Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists

Eye and Contact Lens

Volumn 37, Issue 4, 2011, Pages 233-245

  Varma, Shambhu D ^a   Kovtun, Svitlana ^a   Hegde, Kavita R ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Criminal Justice and Applied Social and Political Sciences Department   (United States)

Author keywords

Antioxidants; Cataracts; Oxidative stress; Ultraviolet irradiation

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAFFEINE; DRINKING WATER; GALACTOSE; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; PLACEBO; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; RIBOFLAVIN; SINGLET OXYGEN; SODIUM SELENITE; SUPEROXIDE; TRYPTOPHAN;

ACTIVE TRANSPORT; APOPTOSIS; BLINDNESS; CATARACT; CATARACTOGENESIS; CORNEA OPACITY; DIABETES MELLITUS; DIABETIC RETINOPATHY; GALACTOSEMIA; GLAUCOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LENS; MEMBRANE TRANSPORT; NONHUMAN; ONCHOCERCIASIS; ORGAN CULTURE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHOTOCHEMISTRY; PHOTOOXIDATION; PHOTOSENSITIZATION; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SUNLIGHT; TRACHOMA; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET IRRADIATION;

ANIMALS; ANTIOXIDANTS; CATARACT; HUMANS; LENS, CRYSTALLINE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; ULTRAVIOLET RAYS;

EID: 79959920831     PISSN: 15422321     EISSN: 1542233X     Source Type: Journal    
DOI: 10.1097/ICL.0b013e31821ec4f2     Document Type: Review

References (55)

1. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ 2004;82:844-851. (Pubitemid 39573742)
2. Stark WJ Jr, Maumenee AE, Fagadau W, et al. Cystoid macular edema in pseudophakia. Surv Ophthalmol 1984;28:442-451. (Pubitemid 14076503)
3. Fine BS, Brucker AJ. Macular edema and cystoid macular edema. Am J Ophthalmol 1981;92:466-481. (Pubitemid 11030201)
4. Clayman HM, Jaffe NS, Light DS, et al. Intraocular lenses, axial length, and retinal detachment. Am J Ophthalmol 1981;92:778-780. (Pubitemid 12245749)
5. Smith PW, Stark WJ, Maumenee AE, et al. Retinal detachment after cataract extraction with posterior chamber intraocular lens. Ophthalmology 1987;94: 495-504. (Pubitemid 17077118)
6. Robertson JM, Donner AP, Trevithick JR. A possible role for vitamins C and E in cataract prevention. Am J Clin Nutr 1991;53:346S-351S.
7. Zhao W, Devamanoharan PS, Henein M, et al. Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. Diabetes Obes Metab 2000;2:165-174. (Pubitemid 33072185)
8. Hegde KR, Varma SD. Prevention of cataract by pyruvate in experimentally diabetic mice. Mol Cell Biochem 2005;269:115-120. (Pubitemid 40287808)
9. Jacques PF, Hartz SC, Chylack LT Jr, et al. Nutritional status in persons with and without senile cataracts: blood vitamin and mineral levels. Am J Clin Nutr 1988;48:152-158.
10. Taylor A, Jacques PF, Chylack LY Jr, et al. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. Am J Clin Nutr 2002;75:540-549. (Pubitemid 34174949)
11. Pirie A. Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight. Biochem J 1971;125:203-208.
12. Lerman S, Borkman R. Spectroscopic evaluation and classification of the normal aging and cataractous lens. Ophthalmol Res 1976;8:335-353. (Pubitemid 8073124)
13. Grover D, Zigman S. Coloration of human lens by near UV photolyzed tryptophane. Exp Eye Res 1972;23:70-75.
14. Van Henyingen R. Fluorescent glucosides in the human lens. Nature 1970; 230:393-394.
15. Bando M, Nakajima A, Satoh K. Spectrophotometric estimation of 3-OH L-kynurenine-O-beta-glucoside in human lens. J Biochem 1981;89:103-109. (Pubitemid 11118216)
16. Schocket SS, Esterson J, Bradford B, et al. Induction of cataracts in mice by exposure to oxygen. Israel J Med Sci 1972;8:1596-1601.
17. Palmquist B-M, Philipson B, Barr P-O. Nuclear cataract and myopia during hyperbaric oxygen therapy. Br J Ophthalmol 1984;68:113-117. (Pubitemid 15134750)
18. Varma SD, Ets TK, Richards RD. Protection against superoxide radicals in rat lens. Ophthalmic Res 1977;9:421-431. (Pubitemid 8321452)
19. Varma SD, Chand D, Sharma YR, et al. Oxidative stress on lens and cataract formation. Role of light and oxygen. Curr Eye Res 1984;3:35-57. (Pubitemid 14163864)
20. Varma SD, Kumar S, Richards RD. Light-induced damage to ocular lens cation pump: prevention by vitamin C. Proc Natl Acad Sci U S A 1979;76: 3504-3506. (Pubitemid 9233171)
21. Blum HF. Photodynamic action. Physiol Rev 1932;12:23-55.
22. Bessey OA, Lowry OH. Factors affecting the riboflavin content of the cornea. J Biol Chem 1944;155:635-643.
23. Philpot PJ, Pirie A. Riboflavin adenine dinucleotide in ox ocular tissue. Biochem J 1943;37:250-254.
24. Kinsey EV, Frohman CE. Studies on crystalline lens. Distribution of cytochrome, total riboflavin, lactate and pyruvate and their metabolic significance. AMA Arch Ophthalmol 1951;46:536-541.
25. Macheroux P. UV-visible spectroscopy as a tool to study flavoproteins. In: Chapman SK, Reid GA, eds. Flavoprotein Protocols, vol 131. Methods in Molecular Biology. Totowa, NJ, Humana Press Inc., 1999, pp 1-2.
26. Varma SD, Mooney JM. Photodamage to the lens in vitro: implications of the Haber-Weiss reaction. J Free Radic Biol Med 1986;2:57-62. (Pubitemid 17206863)
27. Behndig A, Karlsson K, Reaume AG, et al. In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase. Free Radic Biol Med 2001; 31:738-744. (Pubitemid 32835254)
28. Reddy VN, Kasahara E, Hiraoka M, et al. Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Exp Eye Res 2004;79:859-868. (Pubitemid 40092277)
29. Varma SD, Richards RD. Ascorbic acid and the eye lens. Ophthalmic Res 1988;20:164-173.
30. Varma SD, Morris SM, Bauer SA, et al. In vitro damage to rat lens by xanthinexanthine oxidase: protection by ascorbate. Exp Eye Res 1986;43:1067-1076. (Pubitemid 17231184)
31. 2 radicals. A pulse radioisotope and stopped flow study. J Phys Chem 1983;87:1809-1832.
32. Varma SD, Devamanoharan PS, Mansour S, et al. Studies on Emory mouse cataracts: oxidative factors. Ophthalmic Res 1994;26:141-148. (Pubitemid 24171054)
33. Ayala MN, Soderberg PG. Vitamin E can protect against ultraviolet radiation-induced cataract in albino rats. Ophthalmic Res 2004;36:264-269. (Pubitemid 39664120)
34. Chandra DB, Varma R, Ahamad S, et al. Vitamin C in the human aqueous humor and cataracts. Int J Vitam Nutr Res 1986;56:165-168.
35. Fenton HJH, Jones HO. The oxidation of organic acids in presence of ferrous iron. Part I. J Chem Soc Trans 1900;77:69-76.
36. Holleman MAF. Note on the action of oxygenated water on alpha-keto acids and 1,2, dicetones. Recl Tran Chi Pays-bas Belq 1904;23:169-172.
37. Ervens B, Gligorovski S, Herrmann H. Temperature dependent rate constants for hydroxyl radical reactions with organic compounds in aqueous solutions. Phys Chem Chem Phys 2003;5:1811-1824.
38. Millouki A, Mu YJ. On atmospheric degradation of pyruvic acid in the gas phase. J Photochem Photobiol A Chem 2003;157:295-300.
39. Kraljic I. In: Johnson GRA, Scholes G, eds. Chemistry of Ionization and Excitation. London, United Kingdom, Taylor and Francis Ltd, 1967, pp 303-309.
40. Varma SD, Ramachandran S, Devamanoharan PS, et al. Prevention of oxidative damage to rat lens by pyruvate in vitro: possible attenuation in vivo. Curr Eye Res 1995;14:643-649.
41. Varma SD, Morris SM. Peroxide damage to the eye lens in vitro. Prevention by pyruvate. Free Rad Res Commun 1988;4:283-290.
42. Varma SD, Devamanoharan PS, Morris SM. Photoinduction of cataracts in rat lens in vitro. Preventive effect of pyruvate. Exp Eye Res 1990;50: 805-812. (Pubitemid 20191317)
43. Varma SD, Hegde K. Henein M. Oxidative damage to mouse lens in culture. Protective effect of pyruvate. Biochim Biophys Acta 2003;1621:246-252. (Pubitemid 36638576)
44. Hegde KR, Kovtun S, Varma SD. Inhibition of glycolysis in retina by oxidative stress. Prevention by pyruvate. Mol Cell Biochem 2010;343: 101-105.
45. Devamanoharan PS, Ali AH, Varma SD. Non-enzymatic glycation of lens proteins and hemoglobin. Inhibition by pyruvate. An in vivo study. Diabetes Obes Metabol 1999;1:159-164.
46. Kalakonda S, Hegde KR, Varma SD. Ophthalmoscopic and morphogenetic changes in rat lens induced by galactose: attenuation by pyruvate. Diabetes Obes Metabol 2004;6:216-222. (Pubitemid 38559702)
47. Varma SD, Hegde KR, Kovtun S. Attenuation and delay of diabetic cataracts by antioxidants: effectiveness of pyruvate after onset of cataract. Ophthalmologica 2005;219:309-315. (Pubitemid 41208869)
48. Hegde KR, Varma SD. Morphogenetic and apoptotic changes in diabetic cataract. Prevention by pyruvate. Mol Cell Biochem 2004;262: 233-237. (Pubitemid 39158073)
49. Hegde KR, Kovtun S, Varma SD. Induction of UV cataract in vitro. Prevention by pyruvate. J Ocul Pharmacol Ther 2007;23:492-502. (Pubitemid 350202481)
50. Varma SD, Hegde KR, Kovtun S. UV-B induced damage to the lens in vitro. Prevention by caffeine. J Ocul Pharmacol Therap 2008;24:439-444.
51. Varma SD, Hegde KR. Prevention of oxidative damage to lens by caffeine. J Ocular Pharmacol Therap 2010;26:73-77.
52. Varma SD, Hegde KR. Kynurenine induced photo oxidative damage to lens in vitro. Protective effect of caffeine. Mol Cell Biochem 2010;340:49-54.
53. Varma SD, Hegde KR, Kovtun S. Inhibition of selenite-induced cataract by caffeine. Acta Ophthalmol 2010;88:e245-e249.
54. Varma SD, Hegde KR, Kovtun S. Oxidative stress in lens in vivo. Inhibitory effect of caffeine. A preliminary report. Mol Vis 2010:23:501-505.
55. Varma SD, Hegde KR, Kovtun S Effectiveness of topical caffeine in cataract prevention. Studies with galactose cataract. Mol Vis 2010;16: 2626-2633.