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Volumn 21, Issue 4, 2010, Pages 239-250

Age-related progressive synaptic dysfunction: The critical role of presenilin 1

Author keywords

Aging; Alzheimer's disease; Hippocampus; Plasticity; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; PRESENILIN 1;

EID: 78349246723     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.2010.21.4.239     Document Type: Review
Times cited : (9)

References (110)
  • 1
    • 77149133728 scopus 로고    scopus 로고
    • Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice
    • Auffret A, Gautheron V, Mattson MP, Mariani J, Rovira C. Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice. J Alzheimers Dis 19: 1021-33.
    • J Alzheimers Dis , vol.19 , pp. 1021-1033
    • Auffret, A.1    Gautheron, V.2    Mattson, M.P.3    Mariani, J.4    Rovira, C.5
  • 2
    • 68849122533 scopus 로고    scopus 로고
    • Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease
    • Auffret A, Gautheron V, Repici M, Kraftsik R, Mount HT, Mariani J, Rovira C. Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease. J Neurosci 2009; 29: 10144-52.
    • (2009) J Neurosci , vol.29 , pp. 10144-10152
    • Auffret, A.1    Gautheron, V.2    Repici, M.3    Kraftsik, R.4    Mount, H.T.5    Mariani, J.6    Rovira, C.7
  • 3
    • 0019074711 scopus 로고
    • Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations
    • Ault B, Evans RH, Francis AA, Oakes DJ, Watkins JC. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J Physiol 1980; 307: 413-28.
    • (1980) J Physiol , vol.307 , pp. 413-428
    • Ault, B.1    Evans, R.H.2    Francis, A.A.3    Oakes, D.J.4    Watkins, J.C.5
  • 5
    • 0032972922 scopus 로고    scopus 로고
    • Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice
    • DOI 10.1046/j.1471-4159.1999.0721030.x
    • Begley JG, Duan W, Chan S, Duff K, Mattson MP. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 1999; 72: 1030-9. (Pubitemid 29085017)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.3 , pp. 1030-1039
    • Begley, J.G.1    Duan, W.2    Chan, S.3    Duff, K.4    Mattson, M.P.5
  • 6
    • 50249135503 scopus 로고    scopus 로고
    • Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
    • Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 2008; 31: 454-63.
    • (2008) Trends Neurosci , vol.31 , pp. 454-463
    • Bezprozvanny, I.1    Mattson, M.P.2
  • 7
    • 0023947708 scopus 로고
    • CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices
    • Blake JF, Brown MW, Collingridge GL. CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neurosci Lett 1988; 89: 182-6.
    • (1988) Neurosci Lett , vol.89 , pp. 182-186
    • Blake, J.F.1    Brown, M.W.2    Collingridge, G.L.3
  • 8
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361: 31-9.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 9
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 11
    • 0032488995 scopus 로고    scopus 로고
    • The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
    • DOI 10.1074/jbc.273.6.3205
    • Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 1998; 273: 3205-11. (Pubitemid 28109729)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.6 , pp. 3205-3211
    • Capell, A.1    Grunberg, J.2    Pesold, B.3    Diehlmann, A.4    Citron, M.5    Nixon, R.6    Beyreuther, K.7    Selkoe, D.J.8    Haass, C.9
  • 12
    • 0021133515 scopus 로고
    • Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice
    • Chang FL, Greenough WT. Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice. Brain Res 1984; 309: 35-46.
    • (1984) Brain Res , vol.309 , pp. 35-46
    • Chang, F.L.1    Greenough, W.T.2
  • 15
    • 0023948389 scopus 로고
    • Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus
    • Collingridge GL, Herron CE, Lester RA. Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus. J Physiol 1988; 399: 301-12.
    • (1988) J Physiol , vol.399 , pp. 301-312
    • Collingridge, G.L.1    Herron, C.E.2    Lester, R.A.3
  • 16
    • 0020647470 scopus 로고
    • Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
    • Collingridge GL, Kehl SJ, McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol 1983; 334: 33-46. (Pubitemid 13176081)
    • (1983) Journal of Physiology , vol.VOL. 334 , pp. 33-46
    • Collingridge, G.L.1    Kehl, S.J.2    McLennan, H.3
  • 17
    • 0024362941 scopus 로고
    • Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus
    • Davies SN, Collingridge GL. Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus. Proc R Soc Lond B Biol Sci 1989; 236: 373-84.
    • (1989) Proc R Soc Lond B Biol Sci , vol.236 , pp. 373-384
    • Davies, S.N.1    Collingridge, G.L.2
  • 18
    • 33947591747 scopus 로고    scopus 로고
    • Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles
    • DOI 10.1016/j.mcn.2007.01.001, PII S1044743107000024
    • Daw MI, Scott HL, Isaac JT. Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles. Mol Cell Neurosci 2007; 34: 493-502. (Pubitemid 46483082)
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.4 , pp. 493-502
    • Daw, M.I.1    Scott, H.L.2    Isaac, J.T.R.3
  • 19
    • 36849015889 scopus 로고    scopus 로고
    • Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures
    • DOI 10.1093/cercor/bhm041
    • De Roo M, Klauser P, Mendez P, Poglia L, Muller D. Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures. Cereb Cortex 2008; 18: 151-61. (Pubitemid 350233061)
    • (2008) Cerebral Cortex , vol.18 , Issue.1 , pp. 151-161
    • De Roo, M.1    Klauser, P.2    Mendez, P.3    Poglia, L.4    Muller, D.5
  • 20
    • 0037809277 scopus 로고    scopus 로고
    • Alzheimer's disease: Mental plaque removal
    • DOI 10.1038/423392a
    • De Strooper B, Woodgett J. Alzheimer's disease: Mental plaque removal. Nature 2003; 423: 392-3. (Pubitemid 36626980)
    • (2003) Nature , vol.423 , Issue.6938 , pp. 392-393
    • De Strooper, B.1    Woodgett, J.2
  • 22
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990;27:457-64.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 23
    • 0026065020 scopus 로고
    • Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: Relationship with the intellectual status of 26 cases
    • Delaere P, Duyckaerts C, He Y, Piette F, Hauw JJ. Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases. Acta Neuropathol 1991; 81: 328-35.
    • (1991) Acta Neuropathol , vol.81 , pp. 328-335
    • Delaere, P.1    Duyckaerts, C.2    He, Y.3    Piette, F.4    Hauw, J.J.5
  • 26
    • 37849189265 scopus 로고    scopus 로고
    • A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: Are we progressing toward therapy?
    • Dillen K, Annaert W. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? Int Rev Cytol 2006; 254: 215-300.
    • (2006) Int Rev Cytol , vol.254 , pp. 215-300
    • Dillen, K.1    Annaert, W.2
  • 27
    • 0026579349 scopus 로고
    • Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade
    • Dudek SM, Bear MF. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 1992; 89: 4363-7.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4363-4367
    • Dudek, S.M.1    Bear, M.F.2
  • 28
    • 36949016215 scopus 로고    scopus 로고
    • Alzheimer disease models and human neuropathology: Similarities and differences
    • DOI 10.1007/s00401-007-0312-8
    • Duyckaerts C, Potier MC, Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol 2008; 115: 5-38. (Pubitemid 50005258)
    • (2008) Acta Neuropathologica , vol.115 , Issue.1 , pp. 5-38
    • Duyckaerts, C.1    Potier, M.-C.2    Delatour, B.3
  • 29
    • 0033529082 scopus 로고    scopus 로고
    • Dendritic spine changes associated with hippocampal long-term synaptic plasticity
    • Engert F, Bonhoeffer T. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 1999; 399: 66-70.
    • (1999) Nature , vol.399 , pp. 66-70
    • Engert, F.1    Bonhoeffer, T.2
  • 30
    • 0019782706 scopus 로고
    • Stimulation-induced changes in dimensions of stalks of dendritic spines in the dentate molecular layer
    • Fifkova E, Anderson CL. Stimulation-induced changes in dimensions of stalks of dendritic spines in the dentate molecular layer. Exp Neurol 1981; 74: 621-7. (Pubitemid 12231692)
    • (1981) Experimental Neurology , vol.74 , Issue.2 , pp. 621-627
    • Fifkova, E.1    Anderson, C.L.2
  • 31
    • 0032078861 scopus 로고    scopus 로고
    • Rapid actin-based plasticity in dendritic spines
    • DOI 10.1016/S0896-6273(00)80467-5
    • Fischer M, Kaech S, Knutti D, Matus A. Rapid actin-based plasticity in dendritic spines. Neuron 1998; 20: 847-54. (Pubitemid 28247391)
    • (1998) Neuron , vol.20 , Issue.5 , pp. 847-854
    • Fischer, M.1    Kaech, S.2    Knutti, D.3    Matus, A.4
  • 35
    • 0025779446 scopus 로고
    • Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices
    • Fujii S, Saito K, Miyakawa H, Ito K, Kato H. Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices. Brain Res 1991; 555: 112-22.
    • (1991) Brain Res , vol.555 , pp. 112-122
    • Fujii, S.1    Saito, K.2    Miyakawa, H.3    Ito, K.4    Kato, H.5
  • 37
    • 0033016172 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
    • DOI 10.1038/4789
    • Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 1999; 5: 101-6. (Pubitemid 29051006)
    • (1999) Nature Medicine , vol.5 , Issue.1 , pp. 101-106
    • Guo, Q.1    Fu, W.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6    Mattson, M.P.7
  • 38
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-6. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 39
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
    • DOI 10.1023/A:1021691918517
    • Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 1999; 29: 177-85. (Pubitemid 29500635)
    • (1999) Behavior Genetics , vol.29 , Issue.3 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 41
    • 0030761094 scopus 로고    scopus 로고
    • The presenilins and Alzheimer's disease
    • Hutton M, Hardy J. The presenilins and Alzheimer's disease. Hum Mol Genet 1997; 6: 1639-46.
    • (1997) Hum Mol Genet , vol.6 , pp. 1639-1646
    • Hutton, M.1    Hardy, J.2
  • 45
    • 50349083093 scopus 로고    scopus 로고
    • Dendritic spine loss and synaptic alterations in Alzheimer's disease
    • Knobloch M, Mansuy IM. Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 2008; 37: 73-82.
    • (2008) Mol Neurobiol , vol.37 , pp. 73-82
    • Knobloch, M.1    Mansuy, I.M.2
  • 46
    • 2942557122 scopus 로고    scopus 로고
    • Gamma-secretase: Proteasome of the membrane?
    • Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 2004; 5: 499-504.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 499-504
    • Kopan, R.1    Ilagan, M.X.2
  • 47
    • 33644560354 scopus 로고    scopus 로고
    • Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    • Kopec CD, Li B, Wei W, Boehm J, Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci 2006; 26: 2000-9.
    • (2006) J Neurosci , vol.26 , pp. 2000-2009
    • Kopec, C.D.1    Li, B.2    Wei, W.3    Boehm, J.4    Malinow, R.5
  • 49
    • 0021222306 scopus 로고
    • Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
    • DOI 10.1016/0361-9230(84)90005-4
    • Krug M, Lossner B, Ott T. Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res Bull 1984; 13: 39-42. (Pubitemid 14013179)
    • (1984) Brain Research Bulletin , vol.13 , Issue.1 , pp. 39-42
    • Krug, M.1    Lossner, B.2    Ott, T.3
  • 50
    • 59849093899 scopus 로고    scopus 로고
    • Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing
    • Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing. J Exp Biol 2009; 212: 494-8.
    • (2009) J Exp Biol , vol.212 , pp. 494-498
    • Kumar, V.B.1    Franko, M.2    Banks, W.A.3    Kasinadhuni, P.4    Farr, S.A.5    Vyas, K.6    Choudhuri, V.7    Morley, J.E.8
  • 51
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
    • LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 2002; 3: 862-72.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 862-872
    • LaFerla, F.M.1
  • 52
    • 0037421111 scopus 로고    scopus 로고
    • Transgenic mice expressing the PS1-A246E mutation: Effects on spatial learning, exploration, anxiety, and motor coordination
    • DOI 10.1016/S0166-4328(02)00230-9, PII S0166432802002309
    • Lalonde R, Qian S, Strazielle C. Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination. Behav Brain Res 2003; 138: 71-9. (Pubitemid 35463238)
    • (2003) Behavioural Brain Research , vol.138 , Issue.1 , pp. 71-79
    • Lalonde, R.1    Qian, S.2    Strazielle, C.3
  • 53
    • 20444474852 scopus 로고    scopus 로고
    • PS1 knockin mice with the Japanese I213T mutation: Effects on exploratory activity, motor coordination, and spatial learning
    • DOI 10.1016/j.bbr.2005.02.037, PII S0166432805001142
    • Lalonde R, Strazielle C. PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning. Behav Brain Res 2005; 162: 182-90. (Pubitemid 40828530)
    • (2005) Behavioural Brain Research , vol.162 , Issue.2 , pp. 182-190
    • Lalonde, R.1    Strazielle, C.2
  • 57
    • 61449208917 scopus 로고    scopus 로고
    • Toward structural elucidation of the gamma-secretase complex
    • Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure 2009; 17: 326-34.
    • (2009) Structure , vol.17 , pp. 326-334
    • Li, H.1    Wolfe, M.S.2    Selkoe, D.J.3
  • 60
    • 0022479032 scopus 로고
    • NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
    • MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 1986; 321: 519-22.
    • (1986) Nature , vol.321 , pp. 519-522
    • MacDermott, A.B.1    Mayer, M.L.2    Westbrook, G.L.3    Smith, S.J.4    Barker, J.L.5
  • 61
    • 0035708355 scopus 로고    scopus 로고
    • Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
    • DOI 10.1038/nn736
    • Matsuzaki M, Ellis-Davies GC, Nemoto T, Miyashita Y, Iino M, Kasai H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci 2001; 4: 1086-92. (Pubitemid 34116553)
    • (2001) Nature Neuroscience , vol.4 , Issue.11 , pp. 1086-1092
    • Matsuzaki, M.1    Ellis-Davies, G.C.R.2    Nemoto, T.3    Miyashita, Y.4    Iino, M.5    Kasai, H.6
  • 62
    • 3042554012 scopus 로고    scopus 로고
    • Structural basis of long-term potentiation in single dendritic spines
    • DOI 10.1038/nature02617
    • Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H. Structural basis of long-term potentiation in single dendritic spines. Nature 2004; 429: 761-6. (Pubitemid 38833127)
    • (2004) Nature , vol.429 , Issue.6993 , pp. 761-766
    • Matsuzaki, M.1    Honkura, N.2    Ellis-Davies, G.C.R.3    Kasai, H.4
  • 63
    • 0035232146 scopus 로고    scopus 로고
    • Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease
    • Mattson MP, Gary DS, Chan SL, Duan W. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease. Biochem Soc Symp 2001; 151-62. (Pubitemid 33602683)
    • (2001) Biochemical Society Symposium , vol.67 , pp. 151-162
    • Mattson, M.P.1    Gary, D.S.2    Chan, S.L.3    Duan, W.4
  • 65
    • 38949175007 scopus 로고    scopus 로고
    • A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    • Miller JA, Oldham MC, Geschwind DH. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci 2008; 28: 1410-20.
    • (2008) J Neurosci , vol.28 , pp. 1410-1420
    • Miller, J.A.1    Oldham, M.C.2    Geschwind, D.H.3
  • 68
    • 9644265305 scopus 로고    scopus 로고
    • Bidirectional activity-dependent morphological plasticity in hippocampal neurons
    • DOI 10.1016/j.neuron.2004.11.016, PII S0896627304007299
    • Nagerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T. Bidirectional activity-dependent morphological plasticity in hippocampal neurons. Neuron 2004; 44: 759-67. (Pubitemid 39575630)
    • (2004) Neuron , vol.44 , Issue.5 , pp. 759-767
    • Nagerl, U.V.1    Eberhorn, N.2    Cambridge, S.B.3    Bonhoeffer, T.4
  • 71
    • 0021260967 scopus 로고
    • Magnesium gates glutamate-activated channels in mouse central neurones
    • Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 1984; 307: 462-5. (Pubitemid 14132062)
    • (1984) Nature , vol.307 , Issue.5950 , pp. 462-465
    • Nowak, L.1    Bregestovski, P.2    Ascher, P.3
  • 72
    • 7044270772 scopus 로고    scopus 로고
    • Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
    • DOI 10.1523/JNEUROSCI.2350-04.2004
    • Otmakhov N, Tao-Cheng JH, Carpenter S, Asrican B, Dosemeci A, Reese TS, Lisman J. Persistent accumulation of calcium calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation. J Neurosci 2004; 24: 9324-31. (Pubitemid 39426169)
    • (2004) Journal of Neuroscience , vol.24 , Issue.42 , pp. 9324-9331
    • Otmakhov, N.1    Tao-Cheng, J.-H.2    Carpenter, S.3    Asrican, B.4    Dosemeci, A.5    Reese, T.S.6    Lisman, J.7
  • 73
    • 0032945724 scopus 로고    scopus 로고
    • Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1
    • DOI 10.1006/nbdi.1998.0207
    • Parent A, Linden DJ, Sisodia SS, Borchelt DR. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol Dis 1999; 6: 56-62. (Pubitemid 29156468)
    • (1999) Neurobiology of Disease , vol.6 , Issue.1 , pp. 56-62
    • Parent, A.1    Linden, D.J.2    Sisodia, S.S.3    Borchelt, D.R.4
  • 74
    • 0037117753 scopus 로고    scopus 로고
    • Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha
    • DOI 10.1021/bi015936e
    • Parkin ET, Trew A, Christie G, Faller A, Mayer R, Turner AJ, Hooper NM. Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry 2002; 41: 4972-81. (Pubitemid 34298665)
    • (2002) Biochemistry , vol.41 , Issue.15 , pp. 4972-4981
    • Parkin, E.T.1    Trew, A.2    Christie, G.3    Faller, A.4    Mayer, R.5    Turner, A.J.6    Hooper, N.M.7
  • 75
    • 33748049463 scopus 로고    scopus 로고
    • Storage of spatial information by the maintenance mechanism of LTP
    • DOI 10.1126/science.1128657
    • Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC. Storage of spatial information by the maintenance mechanism of LTP. Science 2006; 313: 1141-4. (Pubitemid 44300243)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1141-1444
    • Pastalkova, E.1    Serrano, P.2    Pinkhasova, D.3    Wallace, E.4    Fenton, A.A.5    Sacktor, T.C.6
  • 76
    • 0014768351 scopus 로고
    • The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
    • Peters A, Kaiserman-Abramof IR. The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines. Am J Anat 1970; 127: 321-55.
    • (1970) Am J Anat , vol.127 , pp. 321-355
    • Peters, A.1    Kaiserman-Abramof, I.R.2
  • 77
    • 0014687804 scopus 로고
    • The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines
    • Peters A, Kaiserman-Abramof IR. The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines. Z Zellforsch Mikrosk Anat 1969; 100: 487-506.
    • (1969) Z Zellforsch Mikrosk Anat , vol.100 , pp. 487-506
    • Peters, A.1    Kaiserman-Abramof, I.R.2
  • 78
  • 79
    • 0037432559 scopus 로고    scopus 로고
    • NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus
    • Raymond CR, Ireland DR, Abraham WC. NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus. Brain Res 2003; 968: 263-72.
    • (2003) Brain Res , vol.968 , pp. 263-272
    • Raymond, C.R.1    Ireland, D.R.2    Abraham, W.C.3
  • 80
    • 0033987838 scopus 로고    scopus 로고
    • Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus
    • DOI 10.1002/(SICI)1098-2396(200002)35:2<96::AID-SYN2>3.0.CO;2-0
    • Ribaut-Barassin C, Moussaoui S, Brugg B, Haeberle AM, Huber G, Imperato A, Delhaye-Bouchaud N, Mariani J, Bailly YJ. Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus. Synapse 2000; 35: 96-110. (Pubitemid 30036186)
    • (2000) Synapse , vol.35 , Issue.2 , pp. 96-110
    • Ribaut-Barassen, C.1    Moussaoui, S.2    Brugg, B.3    Haeberle, A.-M.4    Huber, G.5    Imperato, A.6    Delhaye-Bouchaud, N.7    Mariani, J.8    Bailly, Y.J.9
  • 81
    • 41349089303 scopus 로고    scopus 로고
    • PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage
    • Sacktor TC. PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. Prog Brain Res 2008; 169: 27-40.
    • (2008) Prog Brain Res , vol.169 , pp. 27-40
    • Sacktor, T.C.1
  • 82
    • 0033365730 scopus 로고    scopus 로고
    • Can molecules explain long-term potentiation?
    • Sanes JR, Lichtman JW. Can molecules explain long-term potentiation? Nat Neurosci 1999; 2: 597-604.
    • (1999) Nat Neurosci , vol.2 , pp. 597-604
    • Sanes, J.R.1    Lichtman, J.W.2
  • 84
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • DOI 10.1523/JNEUROSCI.4970-06.2007
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 2007; 27: 2866-75. (Pubitemid 46438992)
    • (2007) Journal of Neuroscience , vol.27 , Issue.11 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 85
    • 70349973683 scopus 로고    scopus 로고
    • Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life
    • Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis 2009; 36(2):293-302.
    • (2009) Neurobiol Dis , vol.36 , Issue.2 , pp. 293-302
    • Shankar, G.M.1    Leissring, M.A.2    Adame, A.3    Sun, X.4    Spooner, E.5    Masliah, E.6    Selkoe, D.J.7    Lemere, C.A.8    Walsh, D.M.9
  • 88
    • 0037383823 scopus 로고    scopus 로고
    • Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    • Smith MA, Ellis-Davies GC, Magee JC. Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons. J Physiol 2003; 548: 245-58.
    • (2003) J Physiol , vol.548 , pp. 245-258
    • Smith, M.A.1    Ellis-Davies, G.C.2    Magee, J.C.3
  • 91
    • 0034573291 scopus 로고    scopus 로고
    • Piecing together Alzheimer's
    • St George-Hyslop PH. Piecing together Alzheimer's. Sci Am 2000; 283: 76-83.
    • (2000) Sci Am , vol.283 , pp. 76-83
    • St George-Hyslop, P.H.1
  • 92
    • 33646945317 scopus 로고    scopus 로고
    • 2+ disruptions in young, adult, and aged Alzheimer's disease mice
    • DOI 10.1523/JNEUROSCI.0739-06.2006
    • Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci 2006; 26: 5180-9. (Pubitemid 44315299)
    • (2006) Journal of Neuroscience , vol.26 , Issue.19 , pp. 5180-5189
    • Stutzmann, G.E.1    Smith, I.2    Caccamo, A.3    Oddo, S.4    LaFerla, F.M.5    Parker, I.6
  • 93
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and alpha-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh YH, Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 2002; 54: 469-525.
    • (2002) Pharmacol Rev , vol.54 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 94
    • 23844532257 scopus 로고    scopus 로고
    • Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation
    • DOI 10.1159/000086426
    • Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neurodegener Dis. 2005;2(1):6-15. (Pubitemid 41158935)
    • (2005) Neurodegenerative Diseases , vol.2 , Issue.1 , pp. 6-15
    • Sun, X.1    Beglopoulos, V.2    Mattson, M.P.3    Shen, J.4
  • 96
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572-80.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 98
    • 57649221135 scopus 로고    scopus 로고
    • Amyloid precursor protein trafficking, processing, and function
    • Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008; 283: 29615-9.
    • (2008) J Biol Chem , vol.283 , pp. 29615-29619
    • Thinakaran, G.1    Koo, E.H.2
  • 99
    • 0033604506 scopus 로고    scopus 로고
    • LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
    • Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 1999; 402: 421-5. (Pubitemid 129544831)
    • (1999) Nature , vol.402 , Issue.6760 , pp. 421-425
    • Toni, N.1    Buchs, P.-A.2    Nikonenko, I.3    Bron, C.R.4    Muller, D.5
  • 104
    • 0035937153 scopus 로고    scopus 로고
    • The Role of presenilins in gamma-secretase activity
    • Wolfe MS, Haass C. The Role of presenilins in gamma-secretase activity. J Biol Chem 2001; 276: 5413-6.
    • (2001) J Biol Chem , vol.276 , pp. 5413-5416
    • Wolfe, M.S.1    Haass, C.2
  • 105
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999; 398: 513-7.
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 106
    • 0025219026 scopus 로고
    • Genomic organization of the human amyloid beta-protein precursor gene
    • DOI 10.1016/0378-1119(90)90310-N
    • Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y. Genomic organization of the human amyloid beta-protein precursor gene. Gene 1990; 87: 257-63. (Pubitemid 20146047)
    • (1990) Gene , vol.87 , Issue.2 , pp. 257-263
    • Yoshikai, S.-I.1    Sasaki, H.2    Doh-ura, K.3    Furuya, H.4    Sakaki, Y.5
  • 108
    • 0034095106 scopus 로고    scopus 로고
    • Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine
    • DOI 10.1006/nbdi.1999.0271
    • Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiol Dis 2000; 7: 54-63. (Pubitemid 30141819)
    • (2000) Neurobiology of Disease , vol.7 , Issue.1 , pp. 54-63
    • Zaman, S.H.1    Parent, A.2    Laskey, A.3    Lee, M.K.4    Borchelt, D.R.5    Sisodia, S.S.6    Malinow, R.7
  • 110
    • 9644278075 scopus 로고    scopus 로고
    • Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
    • DOI 10.1016/j.neuron.2004.11.011, PII S0896627304007226
    • Zhou Q, Homma KJ, Poo MM. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 2004; 44:749-57. (Pubitemid 39575629)
    • (2004) Neuron , vol.44 , Issue.5 , pp. 749-757
    • Zhou, Q.1    Homma, K.J.2    Poo, M.-M.3


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