Polymeric nanoparticles of chitosan derivatives as DNA and siRNA carriers

Advances in Polymer Science

Volumn 243, Issue 1, 2011, Pages 1-22

  Kim, Y K ^a,b   Jiang, H L ^b   Choi, Y J ^a   Park, I K ^c   Cho, M H ^b   Cho, C S ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Chonnam National University Medical School   (South Korea)

Author keywords

Cell specificity; Chitosan; Gene therapy; pH sensitive; Small interfering RNA

Indexed keywords

EID: 80052282202     PISSN: 00653195     EISSN: None     Source Type: Book Series    
DOI: 10.1007/12_2011_110     Document Type: Article

References (74)

1. Kabanov AV, Kabanov VA (1995) DNA complexes with polycations for the delivery of genetic material into cells. Bioconjug Chem 6:7-20
2. Smith AE (1995) Viral vectors in gene therapy. Annu Rev Microbiol 49:807-838
3. Ciccarone TM, MacTough SC, Williams TM et al (1999) Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase. Bioorg Med Chem Lett 9:1991-1996 (Pubitemid 29336388)
4. Felgner PL, Gadek TR, Holm M (1897) Lipofection: a highly efficient, lipid-mediated DNAtransfection procedure. Proc Natl Acad Sci USA 84:7413-7417
5. Danna KJ, Sompayrac LM (1982) Efficient infection of monkey cells with SV40 DNA. II. Use of low-molecular-weight DEAE-dextran for large-scale experiments. J Virol Methods 5:335-341 (Pubitemid 13221632)
6. Wu GY, Wu CH (1987) Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J Biol Chem 262:4429-4432 (Pubitemid 17102799)
7. Boussif O, Lezoualc'h F, Zanta MA et al (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 92:7297-7301
8. Haensler J, Szoka FC Jr (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4:372-379
9. Anderson DG, Akinc A, Hossain N et al (2005) Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol Ther 11:426-434 (Pubitemid 40277319)
10. MacLaughlin FC, Mumper RJ, Wang J (1998) Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 56:259-272 (Pubitemid 28511146)
11. Lee KY, Kwon IC, Kim YH et al (1998) Preparation of chitosan self-aggregates as a gene delivery system. J Control Release 51:213-220 (Pubitemid 28252873)
12. Kim TH, Jiang HL, Jere D et al (2007) Chemical modification of chitosan as a gene carrier in vitro and in vivo. Prog Polym Sci 32:726-753 (Pubitemid 46977435)
13. Kiang T, Wen J, Lim HW et al (2004) The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials 25:5293-5301 (Pubitemid 38523332)
14. Lavertu M, Methot S, Tran-Khanh N et al (2006) High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. Biomaterials 27:4815-4824 (Pubitemid 43880352)
15. Liu X, Howard K, Kjems J (2007) The influence of polymeric properties on chitosan/siRNA nanoparticles formulation and gene silencing. Biomaterials 28:1280-1288 (Pubitemid 44816373)
16. Huang M, Fong CW, Khor E et al (2005) Transfection efficiency of chitosan vectors: effect of polymer molecular weight and degree of deacetylation. J Control Release 106:391-406 (Pubitemid 41187448)
17. Köping-Höggard M, Varum KM, Issa M et al (2004) Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomer. Gene Ther 11:1441-1452 (Pubitemid 39359435)
18. Strand SP, Lelu S, Reitan NK et al (2010) Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. Biomaterials 31:975-987
19. Thibault M, Nimesh S, Lavertu M et al (2010) Intracellular trafficking and decondensation kinetics of chitosan-pDNA polyplexes. Mol Ther 18:1787-1795
20. Centelles MN, Isasi JR, Qian C et al (2010) Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in mice. J Microencapsul 27:460-469
21. Sato T, Ishii T, Okahata Y (2001) In vitro gene delivery mediated by chitosan, effect of pH, serumand molecularmass of chitosan on the transfection efficiency. Biomaterials 22:2075-2080 (Pubitemid 32738750)
22. Nimesh S, Thibault MM, Lavertu M et al (2010) Enhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serum. Mol Biotechnol 46:182-196
23. Ishii T, Okahata Y, Sato T (2001) Mechanism of cell transfection with plasmid/chitosan complexes. Biochim Biophys Acta 1514:51-64 (Pubitemid 32769928)
24. Leong KW, Mao HQ, Truong-Le VL et al (1998) DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release 53:183-193 (Pubitemid 28218701)
25. Techaarpornkul S, Wongkupasert S, Opanasopit P et al (2010) Chitosan-mediated siRNA delivery in vitro: effect of polymer molecular weight, concentration and salt forms. AAPS PharmSciTech 11:64-72
26. Park IK (2002) Ph.D. thesis, Seoul National University
27. Park IK, Park YH, Shin BA et al (2000) Galactosylated chitosan-graft-dextran as hepatocytetargeting DNA carrier. J Control Release 69:97-108
28. Park IK, Kim TH, Park YH et al (2001) Galactosylated chitosan-graft- poly(ethylene glycol) as hepatocyte-targeting DNA carrier. J Control Release 76:349-362 (Pubitemid 32913442)
29. Park IK, Ihm JE, Park YH et al (2003) Galactosylated chitosan (GC)-graft-poly(vinyl pyrrolidone)( PVP) as hepatocyte-targeting DNA carrier. Preparation and physicochemical characterization of GC-graft-PVP/DNA complex(1). J Control Release 86:349-359 (Pubitemid 36084278)
30. Sonawane ND, Szoka FC Jr, Verkman AS (2003) Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 278: 44826-44831 (Pubitemid 37377241)
31. Amiji M (2005) Polymeric gene delivery: principles and applications. CRC, Boca Raton
32. Gao S, Chen J, Xu X et al (2003) Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte-targeting. Int J Pharm 255:57-68 (Pubitemid 36369591)
33. Kim TH, Park IK, Nah JW et al (2004) Galactosylated chitosan/DNA nanoparticles prepared using water-soluble chitosan as a gene carrier. Biomaterials 25:3783-3797
34. Wu CH, Wu GY (1998) Receptor-mediated delivery of foreign genes to hepatocytes. Adv Drug Deliv Rev 29:243-248 (Pubitemid 28090044)
35. Jiang HL, Kwon JT, Kim YK et al (2007) Galactosylated chitosan-graft-polyethylenimine as a gene carrier for hepatocyte targeting. Gene Ther 14:1389-1398
36. Jiang HL, Kwon JT, Kim EM et al (2008) Galactosylated poly(ethylene glycol)-chitosangraft-polyethylenimine as a gene carrier for hepatocyte-targeting. J Control Release 131:150-157
37. Dong L, Gao S, Diao H et al (2008) Galactosylated low molecular weight chitosan as a carrier delivering oligonucleotides to Kupffer cells instead of hepatocytes in vivo. J Biomed Mater Res A 84:777-784 (Pubitemid 351237795)
38. Song B, Zhang W, Peng R et al (2009) Synthesis and cell activity of novel galactosylated chitosan as a gene carrier. Colloids Surf B Biointerfaces 70:181-186
39. Kim TH, Nah JW, Cho MH et al (2006) Receptor-mediated gene delivery into antigen presenting cells using mannosylated chitosan/DNA nanoparticles. J Nanosci Nanotechnol 6:2796-2803 (Pubitemid 44579949)
40. Kim TH, Jin H, Kim HW (2006) Mannosylated chitosan nanoparticles-based cytokine gene therapy suppressed cancer growth in BALB/C mice bearing CT-26 carcinoma cells. Mol Cancer Ther 5:1723-1732 (Pubitemid 44323240)
41. Hashimoto M, Morimoto M, Saimoto H et al (2006) Gene transfer by DNA/mannosylated chitosan complexes into mouse peritoneal macrophages. Biotechnol Lett 28:815-821 (Pubitemid 43926904)
42. Jiang HL, Kim YK, Arote R et al (2009) Mannosylated chitosan-graft- polyethylenimine as a gene carrier for Raw 264.7 cell targeting. Int J Pharm 375:133-139
43. Fernandes JC, Wang H, Jreyssaty C et al (2008) Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticles containing interleukin-1 receptor antagonist gene in rats with adjuvant induced arthritis. Mol Ther 16:1243-1251 (Pubitemid 351866055)
44. Zheng Y, Cai Z, Song X et al (2009) Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. Int J Pharm 382:262-269
45. Morris VB, Sharma CP (2010) Folate mediated histidine derivative of quaternised chitosan as a gene delivery vector. Int J Pharm 389:176-185
46. Morris VB, Sharma CP (2010) Folate mediated in vitro targeting of depolymerised trimethylated chitosan having arginine functionality. J Colloid Interface Sci 348:360-368
47. Jiang HL, Xu CX, Kim YK et al (2009) The suppression of lung tumorigenesis by aerosoldelivered folate-chitosan-graft-polyethylenimine/Akt 1 shRNA complexes through the Akt signaling pathway. Biomaterials 30:5844-5852
48. Mao HQ, Roy K, Troung-Le VL et al (2001) Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 70:399-421 (Pubitemid 32155463)
49. Murata J, Ohya Y, Ouchi T (1997) Design of quaternary chitosan conjugate having antennary galactose residues as a gene delivery tool. Carbohydr Polym 32:105-119
50. Jiang W, Swiggard WJ, Heufler C et al (1995) The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375:151-155
51. Antony AC (1996) Folate receptors. Annu Rev Nutr 16:501-521 (Pubitemid 26286863)
52. Mansouri S, Cuie Y, Winnik F et al (2006) Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 27:2060-2065 (Pubitemid 41759500)
53. Chan P, Kurisawa M, Chung JE et al (2007) Synthesis and characterization of chitosan-g-poly (ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials 28:540-549 (Pubitemid 44602231)
54. Lee D, Lockey R, Mohapatra S (2006) Folate receptor-mediated cancer cell specific gene delivery using folic acid-conjugated oligochitosans. J Nanosci Nanotechnol 6:2860-2866 (Pubitemid 44579956)
55. Deshpande D, Toledo-Velasquez D, Wang LY et al (1994) Receptor-mediated peptide delivery in pulmonary epithelial monolayers. Pharm Res 11:1121-1126 (Pubitemid 24259851)
56. Supaprutsakul S, Chotigeat W, Wanichpakorn S et al (2010) Transfection efficiency of depolymerized chitosan and epidermal growth factor conjugated to chitosan-DNA polyplexes. J Mater Sci Mater Med 21:1553-1561
57. Han HD, Mangala LS, Lee JW et al (2010) Targeted gene silencing using RGD-labeled chitosan nanoparticles. Clin Cancer Res 16:3910-3922
58. Park IK, Kim TH, Kim SI et al (2003) Visualization of transfection of hepatocytes by galactosylated chitosan-graft-poly(ethylene glycol)/DNA complexes by confocal laser scanning microscopy. Int J Pharm 257:103-110 (Pubitemid 36507037)
59. Kim TH, Ihm JE, Choi YJ et al (2003) Efficient gene delivery by urocanic acid-modified chitosan. J Control Release 93:389-402 (Pubitemid 37485960)
60. Jin H, Kim TH, Hwang SK et al (2006) Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol Cancer Ther 5:1041-1049 (Pubitemid 43724605)
61. Jin H, Xu CX, Kim HW et al (2008) Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-ras (LA1) mice. Cancer Gene Ther 15:275-283 (Pubitemid 351508133)
62. Wang W, Yao J, Zhou JP et al (2008) Urocanic acid-modified chitosan-mediated p53 gene delivery inducing apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its antitumor effect in vitro and in vivo. Biochem Biophys Res Commun 377:567-572
63. Ghosn B, Kasturi SP, Roy K (2008) Enhancing polysaccharide-mediated delivery of nucleic acids through functionalization with secondary and tertiary amines. Curr Top Med Chem 8:331-340 (Pubitemid 351791027)
64. Moreira C, Oliveira H, Pires LR et al (2009) Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone. Acta Biomater 5:2995-3006
65. Chang KL, Higuchi Y, Kawakami S et al (2010) Efficient gene transfection by histidinemodified chitosan through enhancement of endosomal escape. Bioconjug Chem 21:1087-1095
66. Ghosn B, Singh A, LiMet al (2010) Efficient gene silencing in lungs and liver using imidazolemodified chitosan as a nanocarrier for small interfering RNA. Oligonucleotides 20:163-172
67. Wong K, Sun G, Zhang X et al (2006) PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjug Chem 17:152-158 (Pubitemid 43157597)
68. Jiang HL, Kim YK, Arote R et al (2007) Chitosan-graft-polyethylenimine as a gene carrier. J Control Release 117:273-280 (Pubitemid 46161875)
69. Lu B, Xu X, Zhang X et al (2008) Low molecular weight polyethylenimine grafted N-maleated chitosan for gene delivery: properties and in vitro transfection studies. Biomacromolecules 9:2594-2600
70. Lu B, Sun Y, Li Y et al (2009) N-succinyl-chitosan grafted with low molecular weight polyethylenimine as a serum-resistant gene vector. Mol Biosyst 5:629-637
71. Lou YL, Peng YS, Chen BH et al (2009) Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors. J Biomed Mater Res A 88:1058-1068
72. Gao JQ, Zhao QQ, Lv TF et al (2010) Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity. Int J Pharm 387:286-294
73. Jere D, Jiang HL, Kim YK et al (2009) Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells. Int J Pharm 378:194-200
74. Dehousse V, Garbacki N, Colige A et al (2010) Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery. Biomaterials 31:1839-1849