-
1
-
-
77149133728
-
Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice
-
Auffret A, Gautheron V, Mattson MP, Mariani J, Rovira C. Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice. J Alzheimers Dis 19: 1021-33.
-
J Alzheimers Dis
, vol.19
, pp. 1021-1033
-
-
Auffret, A.1
Gautheron, V.2
Mattson, M.P.3
Mariani, J.4
Rovira, C.5
-
2
-
-
68849122533
-
Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease
-
Auffret A, Gautheron V, Repici M, Kraftsik R, Mount HT, Mariani J, Rovira C. Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease. J Neurosci 2009; 29: 10144-52.
-
(2009)
J Neurosci
, vol.29
, pp. 10144-10152
-
-
Auffret, A.1
Gautheron, V.2
Repici, M.3
Kraftsik, R.4
Mount, H.T.5
Mariani, J.6
Rovira, C.7
-
3
-
-
0019074711
-
Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations
-
Ault B, Evans RH, Francis AA, Oakes DJ, Watkins JC. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J Physiol 1980; 307: 413-28.
-
(1980)
J Physiol
, vol.307
, pp. 413-428
-
-
Ault, B.1
Evans, R.H.2
Francis, A.A.3
Oakes, D.J.4
Watkins, J.C.5
-
4
-
-
0034058834
-
Functional phenotype in transgenic mice expressing mutant human presenilin-1
-
DOI 10.1006/nbdi.1999.0276
-
Barrow PA, Empson RM, Gladwell SJ, Anderson CM, Killick R, Yu X, Jefferys JG, Duff K. Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiol Dis 2000;7:119-26. (Pubitemid 30241207)
-
(2000)
Neurobiology of Disease
, vol.7
, Issue.2
, pp. 119-126
-
-
Barrow, P.A.1
Empson, R.M.2
Gladwell, S.J.3
Anderson, C.M.4
Killick, R.5
Yu, X.6
Jefferys, J.G.R.7
Duff, K.8
-
5
-
-
0032972922
-
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice
-
DOI 10.1046/j.1471-4159.1999.0721030.x
-
Begley JG, Duan W, Chan S, Duff K, Mattson MP. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 1999; 72: 1030-9. (Pubitemid 29085017)
-
(1999)
Journal of Neurochemistry
, vol.72
, Issue.3
, pp. 1030-1039
-
-
Begley, J.G.1
Duan, W.2
Chan, S.3
Duff, K.4
Mattson, M.P.5
-
6
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 2008; 31: 454-63.
-
(2008)
Trends Neurosci
, vol.31
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
7
-
-
0023947708
-
CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices
-
Blake JF, Brown MW, Collingridge GL. CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neurosci Lett 1988; 89: 182-6.
-
(1988)
Neurosci Lett
, vol.89
, pp. 182-186
-
-
Blake, J.F.1
Brown, M.W.2
Collingridge, G.L.3
-
8
-
-
0027476024
-
A synaptic model of memory: Long-term potentiation in the hippocampus
-
Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361: 31-9.
-
(1993)
Nature
, vol.361
, pp. 31-39
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
9
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
10
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
DOI 10.1074/jbc.273.43.27765
-
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 1998; 273: 27765-7. (Pubitemid 28496060)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.43
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.-N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
Peschon, J.J.6
Johnson, R.S.7
Castner, B.J.8
Cerretti, D.P.9
Black, R.A.10
-
11
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
DOI 10.1074/jbc.273.6.3205
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 1998; 273: 3205-11. (Pubitemid 28109729)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.6
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
12
-
-
0021133515
-
Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice
-
Chang FL, Greenough WT. Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice. Brain Res 1984; 309: 35-46.
-
(1984)
Brain Res
, vol.309
, pp. 35-46
-
-
Chang, F.L.1
Greenough, W.T.2
-
13
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
DOI 10.1038/6374
-
Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 1999; 2: 271-6. (Pubitemid 30491299)
-
(1999)
Nature Neuroscience
, vol.2
, Issue.3
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
Cooper-Blacketer, D.4
Marshall, V.J.5
Irizarry, M.6
Younkin, L.7
Good, M.A.8
Bliss, T.V.P.9
Hyman, B.T.10
Younkin, S.G.11
Hsiao, K.K.12
-
14
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
DOI 10.1038/nm0197-67
-
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3: 67-72. (Pubitemid 27019143)
-
(1997)
Nature Medicine
, vol.3
, Issue.1
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St George Hyslop, P.22
Selkoe, D.J.23
more..
-
15
-
-
0023948389
-
Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus
-
Collingridge GL, Herron CE, Lester RA. Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus. J Physiol 1988; 399: 301-12.
-
(1988)
J Physiol
, vol.399
, pp. 301-312
-
-
Collingridge, G.L.1
Herron, C.E.2
Lester, R.A.3
-
16
-
-
0020647470
-
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
-
Collingridge GL, Kehl SJ, McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol 1983; 334: 33-46. (Pubitemid 13176081)
-
(1983)
Journal of Physiology
, vol.VOL. 334
, pp. 33-46
-
-
Collingridge, G.L.1
Kehl, S.J.2
McLennan, H.3
-
17
-
-
0024362941
-
Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus
-
Davies SN, Collingridge GL. Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus. Proc R Soc Lond B Biol Sci 1989; 236: 373-84.
-
(1989)
Proc R Soc Lond B Biol Sci
, vol.236
, pp. 373-384
-
-
Davies, S.N.1
Collingridge, G.L.2
-
18
-
-
33947591747
-
Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles
-
DOI 10.1016/j.mcn.2007.01.001, PII S1044743107000024
-
Daw MI, Scott HL, Isaac JT. Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles. Mol Cell Neurosci 2007; 34: 493-502. (Pubitemid 46483082)
-
(2007)
Molecular and Cellular Neuroscience
, vol.34
, Issue.4
, pp. 493-502
-
-
Daw, M.I.1
Scott, H.L.2
Isaac, J.T.R.3
-
19
-
-
36849015889
-
Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures
-
DOI 10.1093/cercor/bhm041
-
De Roo M, Klauser P, Mendez P, Poglia L, Muller D. Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures. Cereb Cortex 2008; 18: 151-61. (Pubitemid 350233061)
-
(2008)
Cerebral Cortex
, vol.18
, Issue.1
, pp. 151-161
-
-
De Roo, M.1
Klauser, P.2
Mendez, P.3
Poglia, L.4
Muller, D.5
-
20
-
-
0037809277
-
Alzheimer's disease: Mental plaque removal
-
DOI 10.1038/423392a
-
De Strooper B, Woodgett J. Alzheimer's disease: Mental plaque removal. Nature 2003; 423: 392-3. (Pubitemid 36626980)
-
(2003)
Nature
, vol.423
, Issue.6938
, pp. 392-393
-
-
De Strooper, B.1
Woodgett, J.2
-
21
-
-
34447309716
-
Presenilin dependence of phospholipase C and protein kinase C signaling
-
D ehvari N, Cedazo-Minguez A, Isacsson O, Nilsson T, Winblad B, Karlstrom H, Benedikz E, Cowburn RF. Presenilin dependence of phospholipase C and protein kinase C signaling. J Neurochem 2007; 102: 848-57.
-
(2007)
J Neurochem
, vol.102
, pp. 848-857
-
-
Dehvari, N.1
Cedazo-Minguez, A.2
Isacsson, O.3
Nilsson, T.4
Winblad, B.5
Karlstrom, H.6
Benedikz, E.7
Cowburn, R.F.8
-
22
-
-
0025269152
-
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
-
DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990;27:457-64.
-
(1990)
Ann Neurol
, vol.27
, pp. 457-464
-
-
DeKosky, S.T.1
Scheff, S.W.2
-
23
-
-
0026065020
-
Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: Relationship with the intellectual status of 26 cases
-
Delaere P, Duyckaerts C, He Y, Piette F, Hauw JJ. Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases. Acta Neuropathol 1991; 81: 328-35.
-
(1991)
Acta Neuropathol
, vol.81
, pp. 328-335
-
-
Delaere, P.1
Duyckaerts, C.2
He, Y.3
Piette, F.4
Hauw, J.J.5
-
24
-
-
57749192464
-
Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice
-
Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D, Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F. Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice. Neurobiol Aging 2009; 30: 241-56.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 241-256
-
-
Dewachter, I.1
Filipkowski, R.K.2
Priller, C.3
Ris, L.4
Neyton, J.5
Croes, S.6
Terwel, D.7
Gysemans, M.8
Devijver, H.9
Borghgraef, P.10
Godaux, E.11
Kaczmarek, L.12
Herms, J.13
Van Leuven, F.14
-
25
-
-
40849115110
-
Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1
-
DOI 10.1016/j.neurobiolaging.2006.11.019, PII S0197458006004416
-
Dewachter I, Ris L, Croes S, Borghgraef P, Devijver H, Voets T, Nilius B, Godaux E, Van Leuven F. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiol Aging 2008; 29: 639-52. (Pubitemid 351400824)
-
(2008)
Neurobiology of Aging
, vol.29
, Issue.5
, pp. 639-652
-
-
Dewachter, I.1
Ris, L.2
Croes, S.3
Borghgraef, P.4
Devijver, H.5
Voets, T.6
Nilius, B.7
Godaux, E.8
Van Leuven, F.9
-
26
-
-
37849189265
-
A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: Are we progressing toward therapy?
-
Dillen K, Annaert W. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? Int Rev Cytol 2006; 254: 215-300.
-
(2006)
Int Rev Cytol
, vol.254
, pp. 215-300
-
-
Dillen, K.1
Annaert, W.2
-
27
-
-
0026579349
-
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade
-
Dudek SM, Bear MF. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 1992; 89: 4363-7.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4363-4367
-
-
Dudek, S.M.1
Bear, M.F.2
-
28
-
-
36949016215
-
Alzheimer disease models and human neuropathology: Similarities and differences
-
DOI 10.1007/s00401-007-0312-8
-
Duyckaerts C, Potier MC, Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol 2008; 115: 5-38. (Pubitemid 50005258)
-
(2008)
Acta Neuropathologica
, vol.115
, Issue.1
, pp. 5-38
-
-
Duyckaerts, C.1
Potier, M.-C.2
Delatour, B.3
-
29
-
-
0033529082
-
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
-
Engert F, Bonhoeffer T. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 1999; 399: 66-70.
-
(1999)
Nature
, vol.399
, pp. 66-70
-
-
Engert, F.1
Bonhoeffer, T.2
-
30
-
-
0019782706
-
Stimulation-induced changes in dimensions of stalks of dendritic spines in the dentate molecular layer
-
Fifkova E, Anderson CL. Stimulation-induced changes in dimensions of stalks of dendritic spines in the dentate molecular layer. Exp Neurol 1981; 74: 621-7. (Pubitemid 12231692)
-
(1981)
Experimental Neurology
, vol.74
, Issue.2
, pp. 621-627
-
-
Fifkova, E.1
Anderson, C.L.2
-
31
-
-
0032078861
-
Rapid actin-based plasticity in dendritic spines
-
DOI 10.1016/S0896-6273(00)80467-5
-
Fischer M, Kaech S, Knutti D, Matus A. Rapid actin-based plasticity in dendritic spines. Neuron 1998; 20: 847-54. (Pubitemid 28247391)
-
(1998)
Neuron
, vol.20
, Issue.5
, pp. 847-854
-
-
Fischer, M.1
Kaech, S.2
Knutti, D.3
Matus, A.4
-
32
-
-
0035399822
-
Age-related impairment of synaptic transmission but normal potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
-
Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR. Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J Neurosci 2001; 21: 4691-8. (Pubitemid 32565627)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.13
, pp. 4691-4698
-
-
Fitzjohn, S.M.1
Morton, R.A.2
Kuenzi, F.3
Rosahl, T.W.4
Shearman, M.5
Lewis, H.6
Smith, D.7
Reynolds, D.S.8
Davies, C.H.9
Collingridge, G.L.10
Seabrook, G.R.11
-
33
-
-
3342993335
-
Purification and characterization of the human gamma-secretase complex
-
DOI 10.1021/bi0494976
-
Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Purification and characterization of the human gamma-secretase complex. Biochemistry 2004; 43: 9774-89. (Pubitemid 38993827)
-
(2004)
Biochemistry
, vol.43
, Issue.30
, pp. 9774-9789
-
-
Fraering, P.C.1
Ye, W.2
Strub, J.-M.3
Dolios, G.4
LaVoie, M.J.5
Ostaszewski, B.L.6
Van Dorsselaer, A.7
Wang, R.8
Selkoe, D.J.9
Wolfe, M.S.10
-
34
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
DOI 10.1016/S1534-5807(02)00189-2
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002; 3: 85-97. (Pubitemid 34778398)
-
(2002)
Developmental Cell
, vol.3
, Issue.1
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
35
-
-
0025779446
-
Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices
-
Fujii S, Saito K, Miyakawa H, Ito K, Kato H. Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices. Brain Res 1991; 555: 112-22.
-
(1991)
Brain Res
, vol.555
, pp. 112-122
-
-
Fujii, S.1
Saito, K.2
Miyakawa, H.3
Ito, K.4
Kato, H.5
-
36
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-6.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
37
-
-
0033016172
-
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
-
DOI 10.1038/4789
-
Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 1999; 5: 101-6. (Pubitemid 29051006)
-
(1999)
Nature Medicine
, vol.5
, Issue.1
, pp. 101-106
-
-
Guo, Q.1
Fu, W.2
Sopher, B.L.3
Miller, M.W.4
Ware, C.B.5
Martin, G.M.6
Mattson, M.P.7
-
38
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-6. (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
39
-
-
0032756213
-
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
-
DOI 10.1023/A:1021691918517
-
Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 1999; 29: 177-85. (Pubitemid 29500635)
-
(1999)
Behavior Genetics
, vol.29
, Issue.3
, pp. 177-185
-
-
Holcomb, L.A.1
Gordon, M.N.2
Jantzen, P.3
Hsiao, K.4
Duff, K.5
Morgan, D.6
-
40
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
DOI 10.1073/pnas.96.6.3228
-
Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 1999;96:3228-33. (Pubitemid 29148873)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.6
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
Mcconlogue, L.3
Yu, G.-Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.C.8
Nicoll, R.A.9
Mucke, L.10
-
41
-
-
0030761094
-
The presenilins and Alzheimer's disease
-
Hutton M, Hardy J. The presenilins and Alzheimer's disease. Hum Mol Genet 1997; 6: 1639-46.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1639-1646
-
-
Hutton, M.1
Hardy, J.2
-
42
-
-
65649092174
-
Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation
-
Inoue E, Deguchi-Tawarada M, Togawa A, Matsui C, Arita K, Katahira-Tayama S, Sato T, Yamauchi E, Oda Y, Takai Y. Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation. J Cell Biol 2009; 185: 551-64.
-
(2009)
J Cell Biol
, vol.185
, pp. 551-564
-
-
Inoue, E.1
Deguchi-Tawarada, M.2
Togawa, A.3
Matsui, C.4
Arita, K.5
Katahira-Tayama, S.6
Sato, T.7
Yamauchi, E.8
Oda, Y.9
Takai, Y.10
-
43
-
-
33645520634
-
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
-
Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2006; 103: 5161-6.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
Wu, C.C.2
Redwine, J.M.3
Comery, T.A.4
Arias, R.5
Bowlby, M.6
Martone, R.7
Morrison, J.H.8
Pangalos, M.N.9
Reinhart, P.H.10
Bloom, F.E.11
-
44
-
-
0034622244
-
Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes
-
DOI 10.1016/S0197-4580(00)00107-X, PII S019745800000107X
-
Janus C, D'Amelio S, Amitay O, Chishti MA, Strome R, Fraser P, Carlson GA, Roder JC, St George-Hyslop P, Westaway D. Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiol Aging 2000; 21: 541-9. (Pubitemid 30621492)
-
(2000)
Neurobiology of Aging
, vol.21
, Issue.4
, pp. 541-549
-
-
Janus, C.1
D'Amelio, S.2
Amitay, O.3
Chishti, M.A.4
Strome, R.5
Fraser, P.6
Carlson, G.A.7
Roder, J.C.8
St George-Hyslop, P.9
Westaway, D.10
-
45
-
-
50349083093
-
Dendritic spine loss and synaptic alterations in Alzheimer's disease
-
Knobloch M, Mansuy IM. Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 2008; 37: 73-82.
-
(2008)
Mol Neurobiol
, vol.37
, pp. 73-82
-
-
Knobloch, M.1
Mansuy, I.M.2
-
46
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 2004; 5: 499-504.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
47
-
-
33644560354
-
Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
-
Kopec CD, Li B, Wei W, Boehm J, Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci 2006; 26: 2000-9.
-
(2006)
J Neurosci
, vol.26
, pp. 2000-2009
-
-
Kopec, C.D.1
Li, B.2
Wei, W.3
Boehm, J.4
Malinow, R.5
-
48
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
DOI 10.1038/nm0296-224
-
Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 1996; 2: 224-9. (Pubitemid 26057557)
-
(1996)
Nature Medicine
, vol.2
, Issue.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.-W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsenstein, K.M.10
Hyman, B.T.11
Tanzi, R.E.12
Wasco, W.13
-
49
-
-
0021222306
-
Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
-
DOI 10.1016/0361-9230(84)90005-4
-
Krug M, Lossner B, Ott T. Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res Bull 1984; 13: 39-42. (Pubitemid 14013179)
-
(1984)
Brain Research Bulletin
, vol.13
, Issue.1
, pp. 39-42
-
-
Krug, M.1
Lossner, B.2
Ott, T.3
-
50
-
-
59849093899
-
Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing
-
Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing. J Exp Biol 2009; 212: 494-8.
-
(2009)
J Exp Biol
, vol.212
, pp. 494-498
-
-
Kumar, V.B.1
Franko, M.2
Banks, W.A.3
Kasinadhuni, P.4
Farr, S.A.5
Vyas, K.6
Choudhuri, V.7
Morley, J.E.8
-
51
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 2002; 3: 862-72.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 862-872
-
-
LaFerla, F.M.1
-
52
-
-
0037421111
-
Transgenic mice expressing the PS1-A246E mutation: Effects on spatial learning, exploration, anxiety, and motor coordination
-
DOI 10.1016/S0166-4328(02)00230-9, PII S0166432802002309
-
Lalonde R, Qian S, Strazielle C. Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination. Behav Brain Res 2003; 138: 71-9. (Pubitemid 35463238)
-
(2003)
Behavioural Brain Research
, vol.138
, Issue.1
, pp. 71-79
-
-
Lalonde, R.1
Qian, S.2
Strazielle, C.3
-
53
-
-
20444474852
-
PS1 knockin mice with the Japanese I213T mutation: Effects on exploratory activity, motor coordination, and spatial learning
-
DOI 10.1016/j.bbr.2005.02.037, PII S0166432805001142
-
Lalonde R, Strazielle C. PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning. Behav Brain Res 2005; 162: 182-90. (Pubitemid 40828530)
-
(2005)
Behavioural Brain Research
, vol.162
, Issue.2
, pp. 182-190
-
-
Lalonde, R.1
Strazielle, C.2
-
54
-
-
27444441308
-
A nine-transmembrane domain topology for presenilin 1
-
Laudon H, Hansson EM, Melen K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Naslund J. A nine-transmembrane domain topology for presenilin 1. J Biol Chem 2005; 280: 35352-60.
-
(2005)
J Biol Chem
, vol.280
, pp. 35352-35360
-
-
Laudon, H.1
Hansson, E.M.2
Melen, K.3
Bergman, A.4
Farmery, M.R.5
Winblad, B.6
Lendahl, U.7
Von Heijne, G.8
Naslund, J.9
-
55
-
-
10544229795
-
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
-
Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J Neurosci 1996; 16: 7513-25. (Pubitemid 26389690)
-
(1996)
Journal of Neuroscience
, vol.16
, Issue.23
, pp. 7513-7525
-
-
Lee, M.K.1
Slunt, H.H.2
Martin, L.J.3
Thinakaran, G.4
Kim, G.5
Gandy, S.E.6
Seeger, M.7
Koo, E.8
Price, D.L.9
Sisodia, S.S.10
-
56
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD. A familial Alzheimer's disease locus on chromosome 1. Science 1995; 269: 970-3.
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
Weber, J.L.6
Bird, T.D.7
Schellenberg, G.D.8
-
57
-
-
61449208917
-
Toward structural elucidation of the gamma-secretase complex
-
Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure 2009; 17: 326-34.
-
(2009)
Structure
, vol.17
, pp. 326-334
-
-
Li, H.1
Wolfe, M.S.2
Selkoe, D.J.3
-
58
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
DOI 10.1073/pnas.110126897
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 2000; 97: 6138-43. (Pubitemid 30367536)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.11
, pp. 6138-6143
-
-
Li, Y.-M.1
Lai, M.-T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
Shi, X.-P.7
Yin, K.-C.8
Shafer, J.A.9
Gardell, S.J.10
-
59
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999; 155: 853-62. (Pubitemid 29426831)
-
(1999)
American Journal of Pathology
, vol.155
, Issue.3
, pp. 853-862
-
-
Lue, L.-F.1
Kuo, Y.-M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
60
-
-
0022479032
-
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
-
MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 1986; 321: 519-22.
-
(1986)
Nature
, vol.321
, pp. 519-522
-
-
MacDermott, A.B.1
Mayer, M.L.2
Westbrook, G.L.3
Smith, S.J.4
Barker, J.L.5
-
61
-
-
0035708355
-
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
-
DOI 10.1038/nn736
-
Matsuzaki M, Ellis-Davies GC, Nemoto T, Miyashita Y, Iino M, Kasai H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci 2001; 4: 1086-92. (Pubitemid 34116553)
-
(2001)
Nature Neuroscience
, vol.4
, Issue.11
, pp. 1086-1092
-
-
Matsuzaki, M.1
Ellis-Davies, G.C.R.2
Nemoto, T.3
Miyashita, Y.4
Iino, M.5
Kasai, H.6
-
62
-
-
3042554012
-
Structural basis of long-term potentiation in single dendritic spines
-
DOI 10.1038/nature02617
-
Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H. Structural basis of long-term potentiation in single dendritic spines. Nature 2004; 429: 761-6. (Pubitemid 38833127)
-
(2004)
Nature
, vol.429
, Issue.6993
, pp. 761-766
-
-
Matsuzaki, M.1
Honkura, N.2
Ellis-Davies, G.C.R.3
Kasai, H.4
-
63
-
-
0035232146
-
Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease
-
Mattson MP, Gary DS, Chan SL, Duan W. Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease. Biochem Soc Symp 2001; 151-62. (Pubitemid 33602683)
-
(2001)
Biochemical Society Symposium
, vol.67
, pp. 151-162
-
-
Mattson, M.P.1
Gary, D.S.2
Chan, S.L.3
Duan, W.4
-
64
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999; 46: 860-6.
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
65
-
-
38949175007
-
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
-
Miller JA, Oldham MC, Geschwind DH. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci 2008; 28: 1410-20.
-
(2008)
J Neurosci
, vol.28
, pp. 1410-1420
-
-
Miller, J.A.1
Oldham, M.C.2
Geschwind, D.H.3
-
66
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999; 274: 6483-92.
-
(1999)
J Biol Chem
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reverse, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Haute, C.V.9
Checler, F.10
Godaux, E.11
Cordell, B.12
Van Leuven, F.13
-
67
-
-
0034213718
-
High-level neuronal expression of Abeta(1-42) in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000; 20: 4050-8. (Pubitemid 30365675)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.11
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.-Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
68
-
-
9644265305
-
Bidirectional activity-dependent morphological plasticity in hippocampal neurons
-
DOI 10.1016/j.neuron.2004.11.016, PII S0896627304007299
-
Nagerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T. Bidirectional activity-dependent morphological plasticity in hippocampal neurons. Neuron 2004; 44: 759-67. (Pubitemid 39575630)
-
(2004)
Neuron
, vol.44
, Issue.5
, pp. 759-767
-
-
Nagerl, U.V.1
Eberhorn, N.2
Cambridge, S.B.3
Bonhoeffer, T.4
-
69
-
-
34248185927
-
2+ leak function of presenilin 1
-
DOI 10.1172/JCI30447
-
Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest 2007; 117: 1230-9. (Pubitemid 46718411)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.5
, pp. 1230-1239
-
-
Nelson, O.1
Tu, H.2
Lei, T.3
Bentahir, M.4
De Strooper, B.5
Bezprozvanny, I.6
-
70
-
-
33847049400
-
Alzheimer disease: Amyloidogenesis, the presenilins and animal models
-
DOI 10.1016/j.bbadis.2006.12.001, PII S0925443906002675
-
Newman M, Musgrave IF, Lardelli M. Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochim Biophys Acta 2007; 1772: 285-97. (Pubitemid 46275437)
-
(2007)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1772
, Issue.3
, pp. 285-297
-
-
Newman, M.1
Musgrave, F.I.2
Lardelli, M.3
-
71
-
-
0021260967
-
Magnesium gates glutamate-activated channels in mouse central neurones
-
Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 1984; 307: 462-5. (Pubitemid 14132062)
-
(1984)
Nature
, vol.307
, Issue.5950
, pp. 462-465
-
-
Nowak, L.1
Bregestovski, P.2
Ascher, P.3
-
72
-
-
7044270772
-
Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
-
DOI 10.1523/JNEUROSCI.2350-04.2004
-
Otmakhov N, Tao-Cheng JH, Carpenter S, Asrican B, Dosemeci A, Reese TS, Lisman J. Persistent accumulation of calcium calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation. J Neurosci 2004; 24: 9324-31. (Pubitemid 39426169)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.42
, pp. 9324-9331
-
-
Otmakhov, N.1
Tao-Cheng, J.-H.2
Carpenter, S.3
Asrican, B.4
Dosemeci, A.5
Reese, T.S.6
Lisman, J.7
-
73
-
-
0032945724
-
Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1
-
DOI 10.1006/nbdi.1998.0207
-
Parent A, Linden DJ, Sisodia SS, Borchelt DR. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol Dis 1999; 6: 56-62. (Pubitemid 29156468)
-
(1999)
Neurobiology of Disease
, vol.6
, Issue.1
, pp. 56-62
-
-
Parent, A.1
Linden, D.J.2
Sisodia, S.S.3
Borchelt, D.R.4
-
74
-
-
0037117753
-
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha
-
DOI 10.1021/bi015936e
-
Parkin ET, Trew A, Christie G, Faller A, Mayer R, Turner AJ, Hooper NM. Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry 2002; 41: 4972-81. (Pubitemid 34298665)
-
(2002)
Biochemistry
, vol.41
, Issue.15
, pp. 4972-4981
-
-
Parkin, E.T.1
Trew, A.2
Christie, G.3
Faller, A.4
Mayer, R.5
Turner, A.J.6
Hooper, N.M.7
-
75
-
-
33748049463
-
Storage of spatial information by the maintenance mechanism of LTP
-
DOI 10.1126/science.1128657
-
Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC. Storage of spatial information by the maintenance mechanism of LTP. Science 2006; 313: 1141-4. (Pubitemid 44300243)
-
(2006)
Science
, vol.313
, Issue.5790
, pp. 1141-1444
-
-
Pastalkova, E.1
Serrano, P.2
Pinkhasova, D.3
Wallace, E.4
Fenton, A.A.5
Sacktor, T.C.6
-
76
-
-
0014768351
-
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
-
Peters A, Kaiserman-Abramof IR. The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines. Am J Anat 1970; 127: 321-55.
-
(1970)
Am J Anat
, vol.127
, pp. 321-355
-
-
Peters, A.1
Kaiserman-Abramof, I.R.2
-
77
-
-
0014687804
-
The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines
-
Peters A, Kaiserman-Abramof IR. The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines. Z Zellforsch Mikrosk Anat 1969; 100: 487-506.
-
(1969)
Z Zellforsch Mikrosk Anat
, vol.100
, pp. 487-506
-
-
Peters, A.1
Kaiserman-Abramof, I.R.2
-
78
-
-
58149385218
-
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
-
Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 2008; 28: 14537-45.
-
(2008)
J Neurosci
, vol.28
, pp. 14537-14545
-
-
Puzzo, D.1
Privitera, L.2
Leznik, E.3
Fa, M.4
Staniszewski, A.5
Palmeri, A.6
Arancio, O.7
-
79
-
-
0037432559
-
NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus
-
Raymond CR, Ireland DR, Abraham WC. NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus. Brain Res 2003; 968: 263-72.
-
(2003)
Brain Res
, vol.968
, pp. 263-272
-
-
Raymond, C.R.1
Ireland, D.R.2
Abraham, W.C.3
-
80
-
-
0033987838
-
Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus
-
DOI 10.1002/(SICI)1098-2396(200002)35:2<96::AID-SYN2>3.0.CO;2-0
-
Ribaut-Barassin C, Moussaoui S, Brugg B, Haeberle AM, Huber G, Imperato A, Delhaye-Bouchaud N, Mariani J, Bailly YJ. Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus. Synapse 2000; 35: 96-110. (Pubitemid 30036186)
-
(2000)
Synapse
, vol.35
, Issue.2
, pp. 96-110
-
-
Ribaut-Barassen, C.1
Moussaoui, S.2
Brugg, B.3
Haeberle, A.-M.4
Huber, G.5
Imperato, A.6
Delhaye-Bouchaud, N.7
Mariani, J.8
Bailly, Y.J.9
-
81
-
-
41349089303
-
PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage
-
Sacktor TC. PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. Prog Brain Res 2008; 169: 27-40.
-
(2008)
Prog Brain Res
, vol.169
, pp. 27-40
-
-
Sacktor, T.C.1
-
82
-
-
0033365730
-
Can molecules explain long-term potentiation?
-
Sanes JR, Lichtman JW. Can molecules explain long-term potentiation? Nat Neurosci 1999; 2: 597-604.
-
(1999)
Nat Neurosci
, vol.2
, pp. 597-604
-
-
Sanes, J.R.1
Lichtman, J.W.2
-
83
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668-71.
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Orr, H.T.4
Anderson, L.5
Nemens, E.6
White, J.A.7
Bonnycastle, L.8
Weber, J.L.9
Alonso, M.E.10
-
84
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
DOI 10.1523/JNEUROSCI.4970-06.2007
-
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 2007; 27: 2866-75. (Pubitemid 46438992)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.11
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
85
-
-
70349973683
-
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life
-
Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis 2009; 36(2):293-302.
-
(2009)
Neurobiol Dis
, vol.36
, Issue.2
, pp. 293-302
-
-
Shankar, G.M.1
Leissring, M.A.2
Adame, A.3
Sun, X.4
Spooner, E.5
Masliah, E.6
Selkoe, D.J.7
Lemere, C.A.8
Walsh, D.M.9
-
86
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008; 14: 837-42.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
87
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-60.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
88
-
-
0037383823
-
Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
-
Smith MA, Ellis-Davies GC, Magee JC. Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons. J Physiol 2003; 548: 245-58.
-
(2003)
J Physiol
, vol.548
, pp. 245-258
-
-
Smith, M.A.1
Ellis-Davies, G.C.2
Magee, J.C.3
-
89
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
DOI 10.1038/nn1503
-
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005; 8: 1051-8. (Pubitemid 41061516)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
Paul, S.4
Moran, T.5
Choi, E.Y.6
Nairn, A.C.7
Salter, M.W.8
Lombroso, P.J.9
Gouras, G.K.10
Greengard, P.11
-
91
-
-
0034573291
-
Piecing together Alzheimer's
-
St George-Hyslop PH. Piecing together Alzheimer's. Sci Am 2000; 283: 76-83.
-
(2000)
Sci Am
, vol.283
, pp. 76-83
-
-
St George-Hyslop, P.H.1
-
92
-
-
33646945317
-
2+ disruptions in young, adult, and aged Alzheimer's disease mice
-
DOI 10.1523/JNEUROSCI.0739-06.2006
-
Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci 2006; 26: 5180-9. (Pubitemid 44315299)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.19
, pp. 5180-5189
-
-
Stutzmann, G.E.1
Smith, I.2
Caccamo, A.3
Oddo, S.4
LaFerla, F.M.5
Parker, I.6
-
93
-
-
0036736218
-
Amyloid precursor protein, presenilins, and alpha-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
-
Suh YH, Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 2002; 54: 469-525.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 469-525
-
-
Suh, Y.H.1
Checler, F.2
-
94
-
-
23844532257
-
Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation
-
DOI 10.1159/000086426
-
Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neurodegener Dis. 2005;2(1):6-15. (Pubitemid 41158935)
-
(2005)
Neurodegenerative Diseases
, vol.2
, Issue.1
, pp. 6-15
-
-
Sun, X.1
Beglopoulos, V.2
Mattson, M.P.3
Shen, J.4
-
95
-
-
0023109592
-
Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987; 235: 880-4.
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
96
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572-80.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
97
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
DOI 10.1016/S0896-6273(00)80291-3
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 1996; 17:181-90. (Pubitemid 26251602)
-
(1996)
Neuron
, vol.17
, Issue.1
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
98
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008; 283: 29615-9.
-
(2008)
J Biol Chem
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
99
-
-
0033604506
-
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
-
Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 1999; 402: 421-5. (Pubitemid 129544831)
-
(1999)
Nature
, vol.402
, Issue.6760
, pp. 421-425
-
-
Toni, N.1
Buchs, P.-A.2
Nikonenko, I.3
Bron, C.R.4
Muller, D.5
-
100
-
-
33846003098
-
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers
-
DOI 10.1002/ana.21051
-
Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann Neurol 2006; 60: 668-76. (Pubitemid 46048484)
-
(2006)
Annals of Neurology
, vol.60
, Issue.6
, pp. 668-676
-
-
Townsend, M.1
Cleary, J.P.2
Mehta, T.3
Hofmeister, J.4
Lesne, S.5
O'Hare, E.6
Walsh, D.M.7
Selkoe, D.J.8
-
101
-
-
33846403492
-
Pathological and physiological functions of presenilins
-
DOI 10.1186/1750-1326-1-4
-
Vetrivel KS, Zhang YW, Xu H, Thinakaran G. Pathological and physiological functions of presenilins. Mol Neurodegener 2006; 1: 4. (Pubitemid 46724554)
-
(2006)
Molecular Neurodegeneration
, vol.1
, Issue.1
, pp. 4
-
-
Vetrivel, K.S.1
Zhang, Y.-W.2
Xu, H.3
Thinakaran, G.4
-
102
-
-
0037059598
-
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
-
Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res 2002; 924: 133-40.
-
(2002)
Brain Res
, vol.924
, pp. 133-140
-
-
Wang, H.W.1
Pasternak, J.F.2
Kuo, H.3
Ristic, H.4
Lambert, M.P.5
Chromy, B.6
Viola, K.L.7
Klein, W.L.8
Stine, W.B.9
Krafft, G.A.10
Trommer, B.L.11
-
104
-
-
0035937153
-
The Role of presenilins in gamma-secretase activity
-
Wolfe MS, Haass C. The Role of presenilins in gamma-secretase activity. J Biol Chem 2001; 276: 5413-6.
-
(2001)
J Biol Chem
, vol.276
, pp. 5413-5416
-
-
Wolfe, M.S.1
Haass, C.2
-
105
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999; 398: 513-7.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
106
-
-
0025219026
-
Genomic organization of the human amyloid beta-protein precursor gene
-
DOI 10.1016/0378-1119(90)90310-N
-
Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y. Genomic organization of the human amyloid beta-protein precursor gene. Gene 1990; 87: 257-63. (Pubitemid 20146047)
-
(1990)
Gene
, vol.87
, Issue.2
, pp. 257-263
-
-
Yoshikai, S.-I.1
Sasaki, H.2
Doh-ura, K.3
Furuya, H.4
Sakaki, Y.5
-
107
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notchglp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nicastrin modulates presenilin-mediated notchglp-1 signal transduction and betaAPP processing. Nature 2000; 407: 48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
108
-
-
0034095106
-
Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine
-
DOI 10.1006/nbdi.1999.0271
-
Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiol Dis 2000; 7: 54-63. (Pubitemid 30141819)
-
(2000)
Neurobiology of Disease
, vol.7
, Issue.1
, pp. 54-63
-
-
Zaman, S.H.1
Parent, A.2
Laskey, A.3
Lee, M.K.4
Borchelt, D.R.5
Sisodia, S.S.6
Malinow, R.7
-
109
-
-
67949086707
-
Presenilins are essential for regulating neurotransmitter release
-
Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Sudhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature 2009; 460: 632-6.
-
(2009)
Nature
, vol.460
, pp. 632-636
-
-
Zhang, C.1
Wu, B.2
Beglopoulos, V.3
Wines-Samuelson, M.4
Zhang, D.5
Dragatsis, I.6
Sudhof, T.C.7
Shen, J.8
-
110
-
-
9644278075
-
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
-
DOI 10.1016/j.neuron.2004.11.011, PII S0896627304007226
-
Zhou Q, Homma KJ, Poo MM. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 2004; 44:749-57. (Pubitemid 39575629)
-
(2004)
Neuron
, vol.44
, Issue.5
, pp. 749-757
-
-
Zhou, Q.1
Homma, K.J.2
Poo, M.-M.3
|