The effect of high-frequency random mutagenesis on in vitro protein evolution: A study on TEM-1 β-lactamase

Journal of Molecular Biology

Volumn 285, Issue 2, 1999, Pages 775-783

  Zaccolo, Manuela ^a   Gherardi, Ermanno ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Base analogues; Directed protein evolution; Hypermutagenesis; Protein engineering; TEM 1 lactamase

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE; CEFOTAXIME; NUCLEOSIDE ANALOG; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DNA SYNTHESIS; EVOLUTION; GENETIC ENGINEERING; GENETIC SELECTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); FELIS CATUS;

EID: 0033555718     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2262     Document Type: Article

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