메뉴 건너뛰기




Volumn 130, Issue 1, 2009, Pages 27-33

The effects of IL-6 on CD4 T cell responses

Author keywords

Allergic airway inflammation; Autoimmune disease; CD4 T cell differentiation; IL 21; IL 6; IL 6R; T helper response; Th1 Th2 Th17

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 57149107119     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.08.018     Document Type: Review
Times cited : (416)

References (61)
  • 2
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: discovery of a pleiotropic cytokine
    • Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis. Res. Ther. 8 Suppl. 2 (2006) S2
    • (2006) Arthritis. Res. Ther. , vol.8 , Issue.SUPPL. 2
    • Kishimoto, T.1
  • 3
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: the signal orchestration model
    • Kamimura D., Ishihara K., and Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149 (2003) 1-38
    • (2003) Rev. Physiol. Biochem. Pharmacol. , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 5
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger M.J., Chow D.C., Brevnova E.E., and Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300 (2003) 2101-2104
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 6
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z., Wen Z., and Darnell Jr. J.E. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264 (1994) 95-98
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 7
    • 0029887373 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
    • Gerhartz C., Heesel B., Sasse J., Hemmann U., Landgraf C., Schneider-Mergener J., Horn F., Heinrich P.C., and Graeve L. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J. Biol. Chem. 271 (1996) 12991-12998
    • (1996) J. Biol. Chem. , vol.271 , pp. 12991-12998
    • Gerhartz, C.1    Heesel, B.2    Sasse, J.3    Hemmann, U.4    Landgraf, C.5    Schneider-Mergener, J.6    Horn, F.7    Heinrich, P.C.8    Graeve, L.9
  • 8
    • 0027217386 scopus 로고
    • The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
    • Ramji D.P., Vitelli A., Tronche F., Cortese R., and Ciliberto G. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res. 21 (1993) 289-294
    • (1993) Nucleic Acids Res. , vol.21 , pp. 289-294
    • Ramji, D.P.1    Vitelli, A.2    Tronche, F.3    Cortese, R.4    Ciliberto, G.5
  • 9
    • 0033551802 scopus 로고    scopus 로고
    • Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
    • Chen R.H., Chang M.C., Su Y.H., Tsai Y.T., and Kuo M.L. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J. Biol. Chem. 274 (1999) 23013-23019
    • (1999) J. Biol. Chem. , vol.274 , pp. 23013-23019
    • Chen, R.H.1    Chang, M.C.2    Su, Y.H.3    Tsai, Y.T.4    Kuo, M.L.5
  • 10
    • 0026682873 scopus 로고
    • Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo
    • Saito M., Yoshida K., Hibi M., Taga T., and Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 148 (1992) 4066-4071
    • (1992) J. Immunol. , vol.148 , pp. 4066-4071
    • Saito, M.1    Yoshida, K.2    Hibi, M.3    Taga, T.4    Kishimoto, T.5
  • 11
    • 33750166463 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor: from bench to bedside
    • Scheller J., and Rose-John S. Interleukin-6 and its receptor: from bench to bedside. Med. Microbiol. Immunol. 195 (2006) 173-183
    • (2006) Med. Microbiol. Immunol. , vol.195 , pp. 173-183
    • Scheller, J.1    Rose-John, S.2
  • 13
    • 0028087834 scopus 로고
    • Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism
    • Horiuchi S., Koyanagi Y., Zhou Y., Miyamoto H., Tanaka Y., Waki M., Matsumoto A., Yamamoto M., and Yamamoto N. Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. Eur. J. Immunol. 24 (1994) 1945-1948
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1945-1948
    • Horiuchi, S.1    Koyanagi, Y.2    Zhou, Y.3    Miyamoto, H.4    Tanaka, Y.5    Waki, M.6    Matsumoto, A.7    Yamamoto, M.8    Yamamoto, N.9
  • 16
    • 47249089967 scopus 로고    scopus 로고
    • Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    • Briso E.M., Dienz O., and Rincon M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J. Immunol. 180 (2008) 7102-7106
    • (2008) J. Immunol. , vol.180 , pp. 7102-7106
    • Briso, E.M.1    Dienz, O.2    Rincon, M.3
  • 17
    • 0031570453 scopus 로고    scopus 로고
    • IL-6 rescues resting mouse T cells from apoptosis
    • Teague T.K., Marrack P., Kappler J.W., and Vella A.T. IL-6 rescues resting mouse T cells from apoptosis. J. Immunol. 158 (1997) 5791-5796
    • (1997) J. Immunol. , vol.158 , pp. 5791-5796
    • Teague, T.K.1    Marrack, P.2    Kappler, J.W.3    Vella, A.T.4
  • 18
    • 0023920214 scopus 로고
    • B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
    • Lotz M., Jirik F., Kabouridis P., Tsoukas C., Hirano T., Kishimoto T., and Carson D.A. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J. Exp. Med. 167 (1988) 1253-1258
    • (1988) J. Exp. Med. , vol.167 , pp. 1253-1258
    • Lotz, M.1    Jirik, F.2    Kabouridis, P.3    Tsoukas, C.4    Hirano, T.5    Kishimoto, T.6    Carson, D.A.7
  • 19
    • 0033566826 scopus 로고    scopus 로고
    • Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells
    • Kishimoto H., and Sprent J. Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells. J. Immunol. 163 (1999) 1817-1826
    • (1999) J. Immunol. , vol.163 , pp. 1817-1826
    • Kishimoto, H.1    Sprent, J.2
  • 20
    • 0032402144 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) prevents activation-induced cell death: IL-2-independent inhibition of Fas/fasL expression and cell death
    • Ayroldi E., Zollo O., Cannarile L., Grohmann D.A.F.U., Delfino D.V., and Riccardi C. Interleukin-6 (IL-6) prevents activation-induced cell death: IL-2-independent inhibition of Fas/fasL expression and cell death. Blood 92 (1998) 4212-4219
    • (1998) Blood , vol.92 , pp. 4212-4219
    • Ayroldi, E.1    Zollo, O.2    Cannarile, L.3    Grohmann, D.A.F.U.4    Delfino, D.V.5    Riccardi, C.6
  • 21
    • 17044377812 scopus 로고    scopus 로고
    • IL-6 increases primed cell expansion and survival
    • Rochman I., Paul W.E., and Ben-Sasson S.Z. IL-6 increases primed cell expansion and survival. J. Immunol. 174 (2005) 4761-4767
    • (2005) J. Immunol. , vol.174 , pp. 4761-4767
    • Rochman, I.1    Paul, W.E.2    Ben-Sasson, S.Z.3
  • 24
    • 0031058726 scopus 로고    scopus 로고
    • Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
    • Rincon M., Anguita J., Nakamura T., Fikrig E., and Flavell R.A. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185 (1997) 461-469
    • (1997) J. Exp. Med. , vol.185 , pp. 461-469
    • Rincon, M.1    Anguita, J.2    Nakamura, T.3    Fikrig, E.4    Flavell, R.A.5
  • 27
    • 33744951868 scopus 로고    scopus 로고
    • Role of the CCAAT/enhancer-binding protein NFATc2 transcription factor cascade in the induction of secretory phospholipase A2
    • Yang T.T., Ung P.M., Rincon M., and Chow C.W. Role of the CCAAT/enhancer-binding protein NFATc2 transcription factor cascade in the induction of secretory phospholipase A2. J. Biol. Chem. 281 (2006) 11541-11552
    • (2006) J. Biol. Chem. , vol.281 , pp. 11541-11552
    • Yang, T.T.1    Ung, P.M.2    Rincon, M.3    Chow, C.W.4
  • 28
    • 14044268797 scopus 로고    scopus 로고
    • IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
    • Yang Y., Ochando J., Yopp A., Bromberg J.S., and Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J. Immunol. 174 (2005) 2720-2729
    • (2005) J. Immunol. , vol.174 , pp. 2720-2729
    • Yang, Y.1    Ochando, J.2    Yopp, A.3    Bromberg, J.S.4    Ding, Y.5
  • 29
    • 0033152267 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
    • Kim J.I., Ho I.C., Grusby M.J., and Glimcher L.H. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10 (1999) 745-751
    • (1999) Immunity , vol.10 , pp. 745-751
    • Kim, J.I.1    Ho, I.C.2    Grusby, M.J.3    Glimcher, L.H.4
  • 30
    • 0028036941 scopus 로고
    • Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia
    • Walker C., Bauer W., Braun R.K., Menz G., Braun P., Schwarz F., Hansel T.T., and Villiger B. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. Am. J. Respir. Crit. Care Med. 150 (1994) 1038-1048
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150 , pp. 1038-1048
    • Walker, C.1    Bauer, W.2    Braun, R.K.3    Menz, G.4    Braun, P.5    Schwarz, F.6    Hansel, T.T.7    Villiger, B.8
  • 31
    • 0034292488 scopus 로고    scopus 로고
    • Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation
    • Wang J., Homer R.J., Chen Q., and Elias J.A. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J. Immunol. 165 (2000) 4051-4061
    • (2000) J. Immunol. , vol.165 , pp. 4051-4061
    • Wang, J.1    Homer, R.J.2    Chen, Q.3    Elias, J.A.4
  • 34
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005) 1123-1132
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 35
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 37
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 39
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., and Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8 (2007) 942-949
    • (2007) Nat. Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 41
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe E., Servant N., Zollinger R., Bogiatzi S.I., Hupe P., Barillot E., and Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 9 (2008) 650-657
    • (2008) Nat. Immunol. , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupe, P.5    Barillot, E.6    Soumelis, V.7
  • 42
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N., Unutmaz D., and Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9 (2008) 641-649
    • (2008) Nat. Immunol. , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 43
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+ CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., and Wahl S.M. Conversion of peripheral CD4+ CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 44
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C., and Medzhitov R. Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 299 (2003) 1033-1036
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 46
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 51
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
    • Wurster A.L., Rodgers V.L., Satoskar A.R., Whitters M.J., Young D.A., Collins M., and Grusby M.J. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J. Exp. Med. 196 (2002) 969-977
    • (2002) J. Exp. Med. , vol.196 , pp. 969-977
    • Wurster, A.L.1    Rodgers, V.L.2    Satoskar, A.R.3    Whitters, M.J.4    Young, D.A.5    Collins, M.6    Grusby, M.J.7
  • 56
    • 49149092281 scopus 로고    scopus 로고
    • Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile
    • Yadav M., Rosenbaum J., and Goetzl E.J. Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. J. Immunol. 180 (2008) 2772-2776
    • (2008) J. Immunol. , vol.180 , pp. 2772-2776
    • Yadav, M.1    Rosenbaum, J.2    Goetzl, E.J.3
  • 57
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei L., Laurence A., Elias K.M., and O'Shea J.J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282 (2007) 34605-34610
    • (2007) J. Biol. Chem. , vol.282 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'Shea, J.J.4
  • 58
    • 46749133961 scopus 로고    scopus 로고
    • IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    • Sonderegger I., Kisielow J., Meier R., King C., and Kopf M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 38 (2008) 1833-1838
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1833-1838
    • Sonderegger, I.1    Kisielow, J.2    Meier, R.3    King, C.4    Kopf, M.5
  • 59
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet J.M., Chakravarti S., Smyth M.J., and Godfrey D.I. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180 (2008) 7097-7101
    • (2008) J. Immunol. , vol.180 , pp. 7097-7101
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 60
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (T(FH)) cells in normal and dysregulated immune responses
    • King C., Tangye S.G., and Mackay C.R. T follicular helper (T(FH)) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26 (2008) 741-766
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 61
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T., Tangye S.G., Newton R., Frank N., Hodge M.R., Rolph M.S., and Mackay C.R. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173 (2004) 68-78
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.