Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

British Journal of Clinical Pharmacology

Volumn 70, Issue 2, 2010, Pages 241-251

  Klawitter, Jost ^a,b   Haschke, Manuel ^a   Kahle, Christine ^a   Dingmann, Colleen ^a   Klawitter, Jelena ^a   Leibfritz, Dieter ^c   Christians, Uwe ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Eurofins Medinet Inc   (Germany)

^c UNIVERSITY OF BREMEN   (Germany)

Author keywords

15 F2t isoprostane; ciclosporin; kidney dysfunction markers; metabolomics; nephrotoxicity; pharmacokinetics

Indexed keywords

CITRIC ACID; CREATININE; CYCLOSPORIN A; DRUG METABOLITE; HIPPURIC ACID; ISOPROSTANE DERIVATIVE; LACTIC ACID; PHENYLALANINE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLITE; METABOLOME; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOPROSTANES; LEAST-SQUARES ANALYSIS; MALE; MASS SPECTROMETRY; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 77954507406     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03689.x     Document Type: Article

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