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Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181-1189 (1999). •• Pioneering paper defining the concept of the term metabonomics.
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Good description of the capabilities and applications of NMR-based metabolomics, •
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Lindon JC, Holmes E, Nicholson JK. Metabonomics and its role in drug development and disease diagnosis. Expert. Rev. Mol. Diagn. 4, 189-199 (2004). • Good description of the capabilities and applications of NMR-based metabolomics.
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Highlights the importance of metabolic profiling in systems biology and healthcare, •
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Nicholson JK. Global systems biology, personalized medicine and molecular epidemiology. Mol. Syst. Biol. 1-6 (2006). • Highlights the importance of metabolic profiling in systems biology and healthcare.
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Mol. Syst. Biol
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Nicholson, J.K.1
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8
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Most complete and comprehensive description on more than 2180 endogenous metabolites, ••
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Wishart DS, Tzur D, Knox C et al. HMDB: the Human Metabolome Database. Nucleic Acids Res. 35, D521-D526 (2007). •• Most complete and comprehensive description on more than 2180 endogenous metabolites.
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Excellent overview of the potential applications of metabolite profiling monitoring organ transplants, •
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Wishart DS. Metabolomics: the principles and potential applications to transplantation. Am. J. Transplant. 5, 2814-2820 (2005). • Excellent overview of the potential applications of metabolite profiling monitoring organ transplants.
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1H-NMR-based metabolomics. Expert Rev. Mol. Diagn. 6, 717-731 (2006). •• Covers NMR-based metabolomics and its applications to biomedical science emphasizing translational research in transplantation, oncology and drug toxicity or discovery.
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•• Covers advanced analytical techniques and statistical analysis emphasizing metabolomics applications to pharmaceutical research
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Lindon JC, Holmes E, Nicholson JK. Metabonomics techniques and applications to pharmaceutical research & development. Pharm. Res. 23, 1075-1088 (2006). •• Covers advanced analytical techniques and statistical analysis emphasizing metabolomics applications to pharmaceutical research.
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Excellent introduction to the field with a focus on plant metabolomics, ••
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Fiehn O. Metabolomics - the link between genotype and phenotype. Plant Mol. Biol. 48, 155-171 (2002). •• Excellent introduction to the field with a focus on plant metabolomics.
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Kell, D.B.1
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Makes a good link between metabolomics and chemometrics with a historical perspective, •
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van der Greef J, Smilde AK. Symbiosis of chemometrics and metabolomics: past, present, and future. J. Chemomet. 19, 376-386 (2005). • Makes a good link between metabolomics and chemometrics with a historical perspective.
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25
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Villas-Boas SG, Mas S, Akesson M, Smedsgaard J, Nielsen J. Mass spectrometry in metabolome analysis. Mass Spectrom. Rev. 24, 613-646 (2005). •• Excellent review of the current mass spectrometry status in metabolomics.
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Villas-Boas, S.G.1
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Mohler RE, Dombek KM, Hoggard JC, Young ET, Synovec RE. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry analysis of metabolites in fermenting and respiring yeast cells. Anal. Chem. 78, 2700-2709 (2006).
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Chen H, Venter A, Cooks RG. Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation. Chem. Commun. 19, 2042-2044 (2006).
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Brereton RG. Chemometrics: Data Analysis for the Laboratory and Chemical Plant. Wiley, West Sussex, UK (2003). • Good description on many of the statistical methods used in the metabolomics field.
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35
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First use of the orthogonal signal correction filter in metabolomics to reduce the effect of confounding factors, •
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1H NMR spectra of biofluids. Analyst 127, 1283-1288 (2002). • First use of the orthogonal signal correction filter in metabolomics to reduce the effect of confounding factors.
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Analyst
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Reviews the potentials of magnetic resonance spectroscopy and mass spectrometry techniques for animal tumor metabolomics, •
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Excellent description of sample preparation and NMR experiments for metabolites analysis, ••
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13C HMBC NMR spectroscopy combined with pattern recognition procedures performed on filtered variables. Anal. Chem. 74, 2261-2273 (2002).
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