-
1
-
-
53049084809
-
A new perspective on concepts of asthma severity and control
-
D.R. Taylor, E.D. Bateman, L.-P. Boulet, H.A. Boushey, W.W. Busse, and T.B. Casale A new perspective on concepts of asthma severity and control Eur Respir J 32 2008 545 554
-
(2008)
Eur Respir J
, vol.32
, pp. 545-554
-
-
Taylor, D.R.1
Bateman, E.D.2
Boulet, L.-P.3
Boushey, H.A.4
Busse, W.W.5
Casale, T.B.6
-
2
-
-
80051548564
-
The increasing challenge of discovering asthma drugs
-
10.1016/j.bcp.2011.06.033
-
K. Mullane The increasing challenge of discovering asthma drugs Biochem Pharmacol 2011 10.1016/j.bcp.2011.06.033
-
(2011)
Biochem Pharmacol
-
-
Mullane, K.1
-
3
-
-
84984757387
-
-
Asthma
-
Asthma. Nat Biotechnol 2000;18 Suppl:IT10-1.
-
(2000)
Nat Biotechnol
, vol.18
, Issue.SUPPL.
-
-
-
4
-
-
0034881918
-
New insights into the role of cytokines in asthma
-
DOI 10.1136/jcp.54.8.577
-
J.-C. Renauld New insights into the role of cytokines in asthma J Clin Pathol 54 2001 577 589 (Pubitemid 32756438)
-
(2001)
Journal of Clinical Pathology
, vol.54
, Issue.8
, pp. 577-589
-
-
Renauld, J.-C.1
-
5
-
-
0028455633
-
Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia
-
S.H. Gavett, X. Chen, F. Finkelman, and M. Wills-Karp Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia Am J Respir Cell Mol Biol 10 1994 587 593
-
(1994)
Am J Respir Cell Mol Biol
, vol.10
, pp. 587-593
-
-
Gavett, S.H.1
Chen, X.2
Finkelman, F.3
Wills-Karp, M.4
-
6
-
-
0028966757
-
T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice
-
C.G. Garlisi, A. Falcone, T.T. Kung, D. Stelts, K.J. Pennline, and A.J. Beavis T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice Clin Immunol Immunopathol 75 1995 75 83
-
(1995)
Clin Immunol Immunopathol
, vol.75
, pp. 75-83
-
-
Garlisi, C.G.1
Falcone, A.2
Kung, T.T.3
Stelts, D.4
Pennline, K.J.5
Beavis, A.J.6
-
7
-
-
0030854183
-
The genetics of allergen-induced airway hyperresponsiveness in mice
-
M. Wills-Karp, and S.L. Ewart The genetics of allergen-induced airway hyperresponsiveness in mice Am J Respir Crit Care Med 156 1997 S89 S96
-
(1997)
Am J Respir Crit Care Med
, vol.156
-
-
Wills-Karp, M.1
Ewart, S.L.2
-
8
-
-
0033557718
-
Modulation of airway inflammation by passive transfer of allergen- specific Th1 and Th2 cells in a mouse model of asthma
-
D.A. Randolph, C.J. Carruthers, S.J. Szabo, K.M. Murphy, and D.D. Chaplin Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma J Immunol 162 1999 2375 2383 (Pubitemid 29288865)
-
(1999)
Journal of Immunology
, vol.162
, Issue.4
, pp. 2375-2383
-
-
Randolph, D.A.1
Carruthers, C.J.L.2
Szabo, S.J.3
Murphy, K.M.4
Chaplin, D.D.5
-
9
-
-
0031939693
-
Induction of pulmonary allergic responses by antigen-specific Th2 cells
-
X.M. Li, B.H. Schofield, Q.F. Wang, K.H. Kim, and S.K. Huang Induction of pulmonary allergic responses by antigen-specific Th2 cells J Immunol 160 1998 1378 1384 (Pubitemid 28093438)
-
(1998)
Journal of Immunology
, vol.160
, Issue.3
, pp. 1378-1384
-
-
Li, X.-M.1
Schofield, B.H.2
Wang, Q.-F.3
Kim, K.-H.4
Huang, S.-K.5
-
10
-
-
17144367365
-
+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
-
DOI 10.1084/jem.20042311
-
L.S. Van Rijt, S. Jung, A. Kleinjan, N. Vos, M. Willart, and C. Duez In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma J Exp Med 201 2005 981 991 (Pubitemid 40524467)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.6
, pp. 981-991
-
-
Van Rijt, L.S.1
Jung, S.2
KleinJan, A.3
Vos, N.4
Willart, M.5
Duez, C.6
Hoogsteden, H.C.7
Lambrecht, B.N.8
-
11
-
-
69449101390
-
Differential effects of dendritic cell transfer in airway hyperresponsiveness and inflammation
-
T. Koya, H. Matsuda, S. Matsubara, N. Miyahara, A. Dakhama, and K. Takeda Differential effects of dendritic cell transfer in airway hyperresponsiveness and inflammation Am J Respir Cell Mol Biol 41 2009 271 280
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 271-280
-
-
Koya, T.1
Matsuda, H.2
Matsubara, S.3
Miyahara, N.4
Dakhama, A.5
Takeda, K.6
-
12
-
-
67651227044
-
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways
-
G.R. Zosky, A.N. Larcombe, O.J. White, J.T. Burchell, C. von Garnier, and P.G. Holt Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways Am J Physiol Lung Cell Mol Physiol 297 2009 L373 L379
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Zosky, G.R.1
Larcombe, A.N.2
White, O.J.3
Burchell, J.T.4
Von Garnier, C.5
Holt, P.G.6
-
13
-
-
77953241920
-
Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th transfer model of BALB/c background
-
T. Ohtomo, O. Kaminuma, J. Yamada, N. Kitamura, A. Abe, and N. Kobayashi Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th transfer model of BALB/c background Int Arch Allergy Immunol 152 Suppl. 1 2010 79 82
-
(2010)
Int Arch Allergy Immunol
, vol.152
, Issue.SUPPL. 1
, pp. 79-82
-
-
Ohtomo, T.1
Kaminuma, O.2
Yamada, J.3
Kitamura, N.4
Abe, A.5
Kobayashi, N.6
-
14
-
-
0035190416
-
Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice
-
DOI 10.1067/mai.2001.118794
-
S.P. Chapoval, E.V. Marietta, M.K. Smart, and C.S. David Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice J Allergy Clin Immunol 108 2001 764 771 (Pubitemid 33096208)
-
(2001)
Journal of Allergy and Clinical Immunology
, vol.108
, Issue.5
, pp. 764-771
-
-
Chapoval, S.P.1
Marietta, E.V.2
Smart, M.K.3
David, C.S.4
-
15
-
-
4544304222
-
Defining a link with asthma in mice congenitally deficient in eosinophils
-
DOI 10.1126/science.1099472
-
J.J. Lee, D. Dimina, M.P. Macias, S.I. Ochkur, M.P. McGarry, and K.R. O'Neill Defining a link with asthma in mice congenitally deficient in eosinophils Science 305 2004 1773 1776 (Pubitemid 39249644)
-
(2004)
Science
, vol.305
, Issue.5691
, pp. 1773-1776
-
-
Lee, J.J.1
Dimina, D.2
Macias, M.P.3
Ochkur, S.I.4
McGarry, M.P.5
O'Neill, K.R.6
Protheroe, C.7
Pero, R.8
Nguyen, T.9
Cormier, S.A.10
Lenkiewicz, E.11
Colbert, D.12
Rinaldi, L.13
Ackerman, S.J.14
Irvin, C.G.15
Lee, N.A.16
-
16
-
-
4143098139
-
The relationship between asthma and COPD. Lessons from transgenic mice
-
J. Elias The relationship between asthma and COPD. Lessons from transgenic mice Chest 126 2 Suppl. 2004 159S 161S
-
(2004)
Chest
, vol.126
, Issue.2 SUPPL.
-
-
Elias, J.1
-
17
-
-
0037059509
-
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
-
DOI 10.1126/science.1065544
-
S. Finotto, M.F. Neurath, J.N. Glickman, S. Qin, H.A. Lehr, and F.H.Y. Green Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet Science 295 2002 336 338 (Pubitemid 34074365)
-
(2002)
Science
, vol.295
, Issue.5553
, pp. 336-338
-
-
Finotto, S.1
Neurath, M.F.2
Glickman, J.N.3
Qin, S.4
Lehr, H.A.5
Green, F.H.Y.6
Ackerman, K.7
Haley, K.8
Galle, P.R.9
Szabo, S.J.10
Drazen, J.M.11
De Sanctis, G.T.12
Glimcher, L.H.13
-
18
-
-
55849148482
-
The cytokine network in asthma and chronic obstructive pulmonary disease
-
P.J. Barnes The cytokine network in asthma and chronic obstructive pulmonary disease J Clin Invest 118 2008 3546 3556
-
(2008)
J Clin Invest
, vol.118
, pp. 3546-3556
-
-
Barnes, P.J.1
-
19
-
-
77949897036
-
Importance of cytokines in murine allergic airway disease and human asthma
-
F.D. Finkelman, S.P. Hogan, G.K. Hershey, M.E. Rothenberg, and M. Wills-Karp Importance of cytokines in murine allergic airway disease and human asthma J Immunol 184 2010 1663 1674
-
(2010)
J Immunol
, vol.184
, pp. 1663-1674
-
-
Finkelman, F.D.1
Hogan, S.P.2
Hershey, G.K.3
Rothenberg, M.E.4
Wills-Karp, M.5
-
20
-
-
34447581076
-
Chemokines and their receptors as potential targets for the treatment of asthma
-
DOI 10.1038/sj.bjp.0707263, PII 0707263
-
C. Palmqvist, A.J. Wardlaw, and P. Bradding Chemokines and their receptors as potential targets for the treatment of asthma Br J Pharmacol 151 2007 725 736 (Pubitemid 47075313)
-
(2007)
British Journal of Pharmacology
, vol.151
, Issue.6
, pp. 725-736
-
-
Palmqvist, C.1
Wardlaw, A.J.2
Bradding, P.3
-
21
-
-
78649516124
-
Functions of T cells in asthma: More than just Th2 cells
-
C.M. Lloyd, and E.M. Hessel Functions of T cells in asthma: more than just Th2 cells Nat Rev Immunol 10 2010 838 848
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 838-848
-
-
Lloyd, C.M.1
Hessel, E.M.2
-
22
-
-
74849096564
-
The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
-
S.T. Holgate, G. Roberts, H.S. Arshad, P.H. Howarth, and D.E. Davies The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis Proc Am Thorac Soc 6 2009 655 659
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 655-659
-
-
Holgate, S.T.1
Roberts, G.2
Arshad, H.S.3
Howarth, P.H.4
Davies, D.E.5
-
23
-
-
70049094943
-
Regulatory T cells in asthma
-
C.M. Lloyd, and C.M. Hawrylowicz Regulatory T cells in asthma Immunity 31 2009 438 449
-
(2009)
Immunity
, vol.31
, pp. 438-449
-
-
Lloyd, C.M.1
Hawrylowicz, C.M.2
-
24
-
-
42649137213
-
T cell trafficking in allergic asthma: The ins and outs
-
DOI 10.1146/annurev.immunol.26.021607.090312
-
B.D. Medoff, S.Y. Thomas, and A.D. Luster T cell trafficking in allergic asthma: the ins and outs Annu Rev Immunol 26 2008 205 232 (Pubitemid 351600375)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 205-232
-
-
Medoff, B.D.1
Thomas, S.Y.2
Luster, A.D.3
-
25
-
-
0033985217
-
IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice
-
T. Kodama, T. Matsuyama, K. Kuribayashi, Y. Nishioka, M. Sugita, and S. Akira IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice J Allergy Clin Immunol 105 2000 45 53 (Pubitemid 30059101)
-
(2000)
Journal of Allergy and Clinical Immunology
, vol.105
, Issue.1
, pp. 45-53
-
-
Kodama, T.1
Matsuyama, T.2
Kuribayashi, K.3
Nishioka, Y.4
Sugita, M.5
Akira, S.6
Nakanishi, K.7
Okamura, H.8
-
26
-
-
55449129909
-
Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model
-
S. Yamagata, K. Tomita, R. Sato, A. Niwa, H. Higashino, and Y. Tohda Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model Clin Exp Immunol 154 2008 295 304
-
(2008)
Clin Exp Immunol
, vol.154
, pp. 295-304
-
-
Yamagata, S.1
Tomita, K.2
Sato, R.3
Niwa, A.4
Higashino, H.5
Tohda, Y.6
-
27
-
-
44449136379
-
Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms
-
C. Hartwig, T. Tschernig, M. Mazzega, A. Braun, and D. Neumann Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms Cytokine 42 2008 298 305
-
(2008)
Cytokine
, vol.42
, pp. 298-305
-
-
Hartwig, C.1
Tschernig, T.2
Mazzega, M.3
Braun, A.4
Neumann, D.5
-
28
-
-
25844515028
-
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
-
DOI 10.1038/ni1247, PII N1247
-
B. Zhou, M.R. Comeau, T. De Smedt, H.D. Liggitt, M.E. Dahl, and D.B. Lewis Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice Nat Immunol 6 2005 1047 1053 (Pubitemid 41486190)
-
(2005)
Nature Immunology
, vol.6
, Issue.10
, pp. 1047-1053
-
-
Zhou, B.1
Comeau, M.R.2
De Smedt, T.3
Liggitt, H.D.4
Dahl, M.E.5
Lewis, D.B.6
Gyarmati, D.7
Aye, T.8
Campbell, D.J.9
Ziegler, S.F.10
-
29
-
-
63149121282
-
TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses
-
M.B. Headley, B. Zhou, W.X. Shih, T. Aye, M.R. Comeau, and S.F. Ziegler TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses J Immunol 182 2009 1641 1647
-
(2009)
J Immunol
, vol.182
, pp. 1641-1647
-
-
Headley, M.B.1
Zhou, B.2
Shih, W.X.3
Aye, T.4
Comeau, M.R.5
Ziegler, S.F.6
-
30
-
-
25144525707
-
A role for TSLP in the development of inflammation in an asthma model
-
DOI 10.1084/jem.20050199
-
A. Al-Shami, R. Spolski, J. Kelly, A. Keane-Myers, and W.J. Leonard A role for TSLP in the development of inflammation in an asthma model J Exp Med 202 2005 829 839 (Pubitemid 41345971)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.6
, pp. 829-839
-
-
Al-Shami, A.1
Spolski, R.2
Kelly, J.3
Keane-Myers, A.4
Leonard, W.J.5
-
31
-
-
20444365526
-
Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity
-
S. Ying, B. O'Connor, J. Ratoff, Q. Meng, K. Mallett, and D. Cousins Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity J Immunol 174 2005 8183 8190 (Pubitemid 40806330)
-
(2005)
Journal of Immunology
, vol.174
, Issue.12
, pp. 8183-8190
-
-
Ying, S.1
O'Connor, B.2
Ratoff, J.3
Meng, Q.4
Mallett, K.5
Cousins, D.6
Robinson, D.7
Zhang, G.8
Zhao, J.9
Lee, T.H.10
Corrigan, C.11
-
32
-
-
70349421440
-
The role of costimulatory molecules in allergic disease and asthma
-
V. Lombardi, A.K. Singh, and O. Akbari The role of costimulatory molecules in allergic disease and asthma Int Arch Allergy Immunol 151 2010 179 189
-
(2010)
Int Arch Allergy Immunol
, vol.151
, pp. 179-189
-
-
Lombardi, V.1
Singh, A.K.2
Akbari, O.3
-
33
-
-
65349102966
-
Sequence, structure, function, immunity: Structural genomics of costimulation
-
K. Chattopadhyay, E. Lazar-Molnar, Q. Yan, R. Rubinstein, C. Zhan, and V. Vigdorovich Sequence, structure, function, immunity: structural genomics of costimulation Immunol Rev 229 2009 356 386
-
(2009)
Immunol Rev
, vol.229
, pp. 356-386
-
-
Chattopadhyay, K.1
Lazar-Molnar, E.2
Yan, Q.3
Rubinstein, R.4
Zhan, C.5
Vigdorovich, V.6
-
34
-
-
68949194394
-
Bench to bedside of CTLA-4: A novel immuno-therapeutic agent for inflammatory disorders
-
P. Sakthivel Bench to bedside of CTLA-4: a novel immuno-therapeutic agent for inflammatory disorders Recent Pat Inflamm Allergy Drug Discov 3 2009 84 95
-
(2009)
Recent Pat Inflamm Allergy Drug Discov
, vol.3
, pp. 84-95
-
-
Sakthivel, P.1
-
35
-
-
0031975063
-
Development of murine allergic asthma is dependent upon B7-2 costimulation
-
A.M. Keane-Myers, W.C. Gause, F.D. Finkelman, X.D. Xhou, and M. Wills-Karp Development of murine allergic asthma is dependent upon B7-2 costimulation J Immunol 160 1998 1036 1043 (Pubitemid 28049351)
-
(1998)
Journal of Immunology
, vol.160
, Issue.2
, pp. 1036-1043
-
-
Keane-Myers, A.M.1
Gause, W.C.2
Finkelman, F.D.3
Xhou, X.-D.4
Wills-Karp, M.5
-
36
-
-
33947263596
-
Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy
-
B. Linhart, S. Bigenzahn, A. Hartl, C. Lupinek, J. Thalhamer, and R. Valenta Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy J Immunol 178 2007 3924 3931 (Pubitemid 46417663)
-
(2007)
Journal of Immunology
, vol.178
, Issue.6
, pp. 3924-3931
-
-
Linhart, B.1
Bigenzahn, S.2
Hartl, A.3
Lupinek, C.4
Thalhamer, J.5
Valenta, R.6
Wekerle, T.7
-
37
-
-
0032213337
-
+ T cells into high IL- 4-producing effectors
-
Y. Ohshima, L.P. Yang, T. Uchiyama, Y. Tanaka, P. Baum, and M. Sergerie OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors Blood 92 1998 3338 3345 (Pubitemid 28492342)
-
(1998)
Blood
, vol.92
, Issue.9
, pp. 3338-3345
-
-
Ohshima, Y.1
Yang, L.-P.2
Uchiyama, T.3
Tanaka, Y.4
Baum, P.5
Sergerie, M.6
Hermann, P.7
Delespesse, G.8
-
38
-
-
0038068126
-
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
-
DOI 10.1002/eji.200323455
-
A. Hoshino, Y. Tanaka, H. Akiba, Y. Asakura, Y. Mita, and T. Sakurai Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma Eur J Immunol 33 2003 861 869 (Pubitemid 36546673)
-
(2003)
European Journal of Immunology
, vol.33
, Issue.4
, pp. 861-869
-
-
Hoshino, A.1
Tanaka, Y.2
Akiba, H.3
Asakura, Y.4
Mita, Y.5
Sakurai, T.6
Takaoka, A.7
Nakaike, S.8
Ishii, N.9
Sugamura, K.10
Yagita, H.11
Okumura, K.12
-
39
-
-
59149092952
-
Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor
-
E.J. Scheinman, and O. Avni Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor J Biol Chem 284 2009 3037 3048
-
(2009)
J Biol Chem
, vol.284
, pp. 3037-3048
-
-
Scheinman, E.J.1
Avni, O.2
-
40
-
-
33846935457
-
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
-
K. Maneechotesuwan, Y. Xin, K. Ito, E. Jazrawi, K.Y. Lee, and O.S. Usmani Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3 J Immunol 178 2007 2491 2498 (Pubitemid 46233450)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2491-2498
-
-
Maneechotesuwan, K.1
Xin, Y.2
Ito, K.3
Jazrawi, E.4
Lee, K.-Y.5
Usmani, O.S.6
Barnes, P.J.7
Adcock, I.M.8
-
41
-
-
0036604901
-
T helper cell differentiation: On again, off again
-
DOI 10.1016/S0952-7915(02)00340-0
-
J.L. Grogan, and R.M. Locksley T helper cell differentiation: on again, off again Curr Opin Immunol 14 2002 366 372 (Pubitemid 34327980)
-
(2002)
Current Opinion in Immunology
, vol.14
, Issue.3
, pp. 366-372
-
-
Grogan, J.L.1
Locksley, R.M.2
-
42
-
-
21044452339
-
TH2 cytokines and associated transcription factors as therapeutic targets in asthma
-
DOI 10.2174/1568010053586273
-
Y. Nakamura, and M. Hoshino TH2 cytokines and associated transcription factors as therapeutic targets in asthma Curr Drugs Targets Inflamm Allergy 4 2005 267 270 (Pubitemid 40873109)
-
(2005)
Current Drug Targets: Inflammation and Allergy
, vol.4
, Issue.2
, pp. 267-270
-
-
Nakamura, Y.1
Hoshino, M.2
-
43
-
-
34447642439
-
Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation
-
DOI 10.1016/j.immuni.2007.04.018, PII S107476130700338X
-
T.C. Fang, Y. Yashiro-Ohtani, C. Del Bianco, D.M. Knoblock, S.C. Blacklow, and W.S. Pear Notch directly regulates Gata3 expression during T helper 2 cell differentiation Immunity 27 2007 100 110 (Pubitemid 47096803)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 100-110
-
-
Fang, T.C.1
Yashiro-Ohtani, Y.2
Del Bianco, C.3
Knoblock, D.M.4
Blacklow, S.C.5
Pear, W.S.6
-
44
-
-
16044371529
-
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
-
DOI 10.1073/pnas.93.15.7821
-
J.A. Rankin, D.E. Picarello, G.P. Geba, U.A. Temann, B. Prasad, and B. DiCosmo Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity Proc Natl Acad Sci USA 93 1996 7821 7825 (Pubitemid 26277122)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.15
, pp. 7821-7825
-
-
Rankin, J.A.1
Picarella, D.E.2
Geba, G.P.3
Temann, U.-A.4
Prasad, B.5
Dicosmo, B.6
Tarallo, A.7
Stripp, B.8
Whitsett, J.9
Flavell, R.A.10
-
45
-
-
0029266795
-
Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice
-
G. Brusselle, J. Kips, G. Joos, H. Bluethmann, and R. Pauwels Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice Am J Respir Cell Mol Biol 12 1995 254 259
-
(1995)
Am J Respir Cell Mol Biol
, vol.12
, pp. 254-259
-
-
Brusselle, G.1
Kips, J.2
Joos, G.3
Bluethmann, H.4
Pauwels, R.5
-
46
-
-
0343502999
-
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma
-
W.R. Henderson, E.Y. Chi, and C.R. Maliszewski Soluble IL-4 receptor inhibits airway inflammation following antigen challenge in a mouse model of asthma J Immunol 164 2000 1086 1095 (Pubitemid 30043738)
-
(2000)
Journal of Immunology
, vol.164
, Issue.2
, pp. 1086-1095
-
-
Henderson Jr., W.R.1
Chi, E.Y.2
Maliszewski, C.R.3
-
47
-
-
0031004365
-
Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
-
S.H. Gavett, D.J. O'Hearn, C.L. Karp, E.A. Patel, B.H. Schofield, and F.D. Finkelman Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice Am J Physiol 272 1997 L253 L261
-
(1997)
Am J Physiol
, vol.272
-
-
Gavett, S.H.1
O'Hearn, D.J.2
Karp, C.L.3
Patel, E.A.4
Schofield, B.H.5
Finkelman, F.D.6
-
48
-
-
0034960520
-
New anti-asthma therapies: Suppression of the effect of interleukin (IL)-4 and IL-5
-
DOI 10.1183/09031936.01.17304990
-
J.C. Kips, K.G. Tournoy, and R.A. Pauwels New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5 Eur Respir J 17 2001 499 506 (Pubitemid 32600622)
-
(2001)
European Respiratory Journal
, vol.17
, Issue.3
, pp. 499-506
-
-
Kips, J.C.1
Tournoy, K.G.2
Pauwels, R.A.3
-
49
-
-
77649198441
-
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
-
C.K. Oh, G.P. Geba, and N. Molfino Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma Eur Respir Rev 19 2010 46 54
-
(2010)
Eur Respir Rev
, vol.19
, pp. 46-54
-
-
Oh, C.K.1
Geba, G.P.2
Molfino, N.3
-
50
-
-
0001036177
-
The IL-4 receptor antagonist (BAY-16-9996) reverses airway hyperresponsiveness in a primate model of asthma
-
P. Harris, D. Lindell, N. Fitch, and R. Gundel The IL-4 receptor antagonist (BAY-16-9996) reverses airway hyperresponsiveness in a primate model of asthma Am J Respir Crit Care Med 159 1999 A230
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. 230
-
-
Harris, P.1
Lindell, D.2
Fitch, N.3
Gundel, R.4
-
51
-
-
34250748567
-
Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers
-
DOI 10.1111/j.1365-2222.2007.02735.x
-
A.N. Menzies-Gow, P.T. Flood-Page, D.S. Robinson, and A.B. Kay Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers Clin Exp Allergy 37 2007 1023 1032 (Pubitemid 46955515)
-
(2007)
Clinical and Experimental Allergy
, vol.37
, Issue.7
, pp. 1023-1032
-
-
Menzies-Gow, A.N.1
Flood-Page, P.T.2
Robinson, D.S.3
Kay, A.B.4
-
53
-
-
0036528907
-
Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common β chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma
-
Z. Allakhverdi, M. Allam, and P.M. Renzi Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma Am J Respir Crit Care Med 165 2002 1015 1021 (Pubitemid 34774674)
-
(2002)
American Journal of Respiratory and Critical Care Medicine
, vol.165
, Issue.7
, pp. 1015-1021
-
-
Allakhverdi, Z.1
Allam, M.2
Renzi, P.M.3
-
54
-
-
33845609130
-
Multitargeted approach using antisense oligonucleotides for the treatment of asthma
-
DOI 10.1196/annals.1348.047, Oligonucleotide Therapeutics: First Annual Meeting of the Oligonucleotide Therapeutics Society
-
Z. Allakhverdi, M. Allam, A. Guimond, N. Ferrari, K. Zemzoumi, and R. Séguin Multitargeted approach using antisense oligonucleotides for the treatment of asthma Ann N Y Acad Sci 1082 2006 62 73 (Pubitemid 44955451)
-
(2006)
Annals of the New York Academy of Sciences
, vol.1082
, pp. 62-73
-
-
Allakhverdi, Z.1
Allam, M.2
Guimond, A.3
Ferrari, N.4
Zemzoumi, K.5
Seguin, R.6
Paquet, L.7
Renzi, P.M.8
-
55
-
-
0032487434
-
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
-
DOI 10.1084/jem.188.7.1307
-
U.A. Temann, G.P. Geba, J.A. Rankin, and R.A. Flavell Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness J Exp Med 188 1998 1307 1320 (Pubitemid 28478019)
-
(1998)
Journal of Experimental Medicine
, vol.188
, Issue.7
, pp. 1307-1320
-
-
Temann, U.-A.1
Geba, G.P.2
Rankin, J.A.3
Flavell, R.A.4
-
56
-
-
67650502393
-
Th9 and allergic disease
-
P. Soroosh, and T.A. Doherty Th9 and allergic disease Immunology 127 2009 450 458
-
(2009)
Immunology
, vol.127
, pp. 450-458
-
-
Soroosh, P.1
Doherty, T.A.2
-
57
-
-
33645059692
-
Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthmatic patients
-
E. Truyen, E. Dilissen, L. Overbergh, L.J. Dupont, J.L. Ceuppens, and D.M. Bullens Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthmatic patients Thorax 61 2006 202 208
-
(2006)
Thorax
, vol.61
, pp. 202-208
-
-
Truyen, E.1
Dilissen, E.2
Overbergh, L.3
Dupont, L.J.4
Ceuppens, J.L.5
Bullens, D.M.6
-
58
-
-
77956340493
-
Increase in airway eosinophilia and a th1 cytokine during the chronic asymptomatic phase of asthma
-
C.K. Kim, J. Choi, Z. Callaway, G. Volcheck, and H. Kita Increase in airway eosinophilia and a th1 cytokine during the chronic asymptomatic phase of asthma Respir Med 104 2010 1436 1443
-
(2010)
Respir Med
, vol.104
, pp. 1436-1443
-
-
Kim, C.K.1
Choi, J.2
Callaway, Z.3
Volcheck, G.4
Kita, H.5
-
59
-
-
0032698748
-
Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
-
D.A. Randolph, R. Stephens, C.J. Carruthers, and D.D. Chaplin Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation J Clin Invest 104 1999 1021 1029 (Pubitemid 29536312)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.8
, pp. 1021-1029
-
-
Randolph, D.A.1
Stephens, R.2
Carruthers, C.J.L.3
Chaplin, D.D.4
-
60
-
-
0036394422
-
Cell cooperation in development of eosinophil-predominant inflammation in airways
-
D.D. Chaplin Cell cooperation in development of eosinophil-predominant inflammation in airways Immunol Res 26 2002 55 62 (Pubitemid 35177484)
-
(2002)
Immunologic Research
, vol.26
, Issue.1-3
, pp. 55-62
-
-
Chaplin, D.D.1
-
61
-
-
0027409773
-
+ T cells
-
I. Iwamoto, H. Nakajima, H. Endo, and S. Yoshida Interferon γ regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells J Exp Med 177 1993 573 576 (Pubitemid 23117112)
-
(1993)
Journal of Experimental Medicine
, vol.177
, Issue.2
, pp. 573-576
-
-
Iwamoto, I.1
Nakajima, H.2
Endo, H.3
Yoshida, S.4
-
62
-
-
0030584820
-
Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile
-
A.J. Coyle, S. Tsuyuki, C. Bertrand, S. Huang, M. Aguet, and S.S. Alkan Mice lacking the IFN-γ receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile J Immunol 156 1996 2680 2685 (Pubitemid 126660611)
-
(1996)
Journal of Immunology
, vol.156
, Issue.8
, pp. 2680-2685
-
-
Coyle, A.J.1
Tsuyuki, S.2
Bertrand, C.3
Huang, S.4
Aguet, M.5
Alkan, S.S.6
Anderson, G.P.7
-
63
-
-
33746847023
-
Role of local pulmonary IFN-γ expression in murine allergic airway inflammation
-
DOI 10.1165/rcmb.2005-0293OC
-
M. Koch, M. Witzenrath, C. Reuter, M. Herma, H. Schütte, and N. Suttorp Role of local pulmonary IFN-γ expression in murine allergic airway inflammation Am J Respir Cell Mol Biol 35 2006 211 219 (Pubitemid 44175321)
-
(2006)
American Journal of Respiratory Cell and Molecular Biology
, vol.35
, Issue.2
, pp. 211-219
-
-
Koch, M.1
Witzenrath, M.2
Reuter, C.3
Herma, M.4
Schutte, H.5
Suttorp, N.6
Collins, H.7
Kaufmann, S.H.E.8
-
64
-
-
69549138076
-
Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes
-
A. Kanda, V. Driss, N. Hornez, M. Abdallah, T. Roumier, and G. Abboud Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes J Allergy Clin Immunol 124 2009 573 582
-
(2009)
J Allergy Clin Immunol
, vol.124
, pp. 573-582
-
-
Kanda, A.1
Driss, V.2
Hornez, N.3
Abdallah, M.4
Roumier, T.5
Abboud, G.6
-
65
-
-
0026514960
-
Cytokines in symptomatic asthma airways
-
D.H. Broide, M. Lotz, A.J. Cuomo, D.A. Coburn, E.C. Federman, and S.I. Wasserman Cytokines in symptomatic asthma airways J Allergy Clin Immunol 89 1992 958 967
-
(1992)
J Allergy Clin Immunol
, vol.89
, pp. 958-967
-
-
Broide, D.H.1
Lotz, M.2
Cuomo, A.J.3
Coburn, D.A.4
Federman, E.C.5
Wasserman, S.I.6
-
66
-
-
0025805857
-
T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma
-
C. Walker, J.C. Virchow Jr. , P.L. Bruijnzeel, and K. Blaser T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma J Immunol 146 1991 1829 1835
-
(1991)
J Immunol
, vol.146
, pp. 1829-1835
-
-
Walker, C.1
Virchow Jr., J.C.2
Bruijnzeel, P.L.3
Blaser, K.4
-
67
-
-
49649094299
-
IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo
-
A. Doganci, R. Karwot, J.H. Maxeiner, P. Scholtes, E. Schmitt, and M.F. Neurath IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo J Immunol 181 2008 1917 1926
-
(2008)
J Immunol
, vol.181
, pp. 1917-1926
-
-
Doganci, A.1
Karwot, R.2
Maxeiner, J.H.3
Scholtes, P.4
Schmitt, E.5
Neurath, M.F.6
-
68
-
-
0030934422
-
Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy
-
T. Naseer, E.M. Minshall, D.Y. Leung, S. Laberge, P. Ernst, and R.J. Martin Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy Am J Respir Crit Care Med 155 1997 845 851 (Pubitemid 27133392)
-
(1997)
American Journal of Respiratory and Critical Care Medicine
, vol.155
, Issue.3
, pp. 845-851
-
-
Naseer, T.1
Minshall, E.M.2
Leung, D.Y.M.3
Laberge, S.4
Ernst, P.5
Martin, R.J.6
Hamid, Q.7
-
69
-
-
0028821825
-
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
-
S.H. Gavett, D.J. O'Hearn, X. Li, S.K. Huang, F.D. Finkelman, and M. Wills-Karp Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice J Exp Med 182 1995 1527 1536
-
(1995)
J Exp Med
, vol.182
, pp. 1527-1536
-
-
Gavett, S.H.1
O'Hearn, D.J.2
Li, X.3
Huang, S.K.4
Finkelman, F.D.5
Wills-Karp, M.6
-
70
-
-
0031308181
-
Role of ifn-γ in the inhibition of the allergic airway inflammation caused by IL-12
-
G.G. Bruselle, J.C. Kips, R.A. Peleman, G.F. Joos, R.R. Devos, and J.H. Tavernier Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12 Am J Respir Cell Mol Biol 17 1997 767 771 (Pubitemid 127348668)
-
(1997)
American Journal of Respiratory Cell and Molecular Biology
, vol.17
, Issue.6
, pp. 767-771
-
-
Brusselle, G.G.1
Kips, J.C.2
Peleman, R.A.3
Joos, G.F.4
Devos, R.R.5
Tavernier, J.H.6
Pauwels, R.A.7
-
71
-
-
0029984767
-
Interleukin-10 regulation in normal subjects and patients with asthma
-
DOI 10.1016/S0091-6749(96)70197-5
-
L. Borish, A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, and S. Wenzel Interleukin-10 regulation in normal subjects and patients with asthma J Allergy Clin Immunol 97 1996 1288 1296 (Pubitemid 26192279)
-
(1996)
Journal of Allergy and Clinical Immunology
, vol.97
, Issue.6
, pp. 1288-1296
-
-
Borish, L.1
Aarons, A.2
Rumbyrt, J.3
Cvietusa, P.4
Negri, J.5
Wenzel, S.6
-
72
-
-
0034008781
-
IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice
-
M.R. van Scott, J.P. Justice, J.F. Bradfield, E. Enright, A. Sigounas, and S. Sur IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice Am J Physiol 278 2000 L667 L674
-
(2000)
Am J Physiol
, vol.278
-
-
Van Scott, M.R.1
Justice, J.P.2
Bradfield, J.F.3
Enright, E.4
Sigounas, A.5
Sur, S.6
-
73
-
-
0033219725
-
Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice
-
M.R. Stämpfli, M. Cwiartka, B.U. Gajewska, D. Alvarez, S.A. Ritz, and M.D. Inman Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice Am J Respir Cell Mol Biol 21 1999 586 596 (Pubitemid 129586594)
-
(1999)
American Journal of Respiratory Cell and Molecular Biology
, vol.21
, Issue.5
, pp. 586-596
-
-
Stampfli, M.R.1
Cwiartka, M.2
Gajewska, B.U.3
Alvarez, D.4
Ritz, S.A.5
Inman, M.D.6
Xing, Z.7
Jordana, M.8
-
74
-
-
71849089195
-
Coexpression of TGF-β1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
-
K. Presser, D. Schwinge, M. Wegmann, S. Huber, S. Schmitt, and A. Quaas Coexpression of TGF-β1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity J Immunol 181 2008 7751 7758
-
(2008)
J Immunol
, vol.181
, pp. 7751-7758
-
-
Presser, K.1
Schwinge, D.2
Wegmann, M.3
Huber, S.4
Schmitt, S.5
Quaas, A.6
-
75
-
-
69349093225
-
Interleukin-17 and type 17 helper T cells
-
P. Miossec, T. Korn, and V.K. Kuchroo Interleukin-17 and type 17 helper T cells New Engl J Med 361 2009 888 898
-
(2009)
New Engl J Med
, vol.361
, pp. 888-898
-
-
Miossec, P.1
Korn, T.2
Kuchroo, V.K.3
-
76
-
-
47249125726
-
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
-
J. Pne, S. Chevalier, L. Preisser, E. Vénéreau, M.H. Guillex, and S. Ghannam Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes J Immunol 180 2008 7423 7430
-
(2008)
J Immunol
, vol.180
, pp. 7423-7430
-
-
Pne, J.1
Chevalier, S.2
Preisser, L.3
Vénéreau, E.4
Guillex, M.H.5
Ghannam, S.6
-
77
-
-
33751506710
-
Interleukin-17 is a negative regulator of established allergic asthma
-
DOI 10.1084/jem.20061401
-
S. Schnyder-Candrian, D. Togbe, I. Couillin, I. Mercier, F. Brombacher, and V. Quesniaux Interleukin-17 is a negative regulator of established allergic asthma J Exp Med 203 2006 2715 2725 (Pubitemid 44833347)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.12
, pp. 2715-2725
-
-
Schnyder-Candrian, S.1
Togbe, D.2
Couillin, I.3
Mercier, I.4
Brombacher, F.5
Quesniaux, V.6
Fossiez, F.7
Ryffel, B.8
Schnyder, B.9
-
78
-
-
12744262855
-
Increased interleukin 4, interleukin 5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma
-
S.H. Cho, L.A. Stanciu, S.T. Holgate, and S.L. Johnston Increased interleukin 4, interleukin 5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma Am J Respir Crit Care Med 171 2005 224 230
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 224-230
-
-
Cho, S.H.1
Stanciu, L.A.2
Holgate, S.T.3
Johnston, S.L.4
-
79
-
-
59849090359
-
CD8+ T cells in asthma: Friend or foe?
-
R.J. Betts, and D.M. Kemeny CD8+ T cells in asthma: friend or foe? Pharmacol Ther 121 2009 123 131
-
(2009)
Pharmacol Ther
, vol.121
, pp. 123-131
-
-
Betts, R.J.1
Kemeny, D.M.2
-
80
-
-
0028929545
-
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia
-
A.J. Coyle, F. Erard, C. Bertrand, S. Walti, H. Pircher, and G. Le Gros Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia J Exp Med 181 1995 1229 1233
-
(1995)
J Exp Med
, vol.181
, pp. 1229-1233
-
-
Coyle, A.J.1
Erard, F.2
Bertrand, C.3
Walti, S.4
Pircher, H.5
Le Gros, G.6
-
82
-
-
77957843236
-
Increased airway T regulatory cells in asthmatic subjects
-
L.J. Smyth, A. Eustace, U. Kolsum, J. Blaikely, and D. Singh Increased airway T regulatory cells in asthmatic subjects Chest 138 2010 905 912
-
(2010)
Chest
, vol.138
, pp. 905-912
-
-
Smyth, L.J.1
Eustace, A.2
Kolsum, U.3
Blaikely, J.4
Singh, D.5
-
83
-
-
34247526094
-
hi regulatory T cells in pediatric asthma
-
DOI 10.1016/j.jaci.2007.02.023, PII S0091674907004216
-
D. Hartl, B. Koller, A.T. Melhorn, D. Reinhardt, T. Nicolai, and D.J. Schendel Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma J Allergy Clin Immunol 119 2007 1258 1266 (Pubitemid 46654192)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.5
, pp. 1258-1266
-
-
Hartl, D.1
Koller, B.2
Mehlhorn, A.T.3
Reinhardt, D.4
Nicolai, T.5
Schendel, D.J.6
Griese, M.7
Krauss-Etschmann, S.8
-
84
-
-
77957828102
-
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation
-
T.H. Schreiber, D. Wolf, M.S. Tsai, J. Chirinos, V.V. Deyev, and L. Gonzalez Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation J Clin Invest 120 2010 3629 3640
-
(2010)
J Clin Invest
, vol.120
, pp. 3629-3640
-
-
Schreiber, T.H.1
Wolf, D.2
Tsai, M.S.3
Chirinos, J.4
Deyev, V.V.5
Gonzalez, L.6
-
85
-
-
70349481019
-
Modulation of regulatory T cells in health and disease: Role of toll-like receptors
-
M.H. Nyirenda, K. O'Brien, L. Sanvito, C.S. Constantinescu, and B. Gran Modulation of regulatory T cells in health and disease: role of toll-like receptors Inflamm Allergy Drug Targets 8 2009 124 129
-
(2009)
Inflamm Allergy Drug Targets
, vol.8
, pp. 124-129
-
-
Nyirenda, M.H.1
O'Brien, K.2
Sanvito, L.3
Constantinescu, C.S.4
Gran, B.5
-
86
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
DOI 10.1056/NEJMoa063842
-
G. Suntharalingam, M.R. Perry, S. Ward, S.J. Brett, A. Castelo-Cortes, and M.D. Brunner Cytokine storm in a Phase 1 trial of the anti-CD28 monoclonal antibody TGN1412 New Engl J Med 355 2006 1018 1028 (Pubitemid 44343545)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.10
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
Brett, S.J.4
Castello-Cortes, A.5
Brunner, M.D.6
Panoskaltsis, N.7
-
87
-
-
38549153832
-
The role of natural killer T cells in lung inflammation
-
DOI 10.1002/path.2290
-
R. Boyton The role of natural killer T cells in lung inflammation J Pathol 214 2008 276 282 (Pubitemid 351160164)
-
(2008)
Journal of Pathology
, vol.214
, Issue.2
, pp. 276-282
-
-
Boyton, R.1
-
88
-
-
34047261246
-
Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease
-
P. Vijayanand, G. Seumois, C. Pickard, R.M. Powell, G. Angco, and D. Sammut Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease N Engl J Med 356 2007 1401 1422
-
(2007)
N Engl J Med
, vol.356
, pp. 1401-1422
-
-
Vijayanand, P.1
Seumois, G.2
Pickard, C.3
Powell, R.M.4
Angco, G.5
Sammut, D.6
-
89
-
-
70449722931
-
Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma
-
C. Reynolds, J. Barkans, P. Clark, H. Kariyawasam, D. Altmann, and B. Kay Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma J Allergy Clin Immunol 124 2009 860 862
-
(2009)
J Allergy Clin Immunol
, vol.124
, pp. 860-862
-
-
Reynolds, C.1
Barkans, J.2
Clark, P.3
Kariyawasam, H.4
Altmann, D.5
Kay, B.6
-
90
-
-
9044222116
-
Increased allergen-specific, steroid-sensitive γ T cells in bronchoalveolar lavage fluid from patients with asthma
-
F. Spinozzi, E. Agea, O. Bistoni, N. Forenza, A. Monaco, and G. Bassotti Increased allergen-specific, steroid-sensitive gamma delta T cells in bronchoalveolar lavage fluid from patients with asthma Ann Intern Med 124 1996 223 227 (Pubitemid 26026006)
-
(1996)
Annals of Internal Medicine
, vol.124
, Issue.2
, pp. 223-227
-
-
Spinozzi, F.1
Agea, E.2
Bistoni, O.3
Forenza, N.4
Monaco, A.5
Bassotti, G.6
Nicoletti, I.7
Riccardi, C.8
Grignani, F.9
Bertotto, A.10
-
91
-
-
0032846597
-
Negative regulation of airway responsiveness that is dependent on γ T cells and independent of αβ T cells
-
DOI 10.1038/13476
-
M. Lahn, A. Kanehiro, K. Takeda, A. Joetham, J. Schwarze, and G. Kohler Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells Nat Med 5 1999 1150 1156 (Pubitemid 29474419)
-
(1999)
Nature Medicine
, vol.5
, Issue.10
, pp. 1150-1156
-
-
Lahn, M.1
Kanehio, A.2
Takeda, K.3
Joetham, A.4
Schwarze, J.5
Kohler, G.6
O'Brien, R.7
Gelfand, E.W.8
Born, W.9
-
92
-
-
34548595761
-
+γ T cells
-
DOI 10.1111/j.1365-2567.2007.02632.x
-
S. Isogai, A. Athiviraham, R.S. Fraser, R. Taha, Q. Hamid, and J.G. Martin Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells Immunology 122 2007 230 238 (Pubitemid 47389951)
-
(2007)
Immunology
, vol.122
, Issue.2
, pp. 230-238
-
-
Isogai, S.1
Athiviraham, A.2
Fraser, R.S.3
Taha, R.4
Hamid, Q.5
Martin, J.G.6
-
93
-
-
77954551711
-
IL-1 and allergy
-
A. Nambu, and S. Nakae IL-1 and allergy Allergol Int 59 2010 125 135
-
(2010)
Allergol Int
, vol.59
, pp. 125-135
-
-
Nambu, A.1
Nakae, S.2
-
94
-
-
14944342689
-
Soluble CD23 and interleukin-1 receptor antagonist in human asthmatics following antigen challenge
-
DOI 10.1081/JAS-200044761
-
D.J. Amrol, D.D. Hagaman, J.R. Sheller, and J.J. Murray Soluble CD23 and interleukin-1 receptor antagonist in human asthmatics following antigen challenge J Asthma 42 2005 73 76 (Pubitemid 40365733)
-
(2005)
Journal of Asthma
, vol.42
, Issue.1
, pp. 73-76
-
-
Amrol, D.J.1
Hagaman, D.D.2
Sheller, J.R.3
Murray, J.J.4
-
95
-
-
77955366373
-
Type i IL-1 receptor (IL-1RI) as a potential new therapeutic target for bronchial asthma
-
10.1155/2010/567351
-
J.-H. Lee, L.-C. Wang, H.-H. Yu, Y.-T. Lin, Y.-H. Yang, and B.-L. Chiang Type I IL-1 receptor (IL-1RI) as a potential new therapeutic target for bronchial asthma Mediators Inflamm 2010 2010 567351 10.1155/2010/567351
-
(2010)
Mediators Inflamm
, vol.2010
, pp. 567351
-
-
Lee, J.-H.1
Wang, L.-C.2
Yu, H.-H.3
Lin, Y.-T.4
Yang, Y.-H.5
Chiang, B.-L.6
-
96
-
-
57149107119
-
The effects of IL-6 on CD4 T cell responses
-
O. Dienz, and M. Rincon The effects of IL-6 on CD4 T cell responses Clin Immunol 130 2009 27 33
-
(2009)
Clin Immunol
, vol.130
, pp. 27-33
-
-
Dienz, O.1
Rincon, M.2
-
97
-
-
23944471116
-
Pathological role of IL-6 in the experimental allergic bronchial asthma in mice
-
A. Doganci, K. Sauer, R. Karwot, and S. Finotto Pathological role of IL-6 in the experimental allergic bronchial asthma in mice Clin Rev Allergy Immunol 28 2005 257 270
-
(2005)
Clin Rev Allergy Immunol
, vol.28
, pp. 257-270
-
-
Doganci, A.1
Sauer, K.2
Karwot, R.3
Finotto, S.4
-
98
-
-
77952536377
-
Elevation of Il-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function
-
W.A. Neveu, J.L. Allard, D.M. Raymond, L.M. Bourassa, S.M. Burns, and J.Y. Bunn Elevation of Il-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function Respir Res 11 2010 28
-
(2010)
Respir Res
, vol.11
, pp. 28
-
-
Neveu, W.A.1
Allard, J.L.2
Raymond, D.M.3
Bourassa, L.M.4
Burns, S.M.5
Bunn, J.Y.6
-
99
-
-
20144375594
-
+ Treg development and function during allergic airway inflammation in vivo
-
DOI 10.1172/JCI200522433
-
A. Doganci, T. Eigenbrod, N. Krug, G.T. De Sanctis, M. Hausding, and V.J. Erpenbeck The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo J Clin Invest 115 2005 313 325 (Pubitemid 40385473)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.2
, pp. 313-325
-
-
Doganci, A.1
Eigenbrod, T.2
Krug, N.3
De Sanctis, G.T.4
Hausding, M.5
Erpenbeck, V.J.6
Haddad, E.-B.7
Schmitt, E.8
Bopp, T.9
Kallen, K.-J.10
Herz, U.11
Schmitt, S.12
Luft, C.13
Hecht, O.14
Hohlfeld, J.M.15
Ito, H.16
Nishimoto, N.17
Yoshizaki, K.18
Kishimoto, T.19
Rose-John, S.20
Renz, H.21
Neurath, M.F.22
Galle, P.R.23
Finotto, S.24
more..
-
100
-
-
0030071687
-
Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma
-
V.M. Keatings, P.D. Collins, D.M. Scott, and P.J. Barnes Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma Am J Respir Crit Care Med 153 1996 530 534
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 530-534
-
-
Keatings, V.M.1
Collins, P.D.2
Scott, D.M.3
Barnes, P.J.4
-
101
-
-
28244479315
-
Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
-
DOI 10.1136/thx.2005.045260
-
P.H. Howarth, K.S. Babu, H.S. Arshad, L. Lau, M. Buckley, and W. McConnell Tumour necrosis factor (TNFa) as a novel therapeutic target in symptomatic corticosteroid dependent asthma Thorax 60 2005 1012 1018 (Pubitemid 41705469)
-
(2005)
Thorax
, vol.60
, Issue.12
, pp. 1012-1018
-
-
Howarth, P.H.1
Babu, K.S.2
Arshad, H.S.3
Lau, L.4
Buckley, M.5
McConnell, W.6
Beckett, P.7
Al Ali, M.8
Chauhan, A.9
Wilson, S.J.10
Reynolds, A.11
Davies, D.E.12
Holgate, S.T.13
-
102
-
-
0028983633
-
Tumor necrosis factor-α increases airway responsiveness and sputum neutrophilia in normal human subjects
-
P.S. Thomas, D.H. Yates, and P.J. Barnes Tumor necrosis factor-α increases airway responsiveness and sputum neutrophilia in normal human subjects Am J Respir Crit Care Med 152 1995 76 80
-
(1995)
Am J Respir Crit Care Med
, vol.152
, pp. 76-80
-
-
Thomas, P.S.1
Yates, D.H.2
Barnes, P.J.3
-
103
-
-
36849021091
-
Tumour necrosis factor-α blockade suppresses murine allergic airways inflammation
-
DOI 10.1111/j.1365-2249.2007.03509.x
-
S. Hutchison, B.S. Choo-Kang, R.V. Bundick, A.J. Leishman, J.M. Brewer, and I.B. McInnes Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation Clin Exp Immunol 151 2008 114 122 (Pubitemid 350230978)
-
(2008)
Clinical and Experimental Immunology
, vol.151
, Issue.1
, pp. 114-122
-
-
Hutchison, S.1
Choo-Kang, B.S.W.2
Bundick, R.V.3
Leishman, A.J.4
Brewer, J.M.5
McInnes, I.B.6
Garside, P.7
-
104
-
-
0035348498
-
Eosinophil trafficking in asthma
-
A.J. Wardlaw Eosinophil trafficking in asthma Clin Med 1 2001 214 218 (Pubitemid 33611619)
-
(2001)
Clinical Medicine
, vol.1
, Issue.3
, pp. 214-218
-
-
Wardlaw, A.J.1
-
105
-
-
33846074487
-
Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma
-
DOI 10.1165/rcmb.2006-0188OC
-
M. Wegmann, R. Göggel, S. Sel, S. Sel, K.J. Erb, and F. Kalkbrenner Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma Am J Respir Cell Mol Biol 36 2007 61 67 (Pubitemid 46067708)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.36
, Issue.1
, pp. 61-67
-
-
Wegmann, M.1
Goggel, R.2
Sel, S.3
Sel, S.4
Erb, K.J.5
Kalkbrenner, F.6
Renz, H.7
Garn, H.8
-
106
-
-
77249130857
-
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice
-
M. Komai, H. Tanaka, K. Nagao, M. Ishizaki, D. Kajiwara, and T. Miura A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice J Pharmacol Sci 112 2010 203 213
-
(2010)
J Pharmacol Sci
, vol.112
, pp. 203-213
-
-
Komai, M.1
Tanaka, H.2
Nagao, K.3
Ishizaki, M.4
Kajiwara, D.5
Miura, T.6
-
107
-
-
77952783111
-
Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients
-
P. Vijayanand, K. Durkin, G. Hartmann, J. Morjaria, G. Seumois, and K.J. Staples Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients J Immunol 184 2010 4568 4574
-
(2010)
J Immunol
, vol.184
, pp. 4568-4574
-
-
Vijayanand, P.1
Durkin, K.2
Hartmann, G.3
Morjaria, J.4
Seumois, G.5
Staples, K.J.6
-
108
-
-
66749187255
-
Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation
-
F. Perros, H.C. Hoogsteden, A.J. Coyle, B.N. Lambrecht, and H. Hammad Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation Allergy 64 2009 995 1002
-
(2009)
Allergy
, vol.64
, pp. 995-1002
-
-
Perros, F.1
Hoogsteden, H.C.2
Coyle, A.J.3
Lambrecht, B.N.4
Hammad, H.5
-
109
-
-
69149099167
-
Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation
-
T. Sato, M. Komai, M. Iwase, K. Kobayashi, H. Tahara, and E. Oshima Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation Pharmacology 84 2009 171 182
-
(2009)
Pharmacology
, vol.84
, pp. 171-182
-
-
Sato, T.1
Komai, M.2
Iwase, M.3
Kobayashi, K.4
Tahara, H.5
Oshima, E.6
-
111
-
-
30444451040
-
4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
-
DOI 10.1182/blood-2005-06-2362
-
S.A. Islam, S.Y. Thomas, C. Hess, B.D. Medoff, T.K. Means, and C. Brander The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans Blood 107 2006 444 453 (Pubitemid 43076363)
-
(2006)
Blood
, vol.107
, Issue.2
, pp. 444-453
-
-
Islam, S.A.1
Thomas, S.Y.2
Hess, C.3
Medoff, B.D.4
Means, T.K.5
Brander, C.6
Lilly, C.M.7
Tager, A.M.8
Luster, A.D.9
-
112
-
-
20144389172
-
Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness
-
N. Miyahara, K. Takeda, S. Miyahara, C. Taube, A. Joetham, and T. Koya Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness J Immunol 174 2005 4979 4984
-
(2005)
J Immunol
, vol.174
, pp. 4979-4984
-
-
Miyahara, N.1
Takeda, K.2
Miyahara, S.3
Taube, C.4
Joetham, A.5
Koya, T.6
-
113
-
-
80051551443
-
Blocking the leukotriene B4 receptor 1 inhibits late phase airway responses in established disease
-
[Epub ahead of print]
-
K. Waseda, N. Miyahara, A. Kanehiro, G. Ikeda, H. Koga, and Y. Fuchimoto Blocking the leukotriene B4 receptor 1 inhibits late phase airway responses in established disease Am J Respir Cell Mol Biol March 2011 [Epub ahead of print]
-
(2011)
Am J Respir Cell Mol Biol
, Issue.MARCH
-
-
Waseda, K.1
Miyahara, N.2
Kanehiro, A.3
Ikeda, G.4
Koga, H.5
Fuchimoto, Y.6
-
114
-
-
38149040134
-
Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma
-
S.R. Barthel, M.W. Johansson, D.M. McNamee, and D.F. Mosher Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma J Leukoc Biol 83 2008 1 12
-
(2008)
J Leukoc Biol
, vol.83
, pp. 1-12
-
-
Barthel, S.R.1
Johansson, M.W.2
McNamee, D.M.3
Mosher, D.F.4
-
115
-
-
0032440580
-
Vascular adhesion molecules in nocturnal asthma: A possible role for VCAM-1 in ongoing airway wall inflammation
-
DOI 10.1046/j.1365-2222.1998.00426.x
-
N.H. ten Hacken, D.S. Postma, F. Bosma, G. Drok, B. Rutgers, and J. Kraan Vascular adhesion molecules in nocturnal asthma: a possible role for VCAM-1 in ongoing airway wall inflammation Clin Exp Allergy 28 1998 1518 1525 (Pubitemid 29003327)
-
(1998)
Clinical and Experimental Allergy
, vol.28
, Issue.12
, pp. 1518-1525
-
-
Ten Hacken, N.H.T.1
Postma, D.S.2
Bosma, F.3
Drok, G.4
Rutgers, B.5
Kraan, J.6
Timens, W.7
-
116
-
-
47249153897
-
Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge
-
M.W. Johansson, E.A. Kelly, W.W. Busse, N.N. Jarjour, and D.F. Mosher Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge J Immunol 180 2008 7622 7635
-
(2008)
J Immunol
, vol.180
, pp. 7622-7635
-
-
Johansson, M.W.1
Kelly, E.A.2
Busse, W.W.3
Jarjour, N.N.4
Mosher, D.F.5
-
117
-
-
0030890791
-
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin
-
D.J. Goetz, D.M. Greif, H. Ding, R.T. Camphausen, S. Howes, and K.M. Comess Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin J Cell Biol 137 1997 509 519
-
(1997)
J Cell Biol
, vol.137
, pp. 509-519
-
-
Goetz, D.J.1
Greif, D.M.2
Ding, H.3
Camphausen, R.T.4
Howes, S.5
Comess, K.M.6
-
118
-
-
0344552292
-
Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD
-
DOI 10.1016/j.pupt.2003.10.004
-
P. Vanderslice, R.J. Biediger, D.G. Woodside, K.L. Berens, G.W. Holland, and R.A. Dixon Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD Pulm Pharmacol Ther 17 2004 1 10 (Pubitemid 37468403)
-
(2004)
Pulmonary Pharmacology and Therapeutics
, vol.17
, Issue.1
, pp. 1-10
-
-
Vanderslice, P.1
Biediger, R.J.2
Woodside, D.G.3
Berens, K.L.4
Holland, G.W.5
Dixon, R.A.F.6
-
119
-
-
73149089686
-
Eosinophils and allergic airway disease: There is more to the story
-
E.R. Walsh, and A. August Eosinophils and allergic airway disease: there is more to the story Trends Immunol 31 2010 39 44
-
(2010)
Trends Immunol
, vol.31
, pp. 39-44
-
-
Walsh, E.R.1
August, A.2
-
120
-
-
77956826692
-
The relationship of airway hyperresponsiveness and airway inflammation: Airway hyperresponsiveness in asthma: Its measurement and clinical significance
-
W.W. Busse The relationship of airway hyperresponsiveness and airway inflammation: airway hyperresponsiveness in asthma: its measurement and clinical significance Chest 138 Suppl. 2 2010 4S 10S
-
(2010)
Chest
, vol.138
, Issue.SUPPL. 2
-
-
Busse, W.W.1
-
121
-
-
0025828705
-
Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates
-
R.H. Gundel, L.G. Letts, and G.J. Gleich Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates J Clin Invest 87 1991 1470 1473
-
(1991)
J Clin Invest
, vol.87
, pp. 1470-1473
-
-
Gundel, R.H.1
Letts, L.G.2
Gleich, G.J.3
-
122
-
-
0026513233
-
The onset and recovery from airway hyperresponsiveness: Relationship with inflammatory cell infiltrates and release of cytotoxic granule proteins
-
R.H. Gundel, C.D. Wegner, and L.G. Letts The onset and recovery from airway hyperresponsiveness: relationship with inflammatory cell infiltrates and release of cytotoxic granule proteins Clin Exp Allergy 22 1992 303 308
-
(1992)
Clin Exp Allergy
, vol.22
, pp. 303-308
-
-
Gundel, R.H.1
Wegner, C.D.2
Letts, L.G.3
-
123
-
-
0036126726
-
The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness
-
DOI 10.1067/mai.2002.122459
-
C.A. Rizzo, R. Yang, S. Greenfeder, R.W. Egan, R.A. Pauwels, and J.A. Hey The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness J Allergy Clin Immunol 109 2002 404 409 (Pubitemid 34234188)
-
(2002)
Journal of Allergy and Clinical Immunology
, vol.109
, Issue.3
, pp. 404-409
-
-
Rizzo, C.A.1
Yang, R.2
Greenfeder, S.3
Egan, R.W.4
Pauwels, R.A.5
Hey, J.A.6
-
124
-
-
79955740934
-
Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
-
C. Perkins, N. Yanase, G. Smulian, L. Gildea, T. Orekov, and C. Potter Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice J Exp Med 208 2011 853 867
-
(2011)
J Exp Med
, vol.208
, pp. 853-867
-
-
Perkins, C.1
Yanase, N.2
Smulian, G.3
Gildea, L.4
Orekov, T.5
Potter, C.6
-
125
-
-
69549138076
-
Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes
-
A. Kanda, V. Driss, N. Nornez, M. Abdallah, T. Roumier, and G. Abboud Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes J Allergy Clin Immunol 124 2009 573 582
-
(2009)
J Allergy Clin Immunol
, vol.124
, pp. 573-582
-
-
Kanda, A.1
Driss, V.2
Nornez, N.3
Abdallah, M.4
Roumier, T.5
Abboud, G.6
-
126
-
-
34247127085
-
IFN-γ induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes
-
G. Woszczek, L.Y. Chen, S. Nagineni, S. Alsaaty, A. Harry, and C. Logun IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes J Immunol 178 2007 5262 5270 (Pubitemid 46595311)
-
(2007)
Journal of Immunology
, vol.178
, Issue.8
, pp. 5262-5270
-
-
Woszczek, G.1
Chen, L.-Y.2
Nagineni, S.3
Alsaaty, S.4
Harry, A.5
Logun, C.6
Pawliczak, R.7
Shelhamer, J.H.8
-
127
-
-
28644446476
-
Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa
-
DOI 10.1165/rcmb.2005-0124OC
-
J. Zhu, Y.S. Qiu, D.J. Figueroa, V. Bandi, H. Galczenski, and K. Hamada Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa Am J Respir Cell Mol Biol 33 2005 531 540 (Pubitemid 41753128)
-
(2005)
American Journal of Respiratory Cell and Molecular Biology
, vol.33
, Issue.6
, pp. 531-540
-
-
Zhu, J.1
Qiu, Y.-S.2
Figueroa, D.J.3
Bandi, V.4
Galczenski, H.5
Hamada, K.6
Guntupalli, K.K.7
Evans, J.F.8
Jeffery, P.K.9
-
128
-
-
0033460212
-
Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats
-
D. Ihaku, L. Cameron, M. Suzuki, S. Molet, J. Martin, and Q. Hamid Montelukast, a leukotriene receptor antagonist, inhibits late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats J Allergy Clin Immunol 104 1999 1147 1154 (Pubitemid 30004972)
-
(1999)
Journal of Allergy and Clinical Immunology
, vol.104
, Issue.6
, pp. 1147-1154
-
-
Ihaku, D.1
Cameron, L.2
Suzuki, M.3
Molet, S.4
Martin, J.5
Hamid, Q.6
-
129
-
-
0033869578
-
1 antagonist MK-571
-
DOI 10.1054/plef.2000.0167
-
J.F. Blain, and P. Sirois Involvement of LTD(4) in allergic pulmonary inflammation in mice: modulation by cysLT(1) antagonist MK-571 Prostaglandins Leukot Essent Fatty Acids 62 2000 361 368 (Pubitemid 30623881)
-
(2000)
Prostaglandins Leukotrienes and Essential Fatty Acids
, vol.62
, Issue.6
, pp. 361-368
-
-
Blain, J.F.1
Sirois, P.2
-
130
-
-
0037214475
-
Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse
-
DOI 10.1165/rcmb.4532
-
S.-Y. Eum, K. Maghni, Q. Hamid, H. Campbell, D.H. Eidelman, and J.G. Martin Involvement of cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse Am J Respir Cell Mol Biol 28 2003 25 32 (Pubitemid 36017047)
-
(2003)
American Journal of Respiratory Cell and Molecular Biology
, vol.28
, Issue.1
, pp. 25-32
-
-
Eum, S.-Y.1
Maghni, K.2
Hamid, Q.3
Campbell, H.4
Eidelman, D.H.5
Martin, J.G.6
-
131
-
-
0036839816
-
Effects of montelukast and budesonide on airway responses and airway inflammation in asthma
-
DOI 10.1164/rccm.200206-509OC
-
R. Leigh, D. Vethanayagam, M. Yoshida, R.M. Watson, T. Rerecich, and M.D. Inman Effects of montelukast and budesonide on airway responses and airway inflammation in asthma Am J Respir Crit Care Med 166 2002 1212 1217 (Pubitemid 35222598)
-
(2002)
American Journal of Respiratory and Critical Care Medicine
, vol.166
, Issue.9
, pp. 1212-1217
-
-
Leigh, R.1
Vethanayagam, D.2
Yoshida, M.3
Watson, R.M.4
Rerecich, T.5
Inman, M.D.6
O'Byrne, P.M.7
-
132
-
-
69349105178
-
The leukotriene E4 puzzle: Finding the missing pieces and revealing the pathobiologic implications
-
K.F. Austen, A. Maekawa, Y. Kanaoka, and J.A. Boyce The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications J Allergy Clin Immunol 124 2009 406 414
-
(2009)
J Allergy Clin Immunol
, vol.124
, pp. 406-414
-
-
Austen, K.F.1
Maekawa, A.2
Kanaoka, Y.3
Boyce, J.A.4
-
135
-
-
70449700139
-
Leukotriene E4-induce pulmonary inflammation is mediated by the P2Y12 receptor
-
S. Paruchuri, H. Tashimo, C. Feng, A. Maekawa, W. Xing, and Y. Jiang Leukotriene E4-induce pulmonary inflammation is mediated by the P2Y12 receptor J Exp Med 206 2009 2543 2555
-
(2009)
J Exp Med
, vol.206
, pp. 2543-2555
-
-
Paruchuri, S.1
Tashimo, H.2
Feng, C.3
Maekawa, A.4
Xing, W.5
Jiang, Y.6
-
136
-
-
77954852825
-
Transcellular biosynthesis of eicosanoids
-
A. Sala, G. Folco, and R.C. Murphy Transcellular biosynthesis of eicosanoids Pharmacol Rep 62 2010 503 510
-
(2010)
Pharmacol Rep
, vol.62
, pp. 503-510
-
-
Sala, A.1
Folco, G.2
Murphy, R.C.3
-
137
-
-
70449518325
-
Mouse models of asthma: A comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
-
M.M. Gueders, G. Paulissen, C. Crahay, F. Quesada-Calvo, J. Hacha, and C. Van Hove Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production Inflamm Res 58 2009 845 854
-
(2009)
Inflamm Res
, vol.58
, pp. 845-854
-
-
Gueders, M.M.1
Paulissen, G.2
Crahay, C.3
Quesada-Calvo, F.4
Hacha, J.5
Van Hove, C.6
-
138
-
-
77958610748
-
Choice of mouse strain influences the outcome in a mouse model of chemical-induced asthma
-
V. De Vooght, J.A. Vaniorbeek, K. Luyts, S. Haenen, B. Nemery, and P.H. Hoet Choice of mouse strain influences the outcome in a mouse model of chemical-induced asthma PLoS One 5 9 2010 e12581
-
(2010)
PLoS One
, vol.5
, Issue.9
, pp. 12581
-
-
De Vooght, V.1
Vaniorbeek, J.A.2
Luyts, K.3
Haenen, S.4
Nemery, B.5
Hoet, P.H.6
-
139
-
-
79959988283
-
Strain-dependent genomic factors affect allergen-induced airway hyper-responsiveness in mice
-
[Epub ahead of print]
-
S.N. Kelada, M.S. Wilson, U. Tavarez, K. Kubalanza, B. Borate, and G. Whitehead Strain-dependent genomic factors affect allergen-induced airway hyper-responsiveness in mice Am J Respir Cell Mol Biol March 2011 [Epub ahead of print]
-
(2011)
Am J Respir Cell Mol Biol
, Issue.MARCH
-
-
Kelada, S.N.1
Wilson, M.S.2
Tavarez, U.3
Kubalanza, K.4
Borate, B.5
Whitehead, G.6
-
140
-
-
36448991234
-
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury
-
DOI 10.1111/j.1365-2613.2007.00566.x
-
D. Togbe, S. Schnyder-Candrian, B. Schnyder, E. Doz, N. Noulin, and L. Janot Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury Int J Exp Pathol 88 2007 387 391 (Pubitemid 350173704)
-
(2007)
International Journal of Experimental Pathology
, vol.88
, Issue.6
, pp. 387-391
-
-
Togbe, D.1
Schnyder-Candrian, S.2
Schnyder, B.3
Doz, E.4
Noulin, N.5
Janot, L.6
Secher, T.7
Gasse, P.8
Lima, C.9
Coelho, F.R.10
Vasseur, V.11
Erard, F.12
Ryffel, B.13
Couillin, I.14
Moser, R.15
-
141
-
-
0033049432
-
Selective airway responsiveness in asthma
-
DOI 10.1016/S0165-6147(98)01280-2, PII S0165614798012802
-
B.J. O'Connor, S.D. Crowther, J.F. Costello, and J. Morley Selective airway responsiveness in asthma Trends Pharmacol Sci 20 1999 9 11 (Pubitemid 29304519)
-
(1999)
Trends in Pharmacological Sciences
, vol.20
, Issue.1
, pp. 9-11
-
-
O'Connor, B.J.1
Crowther, S.D.2
Costello, J.F.3
Morley, J.4
-
142
-
-
0042380075
-
Evidence of mast cell activation and leukotriene release after mannitol inhalation
-
DOI 10.1183/09031936.03.00113403
-
J.D. Brannan, M. Gulliksson, S.D. Anderson, N. Chew, and M. Kumlin Evidence of mast cell activation and leukotriene release after mannitol inhalation Eur Respir J 22 2003 491 496 (Pubitemid 37098931)
-
(2003)
European Respiratory Journal
, vol.22
, Issue.3
, pp. 491-496
-
-
Brannan, J.D.1
Gulliksson, M.2
Anderson, S.D.3
Chew, N.4
Kumlin, M.5
-
143
-
-
77953329105
-
Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects
-
S.D. Anderson, J.D. Brannan, C.P. Perry, C. Caillaud, and J.P. Seale Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects J Asthma 47 2010 429 433
-
(2010)
J Asthma
, vol.47
, pp. 429-433
-
-
Anderson, S.D.1
Brannan, J.D.2
Perry, C.P.3
Caillaud, C.4
Seale, J.P.5
-
144
-
-
77953973017
-
Allergen-induced airway inflammation and its therapeutic intervention
-
P.M. O'Byrne Allergen-induced airway inflammation and its therapeutic intervention Allergy Asthma Immunol Res 1 2009 3 9
-
(2009)
Allergy Asthma Immunol Res
, vol.1
, pp. 3-9
-
-
O'Byrne, P.M.1
-
145
-
-
77953119597
-
Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma
-
S. Fernandez-Rodriguez, K.J. Broadley, W.R. Ford, and E.J. Kidd Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma Pulm Pharmacol Ther 23 2010 300 307
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 300-307
-
-
Fernandez-Rodriguez, S.1
Broadley, K.J.2
Ford, W.R.3
Kidd, E.J.4
-
146
-
-
0027364048
-
Allergic bronchospasm and airway hyperreactivity in the guinea pig
-
K. Hoshiko, and J. Morley Allergic bronchospasm and airway hyperreactivity in the guinea-pig Jpn J Pharmacol 63 1993 151 157 (Pubitemid 23337277)
-
(1993)
Japanese Journal of Pharmacology
, vol.63
, Issue.2
, pp. 151-157
-
-
Hoshiko, K.-I.1
Morley, J.2
-
148
-
-
77950810500
-
Airway wall expression of OX40/OX40L and interleukin-4 in asthma
-
S. Siddiqui, V. Mistry, C. Doe, S. Stinson, M. Foster, and C. Brightling Airway wall expression of OX40/OX40L and interleukin-4 in asthma Chest 137 2010 798 804
-
(2010)
Chest
, vol.137
, pp. 798-804
-
-
Siddiqui, S.1
Mistry, V.2
Doe, C.3
Stinson, S.4
Foster, M.5
Brightling, C.6
-
149
-
-
77951535660
-
Monclonal antibodies and other biologic agents in the treatment of asthma
-
A.A. Long Monclonal antibodies and other biologic agents in the treatment of asthma MAbs 1 2009 237 246
-
(2009)
MAbs
, vol.1
, pp. 237-246
-
-
Long, A.A.1
-
150
-
-
0033454115
-
Interleukin-4 receptor in moderate atopic asthma: A phase I/II randomized, placebo-controlled trial
-
L.C. Borish, H.S. Nelson, M.J. Lanz, L. Claussen, J.B. Whitmore, and J.M. Agosti Interleukin-4 receptor in moderate atopic asthma. A Phase I/II randomized, placebo-controlled trial Am J Respir Crit Care Med 160 1999 1816 1823 (Pubitemid 30004681)
-
(1999)
American Journal of Respiratory and Critical Care Medicine
, vol.160
, Issue.6
, pp. 1816-1823
-
-
Borish, L.C.1
Nelson, H.S.2
Lanz, M.J.3
Claussen, L.4
Whitmore, J.B.5
Agosti, J.M.6
Garrison, L.7
-
151
-
-
0034995872
-
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
-
DOI 10.1067/mai.2001.115624
-
L.C. Borish, H.C. Nelson, J. Corren, G. Bensch, W.W. Busse, and J.B. Whitmore Efficacy of soluble IL-4 receptor for the treatment of adults with asthma J Allergy Clin Immunol 107 2001 963 970 (Pubitemid 32523334)
-
(2001)
Journal of Allergy and Clinical Immunology
, vol.107
, Issue.6
, pp. 963-970
-
-
Borish, L.C.1
Nelson, H.S.2
Corren, J.3
Bensch, G.4
Busse, W.W.5
Whitmore, J.B.6
Agosti, J.M.7
-
152
-
-
52049113214
-
New targets for drug development in asthma
-
I.M. Adcock, G. Caramori, and K.F. Chung New targets for drug development in asthma Lancet 372 2008 1073 1087
-
(2008)
Lancet
, vol.372
, pp. 1073-1087
-
-
Adcock, I.M.1
Caramori, G.2
Chung, K.F.3
-
153
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
-
DOI 10.1164/rccm.200206-525OC
-
J.C. Kips, B.J. O'Connor, S.J. Langley, A. Woodcock, H.A.M. Kerstjens, and D.S. Postma Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma. A pilot study Am J Respir Crit Care Med 167 2003 1655 1659 (Pubitemid 36760679)
-
(2003)
American Journal of Respiratory and Critical Care Medicine
, vol.167
, Issue.12
, pp. 1655-1659
-
-
Kips, J.C.1
O'Connor, B.J.2
Langley, S.J.3
Woodcock, A.4
Kerstjens, H.A.M.5
Postma, D.S.6
Danzig, M.7
Cuss, F.8
Pauwels, R.A.9
-
154
-
-
80051546385
-
Reslizumab in the treatment of poorly controlled asthma in patients with eosinophilic airway inflammation
-
[Poster 64]
-
M. Castro, S. Mathur, F. Hargreave, F. Xie, J. Young, and H.J. Wilkins Reslizumab in the treatment of poorly controlled asthma in patients with eosinophilic airway inflammation Abstract at ACAAI meeting, November 2010 [Poster 64]
-
(2010)
Abstract at ACAAI Meeting, November
-
-
Castro, M.1
Mathur, S.2
Hargreave, F.3
Xie, F.4
Young, J.5
Wilkins, H.J.6
-
155
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
M.J. Leckie, A. ten Brinke, J. Khan, Z. Diamant, B.J. O'Connor, and C.M. Walls Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2144 2148
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
Ten Brinke, A.2
Khan, J.3
Diamant, Z.4
O'Connor, B.J.5
Walls, C.M.6
-
156
-
-
0037438409
-
Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
-
DOI 10.1164/rccm.200208-789OC
-
P.T. Flood-Page, A.N. Menzies-Gow, A.B. Kay, and D.S. Robinson Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am J Respir Crit Care Med 167 2003 199 204 (Pubitemid 36076080)
-
(2003)
American Journal of Respiratory and Critical Care Medicine
, vol.167
, Issue.2
, pp. 199-204
-
-
Flood-Page, P.T.1
Menzies-Gow, A.N.2
Kay, A.B.3
Robinson, D.S.4
-
157
-
-
36749065556
-
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
DOI 10.1164/rccm.200701-085OC
-
P.T. Flood-Page, C. Swenson, I. Faiferman, J. Matthews, M. Williams, and L. Brannick A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma Am J Respir Crit Care Med 176 2007 1062 1071 (Pubitemid 350223751)
-
(2007)
American Journal of Respiratory and Critical Care Medicine
, vol.176
, Issue.11
, pp. 1062-1071
-
-
Flood-Page, P.1
Swenson, C.2
Faiferman, I.3
Matthews, J.4
Williams, M.5
Brannick, L.6
Robinson, D.7
Wenzel, S.8
Busse, W.9
Hansel, T.T.10
Barnes, N.C.11
-
158
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
P. Haldar, C.E. Brightling, B. Hargadon, S. Gupta, W. Monteiro, and A. Sousa Mepolizumab and exacerbations of refractory eosinophilic asthma New Engl J Med 360 2009 973 984
-
(2009)
New Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
Gupta, S.4
Monteiro, W.5
Sousa, A.6
-
159
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
P. Nair, M.M.M. Pizzichini, M. Kjarsgaard, M.D. Inman, A. Efthimiadis, and E. Pizzichini Mepolizumab for prednisone-dependent asthma with sputum eosinophilia New Engl J Med 360 2009 985 993
-
(2009)
New Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.M.2
Kjarsgaard, M.3
Inman, M.D.4
Efthimiadis, A.5
Pizzichini, E.6
-
160
-
-
61849152860
-
Eosinophils in asthma - Closing the loop or opening the door?
-
S.E. Wenzel Eosinophils in asthma - closing the loop or opening the door? New Engl J Med 360 2009 1026 1028
-
(2009)
New Engl J Med
, vol.360
, pp. 1026-1028
-
-
Wenzel, S.E.1
-
161
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
R. Kolbeck, A. Kozhich, M. Koike, L. Peng, C.K. Andersson, and M.M. Damschroder MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function J Allergy Clin Immunol 125 2010 1344 1353
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1344-1353
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
Peng, L.4
Andersson, C.K.5
Damschroder, M.M.6
-
162
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
J. Corren, W. Busse, E.O. Meltzer, L. Mansfield, G. Bensch, and J. Fahrenholz A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma Am J Respir Crit Care Med 181 2010 788 796
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
Mansfield, L.4
Bensch, G.5
Fahrenholz, J.6
-
163
-
-
80051545439
-
-
Pipeline Watch, March 18th 2011
-
Pipeline Watch, March 18th 2011. www.scripintelligence.com/multimedia/ archive/00143/Scrip-3539-Pipeline-143239a.pdf.
-
-
-
-
164
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
DOI 10.1016/S0140-6736(07)61600-6, PII S0140673607616006
-
S.E. Wenzel, D. Wilbraham, R. Fuller, E.B. Getz, and M. Longphre Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431 (Pubitemid 47576168)
-
(2007)
Lancet
, vol.370
, Issue.9596
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
Getz, E.B.4
Longphre, M.5
-
165
-
-
80051545902
-
-
Phase 2b Clinical Trial Results Show Aerovance's Aerovant™ is Effective in Patients with Eosinophilic Asthma Press release June 8, 2010
-
Phase 2b Clinical Trial Results Show Aerovance's Aerovant™ is Effective in Patients with Eosinophilic Asthma. Statistically Significant Results Support Novel Inhaled IL-4/IL-13 Inhibitor's Continued Clinical Development. Press release June 8, 2010. http://www.aerovance.com/news/press- releases/Press-Releases/Phase-2b-Clinical-Trial-Results-Show-Aerovances- Aerovant-is-Effective-in-Patients-with-Eosinophilic-Asthma-92/.
-
Statistically Significant Results Support Novel Inhaled IL-4/IL-13 Inhibitor's Continued Clinical Development
-
-
-
166
-
-
79954583416
-
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
-
G.M. Gauvreau, L.P. Boulet, D.W. Cockcroft, J.M. Fitzgerald, C. Carlsten, and B.E. Davis Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma Am J Respir Crit Care Med 183 2011 1007 1014
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 1007-1014
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Cockcroft, D.W.3
Fitzgerald, J.M.4
Carlsten, C.5
Davis, B.E.6
-
167
-
-
79961128164
-
Dose-response effects of TPI ASM8 in asthmatics after allergen
-
10.1111/j.1398-9995.2011.02638.x
-
G.M. Gauvreau, R. Pageau, R. Séguin, D. Carballo, J. Gauthier, and H. D'Anjou Dose-response effects of TPI ASM8 in asthmatics after allergen Allergy May 2011 10.1111/j.1398-9995.2011.02638.x
-
(2011)
Allergy
, Issue.MAY
-
-
Gauvreau, G.M.1
Pageau, R.2
Séguin, R.3
Carballo, D.4
Gauthier, J.5
D'Anjou, H.6
-
168
-
-
77950801090
-
MEDI-528, an anti-IL-9 humanized antibody for the treatment of asthma
-
S.A. Antoniu MEDI-528, an anti-IL-9 humanized antibody for the treatment of asthma Curr Opin Mol Ther 12 2010 233 239
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 233-239
-
-
Antoniu, S.A.1
-
169
-
-
79955448185
-
Randomized, double-blind, placebo-controlled, multicenter phase 2a study to evaluate the effect of a humanized interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm
-
J. Parker, S. Brazinsky, D.S. Miller, A. Nayak, P.E. Korenblat, and S. Sari Randomized, double-blind, placebo-controlled, multicenter phase 2a study to evaluate the effect of a humanized interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm Am J Respir Crit Care Med 181 2010 A5394
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 5394
-
-
Parker, J.1
Brazinsky, S.2
Miller, D.S.3
Nayak, A.4
Korenblat, P.E.5
Sari, S.6
-
170
-
-
0027361217
-
Treatment of steroid-dependent asthma with recombinant interferon-gamma
-
M. Boguniewicz, L.C. Schneider, H. Milgrom, D. Newell, N. Kelly, and P. Tam Treatment of steroid-dependent asthma with recombinant interferon-gamma Clin Exp Allergy 23 1993 785 790 (Pubitemid 23294875)
-
(1993)
Clinical and Experimental Allergy
, vol.23
, Issue.9
, pp. 785-790
-
-
Boguniewicz, M.1
Schneider, L.C.2
Milgrom, H.3
Newell, D.4
Kelly, N.5
Tam, P.6
Izu, A.E.7
Jaffe, H.S.8
Bucalo, L.R.9
Leung, D.Y.M.10
-
171
-
-
0028817164
-
The effects of nebulized recombinant interferon-gamma in asthmatic airways
-
M. Boguniewicz, R.J. Martin, D. Martin, U. Gibson, A. Celniker, and M. Williams The effects of nebulized recombinant interferon-gamma in asthmatic airways J Allergy Clin Immunol 95 1995 133 135
-
(1995)
J Allergy Clin Immunol
, vol.95
, pp. 133-135
-
-
Boguniewicz, M.1
Martin, R.J.2
Martin, D.3
Gibson, U.4
Celniker, A.5
Williams, M.6
-
172
-
-
6644223789
-
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
S.A. Bryan, B.J. O'Connor, S. Matti, M.J. Leckie, V. Kanabar, and J. Khan Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2149 2153
-
(2000)
Lancet
, vol.356
, pp. 2149-2153
-
-
Bryan, S.A.1
O'Connor, B.J.2
Matti, S.3
Leckie, M.J.4
Kanabar, V.5
Khan, J.6
-
173
-
-
0028107947
-
Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial asthma
-
C.S. Park, S.M. Lee, S.W. Chung, S. Uh, H.T. Kim, and Y.H. Kim Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial asthma Chest 106 1994 400 406 (Pubitemid 24252033)
-
(1994)
Chest
, vol.106
, Issue.2
, pp. 400-406
-
-
Choon Sik Park1
Sang Moo Lee2
Sung Whan Chung3
Uh, S.4
Hyeon Tae Kim5
Yong Hoon Kim6
-
174
-
-
57349179165
-
Daclizumab improves asthma control in patients with moderate to severe persistent asthma. A randomized, controlled trial
-
W.W. Busse, E. Israel, H.S. Nelson, J.W. Baker, B.L. Charous, and D.Y. Young Daclizumab improves asthma control in patients with moderate to severe persistent asthma. A randomized, controlled trial Am J Respir Crit Care Med 178 2008 1002 1008
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1002-1008
-
-
Busse, W.W.1
Israel, E.2
Nelson, H.S.3
Baker, J.W.4
Charous, B.L.5
Young, D.Y.6
-
175
-
-
0029658108
-
4 receptor antagonist, LY293111, on allergen induced responses in asthma
-
D.J. Evans, P.J. Barnes, S.M. Spaethe, E.L. van Alstyne, M.I. Mitchell, and B.J. O'Connor Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma Thorax 51 1996 1178 1184 (Pubitemid 26413134)
-
(1996)
Thorax
, vol.51
, Issue.12
, pp. 1178-1184
-
-
Evans, D.J.1
Barnes, P.J.2
Spaethe, S.M.3
Van Alstyne, E.L.4
Mitchell, M.I.5
O'Connor, B.J.6
-
176
-
-
27744541745
-
Effect of a very late antigen-4 receptor antagonist on allergen-induced airway responses and inflammation in asthma
-
DOI 10.1111/j.1365-2222.2005.02296.x
-
Z. Diamant, J. Kuperus, R. Baan, K. Nietzmann, S. Millet, and P. Mendes Effect of a very late antigen-4 receptor antagonist on allergen-induced airway responses and inflammation in asthma Clin Exp Allergy 35 2005 1080 1087 (Pubitemid 41603143)
-
(2005)
Clinical and Experimental Allergy
, vol.35
, Issue.8
, pp. 1080-1087
-
-
Diamant, Z.1
Kuperus, J.2
Baan, R.3
Nietzmann, K.4
Millet, S.5
Mendes, P.6
Miller, B.7
Amin, D.8
Rohatagi, S.9
Sterk, P.J.10
Hoogsteden, H.C.11
Prins, J.B.12
-
177
-
-
33746861050
-
The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma
-
DOI 10.1111/j.1398-9995.2006.01146.x
-
A.J. Ravensberg, B. Luijk, P. Westers, P.S. Hiemstra, P.J. Sterk, and R.W. Lammers The effect of a single inhaled dose of a VLA-4 antagonist in allergen-induced airway responses and airway inflammation in patients with asthma Allergy 61 2006 1097 1103 (Pubitemid 44175217)
-
(2006)
Allergy: European Journal of Allergy and Clinical Immunology
, vol.61
, Issue.9
, pp. 1097-1103
-
-
Ravensberg, A.J.1
Luijk, B.2
Westers, P.3
Hiemstra, P.S.4
Sterk, P.J.5
Lammers, J.W.6
Rabe, K.F.7
-
178
-
-
25844521063
-
Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma
-
DOI 10.1016/j.jaci.2005.04.045, PII S0091674905014892
-
V. Norris, L. Choong, D. Tran, Z. Corden, M. Boyce, and H. Arshad Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma J Allergy Clin Immunol 116 2005 761 767 (Pubitemid 41400538)
-
(2005)
Journal of Allergy and Clinical Immunology
, vol.116
, Issue.4
, pp. 761-767
-
-
Norris, V.1
Choong, L.2
Tran, D.3
Corden, Z.4
Boyce, M.5
Arshad, H.6
Holgate, S.7
O'Connor, B.8
Millet, S.9
Miller, B.10
Rohatagi, S.11
Kirkesseli, S.12
-
179
-
-
0042530461
-
The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma
-
DOI 10.1067/mai.2003.1689
-
G.M. Gauvreau, A.B. Becker, L.P. Boulet, J. Chakir, R.B. Fick, and W.L. Greene The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma J Allergy Clin Immunol 112 2003 331 338 (Pubitemid 36981373)
-
(2003)
Journal of Allergy and Clinical Immunology
, vol.112
, Issue.2
, pp. 331-338
-
-
Gauvreau, G.M.1
Becker, A.B.2
Boulet, L.-P.3
Chakir, J.4
Fick, R.B.5
Greene, W.L.6
Killian, K.J.7
O'Byrne, P.M.8
Reid, J.K.9
Cockcroft, D.W.10
-
180
-
-
0842291756
-
Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses
-
DOI 10.1111/j.1365-2222.2004.01831.x
-
P.C. Avila, H.A. Boushey, H. Wong, H. Grundland, J. Liu, and J.V. Fahy Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses Clin Exp Allergy 34 2004 77 84 (Pubitemid 38183684)
-
(2004)
Clinical and Experimental Allergy
, vol.34
, Issue.1
, pp. 77-84
-
-
Avila, P.C.1
Boushey, H.A.2
Wong, H.3
Grundland, H.4
Liu, J.5
Fahy, J.V.6
-
181
-
-
33645324424
-
Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo-controlled clinical cross-over-trial
-
K.M. Beeh, J. Beier, M. Meyer, R. Buhl, R. Zahlten, and G. Wolff Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial Pulm Pharmacol Ther 19 2006 233 241
-
(2006)
Pulm Pharmacol Ther
, vol.19
, pp. 233-241
-
-
Beeh, K.M.1
Beier, J.2
Meyer, M.3
Buhl, R.4
Zahlten, R.5
Wolff, G.6
-
182
-
-
23344439609
-
Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation
-
DOI 10.1016/j.rmed.2005.02.031, PII S0954611105000661
-
F.N. Rouhani, C.A. Meitin, M. Kaler, D. Miskinis-Hilligoss, M. Stylianou, and S.J. Levine Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation Respir Med 99 2005 1175 1182 (Pubitemid 41102656)
-
(2005)
Respiratory Medicine
, vol.99
, Issue.9
, pp. 1175-1182
-
-
Rouhani, F.N.1
Meitin, C.A.2
Kaler, M.3
Miskinis-Hilligoss, D.4
Stylianou, M.5
Levine, S.J.6
-
183
-
-
32644490529
-
Evidence of a role of tumor necrosis factor α in refractory asthma
-
DOI 10.1056/NEJMoa050580
-
M.A. Berry, B. Hargadon, M. Shelley, D. Parker, D.E. Shaw, and R.H. Green Evidence of a role of tumor necrosis factor alpha in refractory asthma New Engl J Med 354 2006 697 708 (Pubitemid 43247140)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.7
, pp. 697-708
-
-
Berry, M.A.1
Hargadon, B.2
Shelley, M.3
Parker, D.4
Shaw, D.E.5
Green, R.H.6
Bradding, P.7
Brightling, C.E.8
Wardlaw, A.J.9
Pavord, I.D.10
-
184
-
-
47049130758
-
The role of a soluble TNFα receptor fusion protein (etanercept) in corticosteroid refractory asthma: A double blind, randomised, placebo controlled trial
-
DOI 10.1136/thx.2007.086314
-
J.B. Morjaria, A.J. Chauhan, K.S. Babu, R. Polosa, D.E. Davies, and S.T. Holgate The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomized, placebo controlled trial Thorax 63 2008 584 591 (Pubitemid 351969250)
-
(2008)
Thorax
, vol.63
, Issue.7
, pp. 584-591
-
-
Morjaria, J.B.1
Chauhan, A.J.2
Babu, K.S.3
Polosa, R.4
Davies, D.E.5
Holgate, S.T.6
-
185
-
-
33749438560
-
The effects of a monoclonal antibody directed against tumor necrosis factor-α in asthma
-
DOI 10.1164/rccm.200601-072OC
-
E.M. Erin, B.R. Leaker, G.C. Nicholson, A.J. Tan, L.M. Green, and H. Neighbour The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma Am J Respir Crit Care Med 174 2006 753 762 (Pubitemid 44511656)
-
(2006)
American Journal of Respiratory and Critical Care Medicine
, vol.174
, Issue.7
, pp. 753-762
-
-
Erin, E.M.1
Leaker, B.R.2
Nicholson, G.C.3
Tan, A.J.4
Green, L.M.5
Neighbour, H.6
Zacharasiewicz, A.S.7
Turner, J.8
Barnathan, E.S.9
Kon, O.M.10
Barnes, P.J.11
Hansel, T.T.12
-
186
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-a blockade in severe persistent asthma
-
S.E. Wenzel, P.J. Barnes, E.R. Bleecker, J. Bousquet, W. Busse, and S.-E. Dahlé A randomized, double-blind, placebo-controlled study of tumor necrosis factor-a blockade in severe persistent asthma Am J Respir Crit Care Med 179 2009 549 558
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
Bousquet, J.4
Busse, W.5
Dahlé, S.-E.6
-
187
-
-
0031691352
-
Biologic activities of IL-1 and its role in human disease
-
DOI 10.1016/S0091-6749(98)70118-6
-
L.J. Rosenwasser Biologic activities of IL-1 and its role in human disease J Allergy Clin Immunol 102 1998 344 350 (Pubitemid 28471489)
-
(1998)
Journal of Allergy and Clinical Immunology
, vol.102
, Issue.3
, pp. 344-350
-
-
Rosenwasser, L.J.1
-
189
-
-
0037501014
-
Cyclosporin as an oral corticosteroid sparing agent in stable asthma
-
D.J. Evans, P. Cullinan, and D.M. Geddes Cyclosporin as an oral corticosteroid sparing agent in stable asthma Cochrane Database Syst Rev 2 2001 CD002993
-
(2001)
Cochrane Database Syst Rev
, Issue.2
, pp. 002993
-
-
Evans, D.J.1
Cullinan, P.2
Geddes, D.M.3
-
190
-
-
2942744527
-
Azathioprine as an oral corticosteroid sparing agent for asthma
-
T. Dean, A. Dewey, A. Bara, T.J. Lasserson, and E.H. Walters Azathioprine as an oral corticosteroid sparing agent for asthma Cochrane Database Syst Rev 1 2004 CD003270
-
(2004)
Cochrane Database Syst Rev
, Issue.1
, pp. 003270
-
-
Dean, T.1
Dewey, A.2
Bara, A.3
Lasserson, T.J.4
Walters, E.H.5
-
192
-
-
0033057149
-
Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: A double-blind, placebo-controlled, randomized trial
-
DOI 10.1016/S0091-6749(99)70424-0
-
L.M. Salmun, I. Barlan, H.M. Wolf, M. Eibl, F.J. Twarog, and R.S. Geha Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: a double-blind, placebo-controlled, randomized trial J Allergy Clin Immunol 103 1999 810 815 (Pubitemid 29297583)
-
(1999)
Journal of Allergy and Clinical Immunology
, vol.103
, pp. 810-815
-
-
Salmun, L.M.1
Barlan, I.2
Wolf, H.M.3
Eibl, M.4
Twarog, F.J.5
Geha, R.S.6
Schneider, L.C.7
-
193
-
-
0032480574
-
Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
-
DOI 10.1016/S0140-6736(97)12261-9
-
O.M. Kon, B.S. Sihra, C.H. Compton, T.B. Leonard, A.B. Kay, and N.C. Barnes Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma Lancet 352 1998 1109 1113 (Pubitemid 28448517)
-
(1998)
Lancet
, vol.352
, Issue.9134
, pp. 1109-1113
-
-
Kon, O.M.1
Sihra, B.S.2
Compton, C.H.3
Leonard, T.B.4
Kay, A.B.5
Barnes, N.C.6
-
194
-
-
0034906753
-
The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma
-
DOI 10.1183/09031936.01.00064101
-
O.M. Kon, B.S. Sihra, L.C. Loh, J. Barkans, C.H. Compton, and N.C. Barnes The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma Eur Respir J 18 2001 45 52 (Pubitemid 32717430)
-
(2001)
European Respiratory Journal
, vol.18
, Issue.1
, pp. 45-52
-
-
Kon, O.M.1
Sihra, B.S.2
Loh, L.C.3
Barkans, J.4
Compton, C.H.5
Barnes, N.C.6
Larche, M.7
Kay, A.B.8
-
195
-
-
77953073669
-
IL-4 and IL-13 dual antagonism: A promising approach to the dilemma of generating effective asthma biotherapeutics
-
L. Borish IL-4 and IL-13 dual antagonism: a promising approach to the dilemma of generating effective asthma biotherapeutics Am J Respir Crit Care Med 181 2010 769 770
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 769-770
-
-
Borish, L.1
-
196
-
-
0003699334
-
-
First published in 1935 by Verlag von Julius Springer, Vienna, Austria. Published as a Routledge Classic in 2002, by Routledge, London and NY
-
Popper K. The logic of scientific discovery. First published in 1935 by Verlag von Julius Springer, Vienna, Austria. Published as a Routledge Classic in 2002, by Routledge, London and NY.
-
The Logic of Scientific Discovery
-
-
Popper, K.1
-
197
-
-
0037202790
-
Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
-
DOI 10.1016/S0140-6736(02)11679-5
-
R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721 (Pubitemid 35447900)
-
(2002)
Lancet
, vol.360
, Issue.9347
, pp. 1715-1721
-
-
Green, R.H.1
Brightling, C.E.2
McKenna, S.3
Hargadon, B.4
Parker, D.5
Bradding, P.6
Wardlaw, A.J.7
Pavord, I.D.8
-
198
-
-
33344476409
-
Determining asthma treatment by monitoring sputum cell counts: Effect on exacerbations
-
DOI 10.1183/09031936.06.00137704
-
L. Jayaram, M.M. Pizzichini, R.J. Cook, L.P. Boulet, C. Lemire, and E. Pizzichini Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations Eur Respir J 27 2006 483 494 (Pubitemid 43372521)
-
(2006)
European Respiratory Journal
, vol.27
, Issue.3
, pp. 483-494
-
-
Jayaram, L.1
Pizzichini, M.M.2
Cook, R.J.3
Boulet, L.-P.4
Lemiere, C.5
Pizzichini, E.6
Cartier, A.7
Hussack, P.8
Goldsmith, C.H.9
Laviolette, M.10
Parameswaran, K.11
Hargreave, F.E.12
-
199
-
-
69249150516
-
T-helper Type 2-driven inflammation defines major subphenotypes of asthma
-
P.G. Woodruff, B. Modrek, D.F. Choy, G. Jia, A.R. Abbas, and A. Ellwager T-helper Type 2-driven inflammation defines major subphenotypes of asthma Am J Respir Crit Care Med 180 2009 388 395
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
Jia, G.4
Abbas, A.R.5
Ellwager, A.6
-
200
-
-
77955269402
-
Chronic inflammation and asthma
-
J.R. Murdoch, and C.M. Lloyd Chronic inflammation and asthma Mutat Res 690 2010 24 39
-
(2010)
Mutat Res
, vol.690
, pp. 24-39
-
-
Murdoch, J.R.1
Lloyd, C.M.2
-
201
-
-
0028216832
-
The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat
-
H.A. Rabb, R. Olivenstein, T.B. Issekutz, P.M. Renzi, and J.G. Martin The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat Am J Respir Crit Care Med 149 1994 1186 1191 (Pubitemid 24147059)
-
(1994)
American Journal of Respiratory and Critical Care Medicine
, vol.149
, Issue.5
, pp. 1186-1191
-
-
Rabb, H.A.1
Olivenstein, R.2
Issekutz, T.B.3
Renzi, P.M.4
Martin, J.G.5
|