Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 21, Issue 5, 1999, Pages 586-596

  Stämpfli, Martin R ^a   Cwiartka, Monika ^a   Gajewska, Beata U ^a   Alvarez, David ^a   Ritz, Stacey A ^a   Inman, Mark D ^a   Xing, Zhou ^a   Jordana, Manel ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; MURINAE;

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; INTERLEUKIN 10; MEMBRANE ANTIGEN; OVALBUMIN;

ADENOVIRUS; ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; EOSINOPHILIA; FEMALE; GENE TRANSFER; GENETICS; IMMUNOLOGY; LUNG LAVAGE; METABOLISM; MOUSE; MOUSE MUTANT; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT MUCOSA; T LYMPHOCYTE;

ADENOVIRIDAE; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, SURFACE; BRONCHOALVEOLAR LAVAGE FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; FEMALE; GENE TRANSFER TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOGLOBULIN E; INTERFERON TYPE II; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY MUCOSA; T-LYMPHOCYTES;

EID: 0033219725     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.21.5.3755     Document Type: Article

References (53)

1. Manfreda, J., A. B. Becker, P.-Z. Wang, L. L. Roos, and N. R. Anthonisen. 1993. Trends in physician-diagnosed asthma prevalence in Manitoba between 1980 and 1990. Chest 103:151-157.
2. Farber, H. J., W. Wattigney, and G. Berenson. 1997. Trends in asthma prevalence: the Bogalusa heart study. Ann. Allergy Asthma Immunol. 78:265-269.
3. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178:889-899.
4. McMenamin, C., C. Pimm, M. McKersey, and P. G, Holt. 1994. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 265:1869-1871.
5. + T cells or interferon γ in a murine model of allergen sensitization. J. Exp. Med. 187:721-731.
6. Holt, P. G., and C. McMenamin. 1989. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin. Exp. Allergy 19: 255-262.
7. Borish, L., A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, and S. Wenzel. 1996. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97:1288-1296.
8. Hobbs, K., J. Negri, M. Klinnert, L. J. Rosenwasser, and L. Borish. 1998. Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. 158:1958-1962.
9. de Vries, J. E. 1995. Immunosuppressive and anti-inflammatory properties of interleukin-10. Ann. Med. 27:537-541.
10. Borish, L. 1998. IL-10: evolving concepts. J. Allergy Clin. Immunol. 101: 293-297.
11. Pretolani, M., and M. Goldman. 1997. IL-10: a potential therapy for allergic inflammation. Immunol. Today 18:277-280.
12. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E, de Vries. 1991, Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209-1220.
13. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
14. de Waal Malefyt, R., C. G. Figdor, R. Huijbens, S. Mohan-Peterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski, and J. E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-γ or IL-10. J. Immunol. 151:6370-6381.
15. Cassatella, M. A., L. Meda, S. Bonora, M. Ceska, and G. Constantin. 1993. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes: evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J. Exp. Med. 178:2207-2211.
16. Kasama, T., R. M. Strieter, N. W. Lukacs, M. D. Burdick, and S. L. Kunkel. 1994. Regulation of neutrophil-derived chemokine expression by IL-10. J. Immunol. 152:3559-3569.
17. Takanaski, S., R. Nonaka, Z. Xing, P. O'Byrne, J. Dolovich, and M. Jordana. 1994. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. J. Exp. Med. 180:711-715.
18. + T cell clones and resting T cells. J. Immunol. 150:4754-4765.
19. de Waal Malefyt, R., J. Haanen, H. Spits, M. G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915-924.
20. + T cells. J Exp. Med. 184:19-29.
21. Howard, M., T. Muchamuel, S. Andrade, and S. Menon. 1993. Interleukin10 protects mice from lethal endotoximia. J. Exp. Med. 177:1205-1208.
22. Xing, Z., Y. Ohkawara, M. Jordana, F. L. Graham, and J. Gauldie. 1997. Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Ther. 4:140-149.
23. Mignon-Godfroy, K., O. Rott, M.-P, Brazillet, and J. Charreire. 1995. Curative and protective effects of IL-10 in experimental autoimmune thyroiditis. J. Immunol. 154:6634-6643.
24. Mulligan, M. S., R. L. Warner, J. L. Foreback, T. P. Shanley, and P. A. Ward. 1997. Protective effects of 1L-4, IL-10, IL-12, and IL-13 in IgG immune complex-induced lung injury: role of endogenous IL-12. J. Immunol, 159:3483-3489.
25. Zuany-Amorim, C., S. Haile, D. Leduc, C. Dumarey, M. Huerre, B. B. Vargaftig, and M. Pretolani. 1995. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95: 2644-2651.
26. Tumpey, T. M., V. M. Elner, S. H. Chen, J. E. Oakes, and R. N. Lausch. 1994. Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. J. Immunol. 153:2258-2265.
27. Groux, H., F. Cottrez, M. Rouleau, S. Mauze, S. Antonenko, S. Hurst, T. McNeil, M. Bigler, M.-G. Roncarolo, and R. L. Coffman. 1999, A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J. Immunol. 162:1723-1729.
28. Stämpfli, M. R., R. E. Wiley, G. S. Neigh, B. U. Gajewska, X.-F. Lei, D. P. Snider, Z. Xing, and M. Jordana. 1998. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J. Clin. Invest. 102:1704-1714.
29. Xing, Z., Y. Ohkawara, M. Jordana, E. L. Graham, and J. Gauldic. 1996. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J. Clin. Invest. 97:1102-1110.
30. Bett, A. J., W. Haddara, L. Prevec, and F. L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91:8802-8806.
31. Ohkawara, Y., X.-F. Lei, M. R. Stämpfli, J. S. Marshall, Z. Xing, and M. Jordana. 1997. Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation. Am. J. Respir. Cell Mol. Biol. 16:510-520.
32. Ewart, S. L., W. Mitzner, D. A. DiSilvestre, D. A. Meyers, and R. C. Levitt. 1996. Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am. J. Respir. Cell Mol. Biol. 14:487-495.
33. Papioannou, V. E., and J. G. Fox. 1993. Efficacy of tribromoethanol anesthesia in mice. Lab. Anim. Science 43:189-192.
34. Lei, X.-F., Y. Ohkawara, M. R. Stämpfli, J. Gauldie, K. Croitoru, M. Jordana, and Z. Xing. 1998. Compartmentalized transgene expression of granulocyte-macrophage colony stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Clin. Exp. Immunol. 113:157-165.
35. Vremee, D., and K. Shortman. 1997. Dendritic cell subtypes in mouse lymphoid organs. J. Immunol. 159:565-573.
36. Matsushima, G. K., and S. A. Stohlman, 1991. Distinct subsets of accessory cells activate Thy-1 triple negative (CD3 , CD4 , CD8 ) cells and Th-1 delayed-type hypersensitivity effector T cells. J. Immunol. 146:3322-3331.
37. Stämpfli, M. R., S. A. Ritz, G. S. Neigh, P. J. Sime, X.-F. Lei, Z. Xing, K. Croitoru, and M. Jordana. 1998. Adenoviral infection inhibits allergic airways inflammation in mice. Clin. Exp. Allergy 28:1581-1590.
38. Garlisi, C. G., A. Falcone, M. M. Billah, R. W. Egan, and S. P. Umland. 1996. T cells are the predominant source of interleukin-5 but not interleukin 4 mRNA expression in the lungs of antigen-challenged allergic mice. Am. J. Respir. Cell Mol. Biol. 15:420-428.
39. Gordon, J. R., and S. J. Galli. 1990. Mast cells as a source of both preformed and immunologically inducible TNF-α/Cachectin. Nature 346:274-276.
40. Bradding, P., I. H. Feather, S. Wilson, P. G. Bardin, C. H. Heusser, S. T. Holgate, and P. H. Howarth. 1993. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects: the mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J. Immunol. 151:3853-3865.
41. Finotto, S., I. Ohno, J. S. Marshall, J. Gauldie, J. A. Denburg, J. Dolovich, D. A. Clark, and M. Jordana. 1994. TNF-α production by cosinophils in upper airways inflammation (nasal polyposis). J. Immunol. 153:2278-2289.
42. Nonaka, M., R. Nonaka, K. Woolley, E. Adelroth, K. Miura, Y. Ohkawara, M. Glibetic, K. Nakano, P. O'Byrne, J. Dolovich, and M. Jordana. 1995. Distinct immunohistochemical localization of IL-4 in human inflamed airway tissue. J. Immunol. 155:3234-3244.
43. Marshall, J. S., I. Leal-Berumen, L. Nielsen, M. Glibetic, and M. Jordana. 1996. Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells. J. Clin. Invest. 97:1122-1128.
44. Schultze, J., L. M. Nadler, and J. G. Gribben. 1996. B7-mediated costimulation and the immune response. Blood Rev. 10:111-127.
45. Mitra, R. S., T. A. Judge, F. O. Nestle, L. A. Turka, and B. J. Nickoloff. 1995. Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10: differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J. Immunol. 154:2668-2677.
46. Buelens, C., F. Willems, A. Delvaux, G. Pierard, J. P. Delville, T. Velu, and M. Goldman. 1995. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur. J. Immunol. 25:2668-2672.
47. Morel, A. S., S. Ouaratino, D. C. Douek, and M. Londei. 1997. Split activity of interleukin-10 on antigen capture and antigen presentation by human dendritic cells: definition of a maturative step. Eur. J. Immunol. 27:26-34.
48. Thomssen, H., M. Kahan, and M. Londei. 1995. Differential effects of interleukin-10 on the expression of HLA class II and CD1 molecules induced by granulocyte/macrophage colony-stimulating factor/interleukin-4. Eur. J. Immunol. 25:2465-2470.
49. McWilliam, A. S., S. Napoli, A. M. Marsh, F. L. Pemper, D. J. Nelson, C. L. Pimm, P. A. Stumbles, T. N. Wells, and P. G. Holt. 1996. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J. Exp. Med. 184:2429-2432.
50. Buelens, C., V. Verhasselt, D. De Groote, K. Thielemans, M. Goldman, and F. Willems. 1997. Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur. J. Immunol. 27:756-762.
51. Allavena, P., L. Piemonti, D. Longoni, S, Bernasconi, A. Stoppacciaro, L. Ruco, and A. Mantovaniv. 1998. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur. J. Immunol. 28:359-369.
52. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737-742.
53. Stämpfli, M. R., G. S. Neigh, R. E. Wiley, M. Cwiartka, S. A. Ritz, M. M. Hitt, Z. Xing, and M. Jordana. 1999. Regulation of allergic mucosal sensitization by IL-12 gene transfer to the airway. Am. J. Respir. Cell Mol. Biol. 21:317-326.