The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury

Toxicology and Applied Pharmacology

Volumn 252, Issue 2, 2011, Pages 97-111

  Ellinger Ziegelbauer, Heidrun ^a   Adler, Melanie ^b   Amberg, Alexander ^c   Brandenburg, Arnd ^d   Callanan, John J ^e   Connor, Susan ^d   Fountoulakis, Michael ^d   Gmuender, Hans ^d   Gruhler, Albrecht ^f   Hewitt, Philip ^g   Hodson, Mark ^d   Matheis, Katja A ^h   McCarthy, Diane ⁱ   Raschke, Marian ^a   Riefke, Björn ^a   Schmitt, Christina S ^g   Sieber, Max ^b   Sposny, Alexandra ^g   Suter, Laura ^d   Sweatman, Brian ^d   Mally, Angela ^b   more..

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^d University College Dublin ^*

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f NOVO NORDISK A S   (Denmark)

^g MERCK KGAA   (Germany)

^h BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

ⁱ Bio Rad Inc   (United States)

Author keywords

Drug induced hepatotoxicity; Liver; Metabonomics; Preclinical safety assessment; Toxicogenomics

Indexed keywords

BILE ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT INJURY; CELL MIGRATION; CHOLESTASIS; GENE EXPRESSION; HEPATOBILIARY DISEASE; HISTOPATHOLOGY; INFLAMMATORY CELL; LIVER CELL; LIVER FIBROSIS; LIVER HYPERTROPHY; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEOMICS; RAT; REGENERATION; STRESS; TECHNOLOGY; TRANSCRIPTOMICS;

RATTUS;

EID: 79953713653     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.022     Document Type: Article

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