Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 17, 2003, Pages 9727-9732

  Camps, Manel ^a   Naukkarinen, Jussi ^a   Johnson, Ben P ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; DNA DIRECTED DNA POLYMERASE BETA;

AMINO ACID SUBSTITUTION; ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; DNA REPLICATION; ESCHERICHIA COLI; GENE TARGETING; GENE THERAPY; HYDROLYSIS; IN VIVO STUDY; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANTI-BACTERIAL AGENTS; AZTREONAM; BASE SEQUENCE; BETA-LACTAMASES; DIRECTED MOLECULAR EVOLUTION; DNA POLYMERASE I; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENES, BACTERIAL; GENES, REPORTER; GENETIC ENGINEERING; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PLASMIDS; PROTEIN ENGINEERING;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0043194096     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1333928100     Document Type: Article

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