Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation

Journal of Immunology

Volumn 172, Issue 1, 2004, Pages 418-425

  Kowalski, Michael P ^a   Pier, Gerald B ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; CHOLESTEROL; CYCLODEXTRIN; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRITON X 100;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACTERIUM ADHERENCE; CELL ACTIVATION; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; EXTRACTION; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; IMMUNITY; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PSEUDOMONAS AERUGINOSA; WESTERN BLOTTING;

EID: 0346103721     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.1.418     Document Type: Article

References (43)

1. Pier, G. B. 2002. CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection. Curr. Opin. Microbiol. 5:81.
2. Goldberg, J. B., and G. B. Pier. 2000. The role of the CFTR in susceptibility to Pseudomonas aeruginosa infections in cystic fibrosis. Trends Microbiol. 8:514.
3. Pilewski, J. M., and R. A. Frizzell. 1999. Role of CFTR in airway disease. Physiol. Rev. 79:S215.
4. + currents. Am. J. Physiol. 271:C1565.
5. Jovov, B., Ismailov, I. I., and D. J. Benos. 1995. Cystic fibrosis transmembrane conductance regulator is required for protein kinase A activation of an outwardly rectified anion channel purified from bovine tracheal epithelia. J. Biol. Chem. 270:1521.
6. Jovov, B., Ismailov, I. I., B. K. Berdiev, C. M. Fuller, E. J. Sorscher, J. R. Dedman, M. A. Kaetzel, and D. J. Benos. 1995. Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels. J. Biol. Chem. 270:29194.
7. Estell, K., G. Braunstein, T. Tucker, K. Varga, J. F. Collawn, and L. M. Schwiebert. 2003. Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif. Mol. Cell. Biol. 23:594.
8. Schwiebert, L. M., K. Estell, and S. M. Propst. 1999. Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. Am. J. Physiol. 276:C700.
9. Colin, A. A., and M. E. Wohl. 1994. Cystic fibrosis. Pediatr. Rev. 15:192.
10. Lyczak, J. B., C. L. Cannon, and G. B. Pier. 2002. Lung infections associated with cystic fibrosis. Clin. Microbiol. Rev. 15:194.
11. Ratjen, F., and G. Doring. 2003. Cystic fibrosis. Lancet 361:681.
12. Pier, G. B. 1997. Rationale for development of immunotherapies that target mucoid Pseudomonas aeruginosa infection in cystic fibrosis patients. Behring Inst. Mitt. 98:350.
13. Rajan, S., and L. Saiman. 2002. Pulmonary infections in patients with cystic fibrosis. Semin. Respir. Infect. 17:47.
14. Davies, J. C. 2002. Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence. Paediatr. Respir. Rev. 3:128.
15. Boucher, R. C. 2002. An overview of the pathogenesis of cystic fibrosis lung disease. Adv. Drug Deliv. Rev. 54:1359.
16. Pier, G. B., M. Grout, T. S. Zaidi, J. C. Olsen, L. G. Johnson, J. R. Yankaskas, and J. B. Goldberg. 1996. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271:64.
17. Pier, G. B., M. Grout, and T. S. Zaidi. 1997. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc. Natl. Acad. Sci. USA 94:12088.
18. Pier, G. B., M. Grout, T. S. Zaidi, and J. B. Goldberg. 1996. How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis. Am. J. Respir. Crit. Care Med. 154:S175.
19. Schroeder, T. H., N. Reiniger, G. Meluleni, M. Grout, F. T. Coleman, and G. B. Pier. 2001. Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J. Immunol. 166:7410.
20. Schroeder, T. H., M. M. Lee, P. W. Yacono, C. L. Cannon, A. A. Gerceker, D. E. Golan, and G. B. Pier. 2002. CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-κB translocation. Proc. Natl. Acad. Sci. USA 99:6907.
21. Kalin, N., A. Claass, M. Sommer, E. Puchelle, and B. Tummler. 1999. DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis. J. Clin. Invest. 103:1379.
22. Cannon, C. L., M. P. Kowalski, K. S. Stopak, and G. B. Pier. 2003. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am. J. Respir. Cell Mol. Biol. 29:188.
23. Jendrossek, V., H. Grassme, I. Mueller, F. Lang, and E. Gulbins. 2001. Pseudomonas aeruginosa-induced apoptosis involves mitochondria and stress-activated protein kinases. Infect. Immun. 69:2675.
24. Grassme, H., S. Kirschnek, J. Riethmueller, A. Riehle, G. von Kurthy, F. Lang, M. Weller, and E. Gulbins. 2000. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290:527.
25. Simons, K., and R. Ehehalt. 2002. Cholesterol, lipid rafts, and disease. J. Clin. Invest. 110:597.
26. Duncan, M. J., J. S. Shin, and S. N. Abraham. 2002. Microbial entry through caveolae: variations on a theme. Cell. Microbiol. 4:783.
27. Manes, S., G. del Real, and C. Martines-A. 2003. Pathogens: raft hijackers. Nat. Rev. Immunol. 3:557.
28. Naslavsky, N., R. Stein, A. Yanai, G. Friedlander, and A. Taraboulos. 1997. Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform. J. Biol. Chem. 272:6324.
29. Scheiffele, P., M. G. Roth, and K. Simons. 1997. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16:5501.
30. Prior, I. A., A. Harding, J. Yan, J. Sluimer, R. G. Parton, and J. F. Hancock. 2001. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell. Biol. 3:368.
31. Grassme, H., V. Jendrossek, A. Riehle, G. von Kurthy, J. Berger, H. Schwarz, M. Weller, R. Kolesnick, and E. Gulbins. 2003. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat. Med. 9:322.
32. Olsen, J. C., L. G. Johnson, M. J. Stutts, B. Sarkadi, J. R. Yankaskas, R. Swanstrom, and R. C. Boucher. 1992. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Hum. Gene Ther. 3:253.
33. Moyer, B. D., J. Loffing, E. M. Schwiebert, D. Loffing-Cueni, P. A. Halpin, K. H. Karlson, I. Ismailov, W. B. Guggino, G. M. Langford, and B. A. Stanton. 1998. Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in Madin-Darby canine kidney cells. J. Biol. Chem. 273:21759.
34. Preston, M. J., P. C. Seed, D. S. Toder, B. H. Iglewski, D. E. Ohman, J. K. Gustin, J. B. Goldberg, and G. B. Pier. 1997. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect. Immun. 65:3086.
35. Hatano, K., and G. B. Pier. 1998. Complex serology and immune response of mice to variant high-molecular-weight O polysaccharides isolated from Pseudomonas aeruginosa serogroup O2 strains. Infect. Immun. 66:3719.
36. Wessel, D., and U. I. Flugge. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138:141.
37. Leers, M. P., W. Kolgen, V. Bjorklund, T. Bergman, G. Tribbick, B. Persson, P. Bjorklund, F. C. Ramaekers, B. Bjorklund, M. Nap, et al. 1999. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J. Pathol. 187:567.
38. Mulvey, M. A., Y. S. Lopez-Boado, C. L. Wilson, R. Roth, W. C. Parks, J. Heuser, and S. J. Hultgren. 1998. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 282:1494.
39. Kerem, E., and B. Kerem. 1996. Genotype-phenotype correlations in cystic fibrosis. Pediatr. Pulmonol. 22:387.
40. Kerem, B., and E. Kerem. 1996. The molecular basis for disease variability in cystic fibrosis. Eur. J. Hum. Genet. 4:65.
41. Delaney, S. J., E. W. Alton, S. N. Smith, D. P. Lunn, R. Farley, P. K. Lovelock, S. A. Thomson, D. A. Hume, D. Lamb, D. J. Porteous, et al. 1996. Cystic fibrosis mice carrying the missense mutation 551D replicate human genotype-phenotype correlations. EMBO J. 15:955.
42. Kristidis, P., D. Bozon, M. Corey, D. Markiewicz, J. Rommens, L. C. Tsui, and P. Durie. 1992. Genetic determination of exocrine pancreatic function in cystic fibrosis. Am. J. Hum. Genet. 50:1178.
43. Oceandy, D., B. J. McMorran, S. N. Smith, R. Schreiber, K. Kunzelmann, E. W. Alton, D. A. Hume, and B. J. Wainwright. 2002. Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum. Mol. Genet. 11:1059.