Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) β-lactamase from Escherichia coli

Journal of Biological Chemistry

Volumn 274, Issue 33, 1999, Pages 23052-23060

  Vakulenko, Sergei B ^a,b   Taibi Tronche, Pascale ^b   Tóth, Márta ^a   Massova, Irina ^b   Lerner, Stephen A ^a   Mobashery, Shahriar ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM; CEFALORIDINE; CEFALOTIN; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN C; CEPHALOSPORIN DERIVATIVE; PENICILLIN G; PIPERACILLIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; DEACYLATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; TURNOVER TIME;

AMINO ACID SUBSTITUTION; ARGININE; BETA-LACTAMASES; BINDING SITES; CATALYSIS; CEFTAZIDIME; ESCHERICHIA COLI; HYDROLYSIS; KINETICS; MUTAGENESIS, SITE-DIRECTED; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0033551827     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.33.23052     Document Type: Article

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