527-544.
    • (2007) Expert Opin. Drug Metab. Toxicol , vol.3 , pp. 527-544
    • Serkova, N.J.1    Niemann, C.U.2
  • 4
    • 38549093441 scopus 로고    scopus 로고
    • Metabolic markers of hypoxia: Systems biology application in biomedicine
    • Serkova, N.J.; Reisdorph, N.A.; van Patot, M.C.T. Metabolic markers of hypoxia: Systems biology application in biomedicine. Toxicol. Mech. Methods 2008, 18, 81-95.
    • (2008) Toxicol. Mech. Methods , vol.18 , pp. 81-95
    • Serkova, N.J.1    Reisdorph, N.A.2    van Patot, M.C.T.3
  • 5
    • 36549000754 scopus 로고    scopus 로고
    • NMR-based metabolomics: Translational application and treatment of cancer
    • Serkova, N.J.; Spratlin, J.L.; Eckhardt, S.G. NMR-based metabolomics: Translational application and treatment of cancer. Curr. Opin. Mol. Ther. 2007, 9, 572-585.
    • (2007) Curr. Opin. Mol. Ther , vol.9 , pp. 572-585
    • Serkova, N.J.1    Spratlin, J.L.2    Eckhardt, S.G.3
  • 7
    • 79952171650 scopus 로고    scopus 로고
    • Biomarkers of immunosuppressant organ toxicity after transplantation: Status, concepts and misconceptions
    • Christians, U.; Klawitter, J.; Brunner, N.; Schmitz, V. Biomarkers of immunosuppressant organ toxicity after transplantation: Status, concepts and misconceptions. Expert Opin. Drug Metab. Toxicol. 2011, 7, 175-200.
    • (2011) Expert Opin. Drug Metab. Toxicol , vol.7 , pp. 175-200
    • Christians, U.1    Klawitter, J.2    Brunner, N.3    Schmitz, V.4
  • 8
    • 79952601264 scopus 로고    scopus 로고
    • Metabolomics and surgical oncology: Potential role for small molecule biomarkers
    • Davis, V.W.; Bathe, O.F.; Schiller, D.E.; Slupsky, C.M.; Sawyer, M.B. Metabolomics and surgical oncology: Potential role for small molecule biomarkers. J. Surg. Oncol. 2011, 103, 451-459.
    • (2011) J. Surg. Oncol , vol.103 , pp. 451-459
    • Davis, V.W.1    Bathe, O.F.2    Schiller, D.E.3    Slupsky, C.M.4    Sawyer, M.B.5
  • 9
    • 79952527112 scopus 로고    scopus 로고
    • Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer
    • Lane, A.N.; Fan, T.W.; Bousamra, M.; Higashi, R.M.; Yan, J.; Miller, D.M. Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer. OMICS 2011, 15, 173-182.
    • (2011) OMICS , vol.15 , pp. 173-182
    • Lane, A.N.1    Fan, T.W.2    Bousamra, M.3    Higashi, R.M.4    Yan, J.5    Miller, D.M.6
  • 10
    • 79251554987 scopus 로고    scopus 로고
    • Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease
    • Li, N.; Liu, J.Y.; Qiu, H.; Harris, T.R.; Sirish, P.; Hammock, B.D.; Chiamvimonvat, N. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest Heart Fail 2011, 17, 42-46.
    • (2011) Congest Heart Fail , vol.17 , pp. 42-46
    • Li, N.1    Liu, J.Y.2    Qiu, H.3    Harris, T.R.4    Sirish, P.5    Hammock, B.D.6    Chiamvimonvat, N.7
  • 13
    • 79955007147 scopus 로고    scopus 로고
    • Exploring airway diseases by NMR-based metabonomics: A review of application to exhaled breath condensate
    • Sofia, M.; Maniscalco, M.; de Laurentiis, G.; Paris, D.; Melck, D.; Motta, A. Exploring airway diseases by NMR-based metabonomics: A review of application to exhaled breath condensate. J. Biomed. Biotechnol. 2011, 2011, 403260:1-403260:7.
    • (2011) J. Biomed. Biotechnol , vol.2011
    • Sofia, M.1    Maniscalco, M.2    de Laurentiis, G.3    Paris, D.4    Melck, D.5    Motta, A.6
  • 14
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics'': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J.K.; Lindon, J.C.; Holmes, E. ''Metabonomics'': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29, 1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 15
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon, J.C.; Holmes, E.; Bollard, M.E.; Stanley, E.G.; Nicholson, J.K. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 2004, 9, 1-31.
    • (2004) Biomarkers , vol.9 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.3    Stanley, E.G.4    Nicholson, J.K.5
  • 16
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • Robertson, D.G. Metabonomics in toxicology: A review. Toxicol. Sci. 2005, 85, 809-822.
    • (2005) Toxicol. Sci , vol.85 , pp. 809-822
    • Robertson, D.G.1
  • 17
    • 0034959944 scopus 로고    scopus 로고
    • Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks
    • Fiehn, O. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genomics 2001, 2, 155-168.
    • (2001) Comp. Funct. Genomics , vol.2 , pp. 155-168
    • Fiehn, O.1
  • 18
    • 28644439024 scopus 로고    scopus 로고
    • Metabolomics: Working toward personalized medicine
    • Bren, L. Metabolomics: Working toward personalized medicine. FDA Consum. 2005, 39, 28-33.
    • (2005) FDA Consum , vol.39 , pp. 28-33
    • Bren, L.1
  • 19
    • 0028239826 scopus 로고
    • Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen
    • Castresana, J.; Lubben, M.; Saraste, M.; Higgins, D.G. Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen. EMBO J. 1994, 13, 2516-2525.
    • (1994) EMBO J , vol.13 , pp. 2516-2525
    • Castresana, J.1    Lubben, M.2    Saraste, M.3    Higgins, D.G.4
  • 20
    • 0028786047 scopus 로고
    • Evolution of energetic metabolism: The respiration-early hypothesis
    • Castresana, J.; Saraste, M. Evolution of energetic metabolism: the respiration-early hypothesis. Trends Biochem. Sci. 1995, 20, 443-448.
    • (1995) Trends Biochem. Sci , vol.20 , pp. 443-448
    • Castresana, J.1    Saraste, M.2
  • 22
    • 0032957595 scopus 로고    scopus 로고
    • Nitric oxide: Discovery and impact on clinical medicine
    • Moncada, S. Nitric oxide: Discovery and impact on clinical medicine. J. R. Soc. Med. 1999, 92, 164-169.
    • (1999) J. R. Soc. Med , vol.92 , pp. 164-169
    • Moncada, S.1
  • 24
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman, J.S.; Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am. J. Physiol. 1996, 271, C1424-C1437.
    • (1996) Am. J. Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 25
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher, P.; Beckman, J.S.; Liaudet, L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007, 87, 315-424.
    • (2007) Physiol. Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 26
    • 0032171420 scopus 로고    scopus 로고
    • Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
    • Wink, D.A.; Mitchell, J.B. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic. Biol. Med. 1998, 25, 434-456.
    • (1998) Free Radic. Biol. Med , vol.25 , pp. 434-456
    • Wink, D.A.1    Mitchell, J.B.2
  • 29
    • 0019206177 scopus 로고
    • Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia
    • Markov, A.K.; Oglethorpe, N.C.; Blake, T.M.; Lehan, P.H.; Hellems, H.K. Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia. Am. Heart J. 1980, 100, 639-646.
    • (1980) Am. Heart J , vol.100 , pp. 639-646
    • Markov, A.K.1    Oglethorpe, N.C.2    Blake, T.M.3    Lehan, P.H.4    Hellems, H.K.5
  • 30
    • 0022999772 scopus 로고
    • Hemodynamics and metabolic effects of fructose 1-6 diphosphate in ischemia and shock-Experimental and clinical observations
    • Markov, A.K. Hemodynamics and metabolic effects of fructose 1-6 diphosphate in ischemia and shock-Experimental and clinical observations. Ann. Emerg. Med. 1986, 15, 1470-1477.
    • (1986) Ann. Emerg. Med , vol.15 , pp. 1470-1477
    • Markov, A.K.1
  • 31
    • 0022973002 scopus 로고
    • Effects of fructose-1,6-diphosphate, glucose, and saline on cardiac resuscitation
    • Farias, L.A.; Willis, M.; Gregory, G.A. Effects of fructose-1,6-diphosphate, glucose, and saline on cardiac resuscitation. Anesthesiology 1986, 65, 595-601.
    • (1986) Anesthesiology , vol.65 , pp. 595-601
    • Farias, L.A.1    Willis, M.2    Gregory, G.A.3
  • 32
    • 0027504332 scopus 로고
    • Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats
    • Kuluz, J.W.; Gregory, G.A.; Han, Y.; Dietrich, W.D.; Schleien, C.L. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats. Stroke 1993, 24, 1576-1583.
    • (1993) Stroke , vol.24 , pp. 1576-1583
    • Kuluz, J.W.1    Gregory, G.A.2    Han, Y.3    Dietrich, W.D.4    Schleien, C.L.5
  • 33
    • 0028178805 scopus 로고
    • Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures
    • Kelleher, J.A.; Gregory, G.A.; Chan, P.H. Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures. Neurochem. Res. 1994, 19, 209-215.
    • (1994) Neurochem. Res , vol.19 , pp. 209-215
    • Kelleher, J.A.1    Gregory, G.A.2    Chan, P.H.3
  • 34
    • 0030575281 scopus 로고    scopus 로고
    • Protection of astrocytes by fructose 1,6-bisphosphate and citrate ameliorates neuronal injury under hypoxic conditions
    • Kelleher, J.A.; Chan, T.Y.; Chan, P.H.; Gregory, G.A. Protection of astrocytes by fructose 1,6-bisphosphate and citrate ameliorates neuronal injury under hypoxic conditions. Brain Res. 1996, 726, 167-173.
    • (1996) Brain Res , vol.726 , pp. 167-173
    • Kelleher, J.A.1    Chan, T.Y.2    Chan, P.H.3    Gregory, G.A.4
  • 35
    • 0027935920 scopus 로고
    • Response of cerebral endothelial cells to hypoxia: Modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists
    • Gobbel, G.T.; Chan, T.Y.; Gregory, G.A.; Chan, P.H. Response of cerebral endothelial cells to hypoxia: Modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists. Brain Res. 1994, 653, 23-30.
    • (1994) Brain Res , vol.653 , pp. 23-30
    • Gobbel, G.T.1    Chan, T.Y.2    Gregory, G.A.3    Chan, P.H.4
  • 36
    • 33846892038 scopus 로고    scopus 로고
    • Influence of fructose-1,6-diphosphate on endotoxin-induced lung injuries in sheep
    • Markov, A.K.; Warren, E.T.; Cohly, H.H.; Sauls, D.J.; Skelton, T.N. Influence of fructose-1,6-diphosphate on endotoxin-induced lung injuries in sheep. J. Surg. Res. 2007, 138, 45-50.
    • (2007) J. Surg. Res , vol.138 , pp. 45-50
    • Markov, A.K.1    Warren, E.T.2    Cohly, H.H.3    Sauls, D.J.4    Skelton, T.N.5
  • 38
    • 0027250865 scopus 로고
    • Neuroprotective activity of fructose-1,6-bisphosphate following transient forebrain ischemia in the Mongolian gerbil
    • Trimarchi, G.R.; Arcadi, F.A.; de Luca, R.; Imperatore, C.; Santoro, G.; Trimarchi, F.; Costa, G. Neuroprotective activity of fructose-1,6-bisphosphate following transient forebrain ischemia in the Mongolian gerbil. Jpn. J. Pharmacol. 1993, 62, 215-222.
    • (1993) Jpn. J. Pharmacol , vol.62 , pp. 215-222
    • Trimarchi, G.R.1    Arcadi, F.A.2    de Luca, R.3    Imperatore, C.4    Santoro, G.5    Trimarchi, F.6    Costa, G.7
  • 39
    • 0029789899 scopus 로고    scopus 로고
    • Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia
    • Bickler, P.E.; Buck, L.T. Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia. J. Neurochem. 1996, 67, 1463-1468.
    • (1996) J. Neurochem , vol.67 , pp. 1463-1468
    • Bickler, P.E.1    Buck, L.T.2
  • 40
    • 0026478823 scopus 로고
    • Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats
    • Bickler, P.E.; Kelleher, J.A. Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats. Stroke 1992, 23, 1617-1622.
    • (1992) Stroke , vol.23 , pp. 1617-1622
    • Bickler, P.E.1    Kelleher, J.A.2
  • 41
    • 0026026528 scopus 로고
    • Fructose-1,6-diphosphate, when given five minutes after injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig
    • LeBlanc, M.H.; Farias, L.A.; Markov, A.K.; Evans, O.B.; Smith, B.; Smith, E.E.; Brown, E.G. Fructose-1,6-diphosphate, when given five minutes after injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. Biol. Neonate 1991, 59, 98-108.
    • (1991) Biol. Neonate , vol.59 , pp. 98-108
    • Leblanc, M.H.1    Farias, L.A.2    Markov, A.K.3    Evans, O.B.4    Smith, B.5    Smith, E.E.6    Brown, E.G.7
  • 42
    • 0025971434 scopus 로고
    • Fructose-1,6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig
    • LeBlanc, M.H.; Farias, L.A.; Evans, O.B.; Vig, V.; Smith, E.E.; Markov, A.K. Fructose-1,6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. Crit. Care Med. 1991, 19, 75-83.
    • (1991) Crit. Care Med , vol.19 , pp. 75-83
    • Leblanc, M.H.1    Farias, L.A.2    Evans, O.B.3    Vig, V.4    Smith, E.E.5    Markov, A.K.6
  • 43
    • 0035903065 scopus 로고    scopus 로고
    • Fructose-1,6-bisphosphate did not affect hippocampal neuronal damage caused by 10 min of complete umbilical cord occlusion in fetal sheep
    • Fujii, E.; Kodama, Y.; Takahashi, N.; Roman, C.; Ferriero, D.; Gregory, G.; Parer, J.T. Fructose-1,6-bisphosphate did not affect hippocampal neuronal damage caused by 10 min of complete umbilical cord occlusion in fetal sheep. Neurosci. Lett. 2001, 309, 49-52.
    • (2001) Neurosci. Lett , vol.309 , pp. 49-52
    • Fujii, E.1    Kodama, Y.2    Takahashi, N.3    Roman, C.4    Ferriero, D.5    Gregory, G.6    Parer, J.T.7
  • 44
    • 0037449426 scopus 로고    scopus 로고
    • Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress
    • Vexler, Z.S.; Wong, A.; Francisco, C.; Manabat, C.; Christen, S.; Tauber, M.; Ferriero, D.M.; Gregory, G. Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain Res. 2003, 960, 90-98.
    • (2003) Brain Res , vol.960 , pp. 90-98
    • Vexler, Z.S.1    Wong, A.2    Francisco, C.3    Manabat, C.4    Christen, S.5    Tauber, M.6    Ferriero, D.M.7    Gregory, G.8
  • 45
    • 0037403558 scopus 로고    scopus 로고
    • Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells
    • Mazzio, E.A.; Soliman, K.F. Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem. Res. 2003, 28, 733-741.
    • (2003) Neurochem. Res , vol.28 , pp. 733-741
    • Mazzio, E.A.1    Soliman, K.F.2
  • 46
    • 5444266140 scopus 로고    scopus 로고
    • Neuroprotection by fructose-1,6-bisphosphate involves ROS alterations via p38 MAPK/ERK
    • Park, J.Y.; Kim, E.J.; Kwon, K.J.; Jung, Y.S.; Moon, C.H.; Lee, S.H.; Baik, E.J. Neuroprotection by fructose-1,6-bisphosphate involves ROS alterations via p38 MAPK/ERK. Brain Res. 2004, 1026, 295-301.
    • (2004) Brain Res , vol.1026 , pp. 295-301
    • Park, J.Y.1    Kim, E.J.2    Kwon, K.J.3    Jung, Y.S.4    Moon, C.H.5    Lee, S.H.6    Baik, E.J.7
  • 47
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn, S.; Cohen, G. The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it. Ann. Neurol. 1992, 32, 804-812.
    • (1992) Ann. Neurol , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 48
    • 0036301275 scopus 로고    scopus 로고
    • Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes
    • Ying, W.; Chen, Y.; Alano, C.C.; Swanson, R.A. Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. J. Cereb. Blood Flow Metab. 2002, 22, 774-779.
    • (2002) J. Cereb. Blood Flow Metab , vol.22 , pp. 774-779
    • Ying, W.1    Chen, Y.2    Alano, C.C.3    Swanson, R.A.4
  • 49
    • 10244221098 scopus 로고    scopus 로고
    • Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices
    • Zeng, J.; Hirai, K.; Yang, G.Y.; Ying, W.; Swanson, R.A.; Kelly, M.; Mayer, M.; James, T.L.; Litt, L. Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J. Bioenerg. Biomembr. 2004, 36, 415-419.
    • (2004) J. Bioenerg. Biomembr , vol.36 , pp. 415-419
    • Zeng, J.1    Hirai, K.2    Yang, G.Y.3    Ying, W.4    Swanson, R.A.5    Kelly, M.6    Mayer, M.7    James, T.L.8    Litt, L.9
  • 50
    • 0035320322 scopus 로고    scopus 로고
    • Ringer's ethyl pyruvate solution: A novel resuscitation fluid
    • Fink, M.P. Ringer's ethyl pyruvate solution: A novel resuscitation fluid. Minerva Anestesiol. 2001, 67, 190-192.
    • (2001) Minerva Anestesiol , vol.67 , pp. 190-192
    • Fink, M.P.1
  • 51
    • 0036514144 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: Potential benefits of resuscitation with Ringer's ethyl pyruvate solution
    • Fink, M.P. Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: Potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Curr. Opin. Clin. Nutr. Metab. Care 2002, 5, 167-174.
    • (2002) Curr. Opin. Clin. Nutr. Metab. Care , vol.5 , pp. 167-174
    • Fink, M.P.1
  • 52
    • 0030956826 scopus 로고    scopus 로고
    • Formation of advanced glycation end (AGE) products in diabetes: Prevention by pyruvate and alpha-keto glutarate
    • Varma, S.D.; Devamanoharan, P.S.; Ali, A.H. Formation of advanced glycation end (AGE) products in diabetes: Prevention by pyruvate and alpha-keto glutarate. Mol. Cell. Biochem. 1997, 171, 23-28.
    • (1997) Mol. Cell. Biochem , vol.171 , pp. 23-28
    • Varma, S.D.1    Devamanoharan, P.S.2    Ali, A.H.3
  • 53
    • 0031838461 scopus 로고    scopus 로고
    • Prevention of intracellular oxidative stress to lens by pyruvate and its ester
    • Varma, S.D.; Devamanoharan, P.S.; Ali, A.H. Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Radic. Res. 1998, 28, 131-135.
    • (1998) Free Radic. Res , vol.28 , pp. 131-135
    • Varma, S.D.1    Devamanoharan, P.S.2    Ali, A.H.3
  • 54
    • 29244486440 scopus 로고    scopus 로고
    • Oxidative damage to lens in culture: Reversibility by pyruvate and ethyl pyruvate
    • Varma, S.D.; Hegde, K.R.; Kovtun, S. Oxidative damage to lens in culture: Reversibility by pyruvate and ethyl pyruvate. Ophthalmologica 2006, 220, 52-57.
    • (2006) Ophthalmologica , vol.220 , pp. 52-57
    • Varma, S.D.1    Hegde, K.R.2    Kovtun, S.3
  • 55
    • 60249089532 scopus 로고    scopus 로고
    • Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress
    • Liu, J.; Segal, M.; Yoo, S.; Yang, G.Y.; Kelly, M.; James, T.L.; Litt, L. Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. Neurochem. Int. 2009, 54, 106-110.
    • (2009) Neurochem. Int , vol.54 , pp. 106-110
    • Liu, J.1    Segal, M.2    Yoo, S.3    Yang, G.Y.4    Kelly, M.5    James, T.L.6    Litt, L.7
  • 56
    • 79960501774 scopus 로고    scopus 로고
    • Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease
    • Huh, S.H.; Chung, Y.C.; Piao, Y.; Jin, M.Y.; Son, H.J.; Yoon, N.S.; Hong, J.Y.; Pak, Y.K.; Kim, Y.S.; Hong, J.K. et al. Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease. J. Immunol. 2011, 187, 960-969.
    • (2011) J. Immunol , vol.187 , pp. 960-969
    • Huh, S.H.1    Chung, Y.C.2    Piao, Y.3    Jin, M.Y.4    Son, H.J.5    Yoon, N.S.6    Hong, J.Y.7    Pak, Y.K.8    Kim, Y.S.9    Hong, J.K.10
  • 57
    • 77954423687 scopus 로고    scopus 로고
    • Kynurenine-induced photo oxidative damage to lens in vitro: Protective effect of caffeine
    • Varma, S.D.; Hegde, K.R. Kynurenine-induced photo oxidative damage to lens in vitro: Protective effect of caffeine. Mol. Cell. Biochem. 2010, 340, 49-54.
    • (2010) Mol. Cell. Biochem , vol.340 , pp. 49-54
    • Varma, S.D.1    Hegde, K.R.2
  • 58
    • 79959920831 scopus 로고    scopus 로고
    • Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists
    • Varma, S.D.; Kovtun, S.; Hegde, K.R. Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists. Eye Contact Lens 2011, 37, 233-245.
    • (2011) Eye Contact Lens , vol.37 , pp. 233-245
    • Varma, S.D.1    Kovtun, S.2    Hegde, K.R.3
  • 60
    • 0142243372 scopus 로고    scopus 로고
    • Antioxidant properties of myocardial fuels
    • Mallet, R.T.; Sun, J. Antioxidant properties of myocardial fuels. Mol. Cell. Biochem. 2003, 253, 103-111.
    • (2003) Mol. Cell. Biochem , vol.253 , pp. 103-111
    • Mallet, R.T.1    Sun, J.2
  • 62
    • 1642317769 scopus 로고    scopus 로고
    • The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro
    • Mazzio, E.A.; Reams, R.R.; Soliman, K.F. The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro. Brain Res. 2004, 1004, 29-44.
    • (2004) Brain Res , vol.1004 , pp. 29-44
    • Mazzio, E.A.1    Reams, R.R.2    Soliman, K.F.3
  • 63
    • 0035121831 scopus 로고    scopus 로고
    • Intramitochondrial pyruvate attenuates hydrogen peroxide-induced apoptosis in bovine pulmonary artery endothelium
    • Kang, Y.H.; Chung, S.J.; Kang, I.J.; Park, J.H.; Bunger, R. Intramitochondrial pyruvate attenuates hydrogen peroxide-induced apoptosis in bovine pulmonary artery endothelium. Mol. Cell. Biochem. 2001, 216, 37-46.
    • (2001) Mol. Cell. Biochem , vol.216 , pp. 37-46
    • Kang, Y.H.1    Chung, S.J.2    Kang, I.J.3    Park, J.H.4    Bunger, R.5
  • 64
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin, L.; Magistretti, P.J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. USA 1994, 91, 10625-10629.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 66
    • 67649496586 scopus 로고    scopus 로고
    • A metabolic switch in brain: Glucose and lactate metabolism modulation by ascorbic acid
    • Castro, M.A.; Beltran, F.A.; Brauchi, S.; Concha, I.I. A metabolic switch in brain: Glucose and lactate metabolism modulation by ascorbic acid. J. Neurochem. 2009, 110, 423-440.
    • (2009) J. Neurochem , vol.110 , pp. 423-440
    • Castro, M.A.1    Beltran, F.A.2    Brauchi, S.3    Concha, I.I.4
  • 67
    • 79960434999 scopus 로고    scopus 로고
    • Brain energy depletion in a rodent model of diffuse traumatic brain injury is not prevented with administration of sodium lactate
    • Prieto, R.; Tavazzi, B.; Taya, K.; Barrios, L.; Amorini, A.M.; di Pietro, V.; Pascual, J.M.; Marmarou, A.; Marmarou, C.R. Brain energy depletion in a rodent model of diffuse traumatic brain injury is not prevented with administration of sodium lactate. Brain Res. 2011, 1404, 39-49.
    • (2011) Brain Res , vol.1404 , pp. 39-49
    • Prieto, R.1    Tavazzi, B.2    Taya, K.3    Barrios, L.4    Amorini, A.M.5    di Pietro, V.6    Pascual, J.M.7    Marmarou, A.8    Marmarou, C.R.9
  • 68
    • 8444233570 scopus 로고    scopus 로고
    • The role of hypotheses in current research, illustrated by hypotheses on the possible role of astrocytes in energy metabolism and cerebral blood flow: From Newton to now
    • Kimelberg, H.K. The role of hypotheses in current research, illustrated by hypotheses on the possible role of astrocytes in energy metabolism and cerebral blood flow: From Newton to now. J. Cereb. Blood Flow Metab. 2004, 24, 1235-1239.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 1235-1239
    • Kimelberg, H.K.1
  • 69
    • 33747019547 scopus 로고    scopus 로고
    • Centering, scaling, and transformations: Improving the biological information content of metabolomics data
    • Van den Berg, R.A.; van der Werf, M.J. Centering, scaling, and transformations: Improving the biological information content of metabolomics data. BMC Genomics 2006, 7, 142.
    • (2006) BMC Genomics , vol.7 , pp. 142
    • van den Berg, R.A.1    van der Werf, M.J.2
  • 71
    • 33748423137 scopus 로고    scopus 로고
    • Chemometric analysis of NMR spectroscopy data: A review
    • Alam, T.M.; Alam, M.K. Chemometric analysis of NMR spectroscopy data: A review. Ann. Rep. NMR Spectrosc. 2004, 54, 41-80.
    • (2004) Ann. Rep. NMR Spectrosc , vol.54 , pp. 41-80
    • Alam, T.M.1    Alam, M.K.2
  • 72
    • 33745700438 scopus 로고    scopus 로고
    • Targeted profiling: Quantitative analysis of 1H NMR metabolomics data
    • Weljie, A.M.; Newton, J.; Mercier, P.; Carlson, E.; Slupsky, C.M. Targeted profiling: Quantitative analysis of 1H NMR metabolomics data. Anal. Chem. 2006, 78, 4430-4442.
    • (2006) Anal. Chem , vol.78 , pp. 4430-4442
    • Weljie, A.M.1    Newton, J.2    Mercier, P.3    Carlson, E.4    Slupsky, C.M.5
  • 73
    • 41049096359 scopus 로고    scopus 로고
    • Quantitative metabolomics using NMR
    • Wishart, D.S. Quantitative metabolomics using NMR. Trends Anal. Chem. 2008, 27, 228-237.
    • (2008) Trends Anal. Chem , vol.27 , pp. 228-237
    • Wishart, D.S.1
  • 74
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton NMR spectra
    • Provencher, S.W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn. Reson. Med. 1993, 30, 672-679.
    • (1993) Magn. Reson. Med , vol.30 , pp. 672-679
    • Provencher, S.W.1
  • 76
    • 34247127891 scopus 로고    scopus 로고
    • Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response
    • Kemp, M.L.; Wille, L.; Lewis, C.L.; Nicholson, L.B.; Lauffenburger, D.A. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. J. Immunol. 2007, 178, 4984-4992.
    • (2007) J. Immunol , vol.178 , pp. 4984-4992
    • Kemp, M.L.1    Wille, L.2    Lewis, C.L.3    Nicholson, L.B.4    Lauffenburger, D.A.5
  • 77
    • 72249105551 scopus 로고    scopus 로고
    • Line-shape analysis of J-resolved NMR spectra: Application to metabolomics and quantification of intensity errors from signal processing and high signal congestion
    • Parsons, H.M.; Ludwig, C.; Viant, M.R. Line-shape analysis of J-resolved NMR spectra: application to metabolomics and quantification of intensity errors from signal processing and high signal congestion. Magn. Reson. Chem. 2009, 47, S86-S95.
    • (2009) Magn. Reson. Chem , vol.47
    • Parsons, H.M.1    Ludwig, C.2    Viant, M.R.3
  • 78
    • 73349091531 scopus 로고    scopus 로고
    • Two-dimensional J-resolved NMR spectroscopy: Review of a key methodology in the metabolomics toolbox
    • Ludwig, C.; Viant, M.R. Two-dimensional J-resolved NMR spectroscopy: Review of a key methodology in the metabolomics toolbox. Phytochem. Anal. 2010, 21, 22-32.
    • (2010) Phytochem. Anal , vol.21 , pp. 22-32
    • Ludwig, C.1    Viant, M.R.2
  • 79
    • 20344367794 scopus 로고    scopus 로고
    • NMR-derived developmental metabolic trajectories: An approach for visualizing the toxic actions of trichloroethylene during embryogenesis
    • Viant, M.R.; Bundy, J.G.; Pincetich, C.A.; de Ropp, J.S.; Tjeerdema, R.S. NMR-derived developmental metabolic trajectories: An approach for visualizing the toxic actions of trichloroethylene during embryogenesis. Metabolomics 2005, 1, 149-158.
    • (2005) Metabolomics , vol.1 , pp. 149-158
    • Viant, M.R.1    Bundy, J.G.2    Pincetich, C.A.3    de Ropp, J.S.4    Tjeerdema, R.S.5
  • 80
    • 34249870845 scopus 로고    scopus 로고
    • Quantification and identification of isotopomer distributions of metabolites in crude cell extracts using 1H TOCSY
    • Lane, A.N.; Fan, T.W.-M. Quantification and identification of isotopomer distributions of metabolites in crude cell extracts using 1H TOCSY. Metabolomics 2007, 3, 79-86.
    • (2007) Metabolomics , vol.3 , pp. 79-86
    • Lane, A.N.1    Fan, T.W.-M.2
  • 81
    • 77952988063 scopus 로고    scopus 로고
    • NMR method for measuring carbon-13 isotopic enrichment of metabolites in complex solutions
    • Lewis, I.A.; Karsten, R.H.; Norton, M.E.; Tonelli, M.; Westler, W.M.; Markley, J.L. NMR method for measuring carbon-13 isotopic enrichment of metabolites in complex solutions. Anal. Chem. 2010, 82, 4558-4563.
    • (2010) Anal. Chem , vol.82 , pp. 4558-4563
    • Lewis, I.A.1    Karsten, R.H.2    Norton, M.E.3    Tonelli, M.4    Westler, W.M.5    Markley, J.L.6
  • 82
    • 79958765503 scopus 로고    scopus 로고
    • NMR-based stable isotope resolved metabolomics in systems biochemistry
    • Fan, T.W.; Lane, A.N. NMR-based stable isotope resolved metabolomics in systems biochemistry. J. Biomol. NMR 2011, 49, 267-280.
    • (2011) J. Biomol. NMR , vol.49 , pp. 267-280
    • Fan, T.W.1    Lane, A.N.2
  • 83
    • 77956370859 scopus 로고    scopus 로고
    • Targeted projection NMR spectroscopy for unambiguous metabolic profiling of complex mixtures
    • Pontoizeau, C.; Herrmann, T.; Toulhoat, P.; Elena-Herrmann, B.; Emsley, L. Targeted projection NMR spectroscopy for unambiguous metabolic profiling of complex mixtures. Magn. Reson. Chem. 2010, 48, 727-733.
    • (2010) Magn. Reson. Chem , vol.48 , pp. 727-733
    • Pontoizeau, C.1    Herrmann, T.2    Toulhoat, P.3    Elena-Herrmann, B.4    Emsley, L.5
  • 86
    • 33746654582 scopus 로고    scopus 로고
    • Synaptic plasticity and dysconnection in schizophrenia
    • Stephan, K.E.; Baldeweg, T.; Friston, K.J. Synaptic plasticity and dysconnection in schizophrenia. Biol. Psychiat. 2006, 59, 929-939.
    • (2006) Biol. Psychiat , vol.59 , pp. 929-939
    • Stephan, K.E.1    Baldeweg, T.2    Friston, K.J.3
  • 89
    • 79956014618 scopus 로고    scopus 로고
    • Oxidative stress in schizophrenia: Pathogenetic and therapeutic implications
    • Yao, J.K.; Reddy, R. Oxidative stress in schizophrenia: Pathogenetic and therapeutic implications. Antioxid. Redox Signal. 2011, 15, 1999-2002.
    • (2011) Antioxid. Redox Signal , vol.15 , pp. 1999-2002
    • Yao, J.K.1    Reddy, R.2
  • 90
    • 80051964408 scopus 로고    scopus 로고
    • The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics
    • Martins-de-Souza, D.; Harris, L.W.; Guest, P.C.; Bahn, S. The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics. Antioxid. Redox Signal. 2011, 15, 2067-2079.
    • (2011) Antioxid. Redox Signal , vol.15 , pp. 2067-2079
    • Martins-de-Souza, D.1    Harris, L.W.2    Guest, P.C.3    Bahn, S.4
  • 91
    • 80051964405 scopus 로고    scopus 로고
    • Genetic association studies of antioxidant pathway genes and schizophrenia
    • Kodavali, C.V.; Mikhil, B.N.; Vishwajit, N.L. Genetic association studies of antioxidant pathway genes and schizophrenia. Antioxid. Redox Signal. 2011, 15, 2037-2045.
    • (2011) Antioxid. Redox Signal , vol.15 , pp. 2037-2045
    • Kodavali, C.V.1    Mikhil, B.N.2    Vishwajit, N.L.3
  • 93
    • 67049134827 scopus 로고    scopus 로고
    • Metabolomics tools for identifying biomarkers for neuropsychiatric diseases
    • Quinones, M.P.; Kaddurah-Daouk, R. Metabolomics tools for identifying biomarkers for neuropsychiatric diseases. Neurobiol. Dis. 2009, 35, 165-176.
    • (2009) Neurobiol. Dis , vol.35 , pp. 165-176
    • Quinones, M.P.1    Kaddurah-Daouk, R.2
  • 94
    • 80051960519 scopus 로고    scopus 로고
    • Antioxidant therapeutics for schizophrenia
    • Reddy, R. Antioxidant therapeutics for schizophrenia. Antioxid. Redox Signal. 2011, 15, 2047-2055.
    • (2011) Antioxid. Redox Signal , vol.15 , pp. 2047-2055
    • Reddy, R.1
  • 95
    • 44649183886 scopus 로고    scopus 로고
    • Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units
    • Hoehn, T.; Hansmann, G.; Buhrer, C.; Simbruner, G.; Gunn, A.J.; Yager, J.; Levene, M.; Hamrick, S.E.; Shankaran, S.; Thoresen, M. Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units. Resuscitation 2008, 78, 7-12.
    • (2008) Resuscitation , vol.78 , pp. 7-12
    • Hoehn, T.1    Hansmann, G.2    Buhrer, C.3    Simbruner, G.4    Gunn, A.J.5    Yager, J.6    Levene, M.7    Hamrick, S.E.8    Shankaran, S.9    Thoresen, M.10
  • 96
    • 79952109192 scopus 로고    scopus 로고
    • Brain cooling therapy
    • Gancia, P.; Pomero, G. Brain cooling therapy. Minerva Pediatr. 2010, 62, 173-175.
    • (2010) Minerva Pediatr , vol.62 , pp. 173-175
    • Gancia, P.1    Pomero, G.2
  • 99
    • 33750362562 scopus 로고    scopus 로고
    • Hypothermia does not improve outcome from traumatic brain injury
    • Seppelt, I. Hypothermia does not improve outcome from traumatic brain injury. Crit. Care Resusc. 2005, 7, 233-237.
    • (2005) Crit. Care Resusc , vol.7 , pp. 233-237
    • Seppelt, I.1
  • 100
    • 0032929640 scopus 로고    scopus 로고
    • Mild hypothermia as a protective therapy during intracranial aneurysm surgery: A randomized prospective pilot trial
    • Hindman, B.J.; Todd, M.M.; Gelb, A.W.; Loftus, C.M.; Craen, R.A.; Schubert, A.; Mahla, M.E.; Torner, J.C. Mild hypothermia as a protective therapy during intracranial aneurysm surgery: A randomized prospective pilot trial. Neurosurgery 1999, 44, 23-32.
    • (1999) Neurosurgery , vol.44 , pp. 23-32
    • Hindman, B.J.1    Todd, M.M.2    Gelb, A.W.3    Loftus, C.M.4    Craen, R.A.5    Schubert, A.6    Mahla, M.E.7    Torner, J.C.8
  • 101
    • 33748661306 scopus 로고    scopus 로고
    • Hypothermia for brain protection and resuscitation
    • Ramani, R. Hypothermia for brain protection and resuscitation. Curr. Opin. Anaesthesiol. 2006, 19, 487-491.
    • (2006) Curr. Opin. Anaesthesiol , vol.19 , pp. 487-491
    • Ramani, R.1
  • 103
    • 0038204205 scopus 로고    scopus 로고
    • Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation
    • Nolan, J.P.; Morley, P.T.; Hoek, T.L.; Hickey, R.W. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003, 57, 231-235.
    • (2003) Resuscitation , vol.57 , pp. 231-235
    • Nolan, J.P.1    Morley, P.T.2    Hoek, T.L.3    Hickey, R.W.4
  • 104
    • 62649138253 scopus 로고    scopus 로고
    • Hospital-based use of therapeutic hypothermia after cardiac arrest in adults
    • Sugerman, N.T.; Abella, B.S. Hospital-based use of therapeutic hypothermia after cardiac arrest in adults. J. Neurotrauma 2009, 26, 371-376.
    • (2009) J. Neurotrauma , vol.26 , pp. 371-376
    • Sugerman, N.T.1    Abella, B.S.2
  • 105
    • 33748547691 scopus 로고    scopus 로고
    • Therapeutic hypothermia after cardiac arrest
    • Sanders, A.B. Therapeutic hypothermia after cardiac arrest. Curr. Opin. Crit. Care 2006, 12, 213-217.
    • (2006) Curr. Opin. Crit. Care , vol.12 , pp. 213-217
    • Sanders, A.B.1
  • 108
    • 85028120844 scopus 로고    scopus 로고
    • Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia
    • Liu, J.; Litt, L.; Segal, M.R.; Kelly, M.J.; Yoshihara, H.A.; James, T.L. Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia. J. Cereb. Blood Flow Metab. 2011, 31, 547-559.
    • (2011) J. Cereb. Blood Flow Metab , vol.31 , pp. 547-559
    • Liu, J.1    Litt, L.2    Segal, M.R.3    Kelly, M.J.4    Yoshihara, H.A.5    James, T.L.6
  • 109
    • 0032531924 scopus 로고    scopus 로고
    • Parkinson's disease. Second of two parts
    • Lang, A.E.; Lozano, A.M. Parkinson's disease. Second of two parts. N. Engl. J. Med. 1998, 339, 1130-1143.
    • (1998) N. Engl. J. Med , vol.339 , pp. 1130-1143
    • Lang, A.E.1    Lozano, A.M.2
  • 110
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang, A.E.; Lozano, A.M. Parkinson's disease. First of two parts. N. Engl. J. Med. 1998, 339, 1044-1053.
    • (1998) N. Engl. J. Med , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 112
    • 59949104645 scopus 로고    scopus 로고
    • Peripheral biomarkers of Parkinson's disease as early reporters of central neurodegeneration
    • Fasano, M.; Alberio, T.; Lopiano, L. Peripheral biomarkers of Parkinson's disease as early reporters of central neurodegeneration. Biomarkers Med. 2008, 2, 465-478.
    • (2008) Biomarkers Med , vol.2 , pp. 465-478
    • Fasano, M.1    Alberio, T.2    Lopiano, L.3
  • 113
    • 77953222106 scopus 로고    scopus 로고
    • Using ''omics'' to define pathogenesis and biomarkers of Parkinson's disease
    • Caudle, W.M.; Bammler, T.K.; Lin, Y.; Pan, S.; Zhang, J. Using ''omics'' to define pathogenesis and biomarkers of Parkinson's disease. Expert Rev. Neurother. 2010, 10, 925-942.
    • (2010) Expert Rev. Neurother , vol.10 , pp. 925-942
    • Caudle, W.M.1    Bammler, T.K.2    Lin, Y.3    Pan, S.4    Zhang, J.5
  • 114
    • 29544435796 scopus 로고    scopus 로고
    • An NMR metabolomic investigation of early metabolic disturbances following traumatic brain injury in a mammalian model
    • Viant, M.R.; Lyeth, B.G.; Miller, M.G.; Berman, R.F. An NMR metabolomic investigation of early metabolic disturbances following traumatic brain injury in a mammalian model. NMR Biomed. 2005, 18, 507-516.
    • (2005) NMR Biomed , vol.18 , pp. 507-516
    • Viant, M.R.1    Lyeth, B.G.2    Miller, M.G.3    Berman, R.F.4
  • 117
    • 0023770113 scopus 로고
    • Free radicals and diabetes
    • Oberley, L.W. Free radicals and diabetes. Free Radic. Biol. Med. 1988, 5, 113-124.
    • (1988) Free Radic. Biol. Med , vol.5 , pp. 113-124
    • Oberley, L.W.1
  • 118
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and ageing
    • Wolff, S.P.; Jiang, Z.Y.; Hunt, J.V. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic. Biol. Med. 1991, 10, 339-352.
    • (1991) Free Radic. Biol. Med , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jiang, Z.Y.2    Hunt, J.V.3
  • 119
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes, J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 1991, 40, 405-412.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 121
    • 68049088805 scopus 로고    scopus 로고
    • Interdependence of signal processing and analysis of urine 1H NMR spectra for metabolic profiling
    • Zhang, S.; Zheng, C.; Lanza, I.R.; Nair, K.S.; Raftery, D.; Vitek, O. Interdependence of signal processing and analysis of urine 1H NMR spectra for metabolic profiling. Anal. Chem. 2009, 81, 6080-6088.
    • (2009) Anal. Chem , vol.81 , pp. 6080-6088
    • Zhang, S.1    Zheng, C.2    Lanza, I.R.3    Nair, K.S.4    Raftery, D.5    Vitek, O.6
  • 122
    • 77954507406 scopus 로고    scopus 로고
    • Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose
    • Klawitter, J.; Haschke, M.; Kahle, C.; Dingmann, C.; Leibfritz, D.; Christians, U. Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br. J. Clin. Pharmacol. 2010, 70, 241-251.
    • (2010) Br. J. Clin. Pharmacol , vol.70 , pp. 241-251
    • Klawitter, J.1    Haschke, M.2    Kahle, C.3    Dingmann, C.4    Leibfritz, D.5    Christians, U.6
  • 123
    • 20844461344 scopus 로고    scopus 로고
    • H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants
    • Serkova, N.; Fuller, T.F.; Klawitter, J.; Freise, C.E.; Niemann, C.U. H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int. 2005, 67, 1142-1151.
    • (2005) Kidney Int , vol.67 , pp. 1142-1151
    • Serkova, N.1    Fuller, T.F.2    Klawitter, J.3    Freise, C.E.4    Niemann, C.U.5
  • 124
    • 70349310440 scopus 로고    scopus 로고
    • Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm
    • Lanz, C.; Patterson, A.D.; Slavik, J.; Krausz, K.W.; Ledermann, M.; Gonzalez, F.J.; Idle, J.R. Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. Radiat. Res. 2009, 172, 198-212.
    • (2009) Radiat. Res , vol.172 , pp. 198-212
    • Lanz, C.1    Patterson, A.D.2    Slavik, J.3    Krausz, K.W.4    Ledermann, M.5    Gonzalez, F.J.6    Idle, J.R.7
  • 125
    • 41949134860 scopus 로고    scopus 로고
    • Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice
    • Chen, C.; Krausz, K.W.; Idle, J.R.; Gonzalez, F.J. Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J. Biol. Chem. 2008, 283, 4543-4559.
    • (2008) J. Biol. Chem , vol.283 , pp. 4543-4559
    • Chen, C.1    Krausz, K.W.2    Idle, J.R.3    Gonzalez, F.J.4
  • 126
    • 39849110282 scopus 로고    scopus 로고
    • Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
    • Wei, L.; Liao, P.; Wu, H.; Li, X.; Pei, F.; Li, W.; Wu, Y. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicol. Appl. Pharmacol. 2008, 227, 417-429.
    • (2008) Toxicol. Appl. Pharmacol , vol.227 , pp. 417-429
    • Wei, L.1    Liao, P.2    Wu, H.3    Li, X.4    Pei, F.5    Li, W.6    Wu, Y.7
  • 128
    • 67651002878 scopus 로고    scopus 로고
    • Metabonomic study of ochratoxin a toxicity in rats after repeated administration: Phenotypic anchoring enhances the ability for biomarker discovery
    • Sieber, M.; Wagner, S.; Rached, E.; Amberg, A.; Mally, A.; Dekant, W. Metabonomic study of ochratoxin a toxicity in rats after repeated administration: Phenotypic anchoring enhances the ability for biomarker discovery. Chem. Res. Toxicol. 2009, 22, 1221-1231.
    • (2009) Chem. Res. Toxicol , vol.22 , pp. 1221-1231
    • Sieber, M.1    Wagner, S.2    Rached, E.3    Amberg, A.4    Mally, A.5    Dekant, W.6
  • 130
    • 77950831363 scopus 로고    scopus 로고
    • Application of metabolomics to investigate the process of human orthotopic liver transplantation: A proof-of-principle study
    • Viant, M.R.; Hrydziuszko, O.; Silva, M.A.; Perera, M.T.P.R.; Richards, D.A.; Murphy, N.; Mirza, D. Application of metabolomics to investigate the process of human orthotopic liver transplantation: A proof-of-principle study. OMICS: J. Integr. Biol. 2010, 14, 143-150.
    • (2010) OMICS: J. Integr. Biol , vol.14 , pp. 143-150
    • Viant, M.R.1    Hrydziuszko, O.2    Silva, M.A.3    Perera, M.T.P.R.4    Richards, D.A.5    Murphy, N.6    Mirza, D.7
  • 131
    • 79958852716 scopus 로고    scopus 로고
    • Changes in the metabolic profile of rat liver after alpha-tocopherol deficiency as revealed by metabolomics analysis
    • Moazzami, A.A.; Andersson, R.; Kamal-Eldin, A. Changes in the metabolic profile of rat liver after alpha-tocopherol deficiency as revealed by metabolomics analysis. NMR Biomed. 2011, 24, 499-505.
    • (2011) NMR Biomed , vol.24 , pp. 499-505
    • Moazzami, A.A.1    Andersson, R.2    Kamal-Eldin, A.3
  • 136
    • 58849084271 scopus 로고    scopus 로고
    • Silent myocardial ischemia is associated with altered plasma phospholipids
    • Gao, P.; Lin, H.L.; Zhang, J. Silent myocardial ischemia is associated with altered plasma phospholipids. J. Clin. Lab. Anal. 2009, 23, 45-50.
    • (2009) J. Clin. Lab. Anal , vol.23 , pp. 45-50
    • Gao, P.1    Lin, H.L.2    Zhang, J.3
  • 139
    • 26244457653 scopus 로고    scopus 로고
    • Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism
    • Mayr, M.; Chung, Y.L.; Mayr, U.; Yin, X.K.; Ly, L.; Troy, H.; Fredericks, S.; Hu, Y.H.; Griffiths, J.R.; Xu, Q.B. Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 2135-2142.
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 2135-2142
    • Mayr, M.1    Chung, Y.L.2    Mayr, U.3    Yin, X.K.4    Ly, L.5    Troy, H.6    Fredericks, S.7    Hu, Y.H.8    Griffiths, J.R.9    Xu, Q.B.10
  • 141
    • 4944256273 scopus 로고    scopus 로고
    • Proteomic and metabolomic analysis of vascular smooth muscle cells - Role of PKC delta
    • Xu, Q.B.; Mayr, M.; Siow, R.; Chung, Y.L.; Mayr, U.; Griffiths, J.R. Proteomic and metabolomic analysis of vascular smooth muscle cells - Role of PKC delta. Circ. Res. 2004, 94, E87-E96.
    • (2004) Circ. Res , vol.94
    • Xu, Q.B.1    Mayr, M.2    Siow, R.3    Chung, Y.L.4    Mayr, U.5    Griffiths, J.R.6
  • 143
    • 77954693378 scopus 로고    scopus 로고
    • Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation
    • Britz-McKibbin, P.; Lee, R. Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation. Electrophoresis 2010, 31, 2328-2337.
    • (2010) Electrophoresis , vol.31 , pp. 2328-2337
    • Britz-McKibbin, P.1    Lee, R.2
  • 144
    • 79961046323 scopus 로고    scopus 로고
    • Phaeochromocytoma: A catecholamine and oxidative stress disorder
    • Pacak, K. Phaeochromocytoma: A catecholamine and oxidative stress disorder. Endocr. Regul. 2011, 45, 65-90.
    • (2011) Endocr. Regul , vol.45 , pp. 65-90
    • Pacak, K.1
  • 148
    • 52049118795 scopus 로고    scopus 로고
    • Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats
    • Zhang, S.; Nagana Gowda, G.A.; Asiago, V.; Shanaiah, N.; Barbas, C.; Raftery, D. Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Anal. Biochem. 2008, 383, 76-84.
    • (2008) Anal. Biochem , vol.383 , pp. 76-84
    • Zhang, S.1    Nagana, G.G.A.2    Asiago, V.3    Shanaiah, N.4    Barbas, C.5    Raftery, D.6
  • 149
    • 36549029196 scopus 로고    scopus 로고
    • Metabolomics as an extension of proteomic analysis: Study of acute kidney injury
    • Portilla, D.; Schnackenberg, L.; Beger, R.D. Metabolomics as an extension of proteomic analysis: Study of acute kidney injury. Semin. Nephrol. 2007, 27, 609-620.
    • (2007) Semin. Nephrol , vol.27 , pp. 609-620
    • Portilla, D.1    Schnackenberg, L.2    Beger, R.D.3


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