Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation

Science

Volumn 329, Issue 5996, 2010, Pages 1197-1201

  Muenzner, Petra ^a   Bachmann, Verena ^a   Zimmermann, Wolfgang ^b   Hentschel, Jochen ^a   Hauck, Christof R ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; ENDOGLIN; BACTERIAL ANTIGEN; BETA INTEGRIN; CARCINOEMBRYONIC ANTIGEN; CEACAM5 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; CYTOSKELETON PROTEIN; ENDOGLIN PROTEIN, MOUSE; ENG PROTEIN, HUMAN; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HYBRID PROTEIN; LEUKOCYTE ANTIGEN; OPACITY PROTEINS; SIGNAL PEPTIDE; ZYX PROTEIN, HUMAN; ZYXIN;

ADHESION; ANTIGEN; BACTERIAL DISEASE; COLONIZATION; CYTOGENETICS; GROWTH REGULATOR; PATHOGEN; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIAL STRAIN; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FOCAL ADHESION; MOUSE; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; UROGENITAL TRACT INFECTION; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; GONORRHEA; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MUCOSA; PATHOGENICITY; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VAGINA;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD; CARCINOEMBRYONIC ANTIGEN; CYTOSKELETAL PROTEINS; EPITHELIAL CELLS; FEMALE; FOCAL ADHESIONS; GLYCOPROTEINS; GONORRHEA; GPI-LINKED PROTEINS; HUMANS; INTEGRIN BETA CHAINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCOUS MEMBRANE; NEISSERIA GONORRHOEAE; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; VAGINA; ZYXIN;

EID: 77956296581     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1190892     Document Type: Article

References (32)

1. J. P. Pearson, I. A. Brownlee, in Colonization of Mucosal Surfaces, J. P. Nataro, P. S. Cohen, H. L. T. Mobley, J. N. Weiser, Eds. (ASM Press, Washington, DC, 2005), pp. 3-16.
2. M. A. Mulvey et al., Science 282, 1494 (1998).
3. M. A. Mulvey, J. D. Schilling, J. J. Martinez, S. J. Hultgren, Proc. Natl. Acad. Sci. U.S.A. 97, 8829 (2000).
4. I. U. Mysorekar, M. A. Mulvey, S. J. Hultgren, J. I. Gordon, J. Biol. Chem. 277, 7412 (2002).
5. P. Muenzner, M. Rohde, S. Kneitz, C. R. Hauck, J. Cell Biol. 170, 825 (2005).
6. M. Kim et al., Nature 459, 578 (2009).
7. WHO, Global Prevalence and Incidence of Selected Curable Sexually Transmitted Infections - Overview and Estimates (World Health Organization, Geneva, 2001).
8. M. A. Melly, C. R. Gregg, Z. A. McGee, J. Infect. Dis. 143, 423 (1981).
9. Z. A. McGee, A. P. Johnson, D. Taylor-Robinson, J. Infect. Dis. 143, 413 (1981).
10. K. F. Tjia, J. P. van Putten, E. Pels, H. C. Zanen, Graefes Arch. Clin. Exp. Ophthalmol. 226, 341 (1988).
11. I. M. Mosleh, H. J. Boxberger, M. J. Sessler, T. F. Meyer, Infect. Immun. 65, 3391 (1997).
12. See supporting material on Science Online.
13. M. Virji, Nat. Rev. Microbiol. 7, 274 (2009).
14. M. Voges, V. Bachmann, R. Kammerer, U. Gophna, C. R. Hauck, BMC Microbiol. 10, 117 (2010).
15. C. R. Hauck, T. F. Meyer, Curr. Opin. Microbiol. 6, 43 (2003).
16. A. M. Eades-Perner et al., Cancer Res. 54, 4169 (1994).
17. J. P. van Putten, S. M. Paul, EMBO J. 14, 2144 (1995).
18. T. Chen, R. J. Belland, J. Wilson, J. Swanson, J. Exp. Med. 182, 511 (1995).
19. B. A. Conley et al., J. Biol. Chem. 279, 27440 (2004).
20. G. Zambruno et al., J. Cell Biol. 129, 853 (1995).
21. M. Guerrero-Esteo et al., Eur. J. Cell Biol. 78, 614 (1999).
22. L. M. Hoffman et al., J. Cell Biol. 172, 771 (2006).
23. A. J. Merz, M. So, Annu. Rev. Cell Dev. Biol. 16, 423 (2000).
24. J. Swanson, O. Barrera, J. Sola, J. Boslego, J. Exp. Med. 168, 2121 (1988).
25. A. E. Jerse et al., J. Exp. Med. 179, 911 (1994).
26. S. Hammarström, Semin. Cancer Biol. 9, 67 (1999).
27. M. Virji, K. Makepeace, D. J. P. Ferguson, S. M. Watt, Mol. Microbiol. 22, 941 (1996).
28. M. Virji et al., Mol. Microbiol. 36, 784 (2000).
29. D. J. Hill, M. Virji, Mol. Microbiol. 48, 117 (2003).
30. C. N. Berger, O. Billker, T. F. Meyer, A. L. Servin, I. Kansau, Mol. Microbiol. 52, 963 (2004).
31. M. Toleman, E. Aho, M. Virji, Cell. Microbiol. 3, 33 (2001).
32. We thank M. C. Beckerle for zyxin-deficient fibroblasts and antibodies; M. Chudakov for the mKate cDNA; J. W. Greiner for sending the CEAtg mice; T. F. Meyer for bacterial strains; D. W. Piston for cDNA of mCerulean; A. J. Schaeffer for hVEC cells; D. Vestweber for providing antibody; C. Hentschel, J. Scharrer, and R. Mak'anyengo for assistance with SEM; and B. Planitz for expert animal care. Supported by Deutsche Forschungsgemeinschaft grant Ha2856/6-1 (C.R.H.).