메뉴 건너뛰기




Volumn 16, Issue 3, 2010, Pages 313-318

Pharmacological correction of a defect in PPAR-γ signaling ameliorates disease severity in Cftr-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; ANGIOPOIETIN; BICARBONATE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IV; CHLORIDE; CXCL1 CHEMOKINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; ROSIGLITAZONE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 77749246086     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2101     Document Type: Article
Times cited : (82)

References (40)
  • 2
    • 36849037262 scopus 로고
    • The pathogenesis of fbrocystic disease of the pancreas; A study of 36 cases with special reference to the pulmonary lesions
    • Zuelzer, W.W. & Newton, W.A. Jr. The pathogenesis of fbrocystic disease of the pancreas; a study of 36 cases with special reference to the pulmonary lesions. Pediatrics 4, 53-69 (1949)
    • (1949) Pediatrics , vol.4 , pp. 53-69
    • Zuelzer, W.W.1
  • 3
    • 10744223051 scopus 로고    scopus 로고
    • Association of cystic fbrosis with abnormalities in fatty acid metabolism
    • Freedman, S.D. et al. Association of cystic fbrosis with abnormalities in fatty acid metabolism. N. Engl. J. Med. 350, 560-569 (2004)
    • (2004) N. Engl. J. Med , vol.350 , pp. 560-569
    • Freedman, S.D.1
  • 4
    • 0030724296 scopus 로고    scopus 로고
    • Insulin resistance is associated with decreased clinical status in cystic fbrosis
    • Hardin, D.S., LeBlanc, A., Lukenbough, S. & Seilheimer, D.K. Insulin resistance is associated with decreased clinical status in cystic fbrosis. J. Pediatr. 130, 948-956 (1997)
    • (1997) J. Pediatr , vol.130 , pp. 948-956
    • Hardin, D.S.1    Leblanc, A.2    Lukenbough, S.3    Seilheimer, D.K.4
  • 5
    • 0026649122 scopus 로고
    • An animal model for cystic fbrosis made by gene targeting
    • Snouwaert, J.N. et al. An animal model for cystic fbrosis made by gene targeting. Science 257, 1083-1088 (1992)
    • (1992) Science , vol.257 , pp. 1083-1088
    • Snouwaert, J.N.1
  • 6
    • 0028828547 scopus 로고
    • Dietary changes improve survival of CFTR S489X homozygous mutant mouse
    • Eckman, E.A., Cotton, C.U., Kube, D.M. & Davis, P.B. Dietary changes improve survival of CFTR S489X homozygous mutant mouse. Am. J. Physiol. 269, L625-L630 (1995)
    • (1995) Am. J. Physiol , vol.269
    • Eckman, E.A.1    Cotton, C.U.2    Kube, D.M.3    Davis, P.B.4
  • 7
    • 0030466804 scopus 로고    scopus 로고
    • Increased survival of CFTR knockout mice with an oral osmotic laxative
    • Clarke, L.L., Gawenis, L.R., Franklin, C.L. & Harline, M.C. Increased survival of CFTR knockout mice with an oral osmotic laxative. Lab. Anim. Sci. 46, 612-618 (1996)
    • (1996) Lab. Anim. Sci , vol.46 , pp. 612-618
    • Clarke, L.L.1    Gawenis, L.R.2    Franklin, C.L.3    Harline, M.C.4
  • 8
    • 0034887203 scopus 로고    scopus 로고
    • Creating the gene ontology resource: Design and implementation
    • Gene Ontology Consortium. Creating the gene ontology resource: design and implementation. Genome Res. 11, 1425-1433 (2001)
    • (2001) Genome Res , vol.11 , pp. 1425-1433
  • 10
    • 0035834654 scopus 로고    scopus 로고
    • Human peroxisome proliferator-activated receptor a (PPARa) supports the induction of peroxisome proliferation in PPARa-defcient mouse liver
    • Yu, S. et al. Human peroxisome proliferator-activated receptor a (PPARa) supports the induction of peroxisome proliferation in PPARa-defcient mouse liver. J. Biol. Chem. 276, 42485-42491 (2001)
    • (2001) J. Biol. Chem , vol.276 , pp. 42485-42491
    • Yu, S.1
  • 11
    • 27644592503 scopus 로고    scopus 로고
    • Gene expression profling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms
    • Tachibana, K. et al. Gene expression profling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl. Recept. 3, 3 (2005)
    • (2005) Nucl. Recept , vol.3 , pp. 3
    • Tachibana, K.1
  • 12
    • 15944422109 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor y ligand rosiglitazone delays the onset of infammatory bowel disease in mice with interleukin 10 defciency
    • Lytle, C. et al. The peroxisome proliferator-activated receptor y ligand rosiglitazone delays the onset of infammatory bowel disease in mice with interleukin 10 defciency. Infamm. Bowel Dis. 11, 231-243 (2005)
    • (2005) Infamm. Bowel Dis , vol.11 , pp. 231-243
    • Lytle, C.1
  • 13
    • 0037031856 scopus 로고    scopus 로고
    • Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    • Madison, B.B. et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277, 33275-33283 (2002)
    • (2002) J. Biol. Chem , vol.277 , pp. 33275-33283
    • Madison, B.B.1
  • 14
    • 33746159991 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor y in colonic epithelial cells protects against experimental infammatory bowel disease
    • Adachi, M. et al. Peroxisome proliferator activated receptor y in colonic epithelial cells protects against experimental infammatory bowel disease. Gut 55, 1104-1113 (2006)
    • (2006) Gut , vol.55 , pp. 1104-1113
    • Adachi, M.1
  • 15
    • 0026937999 scopus 로고
    • CFTR nonsense mutations G542X and W1282X associated with severe reduction of CFTR mRNA in nasal epithelial cells
    • Hamosh, A., Rosenstein, B.J. & Cutting, G.R. CFTR nonsense mutations G542X and W1282X associated with severe reduction of CFTR mRNA in nasal epithelial cells. Hum. Mol. Genet. 1, 542-544 (1992)
    • (1992) Hum. Mol. Genet , vol.1 , pp. 542-544
    • Hamosh, A.1    Rosenstein, B.J.2    Cutting, G.R.3
  • 16
    • 0026148375 scopus 로고
    • A cystic fbrosis bronchial epithelial cell line: Immortalization by adeno-12-SV40 infection
    • Zeitlin, P.L. et al. A cystic fbrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am. J. Respir. Cell Mol. Biol. 4, 313-319 (1991)
    • (1991) Am. J. Respir. Cell Mol. Biol , vol.4 , pp. 313-319
    • Zeitlin, P.L.1
  • 18
    • 3442891826 scopus 로고    scopus 로고
    • The bicarbonate transport metabolon
    • McMurtrie, H.L. et al. The bicarbonate transport metabolon. J. Enzyme Inhib. Med. Chem. 19, 231-236 (2004)
    • (2004) J. Enzyme Inhib. Med. Chem , vol.19 , pp. 231-236
    • McMurtrie, H.L.1
  • 19
    • 15244346301 scopus 로고    scopus 로고
    • Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway
    • Sellers, Z.M. et al. Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G654-G663 (2005)
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol , vol.288
    • Sellers, Z.M.1
  • 20
    • 0028276397 scopus 로고
    • Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
    • Rodríguez, J.C., Gil-Gomez, G., Hegardt, F.G. & Haro, D. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem. 269, 18767-18772 (1994)
    • (1994) J. Biol. Chem , vol.269 , pp. 18767-18772
    • Rodríguez, J.C.1    Gil-Gomez, G.2    Hegardt, F.G.3    Haro, D.4
  • 21
    • 4544274752 scopus 로고    scopus 로고
    • The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofbrate treatment
    • Mandard, S. et al. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofbrate treatment. J. Biol. Chem. 279, 34411-34420 (2004)
    • (2004) J. Biol. Chem , vol.279 , pp. 34411-34420
    • Mandard, S.1
  • 22
    • 0037198679 scopus 로고    scopus 로고
    • Transcription coactivator TRAP220 is required for PPARy2-stimulated adipogenesis
    • Ge, K. et al. Transcription coactivator TRAP220 is required for PPARy2-stimulated adipogenesis. Nature 417, 563-567 (2002)
    • (2002) Nature , vol.417 , pp. 563-567
    • Ge, K.1
  • 23
    • 0032493455 scopus 로고    scopus 로고
    • The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    • Yuan, C.X., Ito, M., Fondell, J.D., Fu, Z.Y. & Roeder, R.G. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 95, 7939-7944 (1998)
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7939-7944
    • Yuan, C.X.1    Ito, M.2    Fondell, J.D.3    Fu, Z.Y.4    Roeder, R.G.5
  • 24
    • 0038813860 scopus 로고    scopus 로고
    • Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor y/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein
    • Wigren, J. et al. Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor y/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein. J. Endocrinol. 177, 207-214 (2003)
    • (2003) J. Endocrinol , vol.177 , pp. 207-214
    • Wigren, J.1
  • 25
    • 34547101243 scopus 로고    scopus 로고
    • 2 catabolism in regulation of peroxisome proliferator-activated receptor y activation
    • 2 catabolism in regulation of peroxisome proliferator-activated receptor y activation. J. Biol. Chem. 282, 18162-18172 (2007)
    • (2007) J. Biol. Chem , vol.282 , pp. 18162-18172
    • Chou, W.L.1
  • 26
    • 52149111858 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-y in cystic fbrosis lung epithelium
    • Perez, A. et al. Peroxisome proliferator-activated receptor-y in cystic fbrosis lung epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L303-L313 (2008)
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.295
    • Perez, A.1
  • 28
    • 0032746173 scopus 로고    scopus 로고
    • A novel therapy for colitis utilizing PPAR-y ligands to inhibit the epithelial infammatory response
    • Su, C.G. et al. A novel therapy for colitis utilizing PPAR-y ligands to inhibit the epithelial infammatory response. J. Clin. Invest. 104, 383-389 (1999)
    • (1999) J. Clin. Invest , vol.104 , pp. 383-389
    • Su, C.G.1
  • 29
    • 0035668404 scopus 로고    scopus 로고
    • An open-label trial of the PPAR-y ligand rosiglitazone for active ulcerative colitis
    • Lewis, J.D. et al. An open-label trial of the PPAR-y ligand rosiglitazone for active ulcerative colitis. Am. J. Gastroenterol. 96, 3323-3328 (2001)
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 3323-3328
    • Lewis, J.D.1
  • 30
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fbrosis airways disease
    • Matsui, H. et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fbrosis airways disease. Cell 95, 1005-1015 (1998)
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1
  • 31
    • 70349223856 scopus 로고    scopus 로고
    • Normal mouse intestinal mucus release requires cystic fbrosis transmembrane regulator-dependent bicarbonate secretion
    • Garcia, M.A., Yang, N. & Quinton, P.M. Normal mouse intestinal mucus release requires cystic fbrosis transmembrane regulator-dependent bicarbonate secretion. J. Clin. Invest. 119, 2613-2622 (2009)
    • (2009) J. Clin. Invest , vol.119 , pp. 2613-2622
    • Garcia, M.A.1    Yang, N.2    Quinton, P.M.3
  • 32
    • 48149090717 scopus 로고    scopus 로고
    • Cystic fbrosis: Impaired bicarbonate secretion and mucoviscidosis
    • Quinton, P.M. Cystic fbrosis: impaired bicarbonate secretion and mucoviscidosis. Lancet 372, 415-417 (2008)
    • (2008) Lancet , vol.372 , pp. 415-417
    • Quinton, P.M.1
  • 33
    • 59449089139 scopus 로고    scopus 로고
    • Anti-infammatory therapies for cystic fbrosis-related lung disease
    • Nichols, D.P., Konstan, M.W. & Chmiel, J.F. Anti-infammatory therapies for cystic fbrosis-related lung disease. Clin. Rev. Allergy Immunol. 35, 135-153 (2008)
    • (2008) Clin. Rev. Allergy Immunol , vol.35 , pp. 135-153
    • Nichols, D.P.1    Konstan, M.W.2    Chmiel, J.F.3
  • 34
    • 0042934009 scopus 로고    scopus 로고
    • Effect of ibuprofen on neutrophil migration in vivo in cystic fbrosis and healthy subjects
    • Konstan, M.W. et al. Effect of ibuprofen on neutrophil migration in vivo in cystic fbrosis and healthy subjects. J. Pharmacol. Exp. Ther. 306, 1086-1091 (2003)
    • (2003) J. Pharmacol. Exp. Ther , vol.306 , pp. 1086-1091
    • Konstan, M.W.1
  • 35
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor y gene in mice results in lowered expression of ABCA1 ABCG1 and apoE in macrophages and reduced cholesterol effux
    • Akiyama, T.E. et al. Conditional disruption of the peroxisome proliferator-activated receptor y gene in mice results in lowered expression of ABCA1, ABCG1 and apoE in macrophages and reduced cholesterol effux. Mol. Cell. Biol. 22, 2607-2619 (2002)
    • (2002) Mol. Cell. Biol , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1
  • 36
    • 0031871001 scopus 로고    scopus 로고
    • Establishment of long-term primary cultures of human small and large intestinal epithelial cells
    • Rogler, G. et al. Establishment of long-term primary cultures of human small and large intestinal epithelial cells. Lab. Invest. 78, 889-890 (1998)
    • (1998) Lab. Invest , vol.78 , pp. 889-890
    • Rogler, G.1
  • 37
    • 5144232850 scopus 로고    scopus 로고
    • A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
    • Ogawa, S. et al. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc. Natl. Acad. Sci. USA 101, 14461-14466 (2004)
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14461-14466
    • Ogawa, S.1
  • 38
    • 69249096994 scopus 로고    scopus 로고
    • Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis
    • Blaho, V.A., Buczynski, M.W., Brown, C.R. & Dennis, E.A. Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. J. Biol. Chem. 284, 21599-21612 (2009)
    • (2009) J. Biol. Chem , vol.284 , pp. 21599-21612
    • Blaho, V.A.1    Buczynski, M.W.2    Brown, C.R.3    Dennis, E.A.4
  • 39
    • 33744530656 scopus 로고    scopus 로고
    • Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine
    • Zarini, S., Gijon, M.A., Folco, G. & Murphy, R.C. Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine. J. Biol. Chem. 281, 10134-10142 (2006)
    • (2006) J. Biol. Chem , vol.281 , pp. 10134-10142
    • Zarini, S.1    Gijon, M.A.2    Folco, G.3    Murphy, R.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.