Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4+ and CD8+ T cells in atopic asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 171, Issue 3, 2005, Pages 224-230

  Cho, Sang Heon ^b   Stanciu, Luminita A ^b   Holgate, Stephen T ^b   Johnston, Sebastian L ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NONE

Author keywords

Asthma; Flow cytometry; Human; Sputum; T lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; ALLERGIC ASTHMA; ARTICLE; BLOOD CYTOLOGY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTOPOIESIS; PRIORITY JOURNAL; SPUTUM CYTODIAGNOSIS; T LYMPHOCYTE; TH2 CELL;

ADULT; ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EOSINOPHILS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; IONOMYCIN; IONOPHORES; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; SPUTUM; T-LYMPHOCYTES, HELPER-INDUCER; TETRADECANOYLPHORBOL ACETATE;

EID: 12744262855     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200310-1416OC     Document Type: Article

References (48)

1. Walker C, Bauer W, Braun RK, Menz G, Braun P, Schwarz F, Hansel TT, Villiger B. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. Am J Respir Crit Care Med 1994;150:1038-1048.
2. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
3. Olivenstein R, Taha R, Minshall EM, Hamid QA. IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash. J Allergy Clin Immunol 1999;103:238-245.
4. + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158:3539-3544.
5. Jung T, Lack G, Schauer U, Uberuck W, Renz H, Gelfand EW, Rieger CH. Decreased frequency of interferon-γ- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level. J Allergy Clin Immunol 1995;96:515-527.
6. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugiu FS, De Carli M, Ricci M, Romagnani S. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of Th1 and Th2 clones. J Immunol 1992;148:2142-2147.
7. Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988;140:4245-4252.
8. Pene J, Rousset F, Briere F, Chretien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai K, Banchereau J, et al. IgE production by normal human lymphocytes is induced by interleukin-4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci USA 1988;85:6880-6884.
9. Lack G, Bradley KL, Hamelmann E, Renz H, Loader J, Leung DY, Larsen G, Gelfand EW. Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J Immunol 1996;157:1432-1439.
10. Tang ML, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet 1994;344:983-985.
11. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax 2002;57:328-332.
12. Corrigan CJ, Kay AB. CD4 T-lymphocyte activation in acute severe asthma: relationship to disease severity and atopic status. Am Rev Respir Dis 1990;141:970-977.
13. Cembrzynska-Nowak M, Szklarz E, Inglot AD, Teodorczyk-Injeyan JA. Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with asthma. Am Rev Respir Dis 1993;147:291-295.
14. Calhoun WJ, Murphy K, Stevens CA, Jarjour NN, Busse WW. Increased interferon-γ and tumor necrosis factor-α in bronchoalveolar lavage (BAL) fluid after antigen challenge in allergic subjects [abstract]. Am Rev Respir Dis 1992;145:A638.
15. ten Hacken NH, Oosterhoff Y, Kauffman HF, Guevarra L, Satoh T, Tollerud DJ, Postma DS. Elevated serum interferon-gamma in atopic asthma correlates with increased airway responsiveness and circadian peak expiratory flow variation. Eur Respir J 1998;11:312-316.
16. Krug N, Madden J, Redington AE, Lackie P, Djukanovic R, Schauer U, Holgate ST, Frew AJ, Howarth PH. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996;14:319-326.
17. + human T cells following a four-step cell separation including magnetic cell sorting (MACS). J Immunol Methods 1996;189:107-115.
18. + T cells in atopic asthma. J Allergy Clin Immunol 1997;100:373-378.
19. + T-cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects. Clin Exp Allergy 2002;32:427-433.
20. Noble A, Truman JP, Vyas B, Vukmanovic-Stejic M, Hirst WJ, Kemeny DM. The balance of protein kinase C and calcium signaling directs T cell subset development. J Immunol 2000;164:1807-1813.
21. +, and gammadelta T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 2001;25:125-131.
22. Brightling CE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2002;110:899-905.
23. Del Prete GF, De Carli M, D'Elios MM, Maestrelli P, Ricci M, Fabbri L, Romagnani S. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 1993;23:1445-1449.
24. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-243.
25. NHBLI/WHO. Global strategy for asthma management and prevention. NHBLI/WHO workshop report, 1995. Publication No. 02-3659.
26. Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SL, Townley RG. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975;56:323-327.
27. Pin I, Gibson PG, Kolendowicz R, Girgis-Gabardo A, Denburg JA, Hargreave FE, Dolovich J. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47:25-29.
28. Pizzichini E, Pizzichini MM, Efthimiadis A, Evans S, Morris MM, Squillace D, Gleich GJ, Dolovich J, Hargreave FE. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid phase measurements. Am J Respir Crit Care Med 1996;154:308-317.
29. Krouwels FH, Hol BE, Bruinier B, Lutter R, Jansen HM, Out TA. Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy subjects. Eur Respir J Suppl 1996;22:95s-103s.
30. Ying S, Durham SR, Corrigan CJ, Hamid Q, Kay AB. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995;12:477-487.
31. Krouwels FH, Nocker RE, Snoek M, Lutter R, van der Zee JS, Weller FR, Jansen HM, Out TA. Immunocytochemical and fluorometric detection of intracellular IL-4, IL-5 and IFN-γ: applications using blood- and airway derived cells. J Immunol Methods 1997;203:89-101.
32. + T cells. Int Arch Allergy Immunol 1995;107:354-355.
33. + cells. Immunol Today 1994;15:107-110.
34. Croft M, Carter L, Swain SL, Dutton RW. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994;180:1715-1728.
35. Poulter LW, Power C, Burke C. The relationship between bronchial immunopathology and hyperresponsiveness in asthma. Eur Respir J 1990;3:792-799.
36. + T lymphocytes contribute to the pathology of asthma death. Am J Respir Crit Care Med 2001;164:560-564.
37. Humbles AA, Conroy DM, Marleau S, Rankin SM, Palframan RT, Proudfoot AE, Wells TN, Li D, Jeffery PK, Griffiths-Johnson DA, et al. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med 1997;186:601-612.
38. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
39. Vercelli D. Regulation of IgE synthesis in humans. J Biol Regul Homeost Agents 1995;9:1-6.
40. Smurthwaite L, Durham SR. Local IgE synthesis in allergic rhinitis and asthma. Curr Allergy Asthma Rep 2002;2:231-238.
41. Court CS, Cook DG, Strachan DP. The descriptive epidemiology of house dust mite-specific and total immunoglobin E in England using a nationally representative sample. Clin Exp Allergy 2002;32:1033-1041.
42. Keatings VM, Evans DJ, O'Connor BJ, Barnes PJ. Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings and bronchoalveolar lavage fluid. Thorax 1997;52:372-374.
43. Maestrelli P, Saetta M, Di Stefano A, Calcagni PG, Turato G, Ruggieri MP, Roggeri A, Mapp CE, Fabbri LM. Comparison of leukocyte counts in sputum, bronchial biopsies and bronchoalveolar lavage. Am J Respir Crit Care Med 1995;152:1926-1931.
44. + T Cells in asthma. Am J Respir Crit Care Med 2000;161:1790-1796.
45. Hartnell A, Kay AB, Wardlaw AJ. IFN-gamma induces the expression of Fc-gamma RII(CD16) on human eosinophils. J Immunol 1992;148:1471-1478.
46. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 1986;137:1893-1896.
47. Look DC, Rapp SR, Keller BT, Holtzman MJ. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells. Am J Physiol 1992;263:L79-L87.
48. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999;103:175-183.