Allergen-induced airway inflammation and its therapeutic intervention

Allergy, Asthma and Immunology Research

Volumn 1, Issue 1, 2009, Pages 3-9

  O'Byrne, Paul M ^a  

^a ST JOSEPH S HOSPITAL   (Canada)

Author keywords

Allergen; Asthma; Drug development; Inflammation

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; IMMUNOGLOBULIN E ANTIBODY; LEUKOTRIENE RECEPTOR BLOCKING AGENT; METHYLXANTHINE DERIVATIVE; MONTELUKAST;

ASTHMA; BASOPHIL; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; DRUG EFFICACY; EOSINOPHIL; HUMAN; INFLAMMATION; INHALATION; PATHOPHYSIOLOGY; PROVOCATION TEST; REVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 77953973017     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2009.1.1.3     Document Type: Review

References (70)

1. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, Fitzgerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
2. Kirby JG, Hargreave FE, Gleich GJ, O'Byrne PM. Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 1987;136:379-83.
3. Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, Pedersen SE; GOAL Investigators Group. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 2004;170:836-44. (Pubitemid 39346477)
4. Blackley CH. Experimental researches on the cause and nature of Catarrhus aestivus (Hay-fever or Hay-asthma). London: Balliere Tindall & Cox; 1873.
5. Herxheimer H. The late bronchial reaction in induced asthma. Int Arch Allergy Appl Immunol 1952;3:323-28.
6. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987;136:740-51.
7. Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy 1977;7:503-13. (Pubitemid 8215959)
8. Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE. Allergen- induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol 1982;70:170-7.
9. De Monchy JG, Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, De Vries K. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985;131:373-6. (Pubitemid 15133596)
10. Gauvreau GM, Lee JM, Watson RM, Irani AM, Schwartz LB, O'Byrne PM. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med 2000;161:1473-8.
11. Wood-Baker R, Finnerty JP, Holgate ST. Plasma and urinary histamine in allergen-induced early and late phase asthmatic responses. Eur Respir J 1993;6:1138-44. (Pubitemid 23297927)
12. Manning PJ, Rokach J, Malo JL, Ethier D, Cartier A, Girard Y, Charleson S, O'Byrne PM. Urinary leukotriene E4 levels during early and late asthmatic responses. J Allergy Clin Immunol 1990;86:211-20.
13. Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. Single dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33:1302-8.
14. Cockcroft DW, McParland CP, Britto SA, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993;342:833-7.
15. Cockcroft DW, O'Byrne PM, Swystun VA, Bhagat R. Regular use of inhaled albuterol and the allergen-induced late asthmatic response. J Allergy Clin Immunol 1995;96:44-9.
16. Gauvreau GM, Jordana M, Watson RM, Cockroft DW, O'Byrne PM. Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects. Am J Respir Crit Care Med 1997;156:1738-45. (Pubitemid 28011776)
17. Twentyman OP, Finnerty JP, Harris A, Palmer J, Holgate ST. Protection against allergen-induced asthma by salmeterol. Lancet 1990;336:1338-42.
18. Dente FL, Bancalari L, Bacci E, Bartoli ML, Carnevali S, Cianchetti S, Di Franco A, Giannini D, Vagaggini B, Testi R, Paggiaro PL. Effect of a single dose of salmeterol on the increase in airway eosinophils induced by allergen challenge in asthmatic subjects. Thorax 1999; 54:622-4.
19. Wong BJ, Dolovich J, Ramsdale EH, O'Byrne P, Gontovnick L, Denburg JA, Hargreave FE. Formoterol compared with beclomethasone and placebo on allergen-induced asthmatic responses. Am Rev Respir Dis 1992;146:1156-60.
20. Pedersen B, Dahl R, Larsen BB, Venge P. The effect of salmeterol on the early- and late-phase reaction to bronchial allergen and post-challenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein, and serum eosinophil protein X. Allergy 1993;48:377-82.
21. Weersink EJ, Aalbers R, Koeter GH, Kauffman HF, De Monchy JG, Postma DS. Partial inhibition of the early and late asthmatic response by a single dose of salmeterol. Am J Respir Crit Care Med 1994;150:1262-7.
22. Pizzichini MM, Kidney JC, Wong BJ, Morris MM, Efthimiadis A, Dolovich J, Hargreave FE. Effect of salmeterol compared with beclomethasone on allergen-induced asthmatic and inflammatory responses. Eur Respir J 1996;9:449-55.
23. Brusasco V, Crimi E, Gherson G, Nardelli R, Oldani V, Francucci B, Della Cioppa G, Senn S, Fabbri LM. Actions other than smooth muscle relaxation may play a role in the protective effects of formoterol on the allergen-induced late asthmatic reaction. Pulm Pharmacol Ther 2002;15:399-406.
24. Calhoun WJ, Hinton KL, Kratzenberg JJ. The effect of salmeterol on markers of airway inflammation following segmental allergen challenge. Am J Respir Crit Care Med 2001;163:881-6.
25. Dente FL, Bacci E, Bartoli ML, Cianchetti S, Di Franco A, Giannini D, Taccola M, Vagaggini B, Paggiaro PL. One week treatment with salmeterol does not prevent early and late asthmatic responses and sputum eosinophilia induced by allergen challenge in asthmatics. Pulm Pharmacol Ther 2004;17:147-53.
26. Pauwels R, Van RD, Van der SM, Johannesson N, Persson CG. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. J Allergy Clin Immunol 1985;76:583-90.
27. Crescioli S, Spinazzi A, Plebani M, Pozzani M, Mapp CE, Boschetto P, Fabbri LM. Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects. Ann Allergy 1991;66:245-51.
28. Hendeles L, Harman E, Huang D, O'Brien R, Blake K, Delafuente J. Theophylline attenuation of airway responses to allergen: comparison with cromolyn metered-dose inhaler. J Allergy Clin Immunol 1995;95:505-14.
29. Kraft M, Pak J, Borish L, Martin RJ. Theophylline's effect on neutrophil function and the late asthmatic response. J Allergy Clin Immunol 1996;98:251-7. (Pubitemid 26326117)
30. Cockcroft DW, Murdock KY, Gore BP, O'Byrne PM, Manning P. Theophylline does not inhibit allergen-induced increase in airway responsiveness to methacholine. J Allergy Clin Immunol 1989;83:913-20.
31. Jaffar ZH, Sullivan P, Page C, Costello J. Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics. Eur Respir J 1996;9:456-62.
32. Barnes PJ, Pedersen S, Busse WW. Efficacy and safety of inhaled corticosteroids. New developments. Am J Respir Crit Care Med 1998;157:S1-53.
33. Cockcroft DW, McParland CP, O'Byrne PM, Manning P, Friend JL, Rutherford BC, Swystun VA. Beclomethasone given after the early asthmatic response inhibits the late response and the increased methacholine responsiveness and cromolyn does not. J Allergy Clin Immunol 1993;91:1163-8.
34. Cockcroft DW, Murdock KY. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses,late asthmatic responses,and increased bronchial responsiveness to histamine. J Allergy Clin Immunol 1987;79:734-40.
35. Pepys J, Davies RJ, Breslin AB, Hendrick DJ, Hutchcroft BJ. The effects of inhaled beclomethasone dipropionate (Becotide) and sodium cromoglycate on asthmatic reactions to provocation tests. Clin Allergy 1974;4:13-24.
36. Kidney JC, Boulet LP, Hargreave FE, Deschesnes F, Swystun VA, O'Byrne PM, Choudry N, Morris MM, Jennings B, Andersson N, Andreasson A, Cockcroft DW. Evaluation of single-dose inhaled corticosteroid activity with an allergen challenge model. J Allergy Clin Immunol 1997;100:65-70.
37. Pepys J. Atopy. In: Gell PGH, Coombs RRA, Lachman PJ, editors. Clinical aspects of immunology. Oxford: Blackwell Scientific Publications; 1975. p. 877-902.
38. Burge PS, Efthimiou J, Turner-Warwick M, Nelmes PT. Doubleblind trials of inhaled beclomethasone diproprionate and fluocortin butyl ester in allergen-induced immediate and late asthmatic reactions. Clin Allergy 1982;12:523-31. (Pubitemid 13221262)
39. De Baets FM, Goeteyn M, Kerrebijn KF. The effect of two months of treatment with inhaled budesonide on bronchial responsiveness to histamine and house-dust mite antigen in asthmatic children. Am Rev Respir Dis 1990;142:581-6. (Pubitemid 20292719)
40. Swystun VA, Bhagat R, Kalra S, Jennings B, Cockcroft DW. Comparison of 3 different doses of budesonide and placebo on the early asthmatic response to inhaled allergen. J Allergy Clin Immunol 1998;102:363-7.
41. Wong CS, Wahedna I, Pavord ID, Tattersfield AE. Effect of regular terbutaline and budesonide on bronchial reactivity to allergen challenge. Am J Respir Crit Care Med 1994;150:1268-73. (Pubitemid 24356639)
42. Booij-Noord H, Orie NG, De VK. Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy Clin Immunol 1971;48:344-54.
43. Pepys J, Hargreave FE, Chan M, McCarthy DS. Inhibitory effects of disodium cromoglycate on allergen-inhalation tests. Lancet 1968;2:134-7.
44. Dahl R, Pedersen B. Influence of nedocromil sodium on the dual asthmatic reaction after allergen challenge: a double-blind, placebo- controlled study. Eur J Respir Dis 1986;69:263-5.
45. Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl- leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991;337:690-4.
46. Dahlen B, Zetterstrom O, Bjorck T, Dahlen SE. The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. Eur Respir J 1994;7:324-31. (Pubitemid 24138000)
47. Hamilton A, Faiferman I, Stober P, Watson RM, O'Byrne PM. Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early- and late-phase bronchoconstriction and airway hyperresponsiveness in asthmatic subjects. J Allergy Clin Immunol 1998;102:177-83.
48. Diamant Z, Grootendorst DC, Veselic-Charvat M, Timmers MC, De Smet M, Leff JA, Seidenberg BC, Zwinderman AH, Peszek I, Sterk PJ. The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma. Clin Exp Allergy 1999;29:42-51.
49. Leigh R, Vethanayagam D, Yoshida M, Watson RM, Rerecich T, Inman MD, O'Byrne PM. Effects of montelukast and budesonide on airway responses and airway inflammation in asthma. Am J Respir Crit Care Med 2002;166:1212-7.
50. Palmqvist M, Bruce C, Sjostrand M, Arvidsson P, Lotvall J. Differential effects of fluticasone and montelukast on allergen-induced asthma. Allergy 2005;60:65-70.
51. Nakazawa T, Toyoda T, Furukawa M, Taya T, Kobayashi S. Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects. J Allergy Clin Immunol 1976;58:1-9.
52. Adachi M, Kobayashi H, Aoki N, Iijima M, Kokubu F, Furuya A, Takahashi T. A comparison of the inhibitory effects of ketotifen and disodium cromoglycate on bronchial responses to house dust, with special reference to the late asthmatic response. Pharmatherapeutica 1984;4:36-42. (Pubitemid 14003662)
53. Rafferty P, Ng WH, Phillips G, Clough J, Church MK, Aurich R, Ollier S, Holgate ST. The inhibitory actions of azelastine hydrochloride on the early and late bronchoconstrictor responses to inhaled allergen in atopic asthma. J Allergy Clin Immunol 1989;84:649-57.
54. Hamid M, Rafferty P, Holgate ST. The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoconstriction following allergen challenge in atopic asthma. Clin Exp Allergy 1990;20:261-7.
55. Cockcroft DW, Keshmiri M, Murdock KY, Gore BC. Allergen-induced increase in airway responsiveness is not inhibited by acute treatment with ketotifen or clemastine. Ann Allergy 1992;68:245-50.
56. Twentyman OP, Ollier S, Holgate ST. The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. J Allergy Clin Immunol 1993;91:1169-78. (Pubitemid 23173185)
57. Wasserfallen JB, Leuenberger P, Pecoud A. Effect of cetirizine, a new H1 antihistamine, on the early and late allergic reactions in a bronchial provocation test with allergen. J Allergy Clin Immunol 1993;91:1189-97. (Pubitemid 23173187)
58. Boulet LP, Chapman KR, Cote J, Kalra S, Bhagat R, Swystun VA, Laviolette M, Cleland LD, Deschesnes F, Su JQ, DeVault A, Fick RB Jr, Cockcroft DW. Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med 1997;155:1835-40.
59. Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB Jr, Boushey HA. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 1997;155:1828-34.
60. Freitag A, Watson RM, Matsos G, Eastwood C, O'Byrne PM. Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. Thorax 1993;48:594-8. (Pubitemid 23188430)
61. Evans DJ, Barnes PJ, Cluzel M, O'Connor BJ. Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. Am J Respir Crit Care Med 1997;156:11-6.
62. Manning PJ, Stevens WH, Cockcroft DW, O'Byrne PM. The role of thromboxane in allergen-induced asthmatic responses. Eur Respir J 1991;4:667-72.
63. Beasley RC, Featherstone RL, Church MK, Rafferty P, Varley JG, Harris A, Robinson C, Holgate ST. Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. J Appl Physiol 1989;66:1685-93.
64. Norris V, Choong L, Tran D, Corden Z, Boyce M, Arshad H, Holgate S, O'Connor B, Millet S, Miller B, Rohatagi S, Kirkesseli S. Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol 2005;116:761-7.
65. O'Shaughnessy KM, Taylor IK, O'Connor B, O'Connell F, Thomson H, Dollery CT. Potent leukotriene D4 receptor antagonist ICI 204,219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction. Am Rev Respir Dis 1993;147:1431-5.
66. Barnes PJ. New therapies for asthma. Trends Mol Med 2006;12:515-20.
67. Nagai H, Teramachi H, Tuchiya T. Recent advances in the development of anti-allergic drugs. Allergol Int 2006;55:35-42.
68. Holt PG. Key factors in the development of asthma: atopy. Am J Respir Crit Care Med 2000;161:S172-5.
69. Kips JC, Inman MD, Jayaram L, Bel EH, Parameswaran K, Pizzichini MM, Pavord ID, Djukanovic R, Hargreave FE, Sterk PJ. The use of induced sputum in clinical trials. Eur Respir J Suppl 2002;37:47s-50s.
70. Kharitonov SA, Barnes PJ. Exhaled biomarkers. Chest 2006;130:1541-6.