Antioxidant properties of myocardial fuels

Molecular and Cellular Biochemistry

Volumn 253, Issue 1-2, 2003, Pages 103-111

  Mallet, Robert T ^a   Sun, Jie ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Acetoacetate; Cardiac stunning; Citrate; Cyclic AMP; Glutathione; Hydrogen peroxide; Myocardium; Peroxynitrite; Pyruvate

Indexed keywords

ACETOACETIC ACID; ACETYLCYSTEINE; CITRIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; ISOPRENALINE; PEROXIDE; PEROXYNITRITE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANTIOXIDANT ACTIVITY; CARBOXYLATION; CONCENTRATION (PARAMETERS); DRUG POTENTIATION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE REPERFUSION; HEART PERFORMANCE; HEART PROTECTION; HUMAN; INOTROPISM; MOLECULAR MECHANICS; NONHUMAN; REVIEW; STATISTICAL ANALYSIS;

ACETOACETATES; ANIMALS; ANTIOXIDANTS; ENERGY METABOLISM; GLUTATHIONE DISULFIDE; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PYRUVIC ACID; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA;

EID: 0142243372     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026009519783     Document Type: Review

References (67)

1. Alberola A, Such L, Gil F, Zaragoza EJ, Morcillo EJ: Protective effect of N-acetylcysteine on ischaemia-induced myocardial damage in canine heart. Naunyn-Schmiedeberg's Arch Pharmacol 343: 505-510, 1991
2. Tang L-D, Sun J-Z, Wu K, Sun C-P, Tang Z-M: Beneficial effects of N-acetylcysteine and cysteine in stunned myocardium in perfused rat heart. Br J Pharmacol 102: 601-606, 1991
3. Bolli R, Marbán E: Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 79: 609-634, 1999
4. Kuo W-N, Kreahling JM, Shanbhag VP, Shanbhag PP, Mewar M: Protein nitration. Mol Cell Biochem 214: 121-129, 2000
5. Dhalla NS, Elmoselhi AB, Hata T, Makino N: Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 47: 446-456, 2000
6. Schafer FQ, Buettner GR: Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30: 1191-1212, 2001
7. Kukreja RC, Hess ML: The oxygen free radical system: From equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res 26: 641-655, 1992
8. Charlat ML, O'Neill PG, Egan JM, Abernethy DR, Michael LH, Myers ML, Roberts R, Bolli R: Evidence for a pathogenetic role of xanthine oxidase in the 'stunned' myocardium. Am J Physiol Heart Circ Physiol 252: H566-H577, 1987
9. Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev 74: 139-162, 1994
10. Beckman JS, Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol Cell Physiol 271: C1424-C1437, 1996
11. Savvides SN, Scheiwein M, Böhme CC, Arteel GE, Karplus PA, Becker K, Schirmer RH: Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J Biol Chem 277: 2779-2784, 2002
12. Radi R, Beckman JS, Bush KM, Freeman BA: Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 288: 481-487, 1991
13. Cheung P-Y, Wang W, Schulz R: Glutathione protects against myocardial ischemia-reperfusion injury by detoxifying peroxynitrite. J Mol Cell Cardiol 32: 1669-1678, 2000
14. Heales SJR, Bolaños JP: Impairment of brain mitochondrial function by reactive nitrogen species: The role of glutathione in dictating susceptibility. Neurochem Int 40: 469-474, 2002
15. Yasmin W, Strynadka KD, Schulz R: Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc Res 33: 422-432, 1997
16. Bolli R: Postischemic myocardial 'stunning': Pathogenesis, pathophysiology, and clinical relevance. In: D.M. Yellon, R.B. Jennings (eds). Myocardial Protection: The Pathophysiology of Reperfusion and Reperfusion Injury. Raven Press, New York, 1992, pp 105-149
17. Bolli R, Jeroudi MO, Patel BS, Aruoma OI, Halliwell B, Lai EK, McCay PB: Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Circ Res 65: 607-622, 1989
18. Weisel RD, Mickle DAG, Finkle CD, Tumiati LC, Madonik MM, Ivanov J, Burton GW, Ingold KU: Myocardial free-radical injury after cardioplegia. Circulation 80(suppl III): III14-III18, 1989
19. Janero DR, Hreniuk D, Sharif HM: Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): Lethal peroxidative membrane injury. J Cell Physiol 149: 347-364, 1991
20. Bagchi M, Prasad MR, Engleman RM, Das DK: Effects of free radicals on the fluidity of myocardial membranes. Free Radic Res Commun 7: 375-380, 1989
21. Lebedev AV, Levitsky DO, Loginov VA, Smirnov VN: The effect of primary products of lipid peroxidation on the transmembrane transport of calcium ions. J Mol Cell Cardiol 14(suppl 3): 99-103, 1982
22. Eaton P, Hearse DJ, Shattock MJ: Lipid hydroperoxide modification of proteins during myocardial ischemia. Cardiovasc Res 51: 294-303, 2001
23. Chatham JC, Gilbert HF, Radda GK: The metabolic consequences of hydroperoxide perfusion on the isolated rat heart. Eur J Biochem 184: 657-662, 1989
24. Janero DR, Hreniuk D, Sharif HM: Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism. Am J Physiol Cell Physiol 266: C179-C188, 1994
25. Vlessis AA, Muller P, Bartos D, Trunkey D: Mechanism of peroxide-induced cellular injury in cultured adult cardiac myocytes. FASEB J 5: 2600-2605, 1991
26. Radi R, Rodriguez M, Castro L, Telleri R: Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308: 89-95, 1994
27. Tretter L, Adam-Vizi V: Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of α-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J Neurosci 20: 8972-8979, 2000
28. Tatsumi T, Kako KJ: Effects of hydrogen peroxide on mitochondrial enzyme function studied in situ in rat heart myocytes. Basic Res Cardiol 88: 199-211, 1993
29. Goldhaber JI, Qayyum MS: Oxygen free radicals and excitation-contraction coupling. Antioxid Redox Signal 2: 55-64, 2000
30. +-ATPase: Inactivation by neutrophil-derived free radicals and oxidants. Am J Physiol Heart Circ Physiol 259: H1330-H1336, 1990
31. + ATPase by oxyradical generating systems. Mol Cell Biochem 147: 139-144, 1995
32. Josephson RA, Silverman HS, Lakatta EG, Stern MD, Zweier JL: Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J Biol Chem 266: 2354-2361, 1991
33. Molina H, Garcia M: Enzymatic defenses of the rat heart against lipid peroxidation. Mech Ageing Dev 97: 1-7, 1997
34. Jung CH, Thomas JA: S-glutathiolated hepatocyte proteins and insulin disulfides as substrates for reduction by glutaredoxin, thioredoxin, protein disulfide isomerase, and glutathione. Arch Biochem Biophys 335: 61-72, 1996
35. Freislaben H-J, Packer L: Free-radical scavenging activities, interactions and recycling of antioxidants. Biochem Soc Trans 21: 325-330, 1993
36. Kehrer JP, Lund LG: Cellular reducing equivalents and oxidative stress. Free Radic Biol Med 17: 65-75, 1994
37. Mallet RT: Pyruvate: Metabolic protector of cardiac performance. Proc Soc Exp Biol Med 223: 136-148, 2000
38. 2+ uptake. Biochim Biophys Acta 1224: 22-32, 1994
39. Mallet RT, Sun J: Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics. Cardiovasc Res 42: 149-161, 1999
40. Martin BJ, Valdivia HH, Bünger R, Lasley RD, Mentzer RM Jr: Pyruvate augments calcium transients in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 274: H8-H17, 1998
41. 19F nuclear magnetic resonance study. Circ Res 83: 898-907, 1998
42. Zhou Z, Lasley RD, Hegge JO, Bünger R, Mentzer RM Jr: Myocardial stunning: A therapeutic conundrum. J Thorac Cardiovasc Surg 110: 1391-1401, 1995
43. Zhang J, Toher C, Erhard M, Zhang Y, Ugurbil K, Bache RJ, Lange T, Homans DC: Relationships between myocardial bioenergetic and left ventricular function in hearts with volume-overload hypertrophy. Circulation 96: 334-343, 1997
44. Tejero-Taldo MI, Sun J, Caffrey JL, Mallet RT: Pyruvate potentiates β-adrenergic inotropism of stunned guinea-pig myocardium. J Mol Cell Cardiol 30: 2327-2339, 1998
45. Kiuchi K, Shen YT, Vatner SF, Vatner DE: Mechanisms mediating responsiveness to beta-adrenergic stimulation after coronary reperfusion in conscious dogs. Am J Physiol Heart Circ Physiol 267: H1578-H1588, 1994
46. Persad S, Takeda S, Panagia V, Dhalla NS: β-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals. J Mol Cell Cardiol 29: 545-558, 1997
47. 2. Am J Physiol Heart Circ Physiol 274: H416-H423, 1998
48. Tejero-Taldo MI, Caffrey JL, Sun J, Mallet RT: Antioxidant properties of pyruvate mediate its potentiation of β-adrenergic inotropism in stunned myocardium. J Mol Cell Cardiol 31: 1863-1872, 1999
49. Constantopoulos G, Barranger JA: Nonenzymatic decarboxylation of pyruvate. Anal Biochem 139: 353-358, 1984
50. Vásquez-Vivar J, Denicola A, Radi R, Augusto O: Peroxynitrite-mediated decarboxylation of pyruvate to both carbon dioxide and carbon dioxide radical anion. Chem Res Toxicol 10: 786-794, 1997
51. 13C mass isotopomer study of anaplerotic pyruvate carboxylation in perfused rat hearts. J Biol Chem 272: 26125-26131, 1997
52. Peuhkurinen KJ, Hassinen IE: Pyruvate carboxylation as an anaplerotic mechanism in the isolated perfused rat heart. Biochem J 202: 67-76, 1982
53. Russell RR III, Taegtmeyer H: Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate. Am J Physiol Heart Circ Physiol 261: H1756-H1762, 1991
54. Garland PB, Randle PJ, Newsholme EA: Citrate as an intermediary in the inhibition of phosphofructokinase in rat heart muscle by fatty acids, ketone bodies, pyruvate, diabetes and starvation. Nature 200: 169-170, 1963
55. 2+ in rabbit cardiac muscle preparations. Am J Physiol Heart Circ Physiol 279: H702-H708, 2000
56. Hermann HP, Zeitz O, Lehnart SE, Keweloh B, Datz N, Hasenfuss G, Janssen PM: Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. Cardiovasc Res 53: 116-123, 2002
57. 2-injured myocardium. J Mol Cell Cardiol 33: A115, 2001
58. Squires JE, Sun J, Caffrey JL, Yoshishige D, Mallet RT: Acetoacetate augments β-adrenergic inotropism of stunned myocardium by an antioxidant mechanism. Am J Physiol Heart Circ Physiol 284: H1340-H1347, 2003
59. Goodwin GW, Ahmad F, Doenst T, Taegtmeyer H: Energy provision from glycogen, glucose, and fatty acids on adrenergic stimulation of isolated working rat hearts. Am J Physiol Heart Circ Physiol 274: H1239-H1247, 1998
60. Uppu RM, Pryor WA: Carbon dioxide catalysis of the reaction of peroxynitrite with ethyl acetoacetate: An example of aliphatic nitration with peroxynitrite. Biochem Biophys Res Commun 229: 764-769, 1996
61. Menahan LA, Hron WT: Regulation of acetoacetyl-CoA in isolated perfused rat hearts. Eur J Biochem 119: 295-299, 1981
62. 2. J Biochem 108: 426-431, 1990
63. Mallet RT, Hartman DA, Bünger R: Glucose requirement for postischemic recovery of perfused working heart. Eur J Biochem 188: 481-493, 1990
64. Taegtmeyer H: On the inability of ketone bodies to serve as the only energy providing substrate for rat heart at physiological work load. Basic Res Cardiol 78: 435-450, 1983
65. Humphries KM, Juliano C, Taylor SS: Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem 277: 43505-43511, 2002
66. Hermann H-P, Pieske B, Schwarzmüller E, Keul J, Just H, Hasenfuss G: Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: An open study. Lancet 353: 1321-1323, 1999
67. Olivencia-Yurvati AH, Blair JL, Baig M, Mallet RT: Pyruvate-enhanced cardioprotection during cardiopulmonary bypass surgery. J Cardiothorac Vasc Anesth (in press)