Metabonomic study of ochratoxin A toxicity in rats after repeated administration: Phenotypic anchoring enhances the ability for biomarker discovery

Chemical Research in Toxicology

Volumn 22, Issue 7, 2009, Pages 1221-1231

  Sieber, Maximilian ^a   Wagner, Silvia ^a   Rached, Eva ^a   Amberg, Alexander ^b   Mally, Angela ^a   Dekant, Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Sanofi Acentis Deutschland GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; CREATININE; GLUCOSE; INOSITOL; OCHRATOXIN; PSEUDOURIDINE; PYROGLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; GLUCOSE URINE LEVEL; HISTOPATHOLOGY; KIDNEY INJURY; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS;

ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KIDNEY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; METABOLOMICS; OCHRATOXINS; PHENOTYPE; RATS; TOXICITY TESTS;

ANIMALIA; RATTUS; RODENTIA;

EID: 67651002878     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx800459q     Document Type: Article

References (38)

1. Robertson, D. G. (2005) Metabonomics in toxicology: A review. Toxicol. Sci. 85, 809-822.
2. Coen, M., Holmes, E., Lindon, J. C., and Nicholson, J. K. (2008) NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology. Chem. Res. Toxicol. 21, 9-27.
3. Lu, X., Zhao, X., Bai, C., Zhao, C., Lu, G., and Xu, G. (2008) LCMS-based metabonomics analysis. J. Chromatogr. B 866, 64-76.
4. Wilson, I. D., Nicholson, J. K., Castro-Perez, J., Granger, J. H., Johnson, K. A., Smith, B. W., and Plumb, R. S. (2005) High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 4, 591-598.
5. Idborg, H., Zamani, L., Edlund, P.-O., Schuppe-Koistinen, I., and Jacobsson, S. P. (2005) Metabolic fingerprinting of rat urine by LC/MS. Part 1. Analysis by hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B 828, 9-13.
6. Gates, S. C., and Sweeley, C. C. (1978) Quantitative metabolic profiling based on gas chromatography. Clin. Chem. 24, 1663-1673.
7. Kopka, J. (2006) Current challenges and developments in GC-MS based metabolite profiling technology. J. Biotechnol. 124, 312-322.
8. Halket, J. M., Waterman, D., Przyborowska, A. M., Patel, R. K. P., Fraser, P. D., and Bramley, P. M. (2005) Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. J. Exp. Bot. 56, 219-243.
9. Ni, Y., Su, M., Qiu, Y., Chen, M., Liu, Y., Zhao, A., and Jia, W. (2007) Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat. FEBS Lett. 581, 707-711.
10. Zhang, Q., Wang, G., Du, Y., Zhu, L., and A, J. (2007) GC/MS analysis of the rat urine for metabonomic research. J. Chromatogr. B 854, 20-25.
11. Trygg, J., Holmes, E., and Lundstedt, T. (2007) Chemometrics in metabonomics. J. Proteome Res. 6, 469-479.
12. Trygg, J., and Wold, S. (2002) Orthogonal projections to latent structures (O-PLS). J. Chemom. 16, 119-128.
13. Rached, E., Hard Gordon, C., Blumbach, K., Weber, K., Draheim, R., Lutz Werner, K., Ozden, S., Steger, U., Dekant, W., and Mally, A. (2007) Ochratoxin A: 13-week oral toxicity and cell proliferation in male f344/n rats. Toxicol. Sci. 97, 288-298.
14. Sangster, T., Major, H., Plumb, R., Wilson, A. J., and Wilson, I. D. (2006) A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. Analyst 131, 1075-1078.
15. Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., and Siuzdak, G. (2006) XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. Chem. 78, 779-787.
16. Wiklund, S., Johansson, E., Sjoestroem, L., Mellerowicz, E. J., Edlund, U., Shockcor, J. P., Gottfries, J., Moritz, T., and Trygg, J. (2007) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 80, 116-123.
17. Stein, S. E. (1999) An integrated method for spectrum extraction and compound identification from gas chromatography/mass spectrometry data. J. Am. Soc. Mass Spectrom. 10, 770-781.
18. Eriksson, L., Johannson, E., Kettaneh-Wold, N., Trygg, J., Wilkstrom, C., and Wold, S. (2006) Multivariate and Megavariate Data Analysis: Basic Principles and Applications (Part I), Umetrics.
19. Pasikanti, K. K., Ho, P. C., and Chan, E. C. Y. (2008) Development and validation of a gas chromatography/mass spectrometry metabonomic platform for the global profiling of urinary metabolites. Rapid Commun. Mass Spectrom. 22, 2984-2992.
20. Pierce, K. M., Hoggard, J. C., Mohler, R. E., and Synovec, R. E. (2008) Recent advancements in comprehensive two-dimensional separations with chemometrics. J. Chromatogr. A 1184, 341-352.
21. Lenz, E. M., and Wilson, I. D. (2007) Analytical strategies in metabonomics. J. Proteome Res. 6, 443-458.
22. Mally, A., Keim-Heusler, H., Amberg, A., Kurz, M., Zepnik, H., Mantle, P., Voelkel, W., Hard, G. C., and Dekant, W. (2005) Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicol. Appl. Pharmacol. 206, 43-53.
23. Boorman, G. A., McDonald, M. R., Imoto, S., and Persing, R. (1992) Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicol. Pathol. 20, 236-245.
24. Nakanishi, T., Balaban, R. S., and Burg, M. B. (1988) Survey of osmolytes in renal cell lines. Am. J. Physiol. 255, C181-191.
25. Xu, E. Y., Perlina, A., Vu, H., Troth, S. P., Brennan, R. J., Aslamkhan, A. G., and Xu, Q. (2008) Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants. Chem. Res. Toxicol. 21, 1548-1561.
26. Lenz, E. M., Bright, J., Knight, R., Wilson, I. D., and Major, H. (2004) A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: Time dependant changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst 129, 535-541.
27. Mally, A., Voelkel, W., Amberg, A., Kurz, M., Wanek, P., Eder, E., Hard, G., and Dekant, W. (2005) Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem. Res. Toxicol. 18, 1242-1252.
28. Aleo, M. D., Wyatt, R. D., and Schnellmann, R. G. (1991) Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules. Toxicol. Appl. Pharmacol. 107, 73-80.
29. Gautier, J. C., Holzhaeuser, D., Markovic, J., Gremaud, E., Schilter, B., and Turesky, R. J. (2001) Oxidative damage and stress response from ochratoxin A exposure in rats. Free Radical Biol. Med. 30, 1089-1098.
30. Hoehler, D., Marquardt, R. R., McIntosh, A. R., and Hatch, G. M. (1997) Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Biochim. Biophys. Acta 1357, 225-233.
31. Rached, E., Pfeiffer, E., Dekant, W., and Mally, A. (2006) Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Toxicol. Sci. 92, 78-86.
32. Klawitter, J., Bendrick-Peart, J., Rudolph, B., Beckey, V., Klawitter, J., Haschke, M., Rivard, C., Chan, L., Leibfritz, D., Christians, U., and Schmitz, V. (2009) Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem. Res. Toxicol. 22, 118-128.
33. Skordi, E., Yap, I. K. S., Claus, S. P., Martin, F.-P. J., Cloarec, O., Lindberg, J., Schuppe-Koistinen, I., Holmes, E., and Nicholson, J. K. (2007) Analysis of time-related metabolic fluctuations induced by ethionine in the rat. J. Proteome Res. 6, 4572-4581.
34. Ghauri, F. Y. K., McLean, A. E. M., Beales, D., Wilson, I. D., and Nicholson, J. K. (1993) Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol). Biochem. Pharmacol. 46, 953-957.
35. Waters, N. J., Waterfield, C. J., Farrant, R. D., Holmes, E., and Nicholson, J. K. (2006) Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: Novel induction of 5-oxoprolinosis. J. Proteome Res. 5, 1448-1459.
36. Cavin, C., Delatour, T., Marin-Kuan, M., Holzhaeuser, D., Higgins, L., Bezencon, C., Guignard, G., Junod, S., Richoz-Payot, J., Gremaud, E., Hayes, J. D., Nestler, S., Mantle, P., and Schilter, B. (2007) Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity. Toxicol. Sci. 96, 30-39.
37. Friesen, R. W., Novak, E. M., Hasman, D., and Innis, S. M. (2007) Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants. J. Nutr. 137, 2641-2646.
38. Tebib, J. G., Reynaud, C., Cedoz, J. P., Letroublon, M. C., and Niveleau, A. (1997) Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. Br. J. Rheumatol. 36, 990-995.