Enhanced leukocyte HIF-1α and HIF-1 DNA binding in humans after rapid ascent to 4300 m

Free Radical Biology and Medicine

Volumn 46, Issue 11, 2009, Pages 1551-1557

  Tissot van Patot, Martha C ^a,b   Serkova, Natalie J ^a   Haschke, Manuel ^a,c   Kominsky, Douglas J ^a   Roach, Robert C ^b   Christians, Uwe ^a   Henthorn, Thomas K ^a   Honigman, Benjamin ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Altitude; Free radicals; Hypoxia; Hypoxia inducible transcription factor; Isoprostane; Metabolomics

Indexed keywords

GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOPROSTANE; LACTIC ACID; SUCCINIC ACID;

ADULT; ALTITUDE; ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOBARISM; HYPOXIA; LEUKOCYTE; MALE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; URINE LEVEL;

ADULT; ALTITUDE; ANOXIA; BIOLOGICAL MARKERS; DINOPROST; DNA; FEMALE; FREE RADICALS; GLUTATHIONE; HEART RATE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; LEUKOCYTES, MONONUCLEAR; MALE; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATIVE STRESS; PROTEIN BINDING; SUCCINIC ACID;

EID: 67349284054     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.03.009     Document Type: Article

References (32)

1. 2 homeostasis. Curr. Opin. Genet. Dev. 8 (1998) 588-594
2. Mole D.R., and Ratcliffe P.J. Cellular oxygen sensing in health and disease. Pediatr. Nephrol. 23 (2008) 681-694
3. Wenger R.H., and Gassmann M. Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem. 378 (1997) 609-616
4. Siddiq A., Aminova L.R., and Ratan R.R. Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem. Res. 32 (2007) 931-946
5. Lee K., Roth R.A., and LaPres J.J. Hypoxia, drug therapy and toxicity. Pharmacol. Ther. 113 (2007) 229-246
6. 1H-NMR-based metabolomics. Expert Rev. Mol. Diagn. 6 (2006) 717-731
7. Serkova N., Fuller T.F., Klawitter J., Freise C.E., and Niemann C.U. H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int. 67 (2005) 1142-1151
8. Haschke M., Zhang Y.L., Kahle C., Klawitter J., Korecka M., Shaw L.M., and Christians U. HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clin. Chem. 53 (2007) 489-497
9. Christians U., Jacobsen W., Serkova N., Benet L.Z., Vidal C., Kf S., Mans M.P., and Kirchner G.I. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J. Chromatogr. B Biomed. Sci. Appl. 748 (2000) 41-53
10. Pialoux V., Mounier R., Ponsot E., Rock E., Mazur A., Dufour S., Richard R., Richalet J.P., Coudert J., and Fellmann N. Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. Eur. J. Clin. Nutr. 60 (2006) 1345-1354
11. Jefferson J.A., Simoni J., Escudero E., Hurtado M.-E., Swenson E.R., Wesson D.E., Schreiner G.F., Schoene R.B., Johnson R.J., and Hurtado A. Increased oxidative stress following acute and chronic high altitude exposure. High Alt. Med. Biol. 5 (2004) 61-69
12. Pratico D., Lawson J.A., Rokach J., and FitzGerald G.A. The isoprostanes in biology and medicine. Trends Endocrinol. Metab. 12 (2001) 243-247
13. Richardson R., and Tucker A. Muscular strength capacity and altitude response. Jpn. J. Physiol. 43 (1993) 75-85
14. Huicho L., Xing G., Qualls C., Rivera-Ch. M., Gamboa J.L., Verma A., and Appenzeller O. Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness. BMC Pediatr. 8 (2008) 47
15. Leon-Velarde F., and Mejia O. Gene expression in chronic high altitude diseases. High Alt. Med. Biol. 9 (2008) 130-139
16. Robach P., Cairo G., Gelfi C., Bernuzzi F., Pilegaard H., Vigano A., Santambrogio P., Cerretelli P., Calbet J.A.L., Moutereau S., and Lundby C. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood 109 (2007) 4724-4731
17. Mounier R., Pialoux V., Cayre A., Schmitt L., Richalet J.-P., Robach P., Lasne F., Roels B., Millet G., Coudert J., Clottes E., and Fellmann N. Leukocyte's Hif-1 expression and training-induced erythropoietic response in swimmers. Med. Sci. Sports Exerc. 38 (2006) 1410-1417
18. Pialoux V., Mounier R., Brown A.D., Steinback C.D., Rawling J.M., and Poulin M.J. Relationship between oxidative stress and HIF-1α mRNA during sustained hypoxia in humans. Free Radic. Biol. Med. 46 (2009) 321-326
19. Brooks J.T.S., Elvidge G.P., Glenny L., Gleadle J.M., Liu C., Ragoussis J., Smith T.G., Talbot N.P., Winchester L., Maxwell P.H., and Robbins P.A. Variations within oxygen-regulated gene expression in humans. J. Appl. Physiol. 106 (2009) 212-220
20. Koivunen P., Hirsila M., Remes A.M., Hassinen E. I., Kivirikko K.I., and Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 282 (2007) 4524-4532
21. Araneda O.F., Garcia C., Lagos N., Quiroga G., Gajigal J., Salazar M.P., and Behn C. Lung oxidative stress as related to exercise and altitude: lipid peroxidation evidence in exhaled breath condensate: a possible predictor of acute mountain sickness. Eur. J. Appl. Physiol. 95 (2005) 383-390
22. Vij A.G., Dutta R., and Satija N.K. Acclimatization to oxidative stress at high altitude. High Alt. Med. Biol. 6 (2005) 301-310
23. Askew E.W. Work at high altitude and oxidative stress: antioxidant nutrients. Toxicology 180 (2002) 107-119
24. Bailey D.M., Davies B., Young S. I., Hullin D.A., and Seddon P.S. A potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sickness. Aviat. Space Environ. Med. 72 (2001) 513-521
25. Maiti P., Singh S.B., Sharma A.K., Muthuraju S., Banerjee P.K., and Ilavazhagan G. Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem. Int. 49 (2006) 709-716
26. Singh S.N., Vats P., Kumria M.M., Ranganathan S., Shyam R., Arora M.P., Jain C.L., and Sridharan K. Effect of high altitude (7,620 m) exposure on glutathione and related metabolism in rats. Eur. J. Appl. Physiol. 84 (2001) 233-237
27. Caceda R., Gamboa J.L., Boero J.A., Monge C.C., and Arregui A. Energetic metabolism in mouse cerebral cortex during chronic hypoxia. Neurosci. Lett. 301 (2001) 171-174
28. Paddenberg R., Goldenberg A., Faulhammer P., Braun-Dullaeus R.C., and Kummer W. Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature. Adv. Exp. Med. Biol. 536 (2003) 163-169
29. Metz T.M., Treyer V., Hefti U., Spengler C.M., Schwarz U., Buck A., and Maggiorini M. Changes in cerebral glucose metabolism after an expedition to high altitudes. High Alt. Med. Biol. 7 (2006) 28-38
30. Delanty N., Reilly M.P., Pratico D., Lawson J.A., McCarthy J.F., Wood A.E., Ohnishi S.T., Fitzgerald D.J., and FitzGerald G. A., 8-Epi PGF2 alpha generation during coronary reperfusion: a potential quantitative marker of oxidant stress in vivo. Circulation 95 (1997) 2492-2499
31. Bailey D.M., Ainslie P.N., Jackson S.K., Richardson R.S., and Ghatei M. Evidence against redox regulation of energy homeostasis in humans at high altitude. Clin. Sci. 107 (2004) 589-600
32. Baillie J.K., Bates M.G.D., Thompson A.A.R., Waring W.S., Partridge R.W., Schnopp M.F., Simpson A., Gulliver-Sloan F., Maxwell S.R.J., and Webb D.J. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Chest 131 (2007) 1473-1478