메뉴 건너뛰기




Volumn 12, Issue 10, 2007, Pages 934-945

Metabolomic mapping of atypical antipsychotic effects in schizophrenia

Author keywords

Antipsychotics; Lipidomics; Metabolic profiling; Metabolomics; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; FATTY ACID; OLANZAPINE; PHOSPHATIDYLETHANOLAMINE; RISPERIDONE; TRIACYLGLYCEROL;

EID: 34748846290     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4002000     Document Type: Article
Times cited : (230)

References (52)
  • 1
    • 0026436979 scopus 로고
    • Schizophrenia: Manifestations, incidence and course in different cultures. A World Health Organization ten-country study
    • Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 1992; 20: 1-97.
    • (1992) Psychol Med Monogr Suppl , vol.20 , pp. 1-97
    • Jablensky, A.1    Sartorius, N.2    Ernberg, G.3    Anker, M.4    Korten, A.5    Cooper, J.E.6
  • 2
    • 34748822550 scopus 로고    scopus 로고
    • Neurochemical theories
    • Lieberman JA, Stroup TS and Perkins DO eds, American Psychiatric Publishing: Washington DC
    • Javitt DC, Laruelle M. Neurochemical theories. In: Lieberman JA, Stroup TS and Perkins DO (eds). Textbook of Schizophrenia. American Psychiatric Publishing: Washington DC, 2006, pp 85-116.
    • (2006) Textbook of Schizophrenia , pp. 85-116
    • Javitt, D.C.1    Laruelle, M.2
  • 3
    • 0023576255 scopus 로고
    • Biological studies in schizophrenia
    • Meltzer HY. Biological studies in schizophrenia. Schizophr Bull 1987; 13: 77-111.
    • (1987) Schizophr Bull , vol.13 , pp. 77-111
    • Meltzer, H.Y.1
  • 4
    • 33744904445 scopus 로고    scopus 로고
    • Mechanisms of action of medicines for Schizophrenia and Bipolar Illness: Status and limitations
    • Scolnick EM. Mechanisms of action of medicines for Schizophrenia and Bipolar Illness: status and limitations. Biol Psychiatry 2006; 59: 1039-1045.
    • (2006) Biol Psychiatry , vol.59 , pp. 1039-1045
    • Scolnick, E.M.1
  • 5
    • 0017342508 scopus 로고
    • Prediction of outcome in schizophrenia. III. Five-year outcome and its predictors
    • Strauss JS, Carpenter Jr WT. Prediction of outcome in schizophrenia. III. Five-year outcome and its predictors. Arch Gen Psychiatry 1977; 34: 159-163.
    • (1977) Arch Gen Psychiatry , vol.34 , pp. 159-163
    • Strauss, J.S.1    Carpenter Jr, W.T.2
  • 6
    • 0027178496 scopus 로고
    • Psychopharmacologic treatment of schizophrenia
    • Kane JM, Marder SR. Psychopharmacologic treatment of schizophrenia. Schizophr Bull 1993; 19: 287-302.
    • (1993) Schizophr Bull , vol.19 , pp. 287-302
    • Kane, J.M.1    Marder, S.R.2
  • 9
    • 0032503039 scopus 로고    scopus 로고
    • The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia
    • Horrobin DF. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr Res 1998; 30: 193-208.
    • (1998) Schizophr Res , vol.30 , pp. 193-208
    • Horrobin, D.F.1
  • 10
    • 34748873413 scopus 로고    scopus 로고
    • Phospholipids in schizophrenia
    • Lieberman JA, Stroup TS, Perkins DO eds, American Psychiatric Publishing: Washington, DC
    • Mahadik SP, Yao JK. Phospholipids in schizophrenia. In: Lieberman JA, Stroup TS, Perkins DO (eds). Textbook of Schizophrenia. American Psychiatric Publishing: Washington, DC, 2006, pp 117-135.
    • (2006) Textbook of Schizophrenia , pp. 117-135
    • Mahadik, S.P.1    Yao, J.K.2
  • 11
    • 1842844950 scopus 로고    scopus 로고
    • American Diabetes Association, A.P.A. American Association of Clinical Endocrinologists, North American Association for the Study of Obesity, Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes. J Clin Psychiatry 2004; 65: 267-272.
    • American Diabetes Association, A.P.A. American Association of Clinical Endocrinologists, North American Association for the Study of Obesity, Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes. J Clin Psychiatry 2004; 65: 267-272.
  • 12
    • 16644402581 scopus 로고    scopus 로고
    • A comparison of weight change during treatment with olanzapine or aripiprazole: Results from a randomized, double-blind study
    • McQuade RD, Stock E, Marcus R, Jody D, Gharbia NA, Vanveggel S et al. A comparison of weight change during treatment with olanzapine or aripiprazole: results from a randomized, double-blind study. J Clin Psychiatry 2004; 65(Suppl 18): 47-56.
    • (2004) J Clin Psychiatry , vol.65 , Issue.SUPPL. 18 , pp. 47-56
    • McQuade, R.D.1    Stock, E.2    Marcus, R.3    Jody, D.4    Gharbia, N.A.5    Vanveggel, S.6
  • 14
    • 0036913503 scopus 로고    scopus 로고
    • Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    • Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW et al. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002; 8: 1439-1444.
    • (2002) Nat Med , vol.8 , pp. 1439-1444
    • Brindle, J.T.1    Antti, H.2    Holmes, E.3    Tranter, G.4    Nicholson, J.K.5    Bethell, H.W.6
  • 15
    • 0037208170 scopus 로고    scopus 로고
    • Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension
    • Brindle JT, Nicholson JK, Schofield PM, Grainger DJ, Holmes E. Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst 2003; 128: 32-36.
    • (2003) Analyst , vol.128 , pp. 32-36
    • Brindle, J.T.1    Nicholson, J.K.2    Schofield, P.M.3    Grainger, D.J.4    Holmes, E.5
  • 17
    • 14844336916 scopus 로고    scopus 로고
    • Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: A pattern-recognition (1)H NMR study
    • Dunne VG, Bhattachayya S, Besser M, Rae C, Griffin JL. Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition (1)H NMR study. NMR Biomed 2005; 18: 24-33.
    • (2005) NMR Biomed , vol.18 , pp. 24-33
    • Dunne, V.G.1    Bhattachayya, S.2    Besser, M.3    Rae, C.4    Griffin, J.L.5
  • 18
    • 33644963733 scopus 로고    scopus 로고
    • Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning
    • Kenny LC, Dunn WB, Ellis DI, Myers J, Baker PN et al. Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. Metabolomics 2005; 1: 277-284.
    • (2005) Metabolomics , vol.1 , pp. 277-284
    • Kenny, L.C.1    Dunn, W.B.2    Ellis, D.I.3    Myers, J.4    Baker, P.N.5
  • 19
    • 24644508329 scopus 로고    scopus 로고
    • Metabolic investigation in psychiatric disorders
    • Yao JK, Reddy RD. Metabolic investigation in psychiatric disorders. Mol Neurobiol 2005; 31: 193-203.
    • (2005) Mol Neurobiol , vol.31 , pp. 193-203
    • Yao, J.K.1    Reddy, R.D.2
  • 20
    • 21644479604 scopus 로고    scopus 로고
    • Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
    • Wang C, Kong H, Guan Y, Yang J, Gu J, Yang S et al. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. Anal Chem 2005; 77: 4108-4116.
    • (2005) Anal Chem , vol.77 , pp. 4108-4116
    • Wang, C.1    Kong, H.2    Guan, Y.3    Yang, J.4    Gu, J.5    Yang, S.6
  • 21
    • 2942527049 scopus 로고    scopus 로고
    • Lipomic profiling in drug discovery, development and clinical trial evaluation
    • Watkins SM. Lipomic profiling in drug discovery, development and clinical trial evaluation. Curr Opin Drug Discov Devel 2004; 7: 112-117.
    • (2004) Curr Opin Drug Discov Devel , vol.7 , pp. 112-117
    • Watkins, S.M.1
  • 23
    • 33845564160 scopus 로고    scopus 로고
    • Lipidomics: A global approach to lipid analysis in biological systems
    • Watson AD. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res 2006; 47: 2101-2111.
    • (2006) J Lipid Res , vol.47 , pp. 2101-2111
    • Watson, A.D.1
  • 25
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.H.3
  • 26
    • 0035074235 scopus 로고    scopus 로고
    • Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids
    • Watkins SM, Lin TY, Davis RM, Ching JR, DePeters EJ, Halpern GM et al. Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. Lipids 2001; 36: 247-254.
    • (2001) Lipids , vol.36 , pp. 247-254
    • Watkins, S.M.1    Lin, T.Y.2    Davis, R.M.3    Ching, J.R.4    DePeters, E.J.5    Halpern, G.M.6
  • 27
    • 0025651858 scopus 로고
    • An improved method for the identification and quantitation of biological lipids by HPLC using laser light-scattering detection
    • Lutzke BS, Braughler JM. An improved method for the identification and quantitation of biological lipids by HPLC using laser light-scattering detection. J Lipid Res 1990; 11: 2127-2130.
    • (1990) J Lipid Res , vol.11 , pp. 2127-2130
    • Lutzke, B.S.1    Braughler, J.M.2
  • 28
    • 33644881910 scopus 로고    scopus 로고
    • Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
    • Warensjo E, Ohrvall M, Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis 2006; 16: 128-136.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , pp. 128-136
    • Warensjo, E.1    Ohrvall, M.2    Vessby, B.3
  • 29
    • 20944444283 scopus 로고    scopus 로고
    • Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma
    • Riserus U, Tan GD, Fielding BA, Neville JM, Currie J, Savage DB et al. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. Diabetes 2005; 54: 1379-1384.
    • (2005) Diabetes , vol.54 , pp. 1379-1384
    • Riserus, U.1    Tan, G.D.2    Fielding, B.A.3    Neville, J.M.4    Currie, J.5    Savage, D.B.6
  • 30
    • 11144357407 scopus 로고    scopus 로고
    • Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
    • Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B et al. Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. J Lipid Res 2004; 45: 914-922.
    • (2004) J Lipid Res , vol.45 , pp. 914-922
    • Shiwaku, K.1    Hashimoto, M.2    Kitajima, K.3    Nogi, A.4    Anuurad, E.5    Enkhmaa, B.6
  • 31
    • 33748324384 scopus 로고    scopus 로고
    • R Development Core Team , R Foundation for Statistical Computing: Vienna, Austria. ISBN 3-900051-07-0, URL
    • R Development Core Team (2006). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria. ISBN 3-900051-07-0, URL: http://www.R-project.org/.
    • (2006) R: A Language and Environment for Statistical Computing
  • 32
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286: 531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3    Huard, C.4    Gaasenbeek, M.5    Mesirov, J.P.6
  • 33
    • 33748339379 scopus 로고    scopus 로고
    • Metabolic profiling of patients with schizophrenia (Letter)
    • Kaddurah-Daouk R. Metabolic profiling of patients with schizophrenia (Letter). PLoS Med 2006; 3: 1222-1223.
    • (2006) PLoS Med , vol.3 , pp. 1222-1223
    • Kaddurah-Daouk, R.1
  • 35
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon JC, Holmes E, Bollard ME, Stanley EG, Nicholson JK. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 2004; 9: 1-31.
    • (2004) Biomarkers , vol.9 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.3    Stanley, E.G.4    Nicholson, J.K.5
  • 36
    • 33748354488 scopus 로고    scopus 로고
    • Metabolic profiling of CSF: Evidence that early intervention may impact on disease progression and outcome in schizophrenia
    • Holmes E, Tsang TM, Huang JT, Leweke FM, Koethe D, Gerth CW et al. Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med 2006; 3: 1420-1428.
    • (2006) PLoS Med , vol.3 , pp. 1420-1428
    • Holmes, E.1    Tsang, T.M.2    Huang, J.T.3    Leweke, F.M.4    Koethe, D.5    Gerth, C.W.6
  • 37
    • 0002345315 scopus 로고
    • Phospholipid and prostaglandin hypotheses of schizophrenia
    • Meltzer NY ed, Raven Press: New York
    • Rotrosen J, Wolkin A. Phospholipid and prostaglandin hypotheses of schizophrenia. In: Meltzer NY (ed). Psychopharmacology, The Third Generation on Progress. Raven Press: New York, 1987, pp 759-764.
    • (1987) Psychopharmacology, The Third Generation on Progress , pp. 759-764
    • Rotrosen, J.1    Wolkin, A.2
  • 39
    • 0027978180 scopus 로고
    • Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naive patients at the onset of psychosis
    • Mahadik SP, Mukherjee S, Correnti EE, Kelkar HS, Wakade CG, Costa RM et al. Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naive patients at the onset of psychosis. Schizophr Res 1994; 13: 239-247.
    • (1994) Schizophr Res , vol.13 , pp. 239-247
    • Mahadik, S.P.1    Mukherjee, S.2    Correnti, E.E.3    Kelkar, H.S.4    Wakade, C.G.5    Costa, R.M.6
  • 40
    • 0034869802 scopus 로고    scopus 로고
    • Effects of antipsychotic treatment on membrane phospholipid metabolism in schizophrenia
    • Schmitt A, Maras A, Petroianu G, Braus DF, Scheuer L, Gattaz WF et al. Effects of antipsychotic treatment on membrane phospholipid metabolism in schizophrenia. J Neural Transm 2001; 108: 1081-1091.
    • (2001) J Neural Transm , vol.108 , pp. 1081-1091
    • Schmitt, A.1    Maras, A.2    Petroianu, G.3    Braus, D.F.4    Scheuer, L.5    Gattaz, W.F.6
  • 41
    • 0026091918 scopus 로고
    • Fatty acid levels in the brains of schizophrenics and normal controls
    • Horrobin DF, Manku MS, Hillman H, Iain A, Glen M. Fatty acid levels in the brains of schizophrenics and normal controls. Biol Psychiatry 1991; 30: 795-805.
    • (1991) Biol Psychiatry , vol.30 , pp. 795-805
    • Horrobin, D.F.1    Manku, M.S.2    Hillman, H.3    Iain, A.4    Glen, M.5
  • 42
    • 0033998227 scopus 로고    scopus 로고
    • Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients
    • Yao JK, Leonard S, Reddy RD. Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schizophr Res 2000; 42: 7-17.
    • (2000) Schizophr Res , vol.42 , pp. 7-17
    • Yao, J.K.1    Leonard, S.2    Reddy, R.D.3
  • 43
    • 0025769846 scopus 로고
    • Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy
    • Pettegrew JW, Keshavan MS, Panchalingam K, Strychor S, Kaplan DB, Tretta MG et al. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch Gen Psychiatry 1991; 48: 563-568.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 563-568
    • Pettegrew, J.W.1    Keshavan, M.S.2    Panchalingam, K.3    Strychor, S.4    Kaplan, D.B.5    Tretta, M.G.6
  • 44
    • 0034765999 scopus 로고    scopus 로고
    • Associations between central and peripheral measures of phospholipid breakdown revealed by cerebral 31-phosphorus magnetic resonance spectroscopy and fatty acid composition of erythrocyte membranes
    • Richardson AJ, Allen SJ, Hajnal JV, Cox IJ, Easton T, Puri BK. Associations between central and peripheral measures of phospholipid breakdown revealed by cerebral 31-phosphorus magnetic resonance spectroscopy and fatty acid composition of erythrocyte membranes. Prog Neuropsychopharmacol Biol Psychiatry 2001; 2: 1513-1521.
    • (2001) Prog Neuropsychopharmacol Biol Psychiatry , vol.2 , pp. 1513-1521
    • Richardson, A.J.1    Allen, S.J.2    Hajnal, J.V.3    Cox, I.J.4    Easton, T.5    Puri, B.K.6
  • 45
    • 0037108020 scopus 로고    scopus 로고
    • Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    • Yao JK, Stanley JA, Reddy RD, Keshavan MS, Pettegrew JW. Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites. Biol Psychiatry 2002; 52: 823-830.
    • (2002) Biol Psychiatry , vol.52 , pp. 823-830
    • Yao, J.K.1    Stanley, J.A.2    Reddy, R.D.3    Keshavan, M.S.4    Pettegrew, J.W.5
  • 46
    • 0029742284 scopus 로고    scopus 로고
    • Schizophrenia as a membrane lipid disorder which is expressed throughout the body
    • Horrobin DF. Schizophrenia as a membrane lipid disorder which is expressed throughout the body. Prostaglandins Leukot Essent Fatty Acids 1996; 55: 3-7.
    • (1996) Prostaglandins Leukot Essent Fatty Acids , vol.55 , pp. 3-7
    • Horrobin, D.F.1
  • 47
    • 0345554317 scopus 로고
    • Essential fatty acid deficiency in humans
    • Galli C, Jacini G, Pecile A eds, Raven Press: New York
    • Holman RT. Essential fatty acid deficiency in humans. In: Galli C, Jacini G, Pecile A (eds). Dietary Lipids and Postnatal Development. Raven Press: New York, 1973, pp 127-143.
    • (1973) Dietary Lipids and Postnatal Development , pp. 127-143
    • Holman, R.T.1
  • 48
    • 0024593168 scopus 로고
    • Essential fatty acids in plasma phospholipids in schizophrenics
    • Horrobin DF, Manku MS, Morse-Fisher NM. Essential fatty acids in plasma phospholipids in schizophrenics. Biol Psychiatry 1989; 25: 562-568.
    • (1989) Biol Psychiatry , vol.25 , pp. 562-568
    • Horrobin, D.F.1    Manku, M.S.2    Morse-Fisher, N.M.3
  • 49
    • 0025914805 scopus 로고
    • Essential and other fatty acids in plasma in schizophrenics and normal individuals from Japan
    • Kaiya H, Horrobin DF, Manku MS, Fisher NM. Essential and other fatty acids in plasma in schizophrenics and normal individuals from Japan. Biol Psychiatry 1991; 30: 357-362.
    • (1991) Biol Psychiatry , vol.30 , pp. 357-362
    • Kaiya, H.1    Horrobin, D.F.2    Manku, M.S.3    Fisher, N.M.4
  • 50
    • 0027978178 scopus 로고
    • Red blood cell membrane dynamics in schizophrenia. III. Correlation of fatty acid abnormalities with clinical measures
    • Yao JK, van Kammen DP, Gurklis J. Red blood cell membrane dynamics in schizophrenia. III. Correlation of fatty acid abnormalities with clinical measures. Schizophr Res 1994; 13: 227-232.
    • (1994) Schizophr Res , vol.13 , pp. 227-232
    • Yao, J.K.1    van Kammen, D.P.2    Gurklis, J.3
  • 51
    • 27144450193 scopus 로고    scopus 로고
    • Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: A novel mechanism of action?
    • Ferno J, Raeder MB, Vik-Mo AO, Skrede S, Glambek M, Tronstad KJ et al. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J 2005; 5: 298-304.
    • (2005) Pharmacogenomics J , vol.5 , pp. 298-304
    • Ferno, J.1    Raeder, M.B.2    Vik-Mo, A.O.3    Skrede, S.4    Glambek, M.5    Tronstad, K.J.6
  • 52
    • 32244431947 scopus 로고    scopus 로고
    • Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells
    • Raeder MB, Ferno J, Glambek M, Stansberg C, Steen VM. Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett 2006; 395: 185-190.
    • (2006) Neurosci Lett , vol.395 , pp. 185-190
    • Raeder, M.B.1    Ferno, J.2    Glambek, M.3    Stansberg, C.4    Steen, V.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.