The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5844-5852

  Jiang, Hu Lin ^a   Xu, Cheng Xiong ^a,b   Kim, You Kyoung ^a   Arote, Rohidas ^a   Jere, Dhananjay ^a   Lim, Hwang Tae ^a   Cho, Myung Haing ^a   Cho, Chong Su ^a  

^a Seoul National University   (South Korea)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aerosol delivery; Akt1 shRNA; Folate chitosan graft polyethylenimine; Gene therapy; Lung tumorigenesis; Non viral vector

Indexed keywords

AEROSOL DELIVERY; AKT1 SHRNA; FOLATE-CHITOSAN-GRAFT-POLYETHYLENIMINE; GENE THERAPY; LUNG TUMORIGENESIS; NON-VIRAL VECTOR;

ATMOSPHERIC AEROSOLS; BIOLOGICAL ORGANS; CELL MEMBRANES; CHITIN; CHITOSAN; COPOLYMERIZATION; DYNAMIC LIGHT SCATTERING; GENE EXPRESSION; GENE TRANSFER; GRAFTING (CHEMICAL); NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACIDS; RNA; SIGNALING; ZETA POTENTIAL;

CYTOTOXICITY;

CHITOSAN; COPOLYMER; FOLIC ACID; IMINE; POLYETHYLENEIMINE; PROTEIN KINASE B; SHORT HAIRPIN RNA; URETHAN;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; GENE TARGETING; GENETIC TRANSFECTION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; LUNG CANCER; LUNG CARCINOGENESIS; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZETA POTENTIAL;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CHITOSAN; DRUG CARRIERS; FOLIC ACID; GENE SILENCING; GENE TARGETING; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; POLYETHYLENEIMINE; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; TREATMENT OUTCOME;

EID: 68549110154     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.07.017     Document Type: Article

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