Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone

Acta Biomaterialia

Volumn 5, Issue 8, 2009, Pages 2995-3006

  Moreira, C ^a,b   Oliveira, H ^a,b   Pires, L R ^a   Simoes S ^c,d   Barbosa, M A ^a,b   Pego A P ^a  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Chitosan; Gene delivery; Nanoparticle; Tissue engineering

Indexed keywords

CHITOSAN; CYTOTOXICITY; DNA; GENES; MOLECULAR BIOLOGY; TISSUE ENGINEERING;

BUFFERING CAPACITIES; DNA COMPLEX; ENDOSOMAL ESCAPES; FUNCTIONALIZED; GENE DELIVERY; IMIDAZOLE MOIETY; MOLAR RATIO; PRIMARY AMINES; TISSUES ENGINEERINGS; TRANSFECTION EFFICIENCY;

GENE TRANSFER;

BETA GALACTOSIDASE; CHITOSAN; DNA; IMIDAZOLE; NANOMATERIAL;

ARTICLE; CELL TRANSPORT; CHEMICAL STRUCTURE; COACERVATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOSOME; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT;

BIOCOMPATIBLE MATERIALS; BUFFERS; CELL LINE; CHITOSAN; DIFFUSION; DNA; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; KIDNEY; MATERIALS TESTING; TRANSFECTION;

EID: 70349162856     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2009.04.021     Document Type: Article

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