Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation

Pharmacology

Volumn 84, Issue 3, 2009, Pages 171-182

  Sato, Takashi ^a   Komai, Masato ^a   Iwase, Miho ^a   Kobayashi, Katsuya ^a   Tahara, Harunobu ^a   Ohshima, Etsuo ^a   Arai, Hitoshi ^a   Miki, Ichiro ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

CCR4 antagonist; CCR4+CD4+ T cells; Chemotaxis; Mouse model of asthma; Th2

Indexed keywords

CHEMOKINE RECEPTOR CCR4; K 327; OVALBUMIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; LUNG ALVEOLUS CELL; LYMPHOCYTE MIGRATION; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TH2 CELL;

ANIMALS; ASTHMA; CELL LINE, TUMOR; CELL MOVEMENT; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; HUMANS; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; PYRIDINES; PYRIMIDINES; RECEPTORS, CCR4; TH2 CELLS;

EID: 69149099167     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235748     Document Type: Article

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