Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 32744-32752

  Qiu, Huawei ^a   Edmunds, Tim ^b   Baker Malcolm, Jennifer ^b   Karey, Kenneth P ^b   Estes, Scott ^b   Schwarz, Cordula ^b   Hughes, Heather ^b   Van Patten, Scott M ^b  

^a GENZYME CORPORATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CHEMICAL MODIFICATION; DISEASE CONTROL; ORGANIC ACIDS; PURIFICATION;

HUMAN ACIDS;

ENZYME KINETICS;

SPHINGOMYELIN PHOSPHODIESTERASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN PROCESSING;

ANIMALS; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; CHO CELLS; COPPER; CRICETINAE; CYSTEINE; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE DELETION; HUMANS; KINETICS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOMYELIN PHOSPHODIESTERASE; SULFHYDRYL COMPOUNDS; TEMPERATURE; TIME FACTORS; TRANSFECTION; ZINC;

EID: 0042858520     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303022200     Document Type: Article

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