-
1
-
-
67651049001
-
The serotonin 5-HT6 receptor: A viable drug target for treating cognitive deficits in Alzheimer's disease
-
Jul;
-
Geldenhuys WJ, Van der Schyf CJ. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. Expert Rev Neurother 2009 Jul; 9 (7): 1073-85
-
(2009)
Expert Rev Neurother
, vol.9
, Issue.7
, pp. 1073-1085
-
-
Geldenhuys, W.J.1
Van Der Schyf, C.J.2
-
2
-
-
52949143104
-
Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease
-
Geldenhuys WJ, Van der Schyf CJ. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease. Curr Top Med Chem 2008; 8 (12): 1035-48
-
(2008)
Curr Top Med Chem
, vol.8
, Issue.12
, pp. 1035-1048
-
-
Geldenhuys, W.J.1
Van Der Schyf, C.J.2
-
3
-
-
77950556899
-
The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs
-
Glennon RA, Siripurapu U, Roth BL, et al. The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs. Curr Top Med Chem 2010; 10 (5): 579-95
-
(2010)
Curr Top Med Chem
, vol.10
, Issue.5
, pp. 579-595
-
-
Glennon, R.A.1
Siripurapu, U.2
Roth, B.L.3
-
4
-
-
33645880762
-
Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents
-
Apr;
-
Holenz J, Pauwels PJ, Diaz JL, et al. Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents. Drug Discov Today 2006 Apr; 11 (7-8): 283-99
-
(2006)
Drug Discov Today
, vol.11
, Issue.7-8
, pp. 283-299
-
-
Holenz, J.1
Pauwels, P.J.2
Diaz, J.L.3
-
5
-
-
52949128037
-
A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory
-
Sep;
-
King MV, Marsden CA, Fone KC. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol Sci 2008 Sep; 29 (9): 482-92
-
(2008)
Trends Pharmacol Sci
, vol.29
, Issue.9
, pp. 482-492
-
-
King, M.V.1
Marsden, C.A.2
Fone, K.C.3
-
6
-
-
0042023711
-
Alzheimer disease in the US population: Prevalence estimates using the 2000 census
-
Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003 Aug; 60 (8): 1119-22
-
Arch Neurol 2003 Aug
, vol.60
, Issue.8
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
-
7
-
-
77955979357
-
Pathways linking Abeta and tau pathologies
-
Aug;
-
LaFerla FM. Pathways linking Abeta and tau pathologies. Biochem Soc Trans 2010 Aug; 38 (4): 993-5
-
(2010)
Biochem Soc Trans
, vol.38
, Issue.4
, pp. 993-995
-
-
Laferla, F.M.1
-
8
-
-
77957017871
-
The development of new therapeutics for Alzheimer's disease
-
Oct;
-
Carter MD, Simms GA, Weaver DF. The development of new therapeutics for Alzheimer's disease. Clin Pharmacol Ther 2010 Oct; 88 (4): 475-86
-
(2010)
Clin Pharmacol Ther
, vol.88
, Issue.4
, pp. 475-486
-
-
Carter, M.D.1
Simms, G.A.2
Weaver, D.F.3
-
9
-
-
79551705492
-
Development of proneurogenic, neuroprotective small molecules
-
Macmillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc 2011; 133 (5): 1428-37
-
(2011)
J Am Chem Soc
, vol.133
, Issue.5
, pp. 1428-1437
-
-
MacMillan, K.S.1
Naidoo, J.2
Liang, J.3
-
10
-
-
0035977026
-
The human serotonin 5-HT4 receptor regulates secretion of nonamyloidogenic precursor protein
-
Nov 30;
-
Robert SJ, Zugaza JL, Fischmeister R, et al. The human serotonin 5-HT4 receptor regulates secretion of nonamyloidogenic precursor protein. J Biol Chem 2001 Nov 30; 276 (48): 44881-8
-
(2001)
J Biol Chem
, vol.276
, Issue.48
, pp. 44881-44888
-
-
Robert, S.J.1
Zugaza, J.L.2
Fischmeister, R.3
-
11
-
-
0028177450
-
5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex
-
Jun 2;
-
Consolo S, Arnaboldi S, Giorgi S, et al. 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. Neuroreport 1994 Jun 2; 5 (10): 1230-2
-
(1994)
Neuroreport
, vol.5
, Issue.10
, pp. 1230-1232
-
-
Consolo, S.1
Arnaboldi, S.2
Giorgi, S.3
-
12
-
-
47849112578
-
6 receptor function in behavioral symptoms of Alzheimer's disease
-
Marcos B,Garcia-Alloza M, Gil-Bea FJ, et al. Involvement of an altered 5-HT-{6} receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimers Dis 2008 May; 14 (1): 43-50 (Pubitemid 352039014)
-
(2008)
Journal of Alzheimer's Disease
, vol.14
, Issue.1
, pp. 43-50
-
-
Marcos, B.1
Garcia-Alloza, M.2
Gil-Bea, F.J.3
Chuang, T.T.4
Francis, P.T.5
Chen, C.P.6
Tsang, S.W.T.Y.7
Lai, M.K.P.8
Ramirez, M.J.9
-
13
-
-
52949099850
-
Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat
-
Oct;
-
Marcos B, Chuang TT, Gil-Bea FJ, et al. Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br J Pharmacol 2008 Oct; 155 (3): 434-40
-
(2008)
Br J Pharmacol
, vol.155
, Issue.3
, pp. 434-440
-
-
Marcos, B.1
Chuang, T.T.2
Gil-Bea, F.J.3
-
14
-
-
57849111780
-
Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse
-
Jan;
-
Da Silva Costa V, Duchatelle P, Boulouard M, et al. Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse. Neuropsychopharmacology 2009 Jan; 34 (2): 488-500
-
(2009)
Neuropsychopharmacology
, vol.34
, Issue.2
, pp. 488-500
-
-
Da Silva Costa, V.1
Duchatelle, P.2
Boulouard, M.3
-
15
-
-
3142704173
-
Serotonin receptors represents highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders
-
Roth BL, Hanizavareh SM, Blum AE. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology (Berl) 2004 Jun; 174 (1): 17-24 (Pubitemid 38925086)
-
(2004)
Psychopharmacology
, vol.174
, Issue.1
, pp. 17-24
-
-
Roth, B.L.1
Hanizavareh, S.M.2
Blum, A.E.3
-
16
-
-
61749086565
-
Serotonin 1A receptors in the pathophysiology of schizophrenia: Development of novel cognition-enhancing therapeutics
-
Oct;
-
Sumiyoshi T, Bubenikova-Valesova V, Horacek J, et al. Serotonin 1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics. Adv Ther 2008 Oct; 25 (10): 1037-56
-
(2008)
Adv Ther
, vol.25
, Issue.10
, pp. 1037-1056
-
-
Sumiyoshi, T.1
Bubenikova-Valesova, V.2
Horacek, J.3
-
17
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993 Mar 1; 90 (5): 1977-81 (Pubitemid 23069980)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.5
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
18
-
-
0023026613
-
A racial difference in apolipoprotein E allele frequencies between the Japanese and Caucasian populations
-
Eto M, Watanabe K, Ishii K. A racial difference in apolipoprotein E allele frequencies between the Japanese and Caucasian populations. Clin Genet 1986 Nov; 30 (5): 422-7 (Pubitemid 17200192)
-
(1986)
Clinical Genetics
, vol.30
, Issue.5
, pp. 422-427
-
-
Eto, M.1
Watanabe, K.2
Ishii, K.3
-
19
-
-
77954369899
-
Beyond the cholinergic hypo thesis: Do current drugs work in Alzheimer's disease?
-
Aug;
-
Martorana A, Esposito Z, Koch G. Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease? CNS Neurosci Ther 2010 Aug; 16 (4): 235-45
-
(2010)
CNS Neurosci Ther
, vol.16
, Issue.4
, pp. 235-245
-
-
Martorana, A.1
Esposito, Z.2
Koch, G.3
-
20
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Jul 30;
-
Bartus RT, Dean 3rd RL, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982 Jul 30; 217 (4558): 408-14
-
(1982)
Science
, vol.217
, Issue.4558
, pp. 408-414
-
-
Bartus, R.T.1
Dean Iii, R.L.2
Beer, B.3
-
21
-
-
0042020173
-
Treatment of Alzheimer's disease: Current status and new perspectives
-
DOI 10.1016/S1474-4422(03)00502-7
-
Scarpini E, Scheltens P, Feldman H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol 2003 Sep; 2 (9): 539-47 (Pubitemid 36994993)
-
(2003)
Lancet Neurology
, vol.2
, Issue.9
, pp. 539-547
-
-
Scarpini, E.1
Scheltens, P.2
Feldman, H.3
-
23
-
-
2942514710
-
Cholinesterase inhibitors used in the treatment of Alzheimer's disease: The relationship between pharmacological effects and clinical efficacy
-
DOI 10.2165/00002512-200421070-00004
-
Wilkinson DG, Francis PT, Schwam E, et al. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging 2004; 21 (7): 453-78 (Pubitemid 38736890)
-
(2004)
Drugs and Aging
, vol.21
, Issue.7
, pp. 453-478
-
-
Wilkinson, D.G.1
Francis, P.T.2
Schwam, E.3
Payne-Parrish, J.4
-
24
-
-
0037096921
-
Guidelines for managing Alzheimer's disease: Part II. Treatment
-
Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part II. Treatment. Am Fam Physician 2002 Jun 15; 65 (12): 2525-34 (Pubitemid 34664744)
-
(2002)
American Family Physician
, vol.65
, Issue.12
, pp. 2525-2534
-
-
Cummings, J.L.1
Frank, J.C.2
Cherry, D.3
Kohatsu, N.D.4
Kemp, B.5
Hewett, L.6
Mittman, B.7
-
25
-
-
0036606398
-
Guidelines for managing Alzheimer's disease: Part I. Assessment
-
Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part I. Assessment. Am Fam Physician 2002 Jun 1; 65 (11): 2263-72 (Pubitemid 34603057)
-
(2002)
American Family Physician
, vol.65
, Issue.11
, pp. 2263-2272
-
-
Cummings, J.L.1
Frank, J.C.2
Cherry, D.3
Kohatsu, N.D.4
Kemp, B.5
Hewett, L.6
Mittman, B.7
-
26
-
-
33750329955
-
Clinical practice with anti-dementia drugs: A consensus statement from British Association for Psychopharmacology
-
DOI 10.1177/0269881106068299
-
Burns A, O'Brien J, Auriacombe S, et al. Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology. J Psychopharmacol 2006 Nov; 20 (6): 732-55 (Pubitemid 44622739)
-
(2006)
Journal of Psychopharmacology
, vol.20
, Issue.6
, pp. 732-755
-
-
Burns, A.1
O'Brien, J.2
-
27
-
-
79952442060
-
Neuroprotective therapeutics for Alzheimer's disease: Progress and prospects
-
Palmer AM. Neuroprotective therapeutics for Alzheimer's disease: progress and prospects. Trends Pharmacol Sci 2011; 32 (3): 141-7
-
(2011)
Trends Pharmacol Sci
, vol.32
, Issue.3
, pp. 141-147
-
-
Palmer, A.M.1
-
28
-
-
34250819839
-
Intracellular amyloidbeta in Alzheimer's disease
-
Jul;
-
LaFerla FM, Green KN, Oddo S. Intracellular amyloidbeta in Alzheimer's disease. Nat Rev Neurosci 2007 Jul; 8 (7): 499-509
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.7
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
29
-
-
56349119351
-
Linking Abeta and tau in late-onset Alzheimer's disease: A dual pathway hypothesis
-
Nov 26;
-
Small SA, Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008 Nov 26; 60 (4): 534-42
-
(2008)
Neuron
, vol.60
, Issue.4
, pp. 534-542
-
-
Small, S.A.1
Duff, K.2
-
30
-
-
35748936729
-
Secretase inhibitors andmodulators for the treatment of Alzheimer's disease
-
Olsen RE, Marcin LR. Secretase inhibitors andmodulators for the treatment of Alzheimer's disease. Annu Rep Med Chem 2007; 42: 27-43
-
(2007)
Annu Rep Med Chem
, vol.42
, pp. 27-43
-
-
Olsen, R.E.1
Marcin, L.R.2
-
31
-
-
78149488153
-
Amyloidindependent mechanisms in Alzheimer's disease pathogenesis
-
Pimplikar SW, Nixon RA, Robakis NK, et al. Amyloidindependent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 2010; 30 (45): 14946-54
-
(2010)
J Neurosci
, vol.30
, Issue.45
, pp. 14946-14954
-
-
Pimplikar, S.W.1
Nixon, R.A.2
Robakis, N.K.3
-
33
-
-
33750510024
-
Alzheimer 100 - Highlights in the history of Alzheimer research
-
DOI 10.1007/s00702-006-0578-3, 100 Years of Alzheimer's Disease
-
Jellinger KA. Alzheimer 100: highlights in the history of Alzheimer research. J Neural Transm 2006 Nov; 113 (11): 1603-23 (Pubitemid 44660049)
-
(2006)
Journal of Neural Transmission
, vol.113
, Issue.11
, pp. 1603-1623
-
-
Jellinger, K.A.1
-
34
-
-
0037315878
-
A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease
-
DOI 10.2174/1389450033346957
-
Lahiri DK, Farlow MR, Sambamurti K, et al. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr Drug Targets 2003 Feb; 4 (2): 97-112 (Pubitemid 36553583)
-
(2003)
Current Drug Targets
, vol.4
, Issue.2
, pp. 97-112
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
Greig, N.H.4
Giacobini, E.5
Schneider, L.S.6
-
35
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Aug;
-
Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008 Aug; 14 (8): 837-42
-
(2008)
Nat Med
, vol.14
, Issue.8
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
-
36
-
-
84862833600
-
Tau in Alzheimer disease and related tauopathies
-
Iqbal K, Liu F, Gong CX, et al. Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res 2010; 7 (8): 656-64
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.8
, pp. 656-664
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
-
37
-
-
77955949134
-
Alzheimer's disease neurofibrillary degeneration: Pivotal and multifactorial
-
Aug;
-
Iqbal K, Wang X, Blanchard J, et al. Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochem Soc Trans 2010 Aug; 38 (4): 962-6
-
(2010)
Biochem Soc Trans
, vol.38
, Issue.4
, pp. 962-966
-
-
Iqbal, K.1
Wang, X.2
Blanchard, J.3
-
38
-
-
78650376641
-
Recent advances in the discovery of GSK-3 inhibitors and a perspective on their utility for the treatment of Alzheimer's disease
-
Gentles RG, Hu S, Dubowchik GM. Recent advances in the discovery of GSK-3 inhibitors and a perspective on their utility for the treatment of Alzheimer's disease. Annu Rep Med Chem 2009; 44: 3-26
-
(2009)
Annu Rep Med Chem
, vol.44
, pp. 3-26
-
-
Gentles, R.G.1
Hu, S.2
Dubowchik, G.M.3
-
39
-
-
78349246723
-
Age-related progressive synaptic dysfunction: The critical role of presenilin 1
-
Auffret A, Mariani J, Rovira C. Age-related progressive synaptic dysfunction: the critical role of presenilin 1. Rev Neurosci 2010; 21 (4): 239-50
-
(2010)
Rev Neurosci
, vol.21
, Issue.4
, pp. 239-250
-
-
Auffret, A.1
Mariani, J.2
Rovira, C.3
-
40
-
-
77957770781
-
Back to the plaque: Emerging studies that refocus attention on the neuritic plaque in Alzheimer's disease
-
Nelson RB. Back to the plaque: emerging studies that refocus attention on the neuritic plaque in Alzheimer's disease. Annu Rep Med Chem 2010; 45: 315-27
-
(2010)
Annu Rep Med Chem
, vol.45
, pp. 315-327
-
-
Nelson, R.B.1
-
41
-
-
0034100397
-
Role of serotonin in memory impairment
-
Buhot MC, Martin S, Segu L. Role of serotonin in memory impairment. Ann Med 2000 Apr; 32 (3): 210-21 (Pubitemid 30237566)
-
(2000)
Annals of Medicine
, vol.32
, Issue.3
, pp. 210-221
-
-
Buhot, M.-C.1
Martin, S.2
Segu, L.3
-
42
-
-
0032918815
-
Serotonin receptors and cognitive behavior - An update
-
Buhot MC, Malleret G, Segu L. Serotonin receptors and cognitive behaviour: an update. IDrugs 1999 May; 2 (5): 426-37 (Pubitemid 29230023)
-
(1999)
IDrugs
, vol.2
, Issue.5
, pp. 426-437
-
-
Buhot, M.-C.1
Malleret, G.2
Segu, L.3
-
43
-
-
51249116716
-
Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role
-
Dec 16;
-
Perez-Garcia G, Meneses A. Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role. Behav Brain Res 2008 Dec 16; 195 (1): 17-29
-
(2008)
Behav Brain Res
, vol.195
, Issue.1
, pp. 17-29
-
-
Perez-Garcia, G.1
Meneses, A.2
-
44
-
-
0031944188
-
Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging
-
DOI 10.1016/S0893-133X(97)00194-2, PII S0893133X97001942
-
Meltzer CC, Smith G, DeKosky ST, et al. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology 1998 Jun; 18 (6): 407-30 (Pubitemid 28202350)
-
(1998)
Neuropsychopharmacology
, vol.18
, Issue.6
, pp. 407-430
-
-
Meltzer, C.C.1
Smith, G.2
Dekosky, S.T.3
Pollock, B.G.4
Mathis, C.A.5
Moore, R.Y.6
Kupfer, D.J.7
Reynolds III, C.F.8
-
45
-
-
0026657470
-
Sub-types of serotonin receptors: Biochemical changes and pharmacological consequences
-
Leonard BE. Sub-types of serotonin receptors: biochemical changes and pharmacological consequences. Int Clin Psychopharmacol 1992; 7 (1): 13-21
-
(1992)
Int Clin Psychopharmacol
, vol.7
, Issue.1
, pp. 13-21
-
-
Leonard, B.E.1
-
47
-
-
0025944364
-
Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain: A combined in situ hybridisation/in vitro receptor autoradiographic study
-
Oct 4;
-
Chalmers DT, Watson SJ. Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain: a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res 1991 Oct 4; 561 (1): 51-60
-
(1991)
Brain Res
, vol.561
, Issue.1
, pp. 51-60
-
-
Chalmers, D.T.1
Watson, S.J.2
-
48
-
-
52949140574
-
5-HT1A receptor, an old target for new therapeutic agents
-
Lacivita E, Leopoldo M, Berardi F, et al. 5-HT1A receptor, an old target for new therapeutic agents. Curr Top Med Chem 2008; 8 (12): 1024-34
-
(2008)
Curr Top Med Chem
, vol.8
, Issue.12
, pp. 1024-1034
-
-
Lacivita, E.1
Leopoldo, M.2
Berardi, F.3
-
49
-
-
77952736758
-
The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists
-
May 27;
-
Childers Jr WE, Havran LM, Asselin M, et al. The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. JMed Chem 2010 May 27; 53 (10): 4066-84
-
(2010)
JMed Chem
, vol.53
, Issue.10
, pp. 4066-4084
-
-
Childers Jr., W.E.1
Havran, L.M.2
Asselin, M.3
-
50
-
-
0037651151
-
1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease
-
DOI 10.1016/S0006-8993(03)02554-X
-
Lai MK, Tsang SW, Francis PT, et al. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain Res 2003 Jun 6; 974 (1-2): 82-7 (Pubitemid 36549222)
-
(2003)
Brain Research
, vol.974
, Issue.1-2
, pp. 82-87
-
-
Lai, M.K.P.1
Tsang, S.W.Y.2
Francis, P.T.3
Esiri, M.M.4
Keene, J.5
Hope, T.6
Chen, C.P.L.-H.7
-
51
-
-
4644357307
-
1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: A combined neurochemical and behavioral analysis
-
DOI 10.1124/jpet.104.069625
-
Millan MJ, Gobert A, Roux S, et al. The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis. J Pharmacol Exp Ther 2004 Oct; 311 (1): 190-203 (Pubitemid 39287799)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.311
, Issue.1
, pp. 190-203
-
-
Millan, M.J.1
Gobert, A.2
Roux, S.3
Porsolt, R.4
Meneses, A.5
Carli, M.6
Di Cara, B.7
Jaffard, R.8
Rivet, J.-M.9
Lestage, P.10
Mocaer, E.11
Peglion, J.-L.12
Dekeyne, A.13
-
52
-
-
0030608470
-
4 receptor mRNA in rat brain by in situ hybridization histochemistry
-
DOI 10.1016/S0169-328X(96)00248-3, PII S0169328X96002483
-
Vilaro MT, Cortes R, Gerald C, et al. Localization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry. Brain Res Mol Brain Res 1996 Dec 31; 43 (1-2): 356-60 (Pubitemid 27042427)
-
(1996)
Molecular Brain Research
, vol.43
, Issue.1-2
, pp. 356-360
-
-
Vilaro, M.T.1
Cortes, R.2
Gerald, C.3
Branchek, T.A.4
Palacios, J.M.5
Mengod, G.6
-
53
-
-
33751403136
-
Activation of 5-HT4 receptors inhibits secretion of β-amyloid peptides and increases neuronal survival
-
DOI 10.1016/j.expneurol.2006.07.021, PII S0014488606004419
-
Cho S, Hu Y. Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. Exp Neurol 2007 Jan; 203 (1): 274-8 (Pubitemid 44821167)
-
(2007)
Experimental Neurology
, vol.203
, Issue.1
, pp. 274-278
-
-
Cho, S.1
Hu, Y.2
-
54
-
-
34047218120
-
4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice
-
DOI 10.1038/sj.bjp.0707178, PII 0707178
-
Cachard-Chastel M, Lezoualc'h F, Dewachter I, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol 2007 Apr; 150 (7): 883-92 (Pubitemid 46536635)
-
(2007)
British Journal of Pharmacology
, vol.150
, Issue.7
, pp. 883-892
-
-
Cachard-Chastel, M.1
Lezoualc'h, F.2
Dewachter, I.3
Delomenie, C.4
Croes, S.5
Devijver, H.6
Langlois, M.7
Van Leuven, F.8
Sicsic, S.9
Gardier, A.M.10
-
55
-
-
17044427967
-
Modifications of 5-HT4 receptor expression in rat brain during memory consolidation
-
Apr 25;
-
Manuel-Apolinar L, Rocha L, Pascoe D, et al. Modifications of 5-HT4 receptor expression in rat brain during memory consolidation. Brain Res 2005 Apr 25; 1042 (1): 73-81
-
(2005)
Brain Res
, vol.1042
, Issue.1
, pp. 73-81
-
-
Manuel-Apolinar, L.1
Rocha, L.2
Pascoe, D.3
-
56
-
-
0036070739
-
4 receptor partial agonist with potent cognition-enhancing properties
-
DOI 10.1124/jpet.102.034249
-
Moser PC, Bergis OE, Jegham S, et al. SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J Pharmacol Exp Ther 2002 Aug; 302 (2): 731-41 (Pubitemid 34787242)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.302
, Issue.2
, pp. 731-741
-
-
Moser, P.C.1
Bergis, O.E.2
Jegham, S.3
Lochead, A.4
Duconseille, E.5
Terranova, J.-P.6
Caille, D.7
Berque-Bestel, I.8
Lezoualc'H, F.9
Fischmeister, R.10
Dumuis, A.11
Bockaert, J.12
George, P.13
Soubrie, P.14
Scatton, B.15
-
57
-
-
0030610872
-
4 receptors improve social olfactory memory in the rat
-
DOI 10.1016/S0028-3908(96)00169-4, PII S0028390896001694
-
Letty S, Child R, Dumuis A, et al. 5-HT4 receptors improve social olfactory memory in the rat. Neuropharmacology 1997 Apr-May; 36 (4-5): 681-7 (Pubitemid 27272114)
-
(1997)
Neuropharmacology
, vol.36
, Issue.4-5
, pp. 681-687
-
-
Letty, S.1
Child, R.2
Dumuis, A.3
Pantaloni, A.4
Bockaert, J.5
Rondouin, G.6
-
58
-
-
9144255761
-
4 receptors partial agonist, and an antagonist
-
DOI 10.1016/j.neuropharm.2004.06.033, PII S0028390804002266
-
Marchetti E, Chaillan FA, Dumuis A, et al. Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist. Neuropharmacology 2004 Dec; 47 (7): 1021-35 (Pubitemid 39539226)
-
(2004)
Neuropharmacology
, vol.47
, Issue.7
, pp. 1021-1035
-
-
Marchetti, E.1
Chaillan, F.A.2
Dumuis, A.3
Bockaert, J.4
Soumireu-Mourat, B.5
Roman, F.S.6
-
59
-
-
44649202735
-
Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats
-
Jul;
-
Marchetti E, Jacquet M, Jeltsch H, et al. Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats. Neurobiol Learn Mem 2008 Jul; 90 (1): 185-91
-
(2008)
Neurobiol Learn Mem
, vol.90
, Issue.1
, pp. 185-191
-
-
Marchetti, E.1
Jacquet, M.2
Jeltsch, H.3
-
61
-
-
33750709697
-
4 receptor partial agonist, in animal models of amnesia
-
DOI 10.1016/j.brainres.2006.08.108, PII S0006899306026588
-
Micale V, Leggio GM, Mazzola C, et al. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. Brain Res 2006 Nov 22; 1121 (1): 207-15 (Pubitemid 44708901)
-
(2006)
Brain Research
, vol.1121
, Issue.1
, pp. 207-215
-
-
Micale, V.1
Marco Leggio, G.2
Mazzola, C.3
Drago, F.4
-
62
-
-
38049112769
-
Prucalopride and donepezil act synergistically to reverse scopolamineinduced memory deficit in C57Bl/6j mice
-
Mar 5
-
Cachard-Chastel M, Devers S, Sicsic S, et al. Prucalopride and donepezil act synergistically to reverse scopolamineinduced memory deficit in C57Bl/6j mice. Behav Brain Res 2008 Mar 5; 187 (2): 455-61
-
(2008)
Behav Brain Res
, vol.187
, Issue.2
, pp. 455-461
-
-
Cachard-Chastel, M.1
Devers, S.2
Sicsic, S.3
-
63
-
-
34548026555
-
4 agonist, enhances memory and hippocampal acetylcholine efflux
-
DOI 10.1016/j.neuropharm.2007.06.016, PII S0028390807001918
-
Mohler EG, Shacham S, Noiman S, et al. VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux. Neuropharmacology 2007 Sep; 53 (4): 563-73 (Pubitemid 47284188)
-
(2007)
Neuropharmacology
, vol.53
, Issue.4
, pp. 563-573
-
-
Mohler, E.G.1
Shacham, S.2
Noiman, S.3
Lezoualc'h, F.4
Robert, S.5
Gastineau, M.6
Rutkowski, J.7
Marantz, Y.8
Dumuis, A.9
Bockaert, J.10
Gold, P.E.11
Ragozzino, M.E.12
-
64
-
-
0142121562
-
Acquisition, retention, and recall of memory after injection of RS67333, a 5-HT4 receptor agonist, into the nucleus basalis magnocellularis of the rat
-
DOI 10.1101/lm.67303
-
Orsetti M, Dellarole A, Ferri S, et al. Acquisition, retention, and recall of memory after injection of RS67333, a 5-HT(4) receptor agonist, into the nucleus basalis magnocellularis of the rat. Learn Mem 2003 Sep-Oct; 10 (5): 420-6 (Pubitemid 37266687)
-
(2003)
Learning and Memory
, vol.10
, Issue.5
, pp. 420-426
-
-
Orsetti, M.1
Dellarole, A.2
Ferri, S.3
Ghi, P.4
-
65
-
-
27844475728
-
6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat
-
DOI 10.1038/sj.npp.1300777, PII 1300777
-
Lieben CK, Blokland A, Sik A, et al. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 2005 Dec; 30 (12): 2169-79 (Pubitemid 41643968)
-
(2005)
Neuropsychopharmacology
, vol.30
, Issue.12
, pp. 2169-2179
-
-
Lieben, C.K.J.1
Blokland, A.2
Sik, A.3
Sung, E.4
Van Nieuwenhuizen, P.5
Schreiber, R.6
-
66
-
-
69349100072
-
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities
-
Oct 15;
-
Schaffhauser H, Mathiasen JR, Dicamillo A, et al. Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. Biochem Pharmacol 2009 Oct 15; 78 (8): 1035-42
-
(2009)
Biochem Pharmacol
, vol.78
, Issue.8
, pp. 1035-1042
-
-
Schaffhauser, H.1
Mathiasen, J.R.2
Dicamillo, A.3
-
67
-
-
0020643057
-
Action of dimebon on histamine receptors
-
Matveeva IA. Action of dimebon on histamine receptors. Farmakol Toksikol 1983 Jul-Aug; 46 (4): 27-9 (Pubitemid 13038960)
-
(1983)
Farmakologiya i Toksikologiya
, vol.46
, Issue.4
, pp. 27-29
-
-
Matveeva, I.A.1
-
68
-
-
77949769167
-
From anti-allergic to anti-Alzheimer's: Molecular pharmacology of dimebon
-
Mar;
-
Okun I, Tkachenko SE, Khvat A, et al. From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr Alzheimer Res 2009 Mar; 7 (2): 97-112
-
(2009)
Curr Alzheimer Res
, vol.7
, Issue.2
, pp. 97-112
-
-
Okun, I.1
Tkachenko, S.E.2
Khvat, A.3
-
69
-
-
0033635668
-
Dimebon improves learning in animals with experimental Alzheimer's disease
-
Jun;
-
Lermontova NN, Lukoyanov NV, Serkova TP, et al. Dimebon improves learning in animals with experimental Alzheimer's disease. Bull Exp Biol Med 2000 Jun; 129 (6): 544-6
-
(2000)
Bull Exp Biol Med
, vol.129
, Issue.6
, pp. 544-546
-
-
Lermontova, N.N.1
Lukoyanov, N.V.2
Serkova, T.P.3
-
70
-
-
77957138323
-
The rise and fall of dimebon
-
Oct;
-
Bezprozvanny I. The rise and fall of dimebon. Drug News Perspect 2010 Oct; 23 (8): 518-23
-
(2010)
Drug News Perspect
, vol.23
, Issue.8
, pp. 518-523
-
-
Bezprozvanny, I.1
-
71
-
-
0034944798
-
Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer
-
Bachurin S, Bukatina E, Lermontova N, et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 2001 Jun; 939: 425-35 (Pubitemid 32620096)
-
(2001)
Annals of the New York Academy of Sciences
, vol.939
, pp. 425-435
-
-
Bachurin, S.1
Bukatina, E.2
Lermontova, N.3
Tkachenko, S.4
Afanasiev, A.5
Grigoriev, V.6
Grigorieva, I.7
Ivanov, Yu.8
Sablin, S.9
Zefirov, N.10
-
72
-
-
47149108940
-
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
DOI 10.1016/S0140-6736(08)61074-0, PII S0140673608610740
-
Doody RS, Gavrilova SI, Sano M, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebocontrolled study. Lancet 2008 Jul 19; 372 (9634): 207-15 (Pubitemid 351978110)
-
(2008)
The Lancet
, vol.372
, Issue.9634
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
Thomas, R.G.4
Aisen, P.S.5
Bachurin, S.O.6
Seely, L.7
Hung, D.8
-
73
-
-
0036218369
-
2+ channels
-
Lermontova NN, Redkozubov AE, Shevtsova EF, et al. Dimebon and tacrine inhibit neurotoxic action of betaamyloid in culture and block L-type Ca(2+) channels. Bull Exp Biol Med 2001 Nov; 132 (5): 1079-83 (Pubitemid 34295938)
-
(2001)
Bulletin of Experimental Biology and Medicine
, vol.132
, Issue.5
, pp. 1079-1083
-
-
Lermontova, N.N.1
Redkozubov, A.E.2
Shevtsova, E.F.3
Serkova, T.P.4
Kireeva, E.G.5
Bachurin, S.O.6
-
74
-
-
0027481384
-
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
-
Monsma Jr FJ, Shen Y, Ward RP, et al. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 1993 Mar; 43 (3): 320-7 (Pubitemid 23081986)
-
(1993)
Molecular Pharmacology
, vol.43
, Issue.3
, pp. 320-327
-
-
Monsma Jr., F.J.1
Shen, Y.2
Ward, R.P.3
Hamblin, M.W.4
Sibley, D.R.5
-
75
-
-
0027212940
-
6) receptor: Molecular cloning, localization and stimulation of cAMP accumulation
-
DOI 10.1006/bbrc.1993.1619
-
Ruat M, Traiffort E, Arrang JM, et al. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem Biophys Res Commun 1993 May 28; 193 (1): 268-76 (Pubitemid 23199942)
-
(1993)
Biochemical and Biophysical Research Communications
, vol.193
, Issue.1
, pp. 268-276
-
-
Ruat, M.1
Traiffort, E.2
Arrang, J.-M.3
Tardivel-Lacombe, J.4
Diaz, J.5
Leurs, R.6
Schwartz, J.-C.7
-
76
-
-
53449090731
-
An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
-
Nov;
-
Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 2008 Nov; 55 (6): 1015-22
-
(2008)
Neuropharmacology
, vol.55
, Issue.6
, pp. 1015-1022
-
-
Fone, K.C.1
-
78
-
-
70349734329
-
Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus
-
Dec 1;
-
West PJ, Marcy VR, Marino MJ, et al. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience 2009 Dec 1; 164 (2): 692-701
-
(2009)
Neuroscience
, vol.164
, Issue.2
, pp. 692-701
-
-
West, P.J.1
Marcy, V.R.2
Marino, M.J.3
-
79
-
-
0347824360
-
Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling
-
DOI 10.1124/mol.64.6.1295
-
Hirst WD, Abrahamsen B, Blaney FE, et al. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol 2003 Dec; 64 (6): 1295-308 (Pubitemid 37532219)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.6
, pp. 1295-1308
-
-
Hirst, W.D.1
Abrahamsen, B.2
Blaney, F.E.3
Calver, A.R.4
Aloj, L.5
Price, G.W.6
Medhurst, A.D.7
-
80
-
-
33746277764
-
A null mutation of the serotonin 6 receptor alters acute responses to ethanol
-
DOI 10.1038/sj.npp.1301030, PII 1301030
-
Bonasera SJ, Chu HM, Brennan TJ, et al. A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology 2006 Aug; 31 (8): 1801-13 (Pubitemid 44106712)
-
(2006)
Neuropsychopharmacology
, vol.31
, Issue.8
, pp. 1801-1813
-
-
Bonasera, S.J.1
Chu, H.-M.2
Brennan, T.J.3
Tecott, L.H.4
-
81
-
-
34247104699
-
6 receptor stimulation
-
DOI 10.1523/JNEUROSCI.3110-06.2007
-
Svenningsson P, Tzavara ET, Qi H, et al. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J Neurosci 2007 Apr 11; 27 (15): 4201-9 (Pubitemid 46597167)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.15
, pp. 4201-4209
-
-
Svenningsson, P.1
Tzavara, E.T.2
Qi, H.3
Carruthers, R.4
Witkin, J.M.5
Nomikos, G.G.6
Greengard, P.7
-
82
-
-
0346973946
-
6 receptor antagonist, Ro 04-6790
-
DOI 10.1007/s00213-003-1552-5
-
Woolley ML, Marsden CA, Sleight AJ, et al. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berl) 2003 Dec; 170 (4): 358-67 (Pubitemid 38010507)
-
(2003)
Psychopharmacology
, vol.170
, Issue.4
, pp. 358-367
-
-
Woolley, M.L.1
Marsden, C.A.2
Sleight, A.J.3
Fone, K.C.F.4
-
83
-
-
0034742606
-
6 receptors in retention of spatial learning in the Morris water maze
-
DOI 10.1016/S0028-3908(01)00056-9, PII S0028390801000569
-
Woolley ML, Bentley JC, Sleight AJ, et al. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 2001 Aug; 41 (2): 210-9 (Pubitemid 32728092)
-
(2001)
Neuropharmacology
, vol.41
, Issue.2
, pp. 210-219
-
-
Woolley, M.L.1
Bentley, J.C.2
Sleight, A.J.3
Marsden, C.A.4
Fone, K.C.F.5
-
84
-
-
33751162382
-
6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models
-
DOI 10.1016/j.ejphar.2006.09.049, PII S0014299906010454
-
Hirst WD, Stean TO, Rogers DC, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol 2006 Dec 28; 553 (1-3): 109-19 (Pubitemid 44779592)
-
(2006)
European Journal of Pharmacology
, vol.553
, Issue.1-3
, pp. 109-119
-
-
Hirst, W.D.1
Stean, T.O.2
Rogers, D.C.3
Sunter, D.4
Pugh, P.5
Moss, S.F.6
Bromidge, S.M.7
Riley, G.8
Smith, D.R.9
Bartlett, S.10
Heidbreder, C.A.11
Atkins, A.R.12
Lacroix, L.P.13
Dawson, L.A.14
Foley, A.G.15
Regan, C.M.16
Upton, N.17
-
85
-
-
22044457309
-
6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task
-
DOI 10.1016/j.pbb.2005.05.005, PII S0091305705001693
-
Perez-Garcia G, Meneses A. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol Biochem Behav 2005 Jul; 81 (3): 673-82 (Pubitemid 40966815)
-
(2005)
Pharmacology Biochemistry and Behavior
, vol.81
, Issue.3
, pp. 673-682
-
-
Perez-Garcia, G.1
Meneses, A.2
-
86
-
-
0346057791
-
6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats
-
DOI 10.1038/sj.npp.1300332
-
Foley AG, Murphy KJ, Hirst WD, et al. The 5-HT(6) receptor antagonist SB-271046 reverses scopolaminedisrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 2004 Jan; 29 (1): 93-100 (Pubitemid 38068018)
-
(2004)
Neuropsychopharmacology
, vol.29
, Issue.1
, pp. 93-100
-
-
Foley, A.G.1
Murphy, K.J.2
Hirst, W.D.3
Gallagher, H.C.4
Hagan, J.J.5
Upton, N.6
Walsh, F.S.7
Regan, C.M.8
-
87
-
-
0037468873
-
6 receptor antagonist
-
DOI 10.1021/jm021085c
-
Riemer C, Borroni E, Levet-Trafit B, et al. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. J Med Chem 2003 Mar 27; 46 (7): 1273-6 (Pubitemid 36428233)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.7
, pp. 1273-1276
-
-
Riemer, C.1
Borroni, E.2
Levet-Trafit, B.3
Martin, J.R.4
Poli, S.5
Porter, R.H.P.6
Bos, M.7
-
88
-
-
0030614562
-
6 receptor-like material in the rat central nervous system
-
DOI 10.1016/S0006-8993(96)01224-3, PII S0006899396012243
-
Gerard C, Martres MP, Lefevre K, et al. Immunolocalization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain Res 1997 Jan 23; 746 (1-2): 207-19 (Pubitemid 27060349)
-
(1997)
Brain Research
, vol.746
, Issue.1-2
, pp. 207-219
-
-
Gerard, C.1
Martres, M.-P.2
Lefevre, K.3
Miquel, M.-C.4
Verge, D.5
Lanfumey, L.6
Doucet, E.7
Hamon, M.8
El Mestikawy, S.9
-
89
-
-
46749118971
-
6 Receptor Antagonists as Novel Cognitive Enhancing Agents for Alzheimer's Disease
-
DOI 10.1016/j.nurt.2008.05.008, PII S1933721308001001
-
Upton N, Chuang TT, Hunter AJ, et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents forAlzheimer's disease. Neurotherapeutics 2008 Jul; 5 (3): 458-69 (Pubitemid 351952494)
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 458-469
-
-
Upton, N.1
Chuang, T.T.2
Hunter, A.J.3
Virley, D.J.4
-
90
-
-
3042561627
-
6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation - An effect sensitive to NMDA receptor antagonism
-
DOI 10.1016/j.neuropharm.2004.03.012, PII S0028390804000863
-
King MV, Sleight AJ, Woolley ML, et al. 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation: an effect sensitive to NMDA receptor antagonism. Neuropharmacology 2004 Aug; 47 (2): 195-204 (Pubitemid 38824643)
-
(2004)
Neuropharmacology
, vol.47
, Issue.2
, pp. 195-204
-
-
King, M.V.1
Sleight, A.J.2
Woolley, M.L.3
Topham, I.A.4
Marsden, C.A.5
Fone, K.C.F.6
-
91
-
-
42049114860
-
6 receptor agonists: WAY-181187 and WAY-208466
-
DOI 10.1038/sj.npp.1301503, PII 1301503
-
Schechter LE, Lin Q, Smith DL, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology 2008 May; 33 (6): 1323-35 (Pubitemid 351521711)
-
(2008)
Neuropsychopharmacology
, vol.33
, Issue.6
, pp. 1323-1335
-
-
Schechter, L.E.1
Lin, Q.2
Smith, D.L.3
Zhang, G.4
Shan, Q.5
Platt, B.6
Brandt, M.R.7
Dawson, L.A.8
Cole, D.9
Bernotas, R.10
Robichaud, A.11
Rosenzweig-Lipson, S.12
Beyer, C.E.13
-
92
-
-
44149105604
-
The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats
-
Jun;
-
Foley AG, Hirst WD, Gallagher HC, et al. The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 2008 Jun; 54 (8): 1166-74
-
(2008)
Neuropharmacology
, vol.54
, Issue.8
, pp. 1166-1174
-
-
Foley, A.G.1
Hirst, W.D.2
Gallagher, H.C.3
-
93
-
-
77950857616
-
New 5-HT(1A) receptor ligands containing a N0-cyanoisonicotinamidine nucleus: Synthesis and in vitro pharmacological evaluation
-
May 1;
-
Fiorino F, Severino B, De Angelis F, et al. New 5-HT(1A) receptor ligands containing a N0-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation. Bioorg Med Chem Lett 2010 May 1; 20 (9): 2978-82
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.9
, pp. 2978-2982
-
-
Fiorino, F.1
Severino, B.2
De Angelis, F.3
-
94
-
-
0026681098
-
SC-53116: The first selective agonist at the newly identified serotonin 5-HT4 receptor subtype
-
Apr 17;
-
Flynn DL, Zabrowski DL, Becker DP, et al. SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. JMed Chem 1992 Apr 17; 35 (8): 1486-9
-
(1992)
JMed Chem
, vol.35
, Issue.8
, pp. 1486-1489
-
-
Flynn, D.L.1
Zabrowski, D.L.2
Becker, D.P.3
-
95
-
-
0028989792
-
The serotonin 5-HT4 receptor: 1. Design of a new class of agonists and receptor map of the agonist recognition site
-
Jun 23;
-
Buchheit KH, Gamse R, Giger R, et al. The serotonin 5-HT4 receptor: 1. Design of a new class of agonists and receptor map of the agonist recognition site. JMed Chem 1995 Jun 23; 38 (13): 2326-30
-
(1995)
JMed Chem
, vol.38
, Issue.13
, pp. 2326-2330
-
-
Buchheit, K.H.1
Gamse, R.2
Giger, R.3
-
96
-
-
0028989793
-
The serotonin 5-HT4 receptor: 2. Structure-activity studies of the indole carbazimidamide class of agonists
-
Jun 23;
-
Buchheit KH, Gamse R, Giger R, et al. The serotonin 5-HT4 receptor: 2. Structure-activity studies of the indole carbazimidamide class of agonists. JMed Chem 1995 Jun 23; 38 (13): 2331-8
-
(1995)
JMed Chem
, vol.38
, Issue.13
, pp. 2331-2338
-
-
Buchheit, K.H.1
Gamse, R.2
Giger, R.3
-
97
-
-
0031042398
-
4 receptors
-
DOI 10.1021/jm960320m
-
Yang D, Soulier JL, Sicsic S, et al. New esters of 4-amino-5-chloro-2- methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem 1997 Feb 14; 40 (4): 608-21 (Pubitemid 27080041)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.4
, pp. 608-621
-
-
Yang, D.1
Soulier, J.-L.2
Sicsic, S.3
Mathe-Allainmat, M.4
Bremont, B.5
Croci, T.6
Cardamone, R.7
Aureggi, G.8
Langlois, M.9
-
98
-
-
33244462168
-
4 agonists using CoMFA and receptor based alignment
-
DOI 10.1016/j.ejmech.2005.07.017, PII S0223523405002448
-
Iskander MN, Leung LM, Buley T, et al. Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment. Eur JMed Chem 2006 Jan; 41 (1): 16-26 (Pubitemid 43276055)
-
(2006)
European Journal of Medicinal Chemistry
, vol.41
, Issue.1
, pp. 16-26
-
-
Iskander, M.N.1
Leung, L.M.2
Buley, T.3
Ayad, F.4
Di Iulio, J.5
Tan, Y.Y.6
Coupar, I.M.7
-
99
-
-
34548487956
-
4 receptor dimers
-
DOI 10.1021/jm070552t
-
Russo O, BerthouzeM, Giner M, et al. Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers. JMed Chem 2007 Sep 6; 50 (18): 4482-92 (Pubitemid 47378844)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.18
, pp. 4482-4492
-
-
Russo, O.1
Berthouze, M.2
Giner, M.3
Soulier, J.-L.4
Rivail, L.5
Sicsic, S.6
Lezoualc'h, F.7
Jockers, R.8
Berque-Bestel, I.9
-
100
-
-
65449154371
-
Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: Application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease
-
Apr 23;
-
Russo O, Cachard-Chastel M, Riviere C, et al. Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease. J Med Chem 2009 Apr 23; 52 (8): 2214-25
-
(2009)
J Med Chem
, vol.52
, Issue.8
, pp. 2214-2225
-
-
Russo, O.1
Cachard-Chastel, M.2
Riviere, C.3
-
101
-
-
0038460888
-
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT (7)
-
Jul 3
-
Glennon RA. Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem 2003 Jul 3; 46 (14): 2795-812
-
(2003)
J Med Chem
, vol.46
, Issue.14
, pp. 2795-2812
-
-
Glennon, R.A.1
-
102
-
-
64249172204
-
Synthesis and SAR of tolylamine 5-HT6 antagonists
-
May 1;
-
Singer JM, Wilson MW, Johnson PD, et al. Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett 2009 May 1; 19 (9): 2409-12
-
(2009)
Bioorg Med Chem Lett
, vol.19
, Issue.9
, pp. 2409-2412
-
-
Singer, J.M.1
Wilson, M.W.2
Johnson, P.D.3
-
103
-
-
72149122407
-
Synthesis and biological activity of 5-styryl and 5-phenethylsubstituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles
-
Jan 1;
-
Ivachtchenko AV, Frolov EB, Mitkin OD, et al. Synthesis and biological activity of 5-styryl and 5-phenethylsubstituted 2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indoles. Bioorg Med Chem Lett 2010 Jan 1; 20 (1): 78-82
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.1
, pp. 78-82
-
-
Ivachtchenko, A.V.1
Frolov, E.B.2
Mitkin, O.D.3
-
104
-
-
77954266958
-
Discovery of a proneurogenic neuroprotective chemical
-
Jul 9;
-
Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell 2010 Jul 9; 142 (1): 39-51
-
(2010)
Cell
, vol.142
, Issue.1
, pp. 39-51
-
-
Pieper, A.A.1
Xie, S.2
Capota, E.3
-
105
-
-
77950067508
-
[(11)C]Dimebon, radiosynthesis and lipophilicity of a new potential PET agent for imaging of Alzheimer's disease and Huntington's disease
-
Apr 15;
-
Gao M, Wang M, Hutchins GD, et al. [(11)C]Dimebon, radiosynthesis and lipophilicity of a new potential PET agent for imaging of Alzheimer's disease and Huntington's disease. BioorgMed Chem Lett 2010 Apr 15; 20 (8): 2529-32
-
(2010)
BioorgMed Chem Lett
, vol.20
, Issue.8
, pp. 2529-2532
-
-
Gao, M.1
Wang, M.2
Hutchins, G.D.3
-
106
-
-
77958107921
-
Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands [letter]
-
Nirogi RVS, Kothmirkar P, Kambhampati R, et al. Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands [letter]. ACS Med Chem Lett 2010; 1 (7): 340-4
-
(2010)
ACS Med Chem Lett
, vol.1
, Issue.7
, pp. 340-344
-
-
Nirogi, R.V.S.1
Kothmirkar, P.2
Kambhampati, R.3
-
107
-
-
64249100991
-
1-Sulfonylindazoles as potent and selective 5-HT6 ligands
-
May 1;
-
Liu KG, Lo JR, Comery TA, et al. 1-Sulfonylindazoles as potent and selective 5-HT6 ligands. Bioorg Med Chem Lett 2009 May 1; 19 (9): 2413-5
-
(2009)
Bioorg Med Chem Lett
, vol.19
, Issue.9
, pp. 2413-2415
-
-
Liu, K.G.1
Lo, J.R.2
Comery, T.A.3
-
109
-
-
77249165570
-
Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists: Molecular mechanisms of receptor inactivation
-
Feb 11;
-
de la Fuente T, Martin-Fontecha M, Sallander J, et al. Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists: molecular mechanisms of receptor inactivation. J Med Chem 2010 Feb 11; 53 (3): 1357-69
-
(2010)
J Med Chem
, vol.53
, Issue.3
, pp. 1357-1369
-
-
De La Fuente, T.1
Martin-Fontecha, M.2
Sallander, J.3
-
110
-
-
21244446301
-
6) receptor antagonists
-
DOI 10.1021/jm050247c
-
Lopez-Rodriguez ML, Benhamu B, de la Fuente T, et al. A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists. J Med Chem 2005 Jun 30; 48 (13): 4216-9 (Pubitemid 40884923)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.13
, pp. 4216-4219
-
-
Lopez-Rodriguez, M.L.1
Benhamu, B.2
De La Fuente, T.3
Sanz, A.4
Pardo, L.5
Campillo, M.6
|