Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 78-82

  Ivachtchenko, Alexandre V ^a,b   Frolov, Eugen B ^b   Mitkin, Oleg D ^a   Tkachenko, Sergei E ^b   Okun, Ilya M ^b   Khvat, Alex V ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

5 HT2C; 5 HT6; 5 HT7; Adrenergic; Alpha 2; Calcium mobilization; Dimebolin; Dimebon; H1; Histamineergic; Pyridoindoles; Receptor; Serotonergic

Indexed keywords

2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE DERIVATIVE; 2,8 DIMETHYL 5 (2 PHENYLVINYL) 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; 2,8 DIMETHYL 5 STYRYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; DIMEBON; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; INDOLE DERIVATIVE; SEROTONIN 2C RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADRENERGIC ALPHA-ANTAGONISTS; CELL LINE; HISTAMINE H1 ANTAGONISTS; HUMANS; INDOLES; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, HISTAMINE H1; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72149122407     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.037     Document Type: Article

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