Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress

Brain Research

Volumn 960, Issue 1-2, 2003, Pages 90-98

  Vexler, Zinaida S ^a   Wong, Arthur ^a   Francisco, Carla ^a   Manabat, Catherine ^a   Christen, Stephan ^b   Täuber, Martin ^b   Ferriero, Donna M ^a   Gregory, George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

6 Bisphosphate; Disorders of the nervous system; Fructose 1; Glutathione; Hypoxia; Ischemia; Reactive oxygen species

Indexed keywords

BUTHIONINE SULFOXIMINE; CARMUSTINE; FRUCTOSE 1,6 BISPHOSPHATE; GLUTATHIONE; GLUTATHIONE REDUCTASE; LINSIDOMINE; NITRIC OXIDE DONOR; OXYGEN; PROTECTIVE AGENT; SUPEROXIDE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL HYPOXIA; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DISEASE DURATION; GLUTATHIONE METABOLISM; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REOXYGENATION;

ANIMALS; BUTHIONINE SULFOXIMINE; CARMUSTINE; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME INHIBITORS; FREE RADICALS; FRUCTOSEDIPHOSPHATES; GLUTATHIONE; GLUTATHIONE REDUCTASE; INTRACELLULAR FLUID; MICE; MOLSIDOMINE; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0037449426     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03777-0     Document Type: Article

References (32)

1. Ben-Yoseph O., Boxer P.A., Ross B.D. Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress. J. Neurochem. 66:1996;2329-2337.
2. Bernasconi C., Piolini M., Bozzini F., Ferraresi I., Agostoni A. In vitro effects of fructose-1,6-diphosphate on oxygen affinity and electrolyte equilibrium in human blood. Res. Commun. Chem. Pathol. Pharmacol. 42:1983;281-292.
3. Bickler P.E., Buck L.T. Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia. J. Neurochem. 67:1996;1463-1468.
4. Bickler P.E., Kelleher J.A. Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats. Stroke. 23:1992;1617-1622.
5. Carro-Ciampi G., Hunt P.G., Turner C.J., Wells P.G. A high-performance liquid chromatographic assay for reduced and oxidised glutathione in embryonic, neonatal, and adult tissues using a porous graphite electrochemical detector. J. Pharmacol. Methods. 19:1988;75-83.
6. 2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling. Brain Res. 917:2001;158-166.
7. Ehringer W.D., Niu W., Chiang B., Wang O.L., Gordon L., Chien S. Membrane permeability of fructose-1,6-diphosphate in lipid vesicles and endothelial cells. Mol. Cell. Biochem. 210:2000;35-45.
8. Farias L.A., Smith E.E., Markov A.K. Prevention of ischemic-hypoxic brain injury and death in rabbits with fructose-1,6-bisphosphate. Stroke. 21:1990;606-613.
9. Farias L.A., Sun J., Markov A.K. Improved brain metabolism with fructose 1,6-diphosphate during insulin-induced hypoglycemic coma. Am. J. Med. Sci. 297:1989;294-299.
10. Flohe L., Gunzler W.A. Assays of glutathione peroxidase. Methods Enzymol. 105:1984;114-121.
11. Gobbel G.T., Chan T.Y., Gregory G.A., Chan P.H. Response of cerebral endothelial cells to hypoxia: modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists. Brain Res. 653:1994;23-30.
12. Gregory G.A., Welsh F.A., Yu A.C., Chan P.H. Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes. Brain Res. 516:1990;310-312.
13. Hardin C.D., Lazzarino G., Tavazzi B., Di Pierro D., Roberts T.M., Giardina B., Rovetto M.J. Myocardial metabolism of exogenous FDP is consistent with transport by a dicarboxylate transporter. Am. J. Physiol. Heart Circ. Physiol. 281:2001;H2654-2660.
14. Hardin C.D., Roberts T.M. Metabolism of exogenously applied fructose 1,6-bisphosphate in hypoxic vascular smooth muscle. Am. J. Physiol. 267:1994;H2325-2332.
15. Kelleher J.A., Chan P.H., Chan T.Y., Gregory G.A. Energy metabolism in hypoxic astrocytes: protective mechanism of fructose-1,6-bisphosphate. Neurochem. Res. 20:1995;785-792.
16. Kelleher J.A., Chan T.Y., Chan P.H., Gregory G.A. Protection of astrocytes by fructose 1,6-bisphosphate and citrate ameliorates neuronal injury under hypoxic conditions. Brain Res. 726:1996;167-173.
17. Kelleher J.A., Gregory G.A., Chan P.H. Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures. Neurochem Res. 19:1994;209-215.
18. Kuluz J.W., Gregory G.A., Han Y., Dietrich D., Schlein C.L. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats. Stroke. 24:1993;1576-1583.
19. Lazzarino G., Cattani L., Costrini R., Mulieri L., Candiani A., Galzigna L. Increase of intraerythrocytic fructose-1,6-diphosphate after incubation of whole human blood with fructose-1,6-diphosphate. Clin. Biochem. 17:1984;42-45.
20. LeBlanc M.H., Farias L.A., Markov A.K., Evans O.B., Smith B., Smith E.E., Brown E.G. Fructose-1,6-diphosphate, when given five min after injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. Biol. Neonate. 59:1991;98-108.
21. LeBlanc M.H., Parker C.C., Vig V., Smith E.E., Brown E.G. Fructose-1,6-bisphosphate does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig. Crit. Care Med. 20:1992;1309-1314.
22. Levine S. Anoxic-ischemic encephalopathy in rats. Am. J. Pathol. 36:1960;1-17.
23. Markov A.K., Oglethorpe N., Grillis M., Neely W.A., Hellems H.K. Therapeutic action of fructose-1,6-diphosphate in traumatic shock. World J. Surg. 7:1983;430-436.
24. Markov A.K., Turner M.D., Oglethorpe N., Neely W.A., Hellems H.K. Fructose-1,6-diphosphate: an agent for treatment of experimental endotoxin shock. Surgery. 90:1981;482-488.
25. Mischel R.E., Kim Y.S., Sheldon R.A., Ferriero D.M. Hydrogen peroxide is selectively toxic to immature murine neurons in vitro. Neurosci. Lett. 231:1997;17-20.
26. Rice J.E.d., Vannucci R.C., Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9:1981;131-141.
27. Rigobello M.P., Galzigna L., Bindoli A. Fructose 1,6-bisphosphate prevents oxidative stress in the isolated and perfused rat heart. Cell Biochem. Funct. 12:1994;69-75.
28. Schinetti M.L., Lazzarino G. Inhibition of phorbol ester-stimulated chemiluminescence and superoxide production in human neutrophils by fructose 1,6-diphosphate. Biochem. Pharmacol. 35:1986;1762-1764.
29. Sola A., Berrios M., Sheldon R.A., Ferriero D.M., Gregory G.A. Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal rat brain. Brain Res. 741:1996;294-299.
30. Trackey J.L., Uliasz T.F., Hewett S.J. SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death. J. Neurochem. 79:2001;445-455.
31. Vanhoefer U., Yin M.B., Harstrick A., Seeber S., Rustum Y.M. Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N-nitrosourea associated with inhibition of multidrug resistance protein (MRP) function. Biochem. Pharmacol. 53:1997;801-809.
32. Vexler Z., Berrios M., Ursell P.C., Sola A., Ferriero D.M., Gregory G.A. Toxicity of fructose-1,6-bisphosphate in developing normoxic rats. Pharmacol. Toxicol. 84:1999;115-121.