The TrkB-Shc site signals neuronal survival and local axon growth via MEK and PI3-Kinase

Neuron

Volumn 27, Issue 2, 2000, Pages 265-277

  Atwal, Jasvinder K ^a   Massie, Bernard ^b   Miller, Freda D ^a   Kaplan, David R ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN;

ARTICLE; BINDING SITE; CELL SURVIVAL; ENZYME ACTIVATION; GROWTH REGULATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033694754     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)00035-0     Document Type: Article

References (54)

1. Overexpression of nerve growth factor in epidermis causes hypertrophy of the peripheral nervous system
2. A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
3. The selective and inducible activation of endogenous PI3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth
4. Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells
5. NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis
6. Trk receptors function as rapid retrograde signal carriers in the adult nervous system
7. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
8. Akt promotes cell survival by phosphorylating and inhibiting a Fork-head transcription factor
9. NGF and the local control of nerve terminal growth
10. Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production
11. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
12. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival
13. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
14. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
15. Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islets
16. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo
17. Characterization of microtubule-associated protein phosphoisoforms present in isolated growth cones
18. Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons. I. Sympathetic neurons
19. Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase
20. Role of neurotrophic factors in neuronal development
21. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
22. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin
23. Neurotrophin signal transduction in the nervous system
24. p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
25. Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells
26. A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth
27. Concentration-dependent regulation of neuronal gene expression by nerve growth factor
28. Improved adenovirus vector provides herpes simplex virus ribonucleotide reductase R1 and R2 subunits very efficiently
29. Inducible overexpression of a toxic protein by an adenovirus vector with a tetracycline-regulatable expression cassette
30. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway
31. The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL
32. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
33. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons
34. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor
35. Nerve growth factor derived from terminals selectively increases the ratio of p75 to trkA NGF receptors on mature sympathetic neurons
36. Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance
37. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses
38. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma
39. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
40. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
41. Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis
42. Identification and characterization of novel substrates of Trk receptors in developing neurons
43. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
44. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
45. Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease
46. Phosphatidylinositol-3-OH kinase as a direct target of Ras
47. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
48. Intracellular signaling pathways activated neurotrophic factors
49. Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures
50. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
51. Signaling through the lipid products of phosphoinositide-3-OH kinase
52. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
53. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
54. Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones