Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract

Journal of Immunology

Volumn 166, Issue 12, 2001, Pages 7410-7418

  Schroeder, T H ^a   Reiniger, N ^a   Meluleni, G ^a   Grout, M ^a   Coleman, F T ^a   Pier, G B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CELL RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; LUNG CLEARANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; RHESUS MONKEY; TRANSGENIC MOUSE;

EID: 0035877054     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.12.7410     Document Type: Article

References (33)

1. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
2. How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis
3. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections
4. Invasion of human epithelial cells by Pseudomonas aeruginosa involves src-like tyrosine kinases p60Src and p59Fyn
5. Advances in immunology: Innate immunity
6. Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread
7. Role of cystic fibrosis transmembrane conductance regulator in pulmonary clearance of Pseudomonas aeruginosa in vivo
8. Lipopolysaccharide outer core is a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa
9. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis
10. A mouse model for the δF508 allele of cystic fibrosis
11. Generation and characterization of a δF508 cystic fibrosis mouse model
12. Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR
13. Enamel mineral composition of normal and cystic fibrosis transgenic mice
14. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
15. The genesis of cystic fibrosis lung disease
16. Cystic fibrosis: An inherited susceptibility to respiratory infections
17. Impact of heterogeneity within cultured cells on bacterial invasion: Analysis of Pseudomonas aeruginosa and Salmonella enterica serovar typhi entry into MDCK cells by using a green fluorescent protein-labelled cystic fibrosis transmembrane conductance regulator receptor
18. Activation of NF-κB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells
19. Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells
20. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease
21. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
22. The effect of alginate on the invasion of cystic fibrosis respiratory epithelial cells by clinical isolates of Pseudomonas aeruginosa
23. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
24. Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract
25. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface
26. Overproduction of the CFTR R domain leads to increased levels of asialoGMI and increased Pseudomonas aeruginosa binding by epithelial cells
27. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
28. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
29. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli
30. Asialo GMI is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelium
31. Differential adhesion of Pseudomonas aeruginosa to human respiratory epithelial cells in primary culture
32. Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium
33. 1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium