Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 64, Issue 7, 2009, Pages 995-1002

  Perros, F ^a   Hoogsteden, H C ^b   Coyle, A J ^c   Lambrecht, B N ^a,b   Hammad, H ^a,b  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Animal model; Asthma; Chemokines; Dendritic cells; Eosinophils

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR4 ANTIBODY; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN P 15095; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5; MACROPHAGE DERIVED CHEMOKINE; RECEPTOR ANTIBODY; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL MIGRATION; CHEMOTAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROVOCATION TEST; SCID MOUSE; SEVERE COMBINED IMMUNODEFICIENCY; TH2 CELL;

ANIMALS; ANTIBODIES; ASTHMA; CHEMOKINE CCL17; CHEMOKINE CCL22; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; LUNG; MICE; MICE, SCID; PYROGLYPHIDAE; RECEPTORS, CCR4; TH2 CELLS;

EID: 66749187255     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2009.02095.x     Document Type: Article

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