Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5259-5265

  Anana, Raymond ^a   Rao, P N Praveen ^b   Chen, Qiao Hong ^b   Knaus, Edward E ^b  

^a Lakeland College   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anti inflammatory and analgesic activity; COX 2 pharmacophore; Cyclooxygenase 1 2 inhibitors; Phenylethynylbenzenesulfonamides

Indexed keywords

2 (PHENYLETHYNYL)BENZENESULFONAMIDE; 2 [2 (3 FLUOROPHENYL)ETHYNYL]BENZENESULFONAMIDE; 2 [2 (4 METHYLPHENYL)ETHYNYL]BENZENESULFONAMIDE; 3 (2 PHENYLETHYNYL)BENZENESULFONAMIDE; 3 [2 (3 FLUOROPHENYL)ETHYNYL]BENZENESULFONAMIDE; 3 [2 (3 METHOXYPHENYL)ETHYNYL]BENZENESULFONAMIDE; 3 [2 (4 METHYLPHENYL)ETHYNYL]BENZENESULFONAMIDE; 4 (2 PHENYLETHYNYL)BENZENESULFONAMIDE; 4 [2 (3 FLUOROPHENYL)ETHYNYL]BENZENESULFONAMIDE; 4 [2 (3 HYDROXYPHENYL)ETHYNYL]BENZENESULFONAMIDE; 4 [2 (3 METHOXYPHENYL)ETHYNYL]BENZENESULFONAMIDE; 4 [2 (4 METHYLPHENYL)ETHYNYL]BENZENESULFONAMIDE; ACETYLSALICYLIC ACID; BENZENESULFONAMIDE DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; PALLADIUM; ROFECOXIB; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PAW EDEMA; RAT; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HINDLIMB; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33745161107     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.050     Document Type: Article

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