Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in mice

Journal of Microencapsulation

Volumn 27, Issue 5, 2010, Pages 460-469

  Centelles, Miguel N ^a   Isasi, José R ^a   Qian, Cheng ^b   Campanero, Miguel A ^a   Irache, Juan M ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Chitosan; DNA; Gene delivery; Hydrodynamics based procedure; Nanoparticles

Indexed keywords

ACETIC ANHYDRIDE; CHITOSAN; DNA; GREEN FLUORESCENT PROTEIN; LUCIFERASE; NANOPARTICLE;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOLUMINESCENCE; COACERVATION; DEACETYLATION; DRUG HALF LIFE; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSFECTION; HYDRODYNAMICS BASED TRANSFECTION; LIVER CLEARANCE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; ZETA POTENTIAL;

ACETYLATION; ANIMALS; CHITOSAN; DNA; FEMALE; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; LUCIFERASES; MICE; MICE, INBRED BALB C; NANOPARTICLES; TRANSFECTION;

EID: 77955444191     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652041003638158     Document Type: Article

References (38)

1. Ahmed OA, Pourzand C, Blagbrough IS. 2006. Varying the usaturation in N4,N9-dioctadecanoyl spermines: Nonviral lipopolyamine vectors for more efficient plasmid DNA formulation. Pharm Res 23:31-40.
2. Aiba S. 1994. Preparation of N-acetylchitooligosaccharides by hydrolysis of chitosan with chitinase followed by N-acetylation. Carbohydr Res 265:323-328.
3. Alino SF, Crespo A, Dasi F. 2003. Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA. Gene Ther 10:1672-1679.
4. Bivas-Benita M, Laloup M, Versteyhe S, Dewit J, De Braekeleer J, Jongert E, et al. 2003. Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles: Preparation, characterization, and preliminary in vivo studies. Int J Pharm 266:17-27.
5. Bivas-Benita M, van Meijgaarden KE, Franken KL, Junginger HE, Borchard G, Ottenhoff TH, et al. 2004. Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A *0201- restricted T-cell epitopes of Mycobacterium tuberculosis. Vaccine 22:1609-1615.
6. Budker V, Zhang G, Knechtle S, Wolff JA. 1996. Naked DNA delivered intraportally expresses efficiently in hepatocytes. Gene Ther 3:593-598.
7. Centelles MN, Qian C, Campanero MA, Irache JM. 2008. New methodologies to characterize the effectiveness of the gene transfer mediated by DNA-chitosan nanoparticles. Int J Nanomedicine 3:451-460.
8. Chu Q, Joseph M, Przybylska M, Yew NS, Scheule RK. 2005. Transient siRNA-mediated attenuation of liver expression from an alpha-galactosidase A plasmid reduces subsequent humoral immune responses to the transgene product in mice. Mol Ther 12:264-273.
9. Crystal RG. 1995. Transfer of genes to humans: Early lessons and obstacles to success. Science 270:404-410.
10. Diez S, Navarro G, de ILarduya CT. 2009. In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma. J Gene Med 11:38-45.
11. Dong L, Gao S, Diao H, Chen J, Zhang J. 2008. Galactosylated low molecular weight chitosan as a carrier delivering oligonucleotides to Kupffer cells instead of hepatocytes in vivo. J Biomed Mater Res A 84:777-784.
12. Ho YP, Chen HH, Leong KW, Wang TH. 2006. Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET. J Contr Rel 116:83-89.
13. Hodges BL, Taylor KM, Joseph MF, Bourgeois SA, Scheule RK. 2004. Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides. Mol Ther 10:269-278.
14. Jabr-Milane L, van Vlerken L, Devalapally H, Shenoy D, Komareddy S, Bhavsar M, et al. 2008. Multi-functional nanocarriers for targeted delivery of drugs and genes. J Contr Rel 130:121-128.
15. Kiang T, Wen J, Lim HW, Leong KW. 2004. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials 25:5293-5301.
16. Kobayashi N, Hirata K, Chen S, Kawase A, Nishikawa M, Takakura Y. 2004. Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: Implications for particulate gene delivery systems. J Gene Med 6:455-463.
17. Koping-Hoggard M, Tubulekas I, Guan H, Edwards K, Nilsson M, Varum KM, et al. 2001. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther 8:1108-1121.
18. Koping-Hoggard M, Varum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, et al. 2004. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 11:1441-1452.
19. Lavertu M, Xia Z, Serreqi AN, Berrada M, Rodrigues A, Wang D, et al. 2003. A validated 1H NMR method for the determination of the degree of deacetylation of chitosan. J Pharm Biomed Anal 32:1149-1158.
20. Lee D, Mohatrapa SS. 2008. Chitosan nanoparticle-mediated gene transfer. Methods Mol Biol 433:127-140.
21. Li W, Ma N, Ong LL, Kaminski A, Skrabal C, Ugurlucan M, et al. 2008. Enhanced thoracic gene delivery by magnetic nanobead-mediated vector. J Gene Med 10:897-909.
22. Liu F, Song YK, Liu D. 1999. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6:1258-1266.
23. Luo D, Saltzman WM. 2000. Synthetic DNA delivery systems. Nat Biotechnol 18:33-37.
24. Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, et al. 2001. Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency. J Contr Rel 70:399-421.
25. Meyer KB, Meyer KB, Thompson MM, Levy MY, Barron LG, Szoka FC. 1995. Intratracheal gene delivery to the mouse airway: Characterization of plasmid DNA expression and pharmacokinetics. Gene Ther 2:450-460.
26. Miller AD. 1992. Human gene therapy comes of age. Nature 357:455-460.
27. Mulligan RC. 1993. The basic science of gene therapy. Science 260:926-932.
28. Muzzarelli RAA, Rocchetti R. 1985. Determination of the degree of acetylation of chitosans by first derivative ultraviolet spectrophotometry. Carbohyd Polym 5:461-472.
29. Nash KL, Jamil B, Maguire J, Alexander GJ, Lever AM. 2004. Hepatocyte-specific gene expression from integrated lentiviral vectors. J Gene Med 6:974-983.
30. Nishikawa M, Takakura Y, Hashida M. 2005. Pharmacokinetics of plasmid DNA-based non-viral gene medicine. Adv Genet 53:47-68.
31. Raska M, Moldoveanu Z, Novak J, Hel Z, Novak L, Bozja J, et al. 2008. Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses. Vaccine 26:1541-1551.
32. Rossmanith W, Chabicovsky M, Herkner K, Schulte-Hermann R. 2002. Cellular gene dose and kinetics of gene expression in mouse livers transfected by high-volume tail-vein injection of naked DNA. DNA Cell Biol 21:847-853.
33. Roy K, Mao HQ, Huang SK, Leong KW. 1999. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 5:380-381.
34. Sebestyen MG, Budker VG, Budker T, Subbotin VM, Zhang G, Monahan SD, et al. 2006. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med 8:852-873.
35. Thanou M, Florea BI, Geldof M, Junginger HE, Borchard G. 2002. Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials 23:153-159.
36. Wolff JA, Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, et al. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
37. Zhang G, Budker V, Wolff JA. 1999. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10:1735-1737.
38. Zhang G, Gao X, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, et al. 2004. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther 11:675-682.