Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2567-2573

  Temperini, Claudia ^a   Cecchi, Alessandro ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Benzothiadiazine; Carbonic anhydrase; Diuretic; Furosemide; Indapamide; Isozyme; Sulfonamide; X ray crystallography

Indexed keywords

BUMETANIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE VB; CARBONATE DEHYDRATASE VII; CARBONATE DEHYDRATASE XII; CARBONATE DEHYDRATASE XIII; CARBONATE DEHYDRATASE XIV; CHLORTALIDONE; DIURETIC AGENT; FUROSEMIDE; HYDROCHLOROTHIAZIDE; HYDROFLUMETHIAZIDE; INDAPAMIDE; ISOENZYME; METOLAZONE; QUINETHAZONE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; IMAGE QUALITY; MAMMAL; PHYSIOLOGY; VERTEBRATE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDAPAMIDE; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

MAMMALIA; VERTEBRATA;

EID: 41949096461     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.051     Document Type: Article

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