Agrin plays an organizing role in the formation of sympathetic synapses

Journal of Cell Biology

Volumn 158, Issue 6, 2002, Pages 1109-1118

  Gingras, Jacinthe ^a   Rassadi, Siamak ^a   Cooper, Ellis ^b   Ferns, Michael ^a,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MGH Research Institute   (Canada)

Author keywords

Agrin knockout; Compound action potential; Neuronal acetylcholine receptors; Superior cervical ganglia; Synaptogenesis

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR; NERVE PROTEIN; RECOMBINANT PROTEIN; SYNAPTOPHYSIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; INTERNEURON; MOUSE; MOUSE STRAIN; NEUROMUSCULAR SYNAPSE; NONHUMAN; POSTSYNAPTIC MEMBRANE; PREGANGLIONIC NERVE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS;

ACTION POTENTIALS; AGRIN; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; CELL COUNT; CELLS, CULTURED; CHOLINERGIC FIBERS; ELECTROPHYSIOLOGY; GANGLIA, SYMPATHETIC; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLINERGIC; RECEPTORS, NICOTINIC; SUPERIOR CERVICAL GANGLION; SYNAPSES; SYNAPTOPHYSIN;

ANIMALIA;

EID: 0037119949     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200203012     Document Type: Article

References (43)

1. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
2. A neuronal inhibitory domain in the N-terminal half of agrin
3. Agrin controls synaptic differentiation in hippocampal neurons
4. The formation of neuromuscular synapses
5. Agrin isoforms with distinct amino termini. Differential expression, localization, and function
6. Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors
7. Agrin: An extracellular matrix heparan sulfate proteoglycan involved in cell interactions and synaptogenesis
8. Identification of extracellular matrix ligands for the heparan sulfate proteoglycan agrin
9. The role of an agrin-growth factor interaction in ACh receptor clustering
10. The making of a synapse: Target-derived signals and presynaptic differentiation
11. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
12. The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans
13. Abnormal synapse formation in agrin-depleted hippocampal neurons
14. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor
15. Cellular and molecular determinants of sympathetic neuron development
16. Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: Evidence for cholinergic, adrenergic, and dual-function neurons
17. Molecular mechanisms of CNS synaptogenesis
18. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
19. Expression and localization of agrin during sympathetic synapse formation in vitro
20. Agrin acts via a MuSK receptor complex
21. Tissue culture of mammalian autonomic neurons
22. Evidence of an agrin receptor in cortical neurons
23. Developmental regulation of highly active alternatively spliced forms of agrin
24. Cloning and characterization of muscle-specific kinase in chicken
25. Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons
26. The developing avian retina expresses agrin isoforms during synaptogenesis
27. Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice
28. Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
29. Progressive restriction of synaptic vesicle protein to the nerve terminal during development of the neuromuscular junction
30. Agrin mRNA variants are differentially regulated in developing chick embryo spinal cord and sensory ganglia
31. Agrin is synthesized by retinal cells and colocalizes with gephyrin
32. Integrins mediate adhesion to agrin and modulate agrin signaling
33. Development of the rat superior cervical ganglion: Ingrowth of preganglionic axons
34. Development of the rat superior cervical ganglion: Initial stages of synapse formation
35. Molecules involved in the formation ofsynaptic connections in muscle and brain
36. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
37. Long-term blockade by toxin F of nicotinic synaptic potentials in cultured sympathetic neurons
38. Development of the vertebrate neuromuscular junction
39. Synapse formation by hippocampal neurons from agrin-deficient mice
40. The diversity of cadherins and implications for a synaptic adhesive code in the CNS
41. Dystroglycan binds nerve and muscle agrin
42. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
43. Selective reduction in the nicotinic acetylcholine receptor and dystroglycan at the postsynaptic apparatus of mdx mouse superior cervical ganglion