Potential role of phenotypic mutations in the evolution of protein expression and stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 15, 2009, Pages 6197-6202

  Goldsmith, Moshe ^a   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Mutational robustness; Protein evolution; Protein stability; Transcriptional errors

Indexed keywords

BETA LACTAMASE TEM 1; ENZYME VARIANT; MESSENGER RNA; PROTEIN; RNA POLYMERASE; AMPICILLIN; BETA LACTAMASE; BETA-LACTAMASE TEM-1; COMPLEMENTARY DNA;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM; ERROR; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; INHERITANCE; MOLECULAR EVOLUTION; MUTANT; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RNA ANALYSIS; SYNTHESIS; WILD TYPE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; NUCLEIC ACID DATABASE;

BACTERIA (MICROORGANISMS);

AMPICILLIN; BETA-LACTAMASES; DATABASES, NUCLEIC ACID; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; MUTATION; PHENOTYPE; SELECTION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 65549084298     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809506106     Document Type: Article

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