Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities

Biochemical Pharmacology

Volumn 78, Issue 8, 2009, Pages 1035-1042

  Schaffhauser, Hervé ^a   Mathiasen, Joanne R ^a   DiCamillo, Amy ^a   Huffman, Mark J ^a   Lu, Lily D ^a   McKenna, Beth A ^a   Qian, Jie ^a   Marino, Michael J ^a  

^a CEPHALON INC   (United States)

Author keywords

5 HT6; Alzheimer's disease; Cognition; Dimebolin; Dimebon

Indexed keywords

CYCLIC AMP; DIMEBON; SB 399885; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; RECOMBINANT PROTEIN; SB-399885; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT TERM MEMORY; AGING; ANIMAL; BRAIN LEVEL; CELL LINE; CELL MEMBRANE; CHO CELL; CLINICAL TRIAL; CRICETULUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; IC 50; KIDNEY; METABOLISM; PHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT; STIMULATION; TIME;

AGING; ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; CELL LINE; CELL MEMBRANE; CHO CELLS; CLINICAL TRIALS AS TOPIC; COGNITION; CRICETINAE; CRICETULUS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; KIDNEY; MALE; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN ANTAGONISTS; STIMULATION, CHEMICAL; SULFONAMIDES; TIME FACTORS; TRANSFECTION;

EID: 69349100072     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.06.021     Document Type: Article

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