Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H2O2 stress

Neurochemistry International

Volumn 54, Issue 2, 2009, Pages 106-110

  Liu, J ^a   Segal, M ^a   Yoo, S ^a   Yang, G Y ^a   Kelly, M ^b   James, T L ^b   Litt, L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antioxidant; Brain slice; Ethyl pyruvate; H2O2; Neonatal; NMR; PBN; Pyruvate; Rat

Indexed keywords

ANTIOXIDANT; GLUCOSE; HYDROGEN PEROXIDE; N TERT BUTYL ALPHA PHENYLNITRONE; PYRUVIC ACID ETHYL ESTER; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CITRIC ACID CYCLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; METABOLOMICS; NONHUMAN; OXIDATIVE STRESS; PARTIAL LEAST SQUARES REGRESSION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STATISTICAL MODEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; CEREBRAL CORTEX; CITRIC ACID CYCLE; CYCLIC N-OXIDES; HYDROGEN PEROXIDE; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PHOSPHOLIPIDS; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 60249089532     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.10.009     Document Type: Article

References (30)

1. Bickler P.E., and Buck L.T. Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia. J. Neurochem. 67 (1996) 1463-1468
2. Breiman L., Friedman J., Stone C.J., and Olshen R.A. Classification and Regression Trees (1984), CRC Press, Boca Raton, Florida
3. Cox I.J. Development and applications of in vivo clinical magnetic resonance spectroscopy. Prog. Biophys. Mol. Biol. 65 (1996) 45-81
4. Efron B., Hastie T.J., Johnstone I., and Tibshirani R.J. Least angle regression. Ann. Stat. 32 (2004) 407-451
5. Eriksson, L., Johansson, E., Kettaneh-Wold, N., Trygg, J., Wikström, C., Wold, S., 2006. Multi- and Megavariate Data Analysis Part I: Basic Principles and Applications, Second revised and enlarged edition.
6. Espanol M.T., Litt L., Yang G.Y., Chang L.H., Chan P.H., James T.L., and Weinstein P.R. Tolerance of low intracellular pH during hypercapnia by rat cortical brain slices: A 31P/1H NMR study. J. Neurochem. 59 (1992) 1820-1828
7. 2+ and phospholipase C. Brain Res. 958 (2002) 43-51
8. Farias L.A., Sun J., and Markov A.K. Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. Am. J. Med. Sci. 297 (1989) 294-299
9. Farias L.A., Willis M., and Gregory G.A. Effects of fructose-1,6-diphosphate, glucose, and saline on cardiac resuscitation. Anesthesiology 65 (1986) 595-601
10. Fink M.P. Ringer's ethyl pyruvate solution: a novel resuscitation fluid. Minerva Anestesiol. 67 (2001) 190-192
11. Fink M.P. Ethyl pyruvate: a novel anti-inflammatory agent. J. Intern. Med. 261 (2007) 349-362
12. Fink M.P. Ethyl pyruvate: a novel treatment for sepsis. Curr. Drug Targets 8 (2007) 515-518
13. Frenzel J., Richter J., and Eschrich K. Pyruvate protects glucose-deprived Muller cells from nitric oxide-induced oxidative stress by radical scavenging. Glia 52 (2005) 276-288
14. Govindaraju V., Young K., and Maudsley A.A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 13 (2000) 129-153
15. Green A.R., Ashwood T., Odergren T., and Jackson D.M. Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059. Pharmacol. Ther. 100 (2003) 195-214
16. Hirai K., Sugawara T., Chan P.H., Basus V.J., James T.L., and Litt L. Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices. J. Neurochem. 83 (2002) 309-319
17. Kelleher J.A., Chan P.H., Chan T.Y., and Gregory G.A. Energy metabolism in hypoxic astrocytes: protective mechanism of fructose-1,6-bisphosphate. Neurochem. Res. 20 (1995) 785-792
18. Kuluz J.W., Gregory G.A., Han Y., Dietrich W.D., and Schleien C.L. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats. Stroke 24 (1993) 1576-1583
19. Markov A.K. Hemodynamics and metabolic effects of fructose-1,6-diphosphate in ischemia and shock-experimental and clinical observations. Ann. Emerg. Med. 15 (1986) 1470-1477
20. Montgomery C.M., Fairhurst A.S., and Webb J.L. Metabolic studies on heart mitochondria. III. The action of parapyruvate on α-ketoglutaric oxidase. J. Biol. Chem. 221 (1956) 369-376
21. Montgomery C.M., and Webb J.L. Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle. J. Biol. Chem. 221 (1956) 359-368
22. Park J.Y., Kim E.J., Kwon K.J., Jung Y.S., Moon C.H., Lee S.H., and Baik E.J. Neuroprotection by fructose-1,6-bisphosphate involves ROS alterations via p38 MAPK/ERK. Brain Res. 1026 (2004) 295-301
23. Toyoda K., Fujii K., Kamouchi M., Nakane H., Arihiro S., Okada Y., Ibayashi S., and Iida M. Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J. Neurol. Sci. 221 (2004) 11-17
24. Varma S.D., Hegde K.R., and Kovtun S. Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate. Ophthalmologica 220 (2006) 52-57
25. Varma S.D., Ramachandran S., Devamanoharan P.S., Morris S.M., and Ali A.H. Prevention of oxidative damage to rat lens by pyruvate in vitro: possible attenuation in vivo. Curr. Eye Res. 14 (1995) 643-649
26. Vexler Z.S., Wong A., Francisco C., Manabat C., Christen S., Tauber M., Ferriero D.M., and Gregory G. Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain Res. 960 (2003) 90-98
27. 13C] NMR spectroscopy. J. Magn. Res. Anal. 2 (1996) 21-32
28. Ying W., Chen Y., Alano C.C., and Swanson R.A. Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. J. Cereb. Blood Flow Metab. 22 (2002) 774-779
29. Zeng J., Liu J., Yang G.Y., Kelly M.J., James T.L., and Litt L. Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology 107 (2007) 630-640
30. Zeng J., Yang G.Y., Ying W., Kelly M., Hirai K., James T.L., Swanson R.A., and Litt L. Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J. Cereb. Blood Flow Metab. 27 (2007) 304-315