Paracrine control of vascular innervation in health and disease

Acta Physiologica

Volumn 203, Issue 1, 2011, Pages 61-86

  Storkebaum, E ^a,b,c   Carmeliet, P ^b,c  

^a MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Blood pressure; Neuro effector junction; Periarterial nerve; Plasticity; Vascular endothelial growth factor; Vascular regulation

Indexed keywords

ACETYLCHOLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE BETA MONOOXYGENASE; NEUROTROPHIN 3; NORADRENALIN; TYROSINE 3 MONOOXYGENASE; VASCULOTROPIN;

AUTONOMIC NERVOUS SYSTEM; BLOOD VESSEL INNERVATION; BLOOD VESSEL TONE; HUMAN; HYPERTENSION; MIGRAINE; MOTOR NERVE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE GROWTH; NERVE PLEXUS; NEUROMODULATION; NONHUMAN; ORTHOSTATIC HYPOTENSION; PARACRINE SIGNALING; PARASYMPATHETIC NERVE; PATHOGENESIS; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FUNCTION; RAYNAUD PHENOMENON; REGULATORY MECHANISM; REVIEW; SENSORY NERVE; SYMPATHETIC NERVE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; ARTERIES; HEMODYNAMICS; HUMANS; PARACRINE COMMUNICATION; VASCULAR RESISTANCE;

EID: 80051670167     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2011.02333.x     Document Type: Review

References (320)

1. Acheson, A.L., Naujoks, K. & Thoenen, H. 1984. Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: specificity and level of regulation. J Neurosci 4, 1771-1780.
2. Albers, K.M., Wright, D.E. & Davis, B.M. 1994. Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 14, 1422-1432.
3. Albers, K.M., Perrone, T.N., Goodness, T.P., Jones, M.E., Green, M.A. & Davis, B.M. 1996. Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation. J Cell Biol 134, 487-497.
4. Albert, V. & Campbell, G.R. 1990. Relationship between the sympathetic nervous system and vascular smooth muscle: a morphometric study of adult and juvenile spontaneously hypertensive rat/Wistar-Kyoto rat caudal artery. Heart Vessels 5, 129-139.
5. Albino-Teixeira, A., Azevedo, I., Branco, D. & Osswald, W. 1990. Purine agonists prevent trophic changes caused by sympathetic denervation. Eur J Pharmacol 179, 141-149.
6. Anderson, E.A., Sinkey, C.A., Lawton, W.J. & Mark, A.L. 1989. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 14, 177-183.
7. Andrews, T.J. & Cowen, T. 1994. In vivo infusion of NGF induces the organotypic regrowth of perivascular nerves following their atrophy in aged rats. J Neurosci 14, 3048-3058.
8. Asmus, S.E., Parsons, S. & Landis, S.C. 2000. Developmental changes in the transmitter properties of sympathetic neurons that innervate the periosteum. J Neurosci 20, 1495-1504.
9. Atwal, J.K., Massie, B., Miller, F.D. & Kaplan, D.R. 2000. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron 27, 265-277.
10. Atwal, J.K., Singh, K.K., Tessier-Lavigne, M., Miller, F.D. & Kaplan, D.R. 2003. Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. J Neurosci 23, 7602-7609.
11. Azzouz, M., Ralph, G.S., Storkebaum, E., Walmsley, L.E., Mitrophanous, K.A., Kingsman, S.M., Carmeliet, P. & Mazarakis, N.D. 2004. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429, 413-417.
12. Bagri, A., Tessier-Lavigne, M. & Watts, R.J. 2009. Neuropilins in tumor biology. Clin Cancer Res 15, 1860-1864.
13. Bakst, R., Merola, J.F., Franks, A.G. Jr & Sanchez, M. 2008. Raynaud's phenomenon: pathogenesis and management. J Am Acad Dermatol 59, 633-653.
14. Baloh, R.H., Tansey, M.G., Lampe, P.A., Fahrner, T.J., Enomoto, H., Simburger, K.S., Leitner, M.L., Araki, T., Johnson, E.M. Jr & Milbrandt, J. 1998. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron 21, 1291-1302.
15. Behar, T.N., Schaffner, A.E., Colton, C.A., Somogyi, R., Olah, Z., Lehel, C. & Barker, J.L. 1994. GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons. J Neurosci 14, 29-38.
16. Bell, C. & Malcolm, S.J. 1978. Observations on the loss of catecholamine fluorescence from intrauterine adrenergic nerves during pregnancy in the guinea-pig. J Reprod Fertil 53, 51-58.
17. Bell, C. & Malcolm, S.J. 1988. Neurochemistry of the sympathetic innervation to the uterus. Clin Exp Pharmacol Physiol 15, 667-674.
18. Benarroch, E.E. 2007. Thermoregulation: recent concepts and remaining questions. Neurology 69, 1293-1297.
19. Bevan, R.D. 1975. Effect of sympathetic denervation on smooth muscle cell proliferation in the growing rabbit ear artery. Circ Res 37, 14-19.
20. Bevan, R.D. & Tsuru, H. 1981. Functional and structural changes in the rabbit ear artery after sympathetic denervation. Circ Res 49, 478-485.
21. Bjorling, D.E., Beckman, M., Clayton, M.K. & Wang, Z.Y. 2002. Modulation of nerve growth factor in peripheral organs by estrogen and progesterone. Neuroscience 110, 155-167.
22. Bradley, J.G. & Davis, K.A. 2003. Orthostatic hypotension. Am Fam Physician 68, 2393-2398.
23. Brauer, M.M. 2008. Cellular and molecular mechanisms underlying plasticity in uterine sympathetic nerves. Auton Neurosci 140, 1-16.
24. Brauer, M.M., Burnstock, G., Thrasivoulou, C. & Cowen, T. 1998. In oculo transplants of myometrium from postpartum guinea pigs fail to support sympathetic reinnervation. J Anat 193, 509-517.
25. Brauer, M.M., Chavez-Genaro, R., Llodra, J., Richeri, A. & Scorza, M.C. 2000a. Effects of chronic oestrogen treatment are not selective for uterine noradrenaline-containing sympathetic nerves: a transplantation study. J Anat 196, 347-355.
26. Brauer, M.M., Shockley, K.P., Chavez, R., Richeri, A., Cowen, T. & Crutcher, K.A. 2000b. The role of NGF in pregnancy-induced degeneration and regeneration of sympathetic nerves in the guinea pig uterus. J Auton Nerv Syst 79, 19-27.
27. Brennan, K.C. & Charles, A. 2010. An update on the blood vessel in migraine. Curr Opin Neurol 23, 266-274.
28. Brock, J.A. & Van Helden, D.F. 1995. Enhanced excitatory junction potentials in mesenteric arteries from spontaneously hypertensive rats. Pflugers Arch 430, 901-908.
29. Brodski, C., Schnurch, H. & Dechant, G. 2000. Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons. Proc Natl Acad Sci U S A 97, 9683-9688.
30. Bronfman, F.C., Escudero, C.A., Weis, J. & Kruttgen, A. 2007. Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases. Dev Neurobiol 67, 1183-1203.
31. Buettner, H.M. & Pittman, R.N. 1991. Quantitative effects of laminin concentration on neurite outgrowth in vitro. Dev Biol 145, 266-276.
32. Bunker, C.B., Terenghi, G., Springall, D.R., Polak, J.M. & Dowd, P.M. 1990. Deficiency of calcitonin gene-related peptide in Raynaud's phenomenon. Lancet 336, 1530-1533.
33. Burnstock, G. 2008. Non-synaptic transmission at autonomic neuroeffector junctions. Neurochem Int 52, 14-25.
34. Burnstock, G. 2009a. Autonomic neurotransmission: 60years since sir Henry Dale. Annu Rev Pharmacol Toxicol 49, 1-30.
35. Burnstock, G. 2009b. Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol 29, 63-72.
36. Cai, D., Shen, Y., De Bellard, M., Tang, S. & Filbin, M.T. 1999. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 22, 89-101.
37. Calza, L., Giardino, L., Giuliani, A., Aloe, L. & Levi-Montalcini, R. 2001. Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors. Proc Natl Acad Sci U S A 98, 4160-4165.
38. Campenot, R.B. 1977. Local control of neurite development by nerve growth factor. Proc Natl Acad Sci U S A 74, 4516-4519.
39. Carmeliet, P. 2003a. Angiogenesis in health and disease. Nat Med 9, 653-660.
40. Carmeliet, P. 2003b. Blood vessels and nerves: common signals, pathways and diseases. Nat Rev Genet 4, 710-720.
41. Carmeliet, P. 2005. Angiogenesis in life, disease and medicine. Nature 438, 932-936.
42. Carmeliet, P. & Tessier-Lavigne, M. 2005. Common mechanisms of nerve and blood vessel wiring. Nature 436, 193-200.
43. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C. et al. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439.
44. Carmignoto, G. & Gomez-Gonzalo, M. 2010. The contribution of astrocyte signalling to neurovascular coupling. Brain Res Rev 63, 138-148.
45. Carretero, O.A. & Oparil, S. 2000. Essential hypertension. Part I: definition and etiology. Circulation 101, 329-335.
46. Causing, C.G., Gloster, A., Aloyz, R., Bamji, S.X., Chang, E., Fawcett, J., Kuchel, G. & Miller, F.D. 1997. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18, 257-267.
47. Chalar, C., Richeri, A., Viettro, L., Chavez-Genaro, R., Bianchimano, P., Marmol, N.M., Crutcher, K., Burnstock, G., Cowen, T. & Brauer, M.M. 2003. Plasticity in developing rat uterine sensory nerves: the role of NGF and TrkA. Cell Tissue Res 314, 191-205.
48. Chao, M.V., Rajagopal, R. & Lee, F.S. 2006. Neurotrophin signalling in health and disease. Clin Sci (Lond) 110, 167-173.
49. Chavez-Genaro, R., Crutcher, K., Viettro, L., Richeri, A., Coirolo, N., Burnstock, G., Cowen, T. & Brauer, M.M. 2002. Differential effects of oestrogen on developing and mature uterine sympathetic nerves. Cell Tissue Res 308, 61-73.
50. Chavez-Genaro, R., Lombide, P. & Anesetti, G. 2006. A quantitative study of rat uterine sympathetic innervation during pregnancy and post partum. Reprod Fertil Dev 18, 525-531.
51. Chen, H., Chedotal, A., He, Z., Goodman, C.S. & Tessier-Lavigne, M. 1997. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19, 547-559.
52. Chen, H., He, Z., Bagri, A. & Tessier-Lavigne, M. 1998. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron 21, 1283-1290.
53. Chotani, M.A., Flavahan, S., Mitra, S., Daunt, D. & Flavahan, N.A. 2000. Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol 278, H1075-H1083.
54. Chun, L.L. & Patterson, P.H. 1977. Role of nerve growth factor in the development of rat sympathetic neurons in vitro. III. Effect on acetylcholine production. J Cell Biol 75, 712-718.
55. Colley, B., Tucker, K. & Fadool, D.A. 2004. Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents. Receptors Channels 10, 25-36.
56. Colley, B.S., Biju, K.C., Visegrady, A., Campbell, S. & Fadool, D.A. 2007. Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression. Neuroscience 144, 531-546.
57. Cordon-Cardo, C., Tapley, P., Jing, S.Q., Nanduri, V., O'Rourke, E., Lamballe, F., Kovary, K., Klein, R., Jones, K.R., Reichardt, L.F. & Barbacid, M. 1991. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66, 173-183.
58. Cosker, K.E., Courchesne, S.L. & Segal, R.A. 2008. Action in the axon: generation and transport of signaling endosomes. Curr Opin Neurobiol 18, 270-275.
59. Cowen, T. & Gavazzi, I. 1998. Plasticity in adult and ageing sympathetic neurons. Prog Neurobiol 54, 249-288.
60. Cowen, T., Jenner, C., Song, G.X., Santoso, A.W. & Gavazzi, I. 1997. Responses of mature and aged sympathetic neurons to laminin and NGF: an in vitro study. Neurochem Res 22, 1003-1011.
61. Crowley, C., Spencer, S.D., Nishimura, M.C., Chen, K.S., Pitts-Meek, S., Armanini, M.P., Ling, L.H., McMahon, S.B., Shelton, D.L., Levinson, A.D. & Phillips, H.S. 1994. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76, 1001-1011.
62. Cuello, A.C. 1996. Effects of trophic factors on the CNS cholinergic phenotype. Prog Brain Res 109, 347-358.
63. Damon, D.H. 2000. VSM growth is stimulated in sympathetic neuron/VSM cocultures: role of TGF-beta2 and endothelin. Am J Physiol Heart Circ Physiol 278, H404-H411.
64. Damon, D.H. 2001. NGF-independent survival of postganglionic sympathetic neurons in neuronal-vascular smooth muscle cocultures. Am J Physiol Heart Circ Physiol 280, H1722-H1728.
65. Damon, D.H. 2005. Sympathetic innervation promotes vascular smooth muscle differentiation. Am J Physiol Heart Circ Physiol 288, H2785-H2791.
66. Damon, D.H., teRiele, J.A. & Marko, S.B. 2010. Eph/ephrin interactions modulate vascular sympathetic innervation. Auton Neurosci 158, 65-70.
67. D'Andrea, G. & Leon, A. 2010. Pathogenesis of migraine: from neurotransmitters to neuromodulators and beyond. Neurol Sci 31(Suppl 1), S1-S7.
68. Davey, M.J. 1986. The pharmacological basis for the use of alpha 1-adrenoceptor antagonists in the treatment of essential hypertension. Br J Clin Pharmacol 21(Suppl 1), 5S-8S.
69. Davey, M. 1987. Mechanism of alpha blockade for blood pressure control. Am J Cardiol 59, 18G-28G.
70. Davies, A.M. 1996. The neurotrophic hypothesis: where does it stand? Philos Trans R Soc Lond B Biol Sci 351, 389-394.
71. Debeir, T., Saragovi, H.U. & Cuello, A.C. 1999. A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat. Proc Natl Acad Sci U S A 96, 4067-4072.
72. Deinhardt, K., Salinas, S., Verastegui, C., Watson, R., Worth, D., Hanrahan, S., Bucci, C. & Schiavo, G. 2006. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 52, 293-305.
73. Delcroix, J.D., Valletta, J.S., Wu, C., Hunt, S.J., Kowal, A.S. & Mobley, W.C. 2003. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39, 69-84.
74. Dimitriadou, V., Aubineau, P., Taxi, J. & Seylaz, J. 1988. Ultrastructural changes in the cerebral artery wall induced by long-term sympathetic denervation. Blood Vessels 25, 122-143.
75. Donoso, M.V., Delpiano, A.M. & Huidobro-Toro, J.P. 2006. Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions. EXS 95, 65-76.
76. Duncker, D.J. & Bache, R.J. 2008. Regulation of coronary blood flow during exercise. Physiol Rev 88, 1009-1086.
77. Easton, R.M., Deckwerth, T.L., Parsadanian, A.S. & Johnson, E.M. Jr 1997. Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: a phenotype indistinguishable from Bax deletion. J Neurosci 17, 9656-9666.
78. Ebendal, T., Olson, L., Seiger, A. & Hedlund, K.O. 1980. Nerve growth factors in the rat iris. Nature 286, 25-28.
79. Edgar, D., Timpl, R. & Thoenen, H. 1988. Structural requirements for the stimulation of neurite outgrowth by two variants of laminin and their inhibition by antibodies. J Cell Biol 106, 1299-1306.
80. ElShamy, W.M., Linnarsson, S., Lee, K.F., Jaenisch, R. & Ernfors, P. 1996. Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. Development 122, 491-500.
81. Engvall, E. 1993. Laminin variants: why, where and when? Kidney Int 43, 2-6.
82. Enomoto, H., Crawford, P.A., Gorodinsky, A., Heuckeroth, R.O., Johnson, E.M. Jr & Milbrandt, J. 2001. RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development 128, 3963-3974.
83. Ernfors, P., Lee, K.F. & Jaenisch, R. 1994a. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147-150.
84. Ernfors, P., Lee, K.F., Kucera, J. & Jaenisch, R. 1994b. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, 503-512.
85. Ernsberger, U. 2001. The development of postganglionic sympathetic neurons: coordinating neuronal differentiation and diversification. Auton Neurosci 94, 1-13.
86. Ernsberger, U. & Rohrer, H. 1999. Development of the cholinergic neurotransmitter phenotype in postganglionic sympathetic neurons. Cell Tissue Res 297, 339-361.
87. Facchiano, F., Fernandez, E., Mancarella, S., Maira, G., Miscusi, M., D'Arcangelo, D., Cimino-Reale, G., Falchetti, M.L., Capogrossi, M.C. & Pallini, R. 2002. Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg 97, 161-168.
88. Fan, X.M., Hendley, E.D. & Forehand, C.J. 1995. Enhanced vascular neuropeptide Y-immunoreactive innervation in two hypertensive rat strains. Hypertension 26, 758-763.
89. Farinas, I., Jones, K.R., Backus, C., Wang, X.Y. & Reichardt, L.F. 1994. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369, 658-661.
90. Felder, E. & Dechant, G. 2007. Neurotrophic factors acutely alter the sorting of the vesicular acetyl choline transporter and the vesicular monoamine transporter 2 in bimodal sympathetic neurons. Mol Cell Neurosci 34, 1-9.
91. Fernandes, E.S., Schmidhuber, S.M. & Brain, S.D. 2009. Sensory-nerve-derived neuropeptides: possible therapeutic targets. Handb Exp Pharmacol 194, 393-416.
92. Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K.S., Powell-Braxton, L., Hillan, K.J. & Moore, M.W. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442.
93. Fink, G.D. 2009. Arthur C. Corcoran Memorial Lecture. Sympathetic activity, vascular capacitance, and long-term regulation of arterial pressure. Hypertension 53, 307-312.
94. Fiore, M., Chaldakov, G.N. & Aloe, L. 2009. Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci 20, 133-145.
95. Flaumenhaft, R. & Rifkin, D.B. 1991. Extracellular matrix regulation of growth factor and protease activity. Curr Opin Cell Biol 3, 817-823.
96. Flavahan, N.A. & Vanhoutte, P.M. 1986. Effect of cooling on alpha-1 and alpha-2 adrenergic responses in canine saphenous and femoral veins. J Pharmacol Exp Ther 238, 139-147.
97. Ford, C.P., Wong, K.V., Lu, V.B., Posse de Chaves, E. & Smith, P.A. 2008. Differential neurotrophic regulation of sodium and calcium channels in an adult sympathetic neuron. J Neurophysiol 99, 1319-1332.
98. Francis, N., Farinas, I., Brennan, C., Rivas-Plata, K., Backus, C., Reichardt, L. & Landis, S. 1999. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors. Dev Biol 210, 411-427.
99. Freedman, R.R. & Ianni, P. 1983. Role of cold and emotional stress in Raynaud's disease and scleroderma. Br Med J (Clin Res Ed) 287, 1499-1502.
100. Furshpan, E.J., Landis, S.C., Matsumoto, S.G. & Potter, D.D. 1986. Synaptic functions in rat sympathetic neurons in microcultures. I. Secretion of norepinephrine and acetylcholine. J Neurosci 6, 1061-1079.
101. Gabella, G. 1984. Size of neurons and glial cells in the intramural ganglia of the hypertrophic intestine of the guinea-pig. J Neurocytol 13, 73-84.
102. Gabella, G., Berggren, T. & Uvelius, B. 1992. Hypertrophy and reversal of hypertrophy in rat pelvic ganglion neurons. J Neurocytol 21, 649-662.
103. Garcia-Carrasco, M., Jimenez-Hernandez, M., Escarcega, R.O., Mendoza-Pinto, C., Pardo-Santos, R., Levy, R., Maldonado, C.G., Chavez, G.P. & Cervera, R. 2008. Treatment of Raynaud's phenomenon. Autoimmun Rev 8, 62-68.
104. Generini, S., Seibold, J.R. & Matucci-Cerinic, M. 2005. Estrogens and neuropeptides in Raynaud's phenomenon. Rheum Dis Clin North Am 31, 177-186, X-XI.
105. Giger, R.J., Urquhart, E.R., Gillespie, S.K., Levengood, D.V., Ginty, D.D. & Kolodkin, A.L. 1998. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron 21, 1079-1092.
106. Gingras, J., Rassadi, S., Cooper, E. & Ferns, M. 2002. Agrin plays an organizing role in the formation of sympathetic synapses. J Cell Biol 158, 1109-1118.
107. Glebova, N.O. & Ginty, D.D. 2004. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24, 743-751.
108. Glebova, N.O. & Ginty, D.D. 2005. Growth and survival signals controlling sympathetic nervous system development. Annu Rev Neurosci 28, 191-222.
109. Glukhova, M.A. & Thiery, J.P. 1993. Fibronectin and integrins in development. Semin Cancer Biol 4, 241-249.
110. Goadsby, P.J., Edvinsson, L. & Ekman, R. 1988. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 23, 193-196.
111. Goadsby, P.J., Edvinsson, L. & Ekman, R. 1990. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28, 183-187.
112. Goldstein, D.S. 1983. Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5, 86-99.
113. Goridis, C. & Rohrer, H. 2002. Specification of catecholaminergic and serotonergic neurons. Nat Rev Neurosci 3, 531-541.
114. Gorin, P.D. & Johnson, E.M. Jr 1980. Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach. Brain Res 198, 27-42.
115. Gradin, K.A., Li, J.Y., Andersson, O. & Simonsen, U. 2003. Enhanced neuropeptide Y immunoreactivity and vasoconstriction in mesenteric small arteries from spontaneously hypertensive rats. J Vasc Res 40, 252-265.
116. Graef, I.A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M. & Crabtree, G.R. 2003. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113, 657-670.
117. Grassi, G., Quarti-Trevano, F., Dell'oro, R. & Mancia, G. 2008. Essential hypertension and the sympathetic nervous system. Neurol Sci 29(Suppl 1), S33-S36.
118. Grassi, G., Seravalle, G. & Quarti-Trevano, F. 2010. The 'neuroadrenergic hypothesis' in hypertension: current evidence. Exp Physiol 95, 581-586.
119. Greene, L.A., Seeley, P.J., Rukenstein, A., DiPiazza, M. & Howard, A. 1984. Rapid activation of tyrosine hydroxylase in response to nerve growth factor. J Neurochem 42, 1728-1734.
120. Grimes, M.L., Zhou, J., Beattie, E.C., Yuen, E.C., Hall, D.E., Valletta, J.S., Topp, K.S., LaVail, J.H., Bunnett, N.W. & Mobley, W.C. 1996. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci 16, 7950-7964.
121. Grunewald, F.S., Prota, A.E., Giese, A. & Ballmer-Hofer, K. 2010. Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim Biophys Acta 1804, 567-580.
122. Gupta, D. & Nair, M.D. 2008. Neurogenic orthostatic hypotension: chasing "the fall". Postgrad Med J 84, 6-14.
123. Guyenet, P.G. 2006. The sympathetic control of blood pressure. Nat Rev Neurosci 7, 335-346.
124. Habecker, B.A., Symes, A.J., Stahl, N., Francis, N.J., Economides, A., Fink, J.S., Yancopoulos, G.D. & Landis, S.C. 1997. A sweat gland-derived differentiation activity acts through known cytokine signaling pathways. J Biol Chem 272, 30421-30428.
125. Hansen-Algenstaedt, N., Algenstaedt, P., Schaefer, C., Hamann, A., Wolfram, L., Cingoz, G., Kilic, N., Schwarzloh, B., Schroeder, M., Joscheck, C., Wiesner, L., Ruther, W. & Ergun, S. 2006. Neural driven angiogenesis by overexpression of nerve growth factor. Histochem Cell Biol 125, 637-649.
126. Heaton, M.B. 1989. Influence of laminin on the responsiveness of early chick embryo neural tube neurons to nerve growth factor. J Neurosci Res 22, 390-396.
127. Heerssen, H.M., Pazyra, M.F. & Segal, R.A. 2004. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat Neurosci 7, 596-604.
128. Hempstead, B.L. 2002. The many faces of p75NTR. Curr Opin Neurobiol 12, 260-267.
129. Hendry, I.A. 1975. The effects of axotomy on the development of the rat superior cervical ganglion. Brain Res 90, 235-244.
130. Hill, M.A., Davis, M.J., Meininger, G.A., Potocnik, S.J. & Murphy, T.V. 2006. Arteriolar myogenic signalling mechanisms: implications for local vascular function. Clin Hemorheol Microcirc 34, 67-79.
131. Ho, T.W., Mannix, L.K., Fan, X., Assaid, C., Furtek, C., Jones, C.J., Lines, C.R. & Rapoport, A.M. 2008. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology 70, 1304-1312.
132. Hobson, M.I., Green, C.J. & Terenghi, G. 2000. VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy. J Anat 197, 591-605.
133. Hodges, G.J. & Johnson, J.M. 2009. Adrenergic control of the human cutaneous circulation. Appl Physiol Nutr Metab 34, 829-839.
134. Hodges, G.J., Jackson, D.N., Mattar, L., Johnson, J.M. & Shoemaker, J.K. 2009. Neuropeptide Y and neurovascular control in skeletal muscle and skin. Am J Physiol Regul Integr Comp Physiol 297, R546-R555.
135. Honma, Y., Araki, T., Gianino, S., Bruce, A., Heuckeroth, R., Johnson, E. & Milbrandt, J. 2002. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 35, 267-282.
136. Howard, M.J. 2005. Mechanisms and perspectives on differentiation of autonomic neurons. Dev Biol 277, 271-286.
137. Howe, C.L., Valletta, J.S., Rusnak, A.S. & Mobley, W.C. 2001. NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron 32, 801-814.
138. Iadecola, C. & Nedergaard, M. 2007. Glial regulation of the cerebral microvasculature. Nat Neurosci 10, 1369-1376.
139. Intengan, H.D., Deng, L.Y., Li, J.S. & Schiffrin, E.L. 1999. Mechanics and composition of human subcutaneous resistance arteries in essential hypertension. Hypertension 33, 569-574.
140. Isaacson, L.G., Saffran, B.N. & Crutcher, K.A. 1992. Nerve growth factor-induced sprouting of mature, uninjured sympathetic axons. J Comp Neurol 326, 327-336.
141. Jassar, B.S., Pennefather, P.S. & Smith, P.A. 1993. Changes in sodium and calcium channel activity following axotomy of B-cells in bullfrog sympathetic ganglion. J Physiol 472, 203-231.
142. Jeyaraj, S.C., Chotani, M.A., Mitra, S., Gregg, H.E., Flavahan, N.A. & Morrison, K.J. 2001. Cooling evokes redistribution of alpha2C-adrenoceptors from Golgi to plasma membrane in transfected human embryonic kidney 293 cells. Mol Pharmacol 60, 1195-1200.
143. Jin, K.L., Mao, X.O. & Greenberg, D.A. 2000. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci U S A 97, 10242-10247.
144. Jin, K., Mao, X.O., Batteur, S.P., McEachron, E., Leahy, A. & Greenberg, D.A. 2001. Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor. Neuroscience 108, 351-358.
145. Jones, K.R., Farinas, I., Backus, C. & Reichardt, L.F. 1994. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, 989-999.
146. Jule, Y. & Szurszewski, J.H. 1983. Electrophysiology of neurones of the inferior mesenteric ganglion of the cat. J Physiol 344, 277-292.
147. Kacem, K., Seylaz, J., Issertial, O. & Aubineau, P. 1995. Chemical sympathectomy favours vimentin expression in arterial smooth muscle cells of young rats. J Auton Nerv Syst 53, 57-68.
148. Katoh-Semba, R., Kaisho, Y., Shintani, A., Nagahama, M. & Kato, K. 1996. Tissue distribution and immunocytochemical localization of neurotrophin-3 in the brain and peripheral tissues of rats. J Neurochem 66, 330-337.
149. Kaufmann, H. 1996. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 6, 125-126.
150. Kawamura, K., Ando, K. & Takebayashi, S. 1989. Perivascular innervation of the mesenteric artery in spontaneously hypertensive rats. Hypertension 14, 660-665.
151. Kawasaki, H., Takasaki, K., Saito, A. & Goto, K. 1988. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335, 164-167.
152. Kawasaki, H., Saito, A. & Takasaki, K. 1990a. Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat. Circ Res 67, 733-743.
153. Kawasaki, H., Saito, A. & Takasaki, K. 1990b. Changes in calcitonin gene-related peptide (CGRP)-containing vasodilator nerve activity in hypertension. Brain Res 518, 303-307.
154. Kirstein, M. & Farinas, I. 2002. Sensing life: regulation of sensory neuron survival by neurotrophins. Cell Mol Life Sci 59, 1787-1802.
155. van Kleef, E.M., Smits, J.F., De Mey, J.G., Cleutjens, J.P., Lombardi, D.M., Schwartz, S.M. & Daemen, M.J. 1992. Alpha 1-adrenoreceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery. Circ Res 70, 1122-1127.
156. Klein, R., Smeyne, R.J., Wurst, W., Long, L.K., Auerbach, B.A., Joyner, A.L. & Barbacid, M. 1993. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75, 113-122.
157. Klein, R., Silos-Santiago, I., Smeyne, R.J., Lira, S.A., Brambilla, R., Bryant, S., Zhang, L., Snider, W.D. & Barbacid, M. 1994. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368, 249-251.
158. Kohn, J., Aloyz, R.S., Toma, J.G., Haak-Frendscho, M. & Miller, F.D. 1999. Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation. J Neurosci 19, 5393-5408.
159. Koistinaho, J., Wadhwani, K.C. & Rapoport, S.I. 1989. Increased density of perivascular adrenergic innervation in tibial and vagus nerves of spontaneously hypertensive rats. J Neurosci Res 24, 424-430.
160. Koles, L., Furst, S. & Illes, P. 2007. Purine ionotropic (P2X) receptors. Curr Pharm Des 13, 2368-2384.
161. Kolodkin, A.L. 1998. Semaphorin-mediated neuronal growth cone guidance. Prog Brain Res 117, 115-132.
162. Kolodkin, A.L., Levengood, D.V., Rowe, E.G., Tai, Y.T., Giger, R.J. & Ginty, D.D. 1997. Neuropilin is a semaphorin III receptor. Cell 90, 753-762.
163. Korsching, S. & Thoenen, H. 1983. Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation. Proc Natl Acad Sci U S A 80, 3513-3516.
164. Krizsan-Agbas, D. & Smith, P.G. 2002. Estrogen modulates myometrium-induced sympathetic neurite formation through actions on target and ganglion. Neuroscience 114, 339-347.
165. Krizsan-Agbas, D., Pedchenko, T., Hasan, W. & Smith, P.G. 2003. Oestrogen regulates sympathetic neurite outgrowth by modulating brain derived neurotrophic factor synthesis and release by the rodent uterus. Eur J Neurosci 18, 2760-2768.
166. Kulik, T., Kusano, Y., Aronhime, S., Sandler, A.L. & Winn, H.R. 2008. Regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology 55, 281-288.
167. Kuruvilla, R., Zweifel, L.S., Glebova, N.O., Lonze, B.E., Valdez, G., Ye, H. & Ginty, D.D. 2004. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118, 243-255.
168. Kuwahira, I., Gonzalez, N.C., Heisler, N. & Piiper, J. 1993. Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats. J Appl Physiol 74, 211-214.
169. Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F., Marklund, S.L., Wyns, S., Thijs, V., Andersson, J., van Marion, I. et al. 2003. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 34, 383-394.
170. Landis, S.C. 1976. Rat sympathetic neurons and cardiac myocytes developing in microcultures: correlation of the fine structure of endings with neurotransmitter function in single neurons. Proc Natl Acad Sci U S A 73, 4220-4224.
171. Lassen, L.H., Haderslev, P.A., Jacobsen, V.B., Iversen, H.K., Sperling, B. & Olesen, J. 2002. CGRP may play a causative role in migraine. Cephalalgia 22, 54-61.
172. Lassere, Y. & Hoff, P. 2004. Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). Eur J Oncol Nurs 8(Suppl 1), S31-S40.
173. Launer, L.J., Terwindt, G.M. & Ferrari, M.D. 1999. The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 53, 537-542.
174. Laurant, P., Touyz, R.M. & Schiffrin, E.L. 1997. Effect of pressurization on mechanical properties of mesenteric small arteries from spontaneously hypertensive rats. J Vasc Res 34, 117-125.
175. 2+ channels in adult frog sympathetic ganglion B cells by nerve growth factor in vitro and in vivo. J Neurophysiol 78, 3359-3370.
176. 2+ channels in adult bullfrog sympathetic neurons by nerve growth factor. J Neurophysiol 80, 1352-1361.
177. Lei, S., Dryden, W.F. & Smith, P.A. 2001. Nerve growth factor regulates sodium but not potassium channel currents in sympathetic B neurons of adult bullfrogs. J Neurophysiol 86, 641-650.
178. Lein, P.J. & Higgins, D. 1989. Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro. Dev Biol 136, 330-345.
179. Lein, P.J., Higgins, D., Turner, D.C., Flier, L.A. & Terranova, V.P. 1991. The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin. J Cell Biol 113, 417-428.
180. Letourneau, P.C., Condic, M.L. & Snow, D.M. 1994. Interactions of developing neurons with the extracellular matrix. J Neurosci 14, 915-928.
181. Levi-Montalcini, R. 1987. The nerve growth factor 35years later. Science 237, 1154-1162.
182. Levi-Montalcini, R. & Booker, B. 1960. Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein. Proc Natl Acad Sci U S A 46, 384-391.
183. Lin, G., Chen, K.C., Hsieh, P.S., Yeh, C.H., Lue, T.F. & Lin, C.S. 2003. Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia. BJU Int 92, 631-635.
184. Linker, R., Gold, R. & Luhder, F. 2009. Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination. Crit Rev Immunol 29, 43-68.
185. Lockhart, S.T., Turrigiano, G.G. & Birren, S.J. 1997. Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. J Neurosci 17, 9573-9582.
186. Lockhart, S.T., Mead, J.N., Pisano, J.M., Slonimsky, J.D. & Birren, S.J. 2000. Nerve growth factor collaborates with myocyte-derived factors to promote development of presynaptic sites in cultured sympathetic neurons. J Neurobiol 42, 460-476.
187. Lonze, B.E., Riccio, A., Cohen, S. & Ginty, D.D. 2002. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34, 371-385.
188. Luff, S.E. 1999. Development of neuromuscular junctions on small mesenteric arteries of the rat. J Neurocytol 28, 47-62.
189. Luff, S.E., Young, S.B. & McLachlan, E.M. 2005. Hyperinnervation of mesenteric arteries in spontaneously hypertensive rats by sympathetic but not primary afferent axons. J Vasc Res 42, 348-358.
190. Luksha, L., Agewall, S. & Kublickiene, K. 2009. Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease. Atherosclerosis 202, 330-344.
191. Luscher, T.F., Boulanger, C.M., Dohi, Y. & Yang, Z.H. 1992. Endothelium-derived contracting factors. Hypertension 19, 117-130.
192. Luther, J.A. & Birren, S.J. 2009. p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents. J Neurosci 29, 5411-5424.
193. Lykissas, M.G., Batistatou, A.K., Charalabopoulos, K.A. & Beris, A.E. 2007. The role of neurotrophins in axonal growth, guidance, and regeneration. Curr Neurovasc Res 4, 143-151.
194. Ma, Y., Campenot, R.B. & Miller, F.D. 1992. Concentration-dependent regulation of neuronal gene expression by nerve growth factor. J Cell Biol 117, 135-141.
195. MacInnis, B.L. & Campenot, R.B. 2002. Retrograde support of neuronal survival without retrograde transport of nerve growth factor. Science 295, 1536-1539.
196. Maggi, C.A. & Meli, A. 1988. The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol 19, 1-43.
197. Maina, F. & Klein, R. 1999. Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci 2, 213-217.
198. Makita, T., Sucov, H.M., Gariepy, C.E., Yanagisawa, M. & Ginty, D.D. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 452, 759-763.
199. Manni, L., Antonelli, A., Costa, N. & Aloe, L. 2005. Stress alters vascular-endothelial growth factor expression in rat arteries: role of nerve growth factor. Basic Res Cardiol 100, 121-130.
200. Marko, S.B. & Damon, D.H. 2008. VEGF promotes vascular sympathetic innervation. Am J Physiol Heart Circ Physiol 294, H2646-H2652.
201. Marzioni, D., Tamagnone, L., Capparuccia, L., Marchini, C., Amici, A., Todros, T., Bischof, P., Neidhart, S., Grenningloh, G. & Castellucci, M. 2004. Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. Dev Dyn 231, 839-848.
202. Mathias, C.J. 1995. Orthostatic hypotension: causes, mechanisms, and influencing factors. Neurology 45, S6-S11.
203. Matsuzaki, H., Tamatani, M., Yamaguchi, A., Namikawa, K., Kiyama, H., Vitek, M.P., Mitsuda, N. & Tohyama, M. 2001. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15, 1218-1220.
204. Max, S.R., Rohrer, H., Otten, U. & Thoenen, H. 1978. Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro. J Biol Chem 253, 8013-8015.
205. McKercher, T.C., Van Orden, L.S. III, Bhatnagar, R.K. & Burke, J.P. 1973. Estrogen-induced biogenic amine reduction in rat uterus. J Pharmacol Exp Ther 185, 514-522.
206. McLatchie, L.M., Fraser, N.J., Main, M.J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M.G. & Foord, S.M. 1998. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393, 333-339.
207. Melemedjian, O.K., Asiedu, M.N., Tillu, D.V., Peebles, K.A., Yan, J., Ertz, N., Dussor, G.O. & Price, T.J. 2010. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci 30, 15113-15123.
208. Melikian, N., Seddon, M.D., Casadei, B., Chowienczyk, P.J. & Shah, A.M. 2009. Neuronal nitric oxide synthase and human vascular regulation. Trends Cardiovasc Med 19, 256-262.
209. Michel, T. & Vanhoutte, P.M. 2010. Cellular signaling and NO production. Pflugers Arch 459, 807-816.
210. Mione, M.C. & Gabella, G. 1991. Nerve fibres in the uterine artery increase in number in pregnant guinea-pigs. Neuroreport 2, 537-540.
211. Nakaki, T., Nakayama, M., Yamamoto, S. & Kato, R. 1990. Alpha 1-adrenergic stimulation and beta 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells. Mol Pharmacol 37, 30-36.
212. Ogoh, S. 2008. Autonomic control of cerebral circulation: exercise. Med Sci Sports Exerc 40, 2046-2054.
213. Ogoh, S. & Ainslie, P.N. 2009. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol 107, 1370-1380.
214. Ogunshola, O.O., Antic, A., Donoghue, M.J., Fan, S.Y., Kim, H., Stewart, W.B., Madri, J.A. & Ment, L.R. 2002. Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J Biol Chem 277, 11410-11415.
215. Olesen, J., Diener, H.C., Husstedt, I.W., Goadsby, P.J., Hall, D., Meier, U., Pollentier, S. & Lesko, L.M. 2004. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med 350, 1104-1110.
216. Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J.V., Hellings, P., Gorselink, M., Heymans, S. et al. 2001. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 28, 131-138.
217. Oppenheim, R.W. 1991. Cell death during development of the nervous system. Annu Rev Neurosci 14, 453-501.
218. O'Regan, R.G. & Majcherczyk, S. 1982. Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J Exp Biol 100, 23-40.
219. Orike, N., Thrasivoulou, C., Wrigley, A. & Cowen, T. 2001. Differential regulation of survival and growth in adult sympathetic neurons: an in vitro study of neurotrophin responsiveness. J Neurobiol 47, 295-305.
220. Otten, U., Schwab, M., Gagnon, C. & Thoenen, H. 1977. Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. Brain Res 133, 291-303.
221. Owman, C., Alm, P., Rosengren, E., Sjoberg, N. & Thorbert, G. 1975. Variations in the level of uterine norepinephrine during pregnancy in the guinea pig. Am J Obstet Gynecol 122, 961-964.
222. Pablo Huidobro-Toro, J. & Veronica Donoso, M. 2004. Sympathetic co-transmission: the coordinated action of ATP and noradrenaline and their modulation by neuropeptide Y in human vascular neuroeffector junctions. Eur J Pharmacol 500, 27-35.
223. Patel, T.D., Jackman, A., Rice, F.L., Kucera, J. & Snider, W.D. 2000. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron 25, 345-357.
224. Pazyra-Murphy, M.F., Hans, A., Courchesne, S.L., Karch, C., Cosker, K.E., Heerssen, H.M., Watson, F.L., Kim, T., Greenberg, M.E. & Segal, R.A. 2009. A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. J Neurosci 29, 6700-6709.
225. Philippidou, P., Valdez, G., Akmentin, W., Bowers, W.J., Federoff, H.J. & Halegoua, S. 2011. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proc Natl Acad Sci U S A 108, 852-857.
226. Piascik, M.T., Soltis, E.E., Piascik, M.M. & Macmillan, L.B. 1996. Alpha-adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates. Pharmacol Ther 72, 215-241.
227. Pope, J., Fenlon, D., Thompson, A., Shea, B., Furst, D., Wells, G. & Silman, A. 2000. Prazosin for Raynaud's phenomenon in progressive systemic sclerosis. Cochrane Database Syst Rev 2, CD000956.
228. Potter, D.D., Landis, S.C., Matsumoto, S.G. & Furshpan, E.J. 1986. Synaptic functions in rat sympathetic neurons in microcultures. II. Adrenergic/cholinergic dual status and plasticity. J Neurosci 6, 1080-1098.
229. Purves, D., Hadley, R.D. & Voyvodic, J.T. 1986. Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice. J Neurosci 6, 1051-1060.
230. Raap, U. & Kapp, A. 2010. Neurotrophins in healthy and diseased skin. G Ital Dermatol Venereol 145, 205-211.
231. Raghavan, S.A. & Dikshit, M. 2004. Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. Pharmacol Res 49, 397-414.
232. Rahmann, A., Wienecke, T., Hansen, J.M., Fahrenkrug, J., Olesen, J. & Ashina, M. 2008. Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Cephalalgia 28, 226-236.
233. Ralevic, V., Kendall, D.A., Randall, M.D. & Smart, D. 2002. Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function. Life Sci 71, 2577-2594.
234. Ramer, M.S., Priestley, J.V. & McMahon, S.B. 2000. Functional regeneration of sensory axons into the adult spinal cord. Nature 403, 312-316.
235. Raucher, S. & Dryer, S.E. 1995. Target-derived factors regulate the expression of Ca(2+)-activated K+ currents in developing chick sympathetic neurones. J Physiol 486, 605-614.
236. Recio-Pinto, E., Rechler, M.M. & Ishii, D.N. 1986. Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J Neurosci 6, 1211-1219.
237. Reichardt, L.F. & Tomaselli, K.J. 1991. Extracellular matrix molecules and their receptors: functions in neural development. Annu Rev Neurosci 14, 531-570.
238. Rich, K.M., Alexander, T.D., Pryor, J.C. & Hollowell, J.P. 1989. Nerve growth factor enhances regeneration through silicone chambers. Exp Neurol 105, 162-170.
239. Robertson, D. 2008. The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 18(Suppl 1), 2-7.
240. Rohrer, H., Otten, U. & Thoenen, H. 1978. On the role of RNA synthesis in the selective induction of tyrosine hydroxylase by nerve growth factor. Brain Res 159, 436-439.
241. Roosen, A., Schober, A., Strelau, J., Bottner, M., Faulhaber, J., Bendner, G., McIlwrath, S.L., Seller, H., Ehmke, H., Lewin, G.R. & Unsicker, K. 2001. Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation. J Neurosci 21, 3073-3084.
242. Ruit, K.G., Osborne, P.A., Schmidt, R.E., Johnson, E.M. Jr & Snider, W.D. 1990. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse. J Neurosci 10, 2412-2419.
243. Ruiz de Almodovar, C., Coulon, C., Salin, P.A., Knevels, E., Chounlamountri, N., Poesen, K., Hermans, K., Lambrechts, D., Van Geyte, K., Dhondt, J. et al. 2010. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci 30, 15052-15066.
244. Saxena, S., Bucci, C., Weis, J. & Kruttgen, A. 2005. The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J Neurosci 25, 10930-10940.
245. Scarisbrick, I.A., Jones, E.G. & Isackson, P.J. 1993. Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat. J Neurosci 13, 875-893.
246. Schlaich, M.P., Lambert, E., Kaye, D.M., Krozowski, Z., Campbell, D.J., Lambert, G., Hastings, J., Aggarwal, A. & Esler, M.D. 2004. Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation. Hypertension 43, 169-175.
247. Schotzinger, R.J. & Landis, S.C. 1988. Cholinergic phenotype developed by noradrenergic sympathetic neurons after innervation of a novel cholinergic target in vivo. Nature 335, 637-639.
248. 2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res 77, 8-18.
249. Schwarz, M.A., Mitchell, M. & Emerson, D.L. 1990. Reconstituted basement membrane enhances neurite outgrowth in PC12 cells induced by nerve growth factor. Cell Growth Differ 1, 313-318.
250. Schwarz, Q., Gu, C., Fujisawa, H., Sabelko, K., Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A.L., Ginty, D.D., Shima, D.T. & Ruhrberg, C. 2004. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev 18, 2822-2834.
251. Schytz, H.W., Birk, S., Wienecke, T., Kruuse, C., Olesen, J. & Ashina, M. 2009. PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132, 16-25.
252. Senger, D.L. & Campenot, R.B. 1997. Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures. J Cell Biol 138, 411-421.
253. Shao, Y., Akmentin, W., Toledo-Aral, J.J., Rosenbaum, J., Valdez, G., Cabot, J.B., Hilbush, B.S. & Halegoua, S. 2002. Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes. J Cell Biol 157, 679-691.
254. Sharma, N., Deppmann, C.D., Harrington, A.W., St Hillaire, C., Chen, Z.Y., Lee, F.S. & Ginty, D.D. 2010. Long-distance control of synapse assembly by target-derived NGF. Neuron 67, 422-434.
255. Shelton, D.L. & Reichardt, L.F. 1984. Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci U S A 81, 7951-7955.
256. Shelton, D.L. & Reichardt, L.F. 1986. Studies on the regulation of beta-nerve growth factor gene expression in the rat iris: the level of mRNA-encoding nerve growth factor is increased in irises placed in explant cultures in vitro, but not in irises deprived of sensory or sympathetic innervation in vivo. J Cell Biol 102, 1940-1948.
257. Silverman, W.F., Krum, J.M., Mani, N. & Rosenstein, J.M. 1999. Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience 90, 1529-1541.
258. Sjostrand, T. 1952. The regulation of the blood distribution in man. Acta Physiol Scand 26, 312-327.
259. Skaper, S.D. 2008. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol Disord Drug Targets 7, 46-62.
260. Slonimsky, J.D., Mattaliano, M.D., Moon, J.I., Griffith, L.C. & Birren, S.J. 2006. Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission. Proc Natl Acad Sci U S A 103, 2915-2919.
261. Smeyne, R.J., Klein, R., Schnapp, A., Long, L.K., Bryant, S., Lewin, A., Lira, S.A. & Barbacid, M. 1994. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368, 246-249.
262. Sofroniew, M.V., Howe, C.L. & Mobley, W.C. 2001. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24, 1217-1281.
263. Sondell, M., Lundborg, G. & Kanje, M. 1999. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J Neurosci 19, 5731-5740.
264. Sondell, M., Sundler, F. & Kanje, M. 2000. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur J Neurosci 12, 4243-4254.
265. Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L.E., Stanton, B.R., Kaplan, D.R., Hunter, T., Nikolics, K. & Parade, L.F. 1991. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65, 895-903.
266. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E., Valenzuela, D.M., Distefano, P.S. & Yancopoulos, G.D. 1991. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65, 885-893.
267. Stead, E.A., Warren, J.V., Merrill, A.J. & Brannon, E.S. 1945. The cardiac output in male subjects as measured by the technique of right atrial catheterization. Normal values with observations on the effect of anxiety and tilting. J Clin Invest 24, 326-331.
268. Steers, W.D., Kolbeck, S., Creedon, D. & Tuttle, J.B. 1991. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88, 1709-1715.
269. Stewart, A.L., Anderson, R.B., Kobayashi, K. & Young, H.M. 2008. Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice. BMC Dev Biol 8, 73.
270. Storkebaum, E., Lambrechts, D. & Carmeliet, P. 2004. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26, 943-954.
271. Storkebaum, E., Lambrechts, D., Dewerchin, M., Moreno-Murciano, M.P., Appelmans, S., Oh, H., Van Damme, P., Rutten, B., Man, W.Y., De Mol, M. et al. 2005. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 8, 85-92.
272. Storkebaum, E., Ruiz de Almodovar, C., Meens, M., Zacchigna, S., Mazzone, M., Vanhoutte, G., Vinckier, S., Miskiewicz, K., Poesen, K., Lambrechts, D. et al. 2010. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation 122, 273-281.
273. Svendsen, C.N., Kew, J.N., Staley, K. & Sofroniew, M.V. 1994. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci 14, 75-87.
274. Thoenen, H., Angeletti, P.U., Levi-Montalcini, R. & Kettler, R. 1971. Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine-hydroxylase in the rat superior cervical ganglia. Proc Natl Acad Sci U S A 68, 1598-1602.
275. Thompson, A.E. & Pope, J.E. 2005. Calcium channel blockers for primary Raynaud's phenomenon: a meta-analysis. Rheumatology (Oxford) 44, 145-150.
276. Thompson, J., Dolcet, X., Hilton, M., Tolcos, M. & Davies, A.M. 2004. HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms. Mol Cell Neurosci 27, 441-452.
277. Thorbert, G. 1978. Regional changes in structure and function of adrenergic nerves in guinea-pig uterus during pregnancy. Acta Obstet Gynecol Scand Suppl 79, 1-32.
278. Thorbert, G., Batra, S., Owman, C.H., Rosengren, E. & Sjoberg, N.O. 1976. Uterine norepinephrine levels as related to plasma and tissue progesterone in pseudopregnant rabbits. Endocrinology 99, 1207-1212.
279. Todd, M.E. & Gowen, B. 1991. Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. Circ Res 69, 438-446.
280. Touyz, R.M. 2000. Molecular and cellular mechanisms regulating vascular function and structure - implications in the pathogenesis of hypertension. Can J Cardiol 16, 1137-1146.
281. Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E. & Ibanez, C.F. 1995. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130, 137-148.
282. Tucker, K.L. 2002. Neurotrophins and the control of axonal outgrowth. Panminerva Med 44, 325-333.
283. Tucker, K. & Fadool, D.A. 2002. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent. J Physiol 542, 413-429.
284. Tucker, K.L., Meyer, M. & Barde, Y.A. 2001. Neurotrophins are required for nerve growth during development. Nat Neurosci 4, 29-37.
285. Tuttle, J.B., Etheridge, R. & Creedon, D.J. 1993. Receptor-mediated stimulation and inhibition of nerve growth factor secretion by vascular smooth muscle. Exp Cell Res 208, 350-361.
286. Valdez, G., Akmentin, W., Philippidou, P., Kuruvilla, R., Ginty, D.D. & Halegoua, S. 2005. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci 25, 5236-5247.
287. Valdez, G., Philippidou, P., Rosenbaum, J., Akmentin, W., Shao, Y. & Halegoua, S. 2007. Trk-signaling endosomes are generated by Rac-dependent macroendocytosis. Proc Natl Acad Sci U S A 104, 12270-12275.
288. Van Den Bosch, L., Storkebaum, E., Vleminckx, V., Moons, L., Vanopdenbosch, L., Scheveneels, W., Carmeliet, P. & Robberecht, W. 2004. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol Dis 17, 21-28.
289. Varol, F.G., Duchemin, A.M., Neff, N.H. & Hadjiconstantinou, M. 2000. Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy. Neurosci Lett 294, 58-62.
290. Venstrom, K.A. & Reichardt, L.F. 1993. Extracellular matrix. 2: role of extracellular matrix molecules and their receptors in the nervous system. FASEB J 7, 996-1003.
291. Verheul, H.M. & Pinedo, H.M. 2007. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 7, 475-485.
292. Voyvodic, J.T. 1989. Peripheral target regulation of dendritic geometry in the rat superior cervical ganglion. J Neurosci 9, 1997-2010.
293. Wang, Y., Marshall, R.J. & Shepherd, J.T. 1960. The effect of changes in posture and of graded exercise on stroke volume in man. J Clin Invest 39, 1051-1061.
294. Watson, F.L., Heerssen, H.M., Moheban, D.B., Lin, M.Z., Sauvageot, C.M., Bhattacharyya, A., Pomeroy, S.L. & Segal, R.A. 1999. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J Neurosci 19, 7889-7900.
295. Webster-Gandy, J.D., How, C. & Harrold, K. 2007. Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre. Eur J Oncol Nurs 11, 238-246.
296. Weems, W.A. & Szurszewski, J.H. 1978. An intracellular analysis of some intrinsic factors controlling neural output from inferior mesenteric ganglion of guinea pigs. J Neurophysiol 41, 305-321.
297. Westfall, T.C., Meldrum, M.J., Carpentier, S., Naes, L. & Zhang, S.Q. 1987. Alterations in the release of norepinephrine at the vascular neuroeffector junction in hypertension. Blood Vessels 24, 94-99.
298. Wick, A., Wick, W., Waltenberger, J., Weller, M., Dichgans, J. & Schulz, J.B. 2002. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 22, 6401-6407.
299. Wigley, F.M. 2002. Clinical practice. Raynaud's Phenomenon. N Engl J Med 347, 1001-1008.
300. Wingerd, K.L., Goodman, N.L., Tresser, J.W., Smail, M.M., Leu, S.T., Rohan, S.J., Pring, J.L., Jackson, D.Y. & Clegg, D.O. 2002. Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart. J Neurosci 22, 10772-10780.
301. Wise, R.A., Wigley, F.M., White, B., Leatherman, G., Zhong, J., Krasa, H., Kambayashi, J., Orlandi, C. & Czerwiec, F.S. 2004. Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study. Arthritis Rheum 50, 3994-4001.
302. Wittko, I.M., Schanzer, A., Kuzmichev, A., Schneider, F.T., Shibuya, M., Raab, S. & Plate, K.H. 2009. VEGFR-1 regulates adult olfactory bulb neurogenesis and migration of neural progenitors in the rostral migratory stream in vivo. J Neurosci 29, 8704-8714.
303. Wolin, M.S., Gupte, S.A., Mingone, C.J., Neo, B.H., Gao, Q. & Ahmad, M. 2010. Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology. Ann N Y Acad Sci 1203, 126-132.
304. Wood, H.M. & Ernst, M.E. 2006. Renin-angiotensin system mediators and Raynaud's phenomenon. Ann Pharmacother 40, 1998-2002.
305. Yamashita, T. & Tohyama, M. 2003. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 6, 461-467.
306. Yan, H., Newgreen, D.F. & Young, H.M. 2003. Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin. Dev Dyn 227, 395-401.
307. Yang, X., Kuo, Y., Devay, P., Yu, C. & Role, L. 1998a. A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis. Neuron 20, 255-270.
308. Yang, X.M., Toma, J.G., Bamji, S.X., Belliveau, D.J., Kohn, J., Park, M. & Miller, F.D. 1998b. Autocrine hepatocyte growth factor provides a local mechanism for promoting axonal growth. J Neurosci 18, 8369-8381.
309. Yang, B., Slonimsky, J.D. & Birren, S.J. 2002. A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor. Nat Neurosci 5, 539-545.
310. Yawo, H. 1987. Changes in the dendritic geometry of mouse superior cervical ganglion cells following postganglionic axotomy. J Neurosci 7, 3703-3711.
311. Yazdani, U. & Terman, J.R. 2006. The semaphorins. Genome Biol 7, 211.
312. Ye, H., Kuruvilla, R., Zweifel, L.S. & Ginty, D.D. 2003. Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. Neuron 39, 57-68.
313. Young, B.C., Levine, R.J. & Karumanchi, S.A. 2010. Pathogenesis of preeclampsia. Annu Rev Pathol 5, 173-192.
314. Zackenfels, K., Oppenheim, R.W. & Rohrer, H. 1995. Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons. Neuron 14, 731-741.
315. Zhang, Y., Moheban, D.B., Conway, B.R., Bhattacharyya, A. & Segal, R.A. 2000. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci 20, 5671-5678.
316. Zhang, X., Huang, J. & McNaughton, P.A. 2005. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J 24, 4211-4223.
317. Zhou, F.Q., Zhou, J., Dedhar, S., Wu, Y.H. & Snider, W.D. 2004. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42, 897-912.
318. Zimmerman, G.C., Keeling, J.H., Lowry, M., Medina, J., Von Hoff, D.D. & Burris, H.A. 1994. Prevention of docetaxel-induced erythrodysesthesia with local hypothermia. J Natl Cancer Inst 86, 557-558.
319. Zoubina, E.V. & Smith, P.G. 2001. Sympathetic hyperinnervation of the uterus in the estrogen receptor alpha knock-out mouse. Neuroscience 103, 237-244.
320. Zweifel, L.S., Kuruvilla, R. & Ginty, D.D. 2005. Functions and mechanisms of retrograde neurotrophin signalling. Nat Rev Neurosci 6, 615-625.