Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity

International Journal of Pharmaceutics

Volumn 387, Issue 1-2, 2010, Pages 286-294

  Gao, Jian Qing ^a   Zhao, Qing Qing ^a   Lv, Teng Fei ^a   Shuai, Wu Ping ^b   Zhou, Jun ^a   Tang, Gu Ping ^a   Liang, Wen Quan ^a   Tabata, Yasuhiko ^c   Hu, Yu Lan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Chitosan; Copolymer; Cytotoxicity; Gene therapy; Polyethylenimine

Indexed keywords

CHITOSAN; COPOLYMER; MACROPHAGE DERIVED CHEMOKINE; POLYETHYLENEIMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CIRCULAR DICHROISM; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA BINDING; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; ZETA POTENTIAL;

ANIMALS; CELL LINE, TUMOR; CHITOSAN; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MICE; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; PARTICLE SIZE; POLYETHYLENEIMINE; TRANSFECTION;

EID: 77649191250     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.12.033     Document Type: Article

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