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Volumn 18, Issue 1, 2008, Pages 81-95

Metabolic markers of hypoxia: Systems biology application in biomedicine

Author keywords

Biomarkers; Chronic and Acute Hypoxia; Drug Toxicity; Mass Spectrometry; Metabolomics; NMR Spectroscopy; Proteomics

Indexed keywords

BIOLOGICAL MARKER;

EID: 38549093441     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510701795769     Document Type: Review
Times cited : (22)

References (92)
  • 1
    • 33750364830 scopus 로고    scopus 로고
    • The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
    • Adachi, J., Kumar, C., Zhang, Y., Olsen, J. V., and Mann, M. 2006. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 7(9):R80.
    • (2006) Genome Biol , vol.7 , Issue.9
    • Adachi, J.1    Kumar, C.2    Zhang, Y.3    Olsen, J.V.4    Mann, M.5
  • 2
    • 0029616317 scopus 로고
    • Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR
    • Agarwal, V. R., Bulun, S. E., and Simpson, E. R. 1995. Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR. Mol. Cell. Probes 9:453-464.
    • (1995) Mol. Cell. Probes , vol.9 , pp. 453-464
    • Agarwal, V.R.1    Bulun, S.E.2    Simpson, E.R.3
  • 3
    • 14844311934 scopus 로고    scopus 로고
    • Candidate-based proteomics in the search for biomarkers of cardiovascular disease
    • Anderson, L. 2005. Candidate-based proteomics in the search for biomarkers of cardiovascular disease. J. Physiol. (Lond). 563(Pt 1):23-60.
    • (2005) J. Physiol. (Lond) , vol.563 , Issue.PART 1 , pp. 23-60
    • Anderson, L.1
  • 5
    • 10344262550 scopus 로고    scopus 로고
    • Evidence against redox regulation of energy homoeostasis in humans at high altitude
    • Bailey, D. M., Ainslie, P. N., Jackson, S. K., Richardson, R. S., and Ghatei, M. 2004a. Evidence against redox regulation of energy homoeostasis in humans at high altitude. Clin. Sci. (Colch). 107(6):589-600.
    • (2004) Clin. Sci. (Colch) , vol.107 , Issue.6 , pp. 589-600
    • Bailey, D.M.1    Ainslie, P.N.2    Jackson, S.K.3    Richardson, R.S.4    Ghatei, M.5
  • 6
    • 1642276896 scopus 로고    scopus 로고
    • Pathophysiological significance of peroxidative stress, neuronal damage, and membrane permeability in acute mountain sickness
    • Bailey, D. M., Kleger, G. -R., Holzgraefe, M., Ballmer, P. E., and Bartsch, P. 2004b. Pathophysiological significance of peroxidative stress, neuronal damage, and membrane permeability in acute mountain sickness. J. Appl. Physiol. 96(4):1459-1463.
    • (2004) J. Appl. Physiol , vol.96 , Issue.4 , pp. 1459-1463
    • Bailey, D.M.1    Kleger, G.-R.2    Holzgraefe, M.3    Ballmer, P.E.4    Bartsch, P.5
  • 7
    • 0034996582 scopus 로고    scopus 로고
    • A potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sickness
    • Bailey, D. M., Davies, B., Young, I. S., Hullin, D. A., and Seddon, P. S. 2001. A potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sickness. Aviation Space Environ. Med. 72(6):513-521.
    • (2001) Aviation Space Environ. Med , vol.72 , Issue.6 , pp. 513-521
    • Bailey, D.M.1    Davies, B.2    Young, I.S.3    Hullin, D.A.4    Seddon, P.S.5
  • 11
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers Definitions Working Group. 2001. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 69(3):89-95.
    • (2001) Clin. Pharmacol. Ther , vol.69 , Issue.3 , pp. 89-95
  • 12
    • 33747619654 scopus 로고    scopus 로고
    • Proteomics in pulmonary medicine
    • Bowler, R. P., Ellison, M. C., and Reisdorph, N. 2006. Proteomics in pulmonary medicine. Chest 130(2):567-574.
    • (2006) Chest , vol.130 , Issue.2 , pp. 567-574
    • Bowler, R.P.1    Ellison, M.C.2    Reisdorph, N.3
  • 13
    • 0036913503 scopus 로고    scopus 로고
    • Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., and Grainger, D. J. 2002. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics [erratum appears in Nat. Med. 2003;9(4):477]. Nat. Med. 8(12):1439-1444.
    • Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., and Grainger, D. J. 2002. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics [erratum appears in Nat. Med. 2003;9(4):477]. Nat. Med. 8(12):1439-1444.
  • 14
    • 34547234150 scopus 로고    scopus 로고
    • Detection of cardiac biomarkers using micellar electrokinetic chromatography and a cleavable tag immunoassay
    • Caulum, M. M., Murphy, B. M., Ramsay, L. M., and Henry, C. S. 2007. Detection of cardiac biomarkers using micellar electrokinetic chromatography and a cleavable tag immunoassay. Anal. Chem. 79(14):5249-5256.
    • (2007) Anal. Chem , vol.79 , Issue.14 , pp. 5249-5256
    • Caulum, M.M.1    Murphy, B.M.2    Ramsay, L.M.3    Henry, C.S.4
  • 15
    • 33846320398 scopus 로고    scopus 로고
    • Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia
    • Dolt, K. S., Karar, J., Mishra, M. K., Salim, J., Kumar, R., Grover, S. K., and Qadar Pasha, M. A. 2007. Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia. Biochem. Biophys. Res. Commun. 354(1):148-153.
    • (2007) Biochem. Biophys. Res. Commun , vol.354 , Issue.1 , pp. 148-153
    • Dolt, K.S.1    Karar, J.2    Mishra, M.K.3    Salim, J.4    Kumar, R.5    Grover, S.K.6    Qadar Pasha, M.A.7
  • 19
    • 0025803078 scopus 로고
    • Differences in prostaglandin metabolism in cultured aortic and pulmonary arterial endothelial cells exposed to acute and chronic hypoxia
    • Farber, H. W., and Barnett, H. F. 1991. Differences in prostaglandin metabolism in cultured aortic and pulmonary arterial endothelial cells exposed to acute and chronic hypoxia. Circ. Res. 68(5):1446-1457.
    • (1991) Circ. Res , vol.68 , Issue.5 , pp. 1446-1457
    • Farber, H.W.1    Barnett, H.F.2
  • 20
    • 0034959944 scopus 로고    scopus 로고
    • Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks
    • Fiehn, O. 2001. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Compar. Funct. Genom. 2:155-168.
    • (2001) Compar. Funct. Genom , vol.2 , pp. 155-168
    • Fiehn, O.1
  • 22
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles, A., Milosevic, M., Hedley, D., Pintilie, M., Levin, W., Manchul, L., and Hill, R. P. 2002. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J. Clin. Oncol. 20(3):680-687.
    • (2002) J. Clin. Oncol , vol.20 , Issue.3 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 24
    • 34548146614 scopus 로고    scopus 로고
    • Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine
    • Gika, H. G., Theodoridis, G. A., Wingate, J. E., and Wilson, I. D. 2007. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine. J. Proteome Res. 6(8):3291-3303.
    • (2007) J. Proteome Res , vol.6 , Issue.8 , pp. 3291-3303
    • Gika, H.G.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4
  • 25
    • 0032374058 scopus 로고    scopus 로고
    • Endothelial cell hypoxic stress proteins
    • Graven, K. K., and Farber, H. W. 1998. Endothelial cell hypoxic stress proteins. J. Lab. Clin. Med. 132(6):456-463.
    • (1998) J. Lab. Clin. Med , vol.132 , Issue.6 , pp. 456-463
    • Graven, K.K.1    Farber, H.W.2
  • 26
    • 0031912776 scopus 로고    scopus 로고
    • Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase
    • Graven, K. K., McDonald, R. J., and Farber, H. W. 1998. Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase. Am. J. Physiol. 274(2 Pt 1):C347-355.
    • (1998) Am. J. Physiol , vol.274 , Issue.2 PART 1
    • Graven, K.K.1    McDonald, R.J.2    Farber, H.W.3
  • 27
    • 2942709840 scopus 로고    scopus 로고
    • Metabolic profiles to define the genome: Can we hear the phenotypes?
    • Griffin, J. L. 2004. Metabolic profiles to define the genome: can we hear the phenotypes?. Philos. Trans. R. Soc. Lond. B Biol. Sci. 359(1446):857-871.
    • (2004) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.359 , Issue.1446 , pp. 857-871
    • Griffin, J.L.1
  • 29
  • 30
    • 0032875697 scopus 로고    scopus 로고
    • Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
    • Gygi, S. P., Rist, B., Gerber, S. A., Turecek, F., Gelb, M. H., and Aebersold, R. 1999. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat. Biotechnol. 17(10):994-999.
    • (1999) Nat. Biotechnol , vol.17 , Issue.10 , pp. 994-999
    • Gygi, S.P.1    Rist, B.2    Gerber, S.A.3    Turecek, F.4    Gelb, M.H.5    Aebersold, R.6
  • 31
    • 12344252950 scopus 로고    scopus 로고
    • Medicinal chemistry, metabolic profiling and drug target discovery: A role for metabolic profiling in reverse pharmacology and chemical genetics
    • Harrigan, G. G., Brackett, D. J., and Boros, L. G. 2005. Medicinal chemistry, metabolic profiling and drug target discovery: a role for metabolic profiling in reverse pharmacology and chemical genetics. Mini Rev. Med. Chem. 5(1):13-20.
    • (2005) Mini Rev. Med. Chem , vol.5 , Issue.1 , pp. 13-20
    • Harrigan, G.G.1    Brackett, D.J.2    Boros, L.G.3
  • 32
    • 0034011393 scopus 로고    scopus 로고
    • Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats
    • Harvey, P. J., Gready, J. E., Yin, Z., and McLean, A. J. 2000. Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats. J. Pharmacol. Exp. Ther. 293(2):641-645.
    • (2000) J. Pharmacol. Exp. Ther , vol.293 , Issue.2 , pp. 641-645
    • Harvey, P.J.1    Gready, J.E.2    Yin, Z.3    McLean, A.J.4
  • 34
    • 0016670964 scopus 로고
    • Metabolic consequences of diving in animals and man
    • Hochachka, P. W., and Storey, K. B. 1975. Metabolic consequences of diving in animals and man. Science. 187(4177):613-621.
    • (1975) Science , vol.187 , Issue.4177 , pp. 613-621
    • Hochachka, P.W.1    Storey, K.B.2
  • 35
    • 0036917875 scopus 로고    scopus 로고
    • Chemometric contributions to the evolution of metabonomics: Mathematical solutions to characterising and interpreting complex biological NMR spectra
    • Holmes, E., and Antti, H. 2002. Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra. Analyst 127(12):1549-1557.
    • (2002) Analyst , vol.127 , Issue.12 , pp. 1549-1557
    • Holmes, E.1    Antti, H.2
  • 36
    • 0141705757 scopus 로고    scopus 로고
    • Hoshikawa, Y., Nana-Sinkam, P., Moore, M. D., Sotto-Santiago, S., Phang, T., Keith, R. L., Morris, K. G., Kondo, T., Tuder, R. M., Voelkel, N. F., and Geraci, M. W. 2003. Hypoxia induces different genes in the lungs of rats compared with mice [erratum appears in Physiol. Genomics 2003;13(1):79]. Physiol. Genomics 12(3):209-219.
    • Hoshikawa, Y., Nana-Sinkam, P., Moore, M. D., Sotto-Santiago, S., Phang, T., Keith, R. L., Morris, K. G., Kondo, T., Tuder, R. M., Voelkel, N. F., and Geraci, M. W. 2003. Hypoxia induces different genes in the lungs of rats compared with mice [erratum appears in Physiol. Genomics 2003;13(1):79]. Physiol. Genomics 12(3):209-219.
  • 38
    • 0034843821 scopus 로고    scopus 로고
    • In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies
    • Hung, T. H., Skepper, J. N., and Burton, G. J. 2001. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am. J. Pathol. 159(3):1031-1043.
    • (2001) Am. J. Pathol , vol.159 , Issue.3 , pp. 1031-1043
    • Hung, T.H.1    Skepper, J.N.2    Burton, G.J.3
  • 39
    • 17444408483 scopus 로고    scopus 로고
    • Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers
    • Irwin, D. C., Tissot van Patot, M. C., Tucker, A., and Bowen, R. 2005. Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers. Am. J. Physiol. Lung Cell. Mol. Physiol. 288(5):L849-859.
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.288 , Issue.5
    • Irwin, D.C.1    Tissot van Patot, M.C.2    Tucker, A.3    Bowen, R.4
  • 41
    • 34248642266 scopus 로고    scopus 로고
    • Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance
    • Kasiganesan, H., Sridharan, V., and Wright, G. 2007. Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance. Acta Physiol. (Oxf). 190(2):163-169.
    • (2007) Acta Physiol. (Oxf) , vol.190 , Issue.2 , pp. 163-169
    • Kasiganesan, H.1    Sridharan, V.2    Wright, G.3
  • 43
    • 1842528125 scopus 로고    scopus 로고
    • Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards
    • Kuhn, E., Wu, J., Karl, J., Liao, H., Zolg, W., and Guild, B. 2004. Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. Proteomics 4(4):1175-1186.
    • (2004) Proteomics , vol.4 , Issue.4 , pp. 1175-1186
    • Kuhn, E.1    Wu, J.2    Karl, J.3    Liao, H.4    Zolg, W.5    Guild, B.6
  • 45
    • 1342283027 scopus 로고    scopus 로고
    • Analysis of expression and posttranslational modification of proteins during hypoxia
    • discussion 1170-1172
    • Kumar, G. K., and Klein, J. B. 2004. Analysis of expression and posttranslational modification of proteins during hypoxia. J. Appl. Physiol. 96(3):1178-1186.discussion 1170-1172
    • (2004) J. Appl. Physiol , vol.96 , Issue.3 , pp. 1178-1186
    • Kumar, G.K.1    Klein, J.B.2
  • 46
    • 33746704370 scopus 로고    scopus 로고
    • Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles
    • Leach, R. M., Sheehan, D. W., Chacko, V. P., and Sylvester, J. T. 1998. Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles. Am. J. Physiol. 275(6 Pt 1):L1051-1060.
    • (1998) Am. J. Physiol , vol.275 , Issue.6 PART 1
    • Leach, R.M.1    Sheehan, D.W.2    Chacko, V.P.3    Sylvester, J.T.4
  • 47
    • 33846415800 scopus 로고    scopus 로고
    • Hypoxia, drug therapy and toxicity
    • Lee, K., Roth, R. A., and LaPres, J. J. 2007. Hypoxia, drug therapy and toxicity. Pharmacol. Ther. 113(2):229-246.
    • (2007) Pharmacol. Ther , vol.113 , Issue.2 , pp. 229-246
    • Lee, K.1    Roth, R.A.2    LaPres, J.J.3
  • 51
    • 34247860855 scopus 로고    scopus 로고
    • Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    • Mikuriya, K., Kuramitsu, Y., Ryozawa, S., Fujimoto, M., Mori, S., Oka, M., Hamano, K., Okita, K., Sakaida, I., and Nakamura, K. 2007. Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int. J. Oncol. 30(4):849-855.
    • (2007) Int. J. Oncol , vol.30 , Issue.4 , pp. 849-855
    • Mikuriya, K.1    Kuramitsu, Y.2    Ryozawa, S.3    Fujimoto, M.4    Mori, S.5    Oka, M.6    Hamano, K.7    Okita, K.8    Sakaida, I.9    Nakamura, K.10
  • 52
    • 33846522259 scopus 로고    scopus 로고
    • Stroke biomarkers: Can they help us to guide stroke thrombolysis?
    • Montaner, J. 2006. Stroke biomarkers: can they help us to guide stroke thrombolysis?. Drug News Perspect. 19(9):523-532.
    • (2006) Drug News Perspect , vol.19 , Issue.9 , pp. 523-532
    • Montaner, J.1
  • 53
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J. K., Lindon, J. C., and Holmes, E. 1999. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11):1181-1189.
    • (1999) Xenobiotica , vol.29 , Issue.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 54
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding 'global' systems biology: metabonomics and the continuum of metabolism
    • Nicholson, J. K., and Wilson, I. D. 2003. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. Drug Discovery 2(8):668-676.
    • (2003) Nat. Rev. Drug Discov. Drug Discovery , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 56
    • 28344439258 scopus 로고    scopus 로고
    • Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers
    • Niemann, C. U., Hirose, R., Liu, T., Behrends, M., Brown, J. L., Kominsky, D. F., Roberts, J. P., and Serkova, N. 2005. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Anesth. Analg. 101(6):1577-1583.
    • (2005) Anesth. Analg , vol.101 , Issue.6 , pp. 1577-1583
    • Niemann, C.U.1    Hirose, R.2    Liu, T.3    Behrends, M.4    Brown, J.L.5    Kominsky, D.F.6    Roberts, J.P.7    Serkova, N.8
  • 57
    • 0036721405 scopus 로고    scopus 로고
    • Close association between the reduction in myocardial energy metabolism and infarct size: Dose-response assessment of cyclosporine
    • Niemann, C. U., Saeed, M., Akbari, H., Jacobsen, W., Benet, L. Z., Christians, U., and Serkova, N. 2002. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J. Pharmacol. Exp. Ther. 302(3):1123-1128.
    • (2002) J. Pharmacol. Exp. Ther , vol.302 , Issue.3 , pp. 1123-1128
    • Niemann, C.U.1    Saeed, M.2    Akbari, H.3    Jacobsen, W.4    Benet, L.Z.5    Christians, U.6    Serkova, N.7
  • 58
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
    • Nordsmark, M., Alsner, J., Keller, J., Nielsen, O. S., Jensen, O. M., Horsman, M. R., and Overgaard, J. 2001. Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br. J. Cancer 84(8):1070-1075.
    • (2001) Br. J. Cancer , vol.84 , Issue.8 , pp. 1070-1075
    • Nordsmark, M.1    Alsner, J.2    Keller, J.3    Nielsen, O.S.4    Jensen, O.M.5    Horsman, M.R.6    Overgaard, J.7
  • 59
    • 26844432832 scopus 로고    scopus 로고
    • There is much more to the recipe than just outflow obstruction [comment]
    • Ommen, S. R. 2005. There is much more to the recipe than just outflow obstruction [comment]. J. Am. Coll. Cardiol. 46(8):1551-1552.
    • (2005) J. Am. Coll. Cardiol , vol.46 , Issue.8 , pp. 1551-1552
    • Ommen, S.R.1
  • 60
    • 24344487195 scopus 로고    scopus 로고
    • Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B
    • Pan, X., Tan, N., Zeng, G., Zhang, Y., and Jia, R. 2005. Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B. Bioorg. Med. Chem. 13(20):5819-5825.
    • (2005) Bioorg. Med. Chem , vol.13 , Issue.20 , pp. 5819-5825
    • Pan, X.1    Tan, N.2    Zeng, G.3    Zhang, Y.4    Jia, R.5
  • 61
    • 33749238497 scopus 로고    scopus 로고
    • Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria
    • Parekh, S. B., Bubb, W. A., Hunt, N. H., and Rae, C. 2006. Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria. Int. J. Parasitol. 36(13):1409-1418.
    • (2006) Int. J. Parasitol , vol.36 , Issue.13 , pp. 1409-1418
    • Parekh, S.B.1    Bubb, W.A.2    Hunt, N.H.3    Rae, C.4
  • 63
    • 12244269071 scopus 로고    scopus 로고
    • High-resolution NMR for metabomics
    • Pelczer, I. 2005. High-resolution NMR for metabomics. Curr. Opin. Drug Discov. Devel. 8:127-133.
    • (2005) Curr. Opin. Drug Discov. Devel , vol.8 , pp. 127-133
    • Pelczer, I.1
  • 65
    • 34147200716 scopus 로고    scopus 로고
    • Protein expression patterns associated with progression of chronic obstructive pulmonary disease in bronchoalveolar lavage of smokers
    • Plymoth, A., Lofdahl, C. -G., Ekberg-Jansson, A., Dahlback, M., Broberg, P., Foster, M., Fehniger, T. E., and Marko-Varga, G. 2007. Protein expression patterns associated with progression of chronic obstructive pulmonary disease in bronchoalveolar lavage of smokers. Clin. Chem. 53(4):636-644.
    • (2007) Clin. Chem , vol.53 , Issue.4 , pp. 636-644
    • Plymoth, A.1    Lofdahl, C.-G.2    Ekberg-Jansson, A.3    Dahlback, M.4    Broberg, P.5    Foster, M.6    Fehniger, T.E.7    Marko-Varga, G.8
  • 66
    • 33947406839 scopus 로고    scopus 로고
    • Hypoxia tolerance in mammals and birds: From the wilderness to the clinic
    • Ramirez, J. -M., Folkow, L. P., and Blix, A. S. 2007. Hypoxia tolerance in mammals and birds: from the wilderness to the clinic. Annu. Rev. Physiol. 69:113-143.
    • (2007) Annu. Rev. Physiol , vol.69 , pp. 113-143
    • Ramirez, J.-M.1    Folkow, L.P.2    Blix, A.S.3
  • 67
    • 0032898594 scopus 로고    scopus 로고
    • In vivo magnetic resonance methods in pharmaceutical research: Current status and perspectives
    • Rudin, M., Beckmann, N., Porszasz, R., Reese, T., Bochelen, D., and Sauter, A. 1999. In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives. NMR Biomed. 12(2):69-97.
    • (1999) NMR Biomed , vol.12 , Issue.2 , pp. 69-97
    • Rudin, M.1    Beckmann, N.2    Porszasz, R.3    Reese, T.4    Bochelen, D.5    Sauter, A.6
  • 69
    • 0037659699 scopus 로고    scopus 로고
    • Metabolite concentrations in human placentae and their changes due to the collection time after delivery
    • Serkova, N., Bendrick-Peart, J., Alexander, B., and Tissot van Patot, M. C. 2003. Metabolite concentrations in human placentae and their changes due to the collection time after delivery. Placenta 24:227-235.
    • (2003) Placenta , vol.24 , pp. 227-235
    • Serkova, N.1    Bendrick-Peart, J.2    Alexander, B.3    Tissot van Patot, M.C.4
  • 70
    • 0030575894 scopus 로고    scopus 로고
    • Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy
    • Serkova, N., Brand, A., Christians, U., and Leibfritz, D. 1996. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim. Biophys. Acta 1314(1-2):93-104.
    • (1996) Biochim. Biophys. Acta , vol.1314 , Issue.1-2 , pp. 93-104
    • Serkova, N.1    Brand, A.2    Christians, U.3    Leibfritz, D.4
  • 72
    • 20844461344 scopus 로고    scopus 로고
    • H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants
    • Serkova, N., Fuller, T. F., Klawitter, J., Freise, C. E., and Niemann, C. U. 2005. H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int. 67(3):1142-1151.
    • (2005) Kidney Int , vol.67 , Issue.3 , pp. 1142-1151
    • Serkova, N.1    Fuller, T.F.2    Klawitter, J.3    Freise, C.E.4    Niemann, C.U.5
  • 73
    • 85047685525 scopus 로고    scopus 로고
    • Biochemical mechanisms of nephrotoxicity: Application for metabolomics
    • Serkova, N., and Niemann, C. U. 2007. Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opin. Drug Metab. Toxicol. 3(4):1-18.
    • (2007) Expert Opin. Drug Metab. Toxicol , vol.3 , Issue.4 , pp. 1-18
    • Serkova, N.1    Niemann, C.U.2
  • 74
    • 34548822408 scopus 로고    scopus 로고
    • Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR
    • Serkova, N., Rose, J. C., Epperson, L. E., Carey, H. V., and Martin, S. L. 2007. Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR. Physiol. Genomics 31:15-24.
    • (2007) Physiol. Genomics , vol.31 , pp. 15-24
    • Serkova, N.1    Rose, J.C.2    Epperson, L.E.3    Carey, H.V.4    Martin, S.L.5
  • 76
    • 33749529146 scopus 로고    scopus 로고
    • Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics
    • Serkova, N. J., and Niemann, C. U. 2006. Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics. Expert Rev. Mol. Diagn. 6(5):717-731.
    • (2006) Expert Rev. Mol. Diagn , vol.6 , Issue.5 , pp. 717-731
    • Serkova, N.J.1    Niemann, C.U.2
  • 77
    • 33750619348 scopus 로고    scopus 로고
    • Glucose metabolism and cancer
    • Shaw, R. J. 2006. Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18:598-608.
    • (2006) Curr. Opin. Cell Biol , vol.18 , pp. 598-608
    • Shaw, R.J.1
  • 79
    • 84934436845 scopus 로고    scopus 로고
    • Gene hunting in hypoxia and exercise
    • Storey, K. B. 2006a. Gene hunting in hypoxia and exercise. Adv. Exp. Med. Biol. 588:293-309.
    • (2006) Adv. Exp. Med. Biol , vol.588 , pp. 293-309
    • Storey, K.B.1
  • 80
    • 33645817231 scopus 로고    scopus 로고
    • Genomic and proteomic approaches in comparative biochemistry and physiology
    • Storey, K. B. 2006b. Genomic and proteomic approaches in comparative biochemistry and physiology. Physiol. Biochem. Zool. 79(2):324-332.
    • (2006) Physiol. Biochem. Zool , vol.79 , Issue.2 , pp. 324-332
    • Storey, K.B.1
  • 81
    • 34248520614 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, lipoprotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemic lupus erythematosus
    • Tanaseanu, C., Tudor, S., Tamsulea, I., Marta, D., Manea, G., and Moldoveanu, E. 2007. Vascular endothelial growth factor, lipoprotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemic lupus erythematosus. Eur. J. Med. Res. 12(4):145-151.
    • (2007) Eur. J. Med. Res , vol.12 , Issue.4 , pp. 145-151
    • Tanaseanu, C.1    Tudor, S.2    Tamsulea, I.3    Marta, D.4    Manea, G.5    Moldoveanu, E.6
  • 82
    • 15444368510 scopus 로고    scopus 로고
    • Genomics, proteomics and integrative "omics" in hypertension research
    • Thongboonkerd, V. 2005. Genomics, proteomics and integrative "omics" in hypertension research. Curr. Opin. Nephrol. Hypertens. 14(2):133-139.
    • (2005) Curr. Opin. Nephrol. Hypertens , vol.14 , Issue.2 , pp. 133-139
    • Thongboonkerd, V.1
  • 84
    • 33847377098 scopus 로고    scopus 로고
    • From exogenous to endogenous: The inevitable imprint of mass spectrometry in metabolomics
    • Want, E. J., Nordstrom, A., Morita, H., and Siuzdak, G. 2007. From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J. Proteome Res. 6(2):459-468.
    • (2007) J. Proteome Res , vol.6 , Issue.2 , pp. 459-468
    • Want, E.J.1    Nordstrom, A.2    Morita, H.3    Siuzdak, G.4
  • 85
    • 32444451016 scopus 로고    scopus 로고
    • Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry
    • Want, E. J., O'Maille, G., Smith, C. A., Brandon, T. R., Uritboonthai, W., Qin, C., Trauger, S. A., and Siuzdak, G. 2006. Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Anal. Chem. 78(3):743-752.
    • (2006) Anal. Chem , vol.78 , Issue.3 , pp. 743-752
    • Want, E.J.1    O'Maille, G.2    Smith, C.A.3    Brandon, T.R.4    Uritboonthai, W.5    Qin, C.6    Trauger, S.A.7    Siuzdak, G.8
  • 86
    • 34147167728 scopus 로고    scopus 로고
    • Cardiovascular proteomics: Past, present, and future
    • White, M. Y., and Van Eyk, J. E. 2007. Cardiovascular proteomics: past, present, and future. Mol. Diagn. Ther. 11(2):83-95.
    • (2007) Mol. Diagn. Ther , vol.11 , Issue.2 , pp. 83-95
    • White, M.Y.1    Van Eyk, J.E.2
  • 87
    • 10444273269 scopus 로고    scopus 로고
    • D-Serine-induced nephrotoxicity: A HPLC-TOF/MS-based metabonomics approach
    • Williams, R. E., Major, H., Lock, E. A., Lenz, E. M., and Wilson, I. D. 2005. D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach. Toxicology 207(2):179-190.
    • (2005) Toxicology , vol.207 , Issue.2 , pp. 179-190
    • Williams, R.E.1    Major, H.2    Lock, E.A.3    Lenz, E.M.4    Wilson, I.D.5
  • 88
    • 33644828213 scopus 로고    scopus 로고
    • Metabolomics: The principles and potential applications to transplantation
    • Wishart, D. S. 2005. Metabolomics: the principles and potential applications to transplantation. Am. J. Transplant 5(12):2814-2820.
    • (2005) Am. J. Transplant , vol.5 , Issue.12 , pp. 2814-2820
    • Wishart, D.S.1
  • 89
    • 33846088138 scopus 로고    scopus 로고
    • Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., Fung, C., Nikolai, L., Lewis, M., Coutouly, M., Forsythe, I., Tang, P., Shrivastava, S., Jeroncic, K., Stothard, P., Amegbey, G., Block, D., Hau, D. D., Wagner, J., Miniaci, J., Clements, M., Gebremedhin, M., Guo, N., Zhang, Y., Duggan, G. E., Macinnis, G. D., Weljie, A. M., Dowlatabadi, R., Bamforth, F., Clive, D., Greiner, R., Li, L., Marrie, T., Sykes, B. D., Vogel, H. J., and Querengesser, L. 2007. HMDB: the Human Metabolome Database. Nucleic Acids Res. 35(Database issue):D521-526.
    • Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., Fung, C., Nikolai, L., Lewis, M., Coutouly, M., Forsythe, I., Tang, P., Shrivastava, S., Jeroncic, K., Stothard, P., Amegbey, G., Block, D., Hau, D. D., Wagner, J., Miniaci, J., Clements, M., Gebremedhin, M., Guo, N., Zhang, Y., Duggan, G. E., Macinnis, G. D., Weljie, A. M., Dowlatabadi, R., Bamforth, F., Clive, D., Greiner, R., Li, L., Marrie, T., Sykes, B. D., Vogel, H. J., and Querengesser, L. 2007. HMDB: the Human Metabolome Database. Nucleic Acids Res. 35(Database issue):D521-526.
  • 90
    • 17844391271 scopus 로고    scopus 로고
    • Mass spectrometry-based expression profiling of clinical prostate cancer
    • Wright, M. E., Han, D. K., and Aebersold, R. 2005. Mass spectrometry-based expression profiling of clinical prostate cancer. Mol. Cell Proteomics 4(4):545-554.
    • (2005) Mol. Cell Proteomics , vol.4 , Issue.4 , pp. 545-554
    • Wright, M.E.1    Han, D.K.2    Aebersold, R.3
  • 91
    • 33750111733 scopus 로고    scopus 로고
    • An integrated metabonomic approach to describe temporal metabolic dysregulation induced in the rat by the model hepatotoxin allyl formate
    • Yap, I. K., Clayton, T. A., Tang, H., Everett, J. R., Hanton, G., Provost, J., Charuel, C., Lindon, J. C., and Nicholson, J. K. 2006. An integrated metabonomic approach to describe temporal metabolic dysregulation induced in the rat by the model hepatotoxin allyl formate. J. Proteome Res. 5(10):2675-2684.
    • (2006) J. Proteome Res , vol.5 , Issue.10 , pp. 2675-2684
    • Yap, I.K.1    Clayton, T.A.2    Tang, H.3    Everett, J.R.4    Hanton, G.5    Provost, J.6    Charuel, C.7    Lindon, J.C.8    Nicholson, J.K.9
  • 92
    • 0025905225 scopus 로고
    • Hypoxia induces a specific set of stress proteins in cultured endothelial cells
    • Zimmerman, L. H., Levine, R. A., and Farber, H. W. 1991. Hypoxia induces a specific set of stress proteins in cultured endothelial cells. J. Clin. Invest. 87(3):908-914.
    • (1991) J. Clin. Invest , vol.87 , Issue.3 , pp. 908-914
    • Zimmerman, L.H.1    Levine, R.A.2    Farber, H.W.3


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