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Volumn 3, Issue 1, 2011, Pages 5-11

Hypoxia inducible factor and hypoxia-mediated pulmonary hypertension

Author keywords

HIF 1; Hypoxia; pulmonary hypertension; transcription factors

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR 2BETA; HYPOXIA INDUCIBLE FACTOR 3ALPHA; HYPOXIA INDUCIBLE FACTOR 3BETA; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 80054749164     PISSN: 09746013     EISSN: 09751602     Source Type: Journal    
DOI: 10.4103/0974-6013.85613     Document Type: Review
Times cited : (3)

References (75)
  • 2
    • 0034963691 scopus 로고    scopus 로고
    • Severe pulmonary hypertension: Critical care clinics
    • McLaughlin VV, Rich S. Severe pulmonary hypertension: Critical care clinics. Crit Care Clin 2001;17:453-67. (Pubitemid 32612724)
    • (2001) Critical Care Clinics , vol.17 , Issue.2 , pp. 453-467
    • McLaughlin, V.V.1    Rich, S.2
  • 3
    • 0034601744 scopus 로고    scopus 로고
    • Secondary pulmonary hypertension in chronic heart failure: The role of the endothelium in pathophysiology and management
    • Moraes DL, Colucci WS, Givertz MM. Secondary pulmonary hypertension in chronic heart failure: The role of the endothelium in pathophysiology and management. Circulation 2000;102: 1718-23.
    • (2000) Circulation , vol.102 , pp. 1718-23
    • Moraes, D.L.1    Colucci, W.S.2    Givertz, M.M.3
  • 4
    • 0032879181 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction
    • DOI 10.1016/S0306-3623(99)00026-9, PII S0306362399000269
    • Dumas JP, Bardou M, Goirand F, Dumas M. Hypoxic pulmonary vasoconstriction. Gen Pharmacol 1999;33:289-97. (Pubitemid 29465734)
    • (1999) General Pharmacology , vol.33 , Issue.4 , pp. 289-297
    • Dumas, J.P.1    Bardou, M.2    Goirand, F.3    Dumas, M.4
  • 5
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder RM, Groves B, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of infammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 1994;144:275-85. (Pubitemid 24165948)
    • (1994) American Journal of Pathology , vol.144 , Issue.2 , pp. 275-285
    • Tuder, R.M.1    Groves, B.2    Badesch, D.B.3    Voelkel, N.F.4
  • 6
    • 0033912022 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension
    • DOI 10.1046/j.1440-1827.2000.01068.x
    • Hirose S, Hosoda Y, Furuya S, Otsuki T, Ikeda E. Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension. Pathol Int 2000;50:472-9. (Pubitemid 30482392)
    • (2000) Pathology International , vol.50 , Issue.6 , pp. 472-479
    • Hirose, S.1    Hosoda, Y.2    Furuya, S.3    Otsuki, T.4    Ikeda, E.5
  • 7
    • 21744460365 scopus 로고    scopus 로고
    • Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells
    • DOI 10.1096/fj.04-3261fje
    • Sakao S, Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF. Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. FASEB J 2005;19:1178-80. (Pubitemid 40946457)
    • (2005) FASEB Journal , vol.19 , Issue.9 , pp. 1178-1180
    • Sakao, S.1    Taraseviciene-Stewart, L.2    Lee, J.D.3    Wood, K.4    Cool, C.D.5    Voelkel, N.F.6
  • 8
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 1988;242:1412-5.
    • (1988) Science , vol.242 , pp. 1412-5
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 10
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-54
    • Semenza, G.L.1    Wang, G.L.2
  • 11
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular o2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular o2 tension. Proc Natl Acad Sci USA 1995;92:5510-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-4
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 12
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995;270:1230-7.
    • (1995) J Biol Chem , vol.270 , pp. 1230-7
    • Wang, G.L.1    Semenza, G.L.2
  • 13
    • 0036320934 scopus 로고    scopus 로고
    • 2- regulated gene expression
    • DOI 10.1096/fj.01-0944rev
    • Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 2002;16:1151-62. (Pubitemid 34815403)
    • (2002) FASEB Journal , vol.16 , Issue.10 , pp. 1151-1162
    • Wenger, R.H.1
  • 14
    • 67651204677 scopus 로고    scopus 로고
    • Oxygen sensing and the activation of the hypoxia inducible factor 1 (HIF-1)-invited article
    • Fandrey J, Gassmann M. Oxygen sensing and the activation of the hypoxia inducible factor 1 (HIF-1)-invited article. Adv Exp Med Biol 2009;648:197-206.
    • (2009) Adv Exp Med Biol , vol.648 , pp. 197-206
    • Fandrey, J.1    Gassmann, M.2
  • 15
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-1
    • Wenger RH, Gassmann M. Oxygen(ES) and the hypoxia-inducible factor-1. Biol Chem 1997;378:609-16. (Pubitemid 27361853)
    • (1997) Biological Chemistry , vol.378 , Issue.7 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 18
    • 0030588298 scopus 로고    scopus 로고
    • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
    • DOI 10.1006/abbi.1996.0469
    • Salceda S, Beck I, Caro J. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 1996;334:389-94. (Pubitemid 26347323)
    • (1996) Archives of Biochemistry and Biophysics , vol.334 , Issue.2 , pp. 389-394
    • Salceda, S.1    Beck, I.2    Caro, J.3
  • 19
    • 0029888061 scopus 로고    scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in arnt-defcient cells
    • Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratclife PJ. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in arnt-defcient cells. J Biol Chem 1996;271:15117-23.
    • (1996) J Biol Chem , vol.271 , pp. 15117-23
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratclife, P.J.5
  • 20
    • 0032891708 scopus 로고    scopus 로고
    • Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α
    • Chilov D, Camenisch G, Kvietikova I, Ziegler U, Gassmann M, Wenger RH. Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of hif-1alpha. J Cell Sci 1999;112:1203-12. (Pubitemid 29218909)
    • (1999) Journal of Cell Science , vol.112 , Issue.8 , pp. 1203-1212
    • Chilov, D.1    Camenisch, G.2    Kvietikova, I.3    Ziegler, U.4    Gassmann, M.5    Wenger, R.H.6
  • 21
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
    • Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, et al. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/P300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 1998;17:6573-86. (Pubitemid 28521792)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6573-6586
    • Kallio, P.J.1    Okamoto, K.2    O'Brien, S.3    Carrero, P.4    Makino, Y.5    Tanaka, H.6    Poellinger, L.7
  • 22
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
    • DOI 10.1074/jbc.271.50.32253
    • Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996;271:32253-9. (Pubitemid 26422262)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.50 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Franklin Bunn, H.4
  • 24
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an o2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an o2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998;95:7987-92.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7987-92
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 25
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1; Definition of regulatory domains within the α subunit
    • DOI 10.1074/jbc.272.17.11205
    • Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1: Defnition of regulatory domains within the alpha subunit. J Biol Chem 1997;272:11205-14. (Pubitemid 27184117)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.17 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 28
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • DOI 10.1126/science.1066373
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-40. (Pubitemid 33063099)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 30
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function
    • DOI 10.1126/science.284.5413.455
    • Stebbins CE, Kaelin WG Jr, Pavletich N P. Structure of the vhl-elonginc-elonginb complex: Implications for VHL tumor suppressor function. Science 1999;284:455-61. (Pubitemid 29289612)
    • (1999) Science , vol.284 , Issue.5413 , pp. 455-461
    • Stebbins, C.E.1    Kaelin Jr., W.G.2    Pavletich, N.P.3
  • 32
    • 0033776182 scopus 로고    scopus 로고
    • Vhl takes HIF's breath away
    • Krek W. Vhl takes HIF's breath away. Nat Cell Biol 2000;2: E121-3.
    • (2000) Nat Cell Biol , vol.2
    • Krek, W.1
  • 33
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1ALPHA ubiquitination by a reconstituted von hippel-lindau (VHL) tumor suppressor complex
    • Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW. Activation of HIF1ALPHA ubiquitination by a reconstituted von hippel-lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 2000;97:10430-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10430-5
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzyk-Krzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 34
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL. Hypoxia-key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47. (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 35
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32. (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 37
    • 33744954065 scopus 로고    scopus 로고
    • Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: The role of HIF-1α, HIF-2α, and other pathways
    • DOI 10.1074/jbc.M511408200
    • Elvidge G P, Glenny L, Appelhof RJ, Ratclife PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate- dependent dioxygenase inhibition: The role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem 2006;281:15215-26. (Pubitemid 43855111)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.22 , pp. 15215-15226
    • Elvidge, G.P.1    Glenny, L.2    Appelhoff, R.J.3    Ratcliffe, P.J.4    Ragoussis, J.5    Gleadle, J.M.6
  • 38
  • 39
    • 77952300971 scopus 로고    scopus 로고
    • Genome-wide identifcation of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profling data and in silico binding site prediction
    • Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L. Genome-wide identifcation of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profling data and in silico binding site prediction. Nucleic Acids Res 2010;38:2332-45.
    • (2010) Nucleic Acids Res , vol.38 , pp. 2332-45
    • Ortiz-Barahona, A.1    Villar, D.2    Pescador, N.3    Amigo, J.4    Del Peso, L.5
  • 40
    • 0031000736 scopus 로고    scopus 로고
    • A novel BHLH-pas factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel BHLH-pas factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-8
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 41
  • 42
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 1998;12:3320-4. (Pubitemid 28520979)
    • (1998) Genes and Development , vol.12 , Issue.21 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 44
    • 0034681378 scopus 로고    scopus 로고
    • A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1α and the HIF-like factor
    • DOI 10.1074/jbc.275.7.4618
    • Lando D, Pongratz I, Poellinger L, Whitelaw ML. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor. J Biol Chem 2000;275:4618-27. (Pubitemid 30108846)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.7 , pp. 4618-4627
    • Lando, D.1    Pongratz, I.2    Poellinger, L.3    Whitelaw, M.L.4
  • 46
    • 0037031808 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus
    • DOI 10.1074/jbc.C200328200
    • Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L. Inhibitory pas domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem 2002;277:32405-8. (Pubitemid 34984738)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32405-32408
    • Makino, Y.1    Kanopka, A.2    Wilson, W.J.3    Tanaka, H.4    Poellinger, L.5
  • 48
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • DOI 10.1172/JCI200315496
    • Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, et al. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 2003;111:1519-27. (Pubitemid 38063284)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.10 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3    Wiesener, M.S.4    Maxwell, P.H.5    Collen, D.6    Carmeliet, P.7
  • 49
    • 77954926596 scopus 로고    scopus 로고
    • Natural selection on epas1 (HIF2ALPHA) associated with low hemoglobin concentration in Tibetan highlanders
    • Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, et al. Natural selection on epas1 (HIF2ALPHA) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA 2010;107:11459-64.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11459-64
    • Beall, C.M.1    Cavalleri, G.L.2    Deng, L.3    Elston, R.C.4    Gao, Y.5    Knight, J.6
  • 52
    • 77949725833 scopus 로고    scopus 로고
    • The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
    • Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, et al. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest 2010;120:827-39.
    • (2010) J Clin Invest , vol.120 , pp. 827-39
    • Hickey, M.M.1    Richardson, T.2    Wang, T.3    Mosqueira, M.4    Arguiri, E.5    Yu, H.6
  • 54
    • 77749291806 scopus 로고    scopus 로고
    • Hypoxia inducible-factor1alpha regulates the metabolic shif of pulmonary hypertensive endothelial cells
    • Fialkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, et al. Hypoxia inducible-factor1alpha regulates the metabolic shif of pulmonary hypertensive endothelial cells. Am J Pathol 2010;176:1130-8.
    • (2010) Am J Pathol , vol.176 , pp. 1130-8
    • Fialkowska, I.1    Xu, W.2    Comhair, S.A.3    Janocha, A.J.4    Mavrakis, L.A.5    Krishnamachary, B.6
  • 55
    • 40849102385 scopus 로고    scopus 로고
    • Dhea decreases hif-1alpha accumulation under hypoxia in human pulmonary artery cells: Potential role in the treatment of pulmonary arterial hypertension
    • Dessouroux A, Akwa Y, Baulieu EE. Dhea decreases hif-1alpha accumulation under hypoxia in human pulmonary artery cells: Potential role in the treatment of pulmonary arterial hypertension. J Steroid Biochem Mol Biol 2008;109:81-9.
    • (2008) J Steroid Biochem Mol Biol , vol.109 , pp. 81-9
    • Dessouroux, A.1    Akwa, Y.2    Baulieu, E.E.3
  • 56
    • 0020647610 scopus 로고
    • Contribution of polycythaemia to pulmonary hypertension in simulated high altitude in rats
    • Barer GR, Bee D, Wach RA. Contribution of polycythaemia to pulmonary hypertension in simulated high altitude in rats. J Physiol 1983;336:27-38. (Pubitemid 13153397)
    • (1983) Journal of Physiology , vol.336 , pp. 27-38
    • Barer, G.R.1    Bee, D.2    Wach, R.A.3
  • 57
    • 0027274063 scopus 로고
    • Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells
    • Carlini RG, Dusso AS, Obialo CI, Alvarez UM, Rothstein M. Recombinant human erythropoietin (RHUEPO) increases endothelin-1 release by endothelial cells. Kidney Int 1993;43: 1010-4. (Pubitemid 23137084)
    • (1993) Kidney International , vol.43 , Issue.5 , pp. 1010-1014
    • Carlini, R.G.1    Dusso, A.S.2    Obialo, C.I.3    Alvarez, U.M.4    Rothstein, M.5
  • 58
    • 0030614967 scopus 로고    scopus 로고
    • Effects of eryrthropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
    • DOI 10.1016/S0895-7061(96)00410-4, PII S0895706196004104
    • Vogel V, Kramer HJ, Backer A, Meyer-Lehnert H, Jelkmann W, Fandrey J. Efects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells. Am J Hypertens 1997;10:289-96. (Pubitemid 27128272)
    • (1997) American Journal of Hypertension , vol.10 , Issue.3 , pp. 289-296
    • Vogel, V.1    Kramer, H.J.2    Backer, A.3    Meyer-Lehnert, H.4    Jelkmann, W.5    Fandrey, J.6
  • 60
    • 34249007471 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling
    • DOI 10.1160/TH06-12-0744
    • Hanze J, Weissmann N, Grimminger F, Seeger W, Rose F. Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling. Thromb Haemost 2007;97:774-87. (Pubitemid 46779962)
    • (2007) Thrombosis and Haemostasis , vol.97 , Issue.5 , pp. 774-787
    • Hanze, J.1    Weissmann, N.2    Grimminger, F.3    Seeger, W.4    Rose, F.5
  • 61
    • 0032971293 scopus 로고    scopus 로고
    • Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells relationship with the mitogenic action of serotonin
    • Eddahibi S, Fabre V, Boni C, Martres MP, Rafestin B, Hamon M, et al. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 1999;84:329-36. (Pubitemid 29095574)
    • (1999) Circulation Research , vol.84 , Issue.3 , pp. 329-336
    • Eddahibi, S.1    Fabre, V.2    Boni, C.3    Martres, M.P.4    Raffestin, B.5    Hamon, M.6    Adnot, S.7
  • 63
    • 0344012597 scopus 로고    scopus 로고
    • Identifcation of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter
    • DOI 10.1074/jbc.M305420200
    • Coulet F, Nadaud S, Agrapart M, Soubrier F. Identifcation of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter. J Biol Chem 2003;278:46230-40. (Pubitemid 37452193)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.47 , pp. 46230-46240
    • Coulet, F.1    Nadaud, S.2    Agrapart, M.3    Soubrier, F.4
  • 64
    • 0031888729 scopus 로고    scopus 로고
    • Hypoxia induces type II nos gene expression in pulmonary artery endothelial cells via HIF-1
    • Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II nos gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 1998;274: L212-9.
    • (1998) Am J Physiol , vol.274
    • Palmer, L.A.1    Semenza, G.L.2    Stoler, M.H.3    Johns, R.A.4
  • 67
    • 12944265473 scopus 로고    scopus 로고
    • Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin
    • Ruschitzka FT, Wenger RH, Stallmach T, Quaschning T, de Wit C, Wagner K, et al. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci USA 2000;97:11609-13.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11609-13
    • Ruschitzka, F.T.1    Wenger, R.H.2    Stallmach, T.3    Quaschning, T.4    De Wit, C.5    Wagner, K.6
  • 69
    • 70349774464 scopus 로고    scopus 로고
    • Role of HIF-1alpha in the regulation ace and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells
    • Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S, et al. Role of HIF-1alpha in the regulation ace and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol 2009;297: L631-40.
    • (2009) Am J Physiol , vol.297
    • Zhang, R.1    Wu, Y.2    Zhao, M.3    Liu, C.4    Zhou, L.5    Shen, S.6
  • 70
    • 0034815688 scopus 로고    scopus 로고
    • Partial HIF-1alpha defciency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
    • Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT. Partial HIF-1alpha defciency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol 2001;281: L202-8.
    • (2001) Am J Physiol , vol.281
    • Shimoda, L.A.1    Manalo, D.J.2    Sham, J.S.3    Semenza, G.L.4    Sylvester, J.T.5
  • 71
    • 33745155785 scopus 로고    scopus 로고
    • An Abnormal mitochondrial-hypoxia inducible factor-1α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • DOI 10.1161/CIRCULATIONAHA.105.609008, PII 0000301720060606000012
    • Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Bonnet S, et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension. Circulation 2006;113:2630-41. (Pubitemid 43948012)
    • (2006) Circulation , vol.113 , Issue.22 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Andrade-Navarro, M.A.4    Thebaud, B.5    Bonnet, S.6    Haromy, A.7    Harry, G.8    Moudgil, R.9    McMurtry, M.S.10    Weir, E.K.11    Archer, S.L.12
  • 73
    • 33746543743 scopus 로고    scopus 로고
    • 2+ in pulmonary arterial smooth muscle cells
    • DOI 10.1161/01.RES.0000227551.68124.98, PII 0000301220060623000014
    • Wang J, Weigand L, Lu W, Sylvester JT, Semenza GL, Shimoda LA. Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular CA2+ in pulmonary arterial smooth muscle cells. Circ Res 2006;98:1528-37. (Pubitemid 44297076)
    • (2006) Circulation Research , vol.98 , Issue.12 , pp. 1528-1537
    • Wang, J.1    Weigand, L.2    Lu, W.3    Sylvester, J.T.4    Semenza, G.L.5    Shimoda, L.A.6
  • 74
    • 47649097740 scopus 로고    scopus 로고
    • Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element
    • Kaluz S, Kaluzova M, Stanbridge EJ. Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element. Clin Chim Acta 2008;395:6-13.
    • (2008) Clin Chim Acta , vol.395 , pp. 6-13
    • Kaluz, S.1    Kaluzova, M.2    Stanbridge, E.J.3
  • 75
    • 34547153223 scopus 로고    scopus 로고
    • Gene regulation under low oxygen: Holding your breath for transcription
    • DOI 10.1016/j.tibs.2007.06.005, PII S096800040700148X
    • Rocha S. Gene regulation under low oxygen: Holding your breath for transcription. Trends Biochem Sci 2007;32:389-97. (Pubitemid 47126857)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.8 , pp. 389-397
    • Rocha, S.1


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